Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cruzipain precursor, putative | 0.0079 | 0.1689 | 0.1365 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0047 | 0.0533 | 0.0163 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0301 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Echinococcus granulosus | cathepsin b | 0.0301 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0292 | 0.9654 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0079 | 0.1689 | 0.1368 |
Brugia malayi | Cathepsin L-like precursor | 0.0055 | 0.0829 | 0.042 |
Echinococcus granulosus | cathepsin l1 | 0.0079 | 0.1689 | 0.1319 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0142 | 0.4053 | 0.3821 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0142 | 0.4053 | 0.3788 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0079 | 0.1689 | 0.1319 |
Giardia lamblia | Cathepsin B precursor | 0.0108 | 0.2793 | 0.2893 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0292 | 0.9654 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0079 | 0.1689 | 0.1319 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0142 | 0.4053 | 0.393 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0047 | 0.0533 | 0.011 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0138 | 0.3897 | 0.376 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0292 | 0.9654 | 0.9638 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0292 | 0.9654 | 0.964 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0079 | 0.1689 | 0.1368 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0079 | 0.1689 | 0.1319 |
Brugia malayi | Cathepsin L-like precursor | 0.0055 | 0.0829 | 0.042 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0292 | 0.9654 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | ctsf protein | 0.0079 | 0.1689 | 0.1365 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0079 | 0.1689 | 0.1319 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0055 | 0.0829 | 0.042 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0301 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0113 | 0.2973 | 0.2759 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0108 | 0.2793 | 0.1386 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0045 | 0.0427 | 0.0053 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.2973 | 0.2759 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0092 | 0.2189 | 0.1841 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0142 | 0.4053 | 0.393 |
Mycobacterium ulcerans | proteasome PrcB | 0.0292 | 0.9654 | 0.5 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0292 | 0.9654 | 0.964 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0063 | 0.1109 | 0.0739 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0292 | 0.9654 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0292 | 0.9654 | 0.9638 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0292 | 0.9654 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | fibroinase | 0.0079 | 0.1689 | 0.1365 |
Loa Loa (eye worm) | cathepsin B | 0.0108 | 0.2793 | 0.2512 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0142 | 0.4053 | 0.3788 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0627 | 0.0261 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Plasmodium vivax | vivapain-2 | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0047 | 0.0533 | 0.0115 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0047 | 0.0533 | 0.011 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0092 | 0.2189 | 0.1841 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0055 | 0.0829 | 0.0435 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0292 | 0.9654 | 0.9638 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0092 | 0.2189 | 0.1841 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0097 | 0.2396 | 0.2135 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0142 | 0.4053 | 0.393 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0108 | 0.2793 | 0.2564 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Echinococcus granulosus | cathepsin l1 | 0.0055 | 0.0829 | 0.042 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0142 | 0.4053 | 0.3788 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0079 | 0.1689 | 0.1319 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Onchocerca volvulus | Cathepsin L homolog | 0.0079 | 0.1689 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0292 | 0.9654 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0829 | 0.047 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0047 | 0.0533 | 0.0115 |
Echinococcus granulosus | cathepsin b | 0.0301 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0045 | 0.0427 | 0.0053 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0055 | 0.0829 | 0.0435 |
Brugia malayi | cathepsin L-like precursor | 0.0055 | 0.0829 | 0.042 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Echinococcus multilocularis | cathepsin b | 0.0301 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0079 | 0.1689 | 0.1365 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0292 | 0.9654 | 0.964 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.1689 | 0.1365 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0079 | 0.1689 | 0.1365 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0301 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0045 | 0.0427 | 0.0053 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0292 | 0.9654 | 1 |
Toxoplasma gondii | cathepsin B | 0.0108 | 0.2793 | 0.1386 |
Echinococcus multilocularis | cysteine protease | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0108 | 0.2793 | 0.2564 |
Entamoeba histolytica | cysteine protease, putative | 0.0079 | 0.1689 | 0.1368 |
Giardia lamblia | Cathepsin B precursor | 0.0108 | 0.2793 | 0.2893 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0113 | 0.2973 | 0.2698 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0047 | 0.0533 | 0.0115 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2189 | 0.1884 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0292 | 0.9654 | 0.9638 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0142 | 0.4053 | 0.3821 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Echinococcus multilocularis | cysteine protease | 0.0079 | 0.1689 | 0.1319 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0292 | 0.9654 | 0.5 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0045 | 0.0427 | 0.0053 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0047 | 0.0533 | 0.0115 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Plasmodium vivax | vivapain-2 | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0079 | 0.1689 | 0.1319 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0047 | 0.0533 | 0.0115 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0292 | 0.9654 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Onchocerca volvulus | Cathepsin L homolog | 0.0079 | 0.1689 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0079 | 0.1689 | 0.1319 |
Trypanosoma cruzi | cysteine protease, putative | 0.0045 | 0.0427 | 0.0053 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.1689 | 0.1365 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.1689 | 0.1365 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0108 | 0.2793 | 0.2893 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0068 | 0.1316 | 0.1363 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0079 | 0.1689 | 0.1368 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.1689 | 0.1368 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0079 | 0.1689 | 0.1319 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.1689 | 0.1365 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0108 | 0.2793 | 0.2512 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0047 | 0.0533 | 0.0115 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0055 | 0.0829 | 0.0435 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Leishmania major | proteasome beta 5 subunit, putative | 0.0292 | 0.9654 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0097 | 0.2396 | 0.2135 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0829 | 0.047 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0142 | 0.4053 | 0.3788 |
Onchocerca volvulus | 0.0079 | 0.1689 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0829 | 0.047 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0108 | 0.2793 | 0.2472 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.1689 | 0.1319 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0055 | 0.0829 | 0.042 |
Loa Loa (eye worm) | cysteine protease | 0.0079 | 0.1689 | 0.1365 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Onchocerca volvulus | Cathepsin F homolog | 0.0079 | 0.1689 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0142 | 0.4053 | 0.393 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0055 | 0.0829 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1689 | 0.1365 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.1689 | 0.1368 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.