Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.056 | 0.5447 | 1 |
Brugia malayi | eukaryotic translation initiation factor 4E-1 | 0.0067 | 0.0092 | 0.0141 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0067 | 0.0092 | 0.5 |
Loa Loa (eye worm) | raf kinase | 0.0681 | 0.6759 | 1 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0067 | 0.0092 | 0.5 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.056 | 0.5447 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.056 | 0.5447 | 1 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0684 | 0.6795 | 1 |
Giardia lamblia | Translation elongation factor | 0.0067 | 0.0092 | 0.5 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.056 | 0.5447 | 1 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.056 | 0.5447 | 1 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0067 | 0.0092 | 0.5 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0684 | 0.6795 | 0.5745 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.056 | 0.5447 | 1 |
Giardia lamblia | hypothetical protein | 0.0067 | 0.0092 | 0.5 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.056 | 0.5447 | 0.8032 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.056 | 0.5447 | 0.3955 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.056 | 0.5447 | 1 |
Brugia malayi | Eukaryotic translation initiation factor 4E type 3, putative | 0.0067 | 0.0092 | 0.0141 |
Giardia lamblia | Hypothetical protein | 0.0067 | 0.0092 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0067 | 0.0092 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.0092 | 0.5 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.056 | 0.5447 | 1 |
Brugia malayi | hypothetical protein | 0.0286 | 0.2468 | 0.3776 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.056 | 0.5447 | 1 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0388 | 0.3579 | 0.523 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.056 | 0.5447 | 1 |
Brugia malayi | Raf kinase | 0.066 | 0.6536 | 1 |
Leishmania major | eukaryotic translation initiation factor-like | 0.056 | 0.5447 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.2468 | 0.3544 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.2468 | 0.3564 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.056 | 0.5447 | 0.8016 |
Onchocerca volvulus | Putative eukaryotic translation initiation factor 4e | 0.0067 | 0.0092 | 1 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.056 | 0.5447 | 1 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.056 | 0.5447 | 1 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.056 | 0.5447 | 0.7988 |
Brugia malayi | translation initiation factor 4E | 0.056 | 0.5447 | 0.8333 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0684 | 0.6795 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.51 | Antisecretory activty in rat pylorus ligation-induced ulcer model determined by ratio of total acidity inhibition in drug treated to untreated control | ChEMBL. | 17045703 |
Activity (functional) | = 0.54 | Antisecretory activty in rat pylorus ligation-induced ulcer model determined by ratio of free acidity inhibition in drug treated to untreated control | ChEMBL. | 17045703 |
IC50 (binding) | Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 30 mins by spectrofluorimetry | ChEMBL. | 22386984 | |
IC50 (binding) | = 315 uM | Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 30 mins by spectrofluorimetry | ChEMBL. | 22386984 |
Inhibition (binding) | = 32 % | Inhibition of gastric H+/K(+)-ATPase activity in Sprague-Dawley rat microsomal vesicles at 10 umol | ChEMBL. | 17045703 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.