TDR Targets

Basic information

Technical information

TDR Targets ID: 433813
Name: 4-bromo-3-(carboxymethyloxy)-5-[3-[[1-[[2-(et hylcarbamoylamino)phenyl]methylsulfonyl]piper idin-4-yl]amino]phenyl]thiophene-2-carboxylic acid
MW: 695.602 | Formula: C28H31BrN4O8S2
H donors: 5 H acceptors: 7 LogP: 4.07 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: CCNC(=O)Nc1ccccc1CS(=O)(=O)N1CCC(CC1)Nc1cccc(c1)c1sc(c(c1Br)OCC(=O)O)C(=O)O
InChi: 1S/C28H31BrN4O8S2/c1-2-30-28(38)32-21-9-4-3-6-18(21)16-43(39,40)33-12-10-19(11-13-33)31-20-8-5-7-17(14-20)25-23(29)24(41-15-22(34)35)26(42-25)27(36)37/h3-9,14,19,31H,2,10-13,15-16H2,1H3,(H,34,35)(H,36,37)(H2,30,32,38)
InChiKey: QEENZXFTRSDPEF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-bromo-3-(carboxymethyloxy)-5-[3-[[1-[[2-(ethylcarbamoylamino)phenyl]methylsulfonyl]-4-piperidyl]amino]phenyl]thiophene-2-carboxylic acid
4-bromo-3-(carboxymethyloxy)-5-[3-[[1-[[2-(ethylcarbamoylamino)phenyl]methylsulfonyl]-4-piperidinyl]amino]phenyl]-2-thiophenecarboxylic acid
4-bromo-3-(carboxymethyloxy)-5-[3-[[1-[2-(ethylcarbamoylamino)benzyl]sulfonyl-4-piperidyl]amino]phenyl]-2-thenoic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein tyrosine phosphatase, non-receptor type 1	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, non-receptor type 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Protein-tyrosine phosphatase containing protein	Get druggable targets OG5_133865	All targets in OG5_133865
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133865	All targets in OG5_133865
Loa Loa (eye worm)	protein-tyrosine phosphatase	Get druggable targets OG5_133865	All targets in OG5_133865
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma japonicum	ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative	Get druggable targets OG5_133865	All targets in OG5_133865

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	protein tyrosine phosphatase	protein tyrosine phosphatase, non-receptor type 2	410 aa	335 aa	25.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	pten, drome, putative	0.0021	0.0077	0.0142
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0056	0.0907	1
Echinococcus multilocularis	thymidine kinase	0.0237	0.5254	0.5254
Echinococcus granulosus	ecdysone induced protein 78C	0.0031	0.0309	0.0309
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0021	0.0077	0.0077
Loa Loa (eye worm)	CYP4Cod1	0.0023	0.0119	0.0119
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0021	0.0077	0.0077
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0434	1	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Echinococcus multilocularis	survival motor neuron protein 1	0.024	0.5329	0.5329
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0085	0.1615	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0031	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0309	0.0309
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0021	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0309	0.0309
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0031	0.0309	0.0309
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0031	0.0309	0.0309
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0031	0.0309	0.0309
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0021	0.0077	0.0077
Echinococcus granulosus	survival motor neuron protein 1	0.024	0.5329	0.5329
Brugia malayi	steroid hormone receptor	0.0031	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Echinococcus granulosus	thymidine kinase	0.0237	0.5254	0.5254
Echinococcus granulosus	thymidine kinase	0.0237	0.5254	0.5254
Onchocerca volvulus	Ribonuclease H1 homolog	0.0022	0.0084	0.0027
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0031	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Trypanosoma brucei	unspecified product	0.0027	0.0202	0.0375
Trypanosoma brucei	ingi protein (ORF1)	0.0027	0.0202	0.0375
Echinococcus multilocularis	hypothetical protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Leishmania major	cytochrome p450-like protein	0.0023	0.0119	0.0221
Loa Loa (eye worm)	MH2 domain-containing protein	0.013	0.2697	0.2697
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0119	0.0119
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0021	0.0077	0.0077
Brugia malayi	MH2 domain containing protein	0.013	0.2697	0.2697
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0309	0.0309
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0085	0.1615	0.1615
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0029	0.0268	0.1661
Schistosoma mansoni	protein tyrosine phosphatase	0.0021	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Schistosoma mansoni	thymidine kinase	0.0237	0.5254	0.5254
Onchocerca volvulus		0.0049	0.0737	0.2444
Trypanosoma brucei	RNA helicase, putative	0.0218	0.4795	0.8888
Brugia malayi	nuclear receptor NHR-88	0.0031	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0021	0.0077	0.0077
Trichomonas vaginalis	thymidine kinase, putative	0.0243	0.5395	1
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0021	0.0077	0.0077
Giardia lamblia	Thymidine kinase	0.0243	0.5395	0.6454
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0031	0.0309	0.0309
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0021	0.0077	0.0142
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0021	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0031	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0309	0.0309
Toxoplasma gondii	hypothetical protein	0.0029	0.0268	0.1661
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0762	0.0762
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0434	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0021	0.0077	0.0142
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0021	0.0077	0.0077
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0119	0.0119
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0031	0.0309	0.0309
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.0309	0.0309
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0031	0.0309	0.0309
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Brugia malayi	RNase H family protein	0.0022	0.0084	0.0084
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0031	0.0309	0.0309
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0029	0.0268	0.1661
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0456	0.0456
Echinococcus granulosus	peptidase Clp S14 family	0.0056	0.0907	0.0907
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Schistosoma mansoni	retinoic acid receptor RXR	0.0031	0.0309	0.0309
Schistosoma mansoni	phosphoglucomutase	0.0022	0.0084	0.0084
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0085	0.1615	1
Schistosoma mansoni	nuclear hormone receptor	0.0031	0.0309	0.0309
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0085	0.1615	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0053	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0309	0.0309
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0021	0.0077	0.0077
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.087	0.087
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0085	0.1615	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Echinococcus multilocularis	ribonuclease H1	0.0022	0.0084	0.0084
Entamoeba histolytica	thymidine kinase, putative	0.0243	0.5395	1
Schistosoma mansoni	phosphoglucomutase	0.0022	0.0084	0.0084
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Toxoplasma gondii	ribonuclease HI protein	0.0022	0.0084	0.0519
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0762	0.0762
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Echinococcus multilocularis		0.0021	0.0077	0.0077
Onchocerca volvulus	Huntingtin homolog	0.0134	0.2779	1
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0119	0.0221
Loa Loa (eye worm)	transcription factor SMAD2	0.013	0.2697	0.2697
Loa Loa (eye worm)	hypothetical protein	0.0054	0.087	0.087
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0031	0.0309	0.0309
Schistosoma mansoni	hypothetical protein	0.005	0.0769	0.0769
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Onchocerca volvulus		0.0031	0.0309	0.0859
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0737	0.0737
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0021	0.0077	0.0142
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0762	0.0762
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0737	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Echinococcus multilocularis	thymidine kinase	0.0237	0.5254	0.5254
Treponema pallidum	ribonuclease H (rnhA)	0.0022	0.0084	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0021	0.0077	0.0077
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0085	0.1615	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0021	0.0077	0.0077
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0021	0.0077	0.0077
Brugia malayi	ecdysteroid receptor	0.0031	0.0309	0.0309
Schistosoma mansoni	hypothetical protein	0.0037	0.0456	0.0456
Trypanosoma cruzi	ribonuclease H1, putative	0.0022	0.0084	0.0155
Giardia lamblia	Deoxynucleoside kinase	0.0366	0.836	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0021	0.0077	0.0077
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0031	0.0309	0.0309
Echinococcus multilocularis	transfer RNA-Ile	0.0237	0.5254	0.5254
Onchocerca volvulus	Protein ultraspiracle homolog	0.0031	0.0309	0.0859
Brugia malayi	RNase H family protein	0.0022	0.0084	0.0084
Brugia malayi	Steroid receptor seven-up type 2	0.0031	0.0309	0.0309
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0031	0.0309	0.0309
Leishmania major	thymidine kinase, putative	0.0243	0.5395	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0031	0.0309	0.0309
Schistosoma mansoni	pcd6 interacting protein-related	0.0021	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0031	0.0309	0.0309
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0021	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Trypanosoma brucei	ingi protein (ORF1)	0.0027	0.0202	0.0375
Schistosoma mansoni	protein tyrosine phosphatase	0.0021	0.0077	0.0077
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0434	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0762	0.0762
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0762	0.0762
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0031	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2779	0.2779
Trichomonas vaginalis	thymidine kinase, putative	0.0243	0.5395	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0021	0.0077	0.0077
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0021	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0021	0.0077	0.0077
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0031	0.0309	0.0309
Onchocerca volvulus	Huntingtin homolog	0.0134	0.2779	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0031	0.0309	0.0309
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2779	0.2779
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0434	1	1
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0119	0.0119
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0031	0.0309	0.0859
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0085	0.1615	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0021	0.0077	0.0077
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0021	0.0077	0.0077
Brugia malayi	hypothetical protein	0.0134	0.2779	0.2779
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0031	0.0309	0.0309
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0056	0.0907	0.0907
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0031	0.0309	0.0309
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.0309	0.0309
Trypanosoma cruzi	ribonuclease H1, putative	0.0022	0.0084	0.0155
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0021	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Schistosoma mansoni	thyroid hormone receptor	0.0153	0.3252	0.3252
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1615	0.1615
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0031	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0309	0.0309
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0031	0.0309	0.0309
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0031	0.0309	0.0309
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0762	0.0762
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0085	0.1615	1
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Trichomonas vaginalis	thymidine kinase, putative	0.0243	0.5395	1
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0021	0.0077	0.0077
Brugia malayi	photoreceptor-specific nuclear receptor	0.0031	0.0309	0.0309
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Trichomonas vaginalis	ribonuclease H1, putative	0.0022	0.0084	0.0155
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0021	0.0077	0.0077
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0056	0.0907	0.4744
Schistosoma mansoni	coup transcription factor	0.0031	0.0309	0.0309
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0085	0.1615	0.5
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0021	0.0077	0.0077
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0021	0.0077	0.0077
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0031	0.0309	0.0309
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0031	0.0309	0.0309
Schistosoma mansoni	hypothetical protein	0.0122	0.2503	0.2503
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0021	0.0077	0.0142
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0031	0.0309	0.0309
Onchocerca volvulus	Bile acid receptor homolog	0.0031	0.0309	0.0859
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0031	0.0309	0.0309
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0021	0.0077	0.0077
Echinococcus granulosus	ribonuclease H1	0.0022	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0031	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0023	0.0119	0.074
Brugia malayi	Protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Giardia lamblia	Protein tyrosine phosphatase	0.0021	0.0077	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase 1	0.0021	0.0077	0.0077
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0085	0.1615	0.1615
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0021	0.0077	0.0077
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0027	0.0202	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0456	0.0456
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0029	0.0268	0.1661
Brugia malayi	hypothetical protein	0.0021	0.0077	0.0077
Echinococcus granulosus	Thymidine kinase 2 mitochondrial	0.0237	0.5254	0.5254
Brugia malayi	hypothetical protein	0.0021	0.0077	0.0077
Echinococcus granulosus	FTZ F1 alpha	0.0031	0.0309	0.0309
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.0309	0.0309
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0762	0.0762
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0021	0.0077	0.0077
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.0309	0.0309
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.087	0.087
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0021	0.0077	0.0077
Trypanosoma brucei	thymidine kinase	0.0243	0.5395	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0031	0.0309	0.0309
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0021	0.0077	0.0077
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0021	0.0077	0.0077
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0119	0.0119
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0021	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0762	0.0762
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0056	0.0907	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0021	0.0077	0.0077
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0031	0.0309	0.0309
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0031	0.0309	0.0309
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Giardia lamblia	Ribonuclease H	0.0022	0.0084	0.01
Echinococcus multilocularis	FTZ F1 alpha	0.0031	0.0309	0.0309
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0085	0.1615	1
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0021	0.0077	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0309	0.0309
Brugia malayi	Probable ClpP-like protease	0.0085	0.1615	0.1615
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0021	0.0077	0.0142
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0022	0.0084	0.0519
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0021	0.0077	0.0077
Trypanosoma brucei	ribonuclease H1	0.0022	0.0084	0.0155
Schistosoma mansoni	protein tyrosine phosphatase	0.0021	0.0077	0.0077
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0021	0.0077	0.0077
Schistosoma mansoni	thyroid hormone receptor	0.0153	0.3252	0.3252
Leishmania major	ribonuclease H1, putative	0.0022	0.0084	0.0155
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0153	0.3252	0.3252
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0085	0.1615	1
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0119	0.0221
Schistosoma mansoni	phosphoglucomutase	0.0022	0.0084	0.0084
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0021	0.0077	0.0142
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0021	0.0077	0.0077
Brugia malayi	nuclear hormone receptor	0.0031	0.0309	0.0309
Brugia malayi	hypothetical protein	0.024	0.5329	0.5329
Trypanosoma cruzi	thymidine kinase, putative	0.0243	0.5395	1
Schistosoma mansoni	peptidase Clp (S14 family)	0.0085	0.1615	0.1615
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Trypanosoma cruzi	thymidine kinase, putative	0.0243	0.5395	1
Brugia malayi	hypothetical protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Brugia malayi	hypothetical protein	0.0021	0.0077	0.0077
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0021	0.0077	0.0077
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0031	0.0309	0.0309
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0021	0.0077	0.0077
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0021	0.0077	0.0077
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0031	0.0309	0.0309
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.2503	0.2503
Leishmania major	tyrosine specific protein phosphatase, putative	0.0021	0.0077	0.0142
Echinococcus multilocularis	ecdysone induced protein 78C	0.0031	0.0309	0.0309
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0762	0.0762
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0021	0.0077	0.0142
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0031	0.0309	0.0309
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0021	0.0077	0.0077
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0031	0.0309	0.0309
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0021	0.0077	0.0077
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.2503	0.2503
Brugia malayi	RNase H family protein	0.0022	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Schistosoma mansoni	hypothetical protein	0.0218	0.4795	0.4795
Brugia malayi	Cytochrome P450 family protein	0.0053	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0309	0.0309
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0021	0.0077	0.0077
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0085	0.1615	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Schistosoma mansoni	hypothetical protein	0.0049	0.0737	0.0737
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Brugia malayi	hypothetical protein	0.0021	0.0077	0.0077
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0031	0.0309	0.0309
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0031	0.0309	0.0309
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0021	0.0077	0.0077
Trypanosoma brucei	cytochrome P450, putative	0.0023	0.0119	0.0221
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0021	0.0077	0.0077
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0021	0.0077	0.0077
Loa Loa (eye worm)	steroid hormone receptor	0.0031	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0077
Trypanosoma brucei	hypothetical protein, conserved	0.0027	0.0202	0.0375
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0077	0.0077
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.087	0.087
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.024	0.5329	0.5329

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.012 uM	Inhibition of human recombinant TCPTP	ChEMBL.	17705360
Ki (binding)	= 0.012 uM	Inhibition of human recombinant TCPTP	ChEMBL.	17705360
Ki (binding)	= 0.014 uM	Inhibition of human recombinant PTP1B	ChEMBL.	17705360
Ki (binding)	= 0.014 uM	Inhibition of human recombinant PTP1B	ChEMBL.	17705360

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL397903
PubChem: 17758809

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 433813