Detailed information for compound 434062

Basic information

Technical information
  • TDR Targets ID: 434062
  • Name: 6-[4-(trifluoromethyl)phenyl]pyrrolo[3,4-b]py razine-5,7-dione
  • MW: 293.201 | Formula: C13H6F3N3O2
  • H donors: 0 H acceptors: 4 LogP: 1.87 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(c2ccc(cc2)C(F)(F)F)C(=O)c2c1nccn2
  • InChi: 1S/C13H6F3N3O2/c14-13(15,16)7-1-3-8(4-2-7)19-11(20)9-10(12(19)21)18-6-5-17-9/h1-6H
  • InChiKey: JMSYUQMFFUOONH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[4-(trifluoromethyl)phenyl]pyrrolo[3,4-b]pyrazine-5,7-quinone
  • MLS000729209
  • SMR000307487
  • ZINC00068919
  • A3663/0155275
  • 6-[4-(trifluoromethyl)phenyl]-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Smad4 0.0024 0.0061 0.0178
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.021
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0544 0.2762 0.3824
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0044 0.0166 0.1379
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0084 0.046
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0061 0.0331
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.002 0.0038 0.005
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0084 0.0248
Schistosoma mansoni hypothetical protein 0.0039 0.014 0.0399
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0166 0.1338
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Brugia malayi hypothetical protein 0.005 0.0192 0.1084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0061
Brugia malayi nuclear receptor NHR-88 0.002 0.0038 0.0216
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0024 0.0017
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0058 0.0237 0.1878
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0038 0.011
Toxoplasma gondii selenide, water dikinase 0.002 0.0038 0.005
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.027
Entamoeba histolytica thioredoxin reductase, putative 0.002 0.0038 0.0336
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0364 0.1828 0.6563
Brugia malayi MH2 domain containing protein 0.0024 0.0061 0.0341
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0074 0.0322 0.2899
Loa Loa (eye worm) AGC/AKT protein kinase 0.0017 0.0024 0.0132
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.1143 0.6254
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0024 0.0017
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0044 0.0166 0.0933
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0038 0.0216
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0024 0.0017
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0038 0.0189
Loa Loa (eye worm) transcription factor SMAD2 0.0354 0.1775 0.9711
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1167 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0132 0.0962
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.002 0.0038 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus multilocularis expressed conserved protein 0.0089 0.0399 0.1175
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0038 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0038 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.051 0.1459
Brugia malayi MH1 domain containing protein 0.0024 0.0061 0.0341
Brugia malayi MH1 domain containing protein 0.0024 0.0061 0.0341
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0132
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0074 0.0322 0.2899
Brugia malayi p70 ribosomal S6 kinase beta 0.0017 0.0024 0.0136
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.051
Plasmodium falciparum phosphodiesterase gamma, putative 0.0044 0.0166 0.1338
Onchocerca volvulus 0.0233 0.1143 0.7856
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0038 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0038 0.0216
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0094 0.0532
Brugia malayi Protein kinase domain containing protein 0.0017 0.0024 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Trypanosoma brucei unspecified product 0.004 0.0143 0.1163
Plasmodium vivax glutathione reductase, putative 0.0215 0.105 1
Entamoeba histolytica disulphide oxidoreductase, putative 0.002 0.0038 0.0336
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0546 0.2773 0.2745
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0074 0.0322 0.0285
Echinococcus granulosus expressed conserved protein 0.0089 0.0399 0.1175
Onchocerca volvulus 0.003 0.0093 0.057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0038 0.0216
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0055 0.0219 0.1234
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0166 0.1338
Schistosoma mansoni sulfide quinone reductase 0.002 0.0038 0.0108
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.002 0.0038 0.0009
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0038 0.0136
Loa Loa (eye worm) hypothetical protein 0.005 0.0192 0.1053
Trichomonas vaginalis DNA polymerase eta, putative 0.0058 0.0237 0.1878
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.002 0.0038 0.0136
Loa Loa (eye worm) hypothetical protein 0.0044 0.0166 0.0906
Trichomonas vaginalis C-MYB, putative 0.0038 0.0132 0.0962
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1379
Onchocerca volvulus 0.002 0.0038 0.0185
Trichomonas vaginalis MYB, putative 0.0038 0.0133 0.097
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1338
Loa Loa (eye worm) PDE1B protein 0.0044 0.0166 0.0906
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0061 0.0178
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.3399 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus granulosus tar DNA binding protein 0.0062 0.0257 0.0756
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0029 0.0047
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0038 0.005
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0132 0.0962
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0166 0.1338
Loa Loa (eye worm) hypothetical protein 0.0079 0.0345 0.1889
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0015 0.0011 0.0033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0257 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0029 0.0047
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0166 0.1338
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0038 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0299 0.0878
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0038 0.005
Echinococcus granulosus geminin 0.0503 0.2547 0.7493
Schistosoma mansoni protein kinase C 0.0015 0.0011 0.0032
Leishmania major hypothetical protein, conserved 0.005 0.0192 0.1601
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0044 0.0166 0.0933
Echinococcus granulosus glutamate synthase 0.002 0.0038 0.0111
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0074 0.0322 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0038 0.0216
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0074 0.0322 0.092
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0132 0.0962
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0038 0.0216
Mycobacterium tuberculosis Probable dehydrogenase 0.0489 0.2478 0.3425
Brugia malayi CHE-14 protein 0.0041 0.0147 0.083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0322 0.2865
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0237 0.2077
Mycobacterium tuberculosis Probable reductase 0.0489 0.2478 0.3425
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.032 0.1598 0.9
Trypanosoma brucei DNA polymerase eta, putative 0.0084 0.0373 0.3397
Brugia malayi hypothetical protein 0.0118 0.055 0.3099
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0024 0.0017
Plasmodium falciparum thioredoxin reductase 0.0074 0.0322 0.2865
Leishmania major hypothetical protein, conserved 0.0044 0.0166 0.1338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0038 0.021
Leishmania major DNA polymerase eta, putative 0.0084 0.0373 0.3365
Loa Loa (eye worm) hypothetical protein 0.0118 0.055 0.3009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0038 0.0113
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0061 0.0178
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0192 0.1601
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus multilocularis protein patched 0.0041 0.0147 0.0433
Giardia lamblia hypothetical protein 0.0044 0.0166 0.076
Giardia lamblia Hypothetical protein 0.0044 0.0166 0.076
Loa Loa (eye worm) hypothetical protein 0.0118 0.055 0.3009
Loa Loa (eye worm) nuclear factor I 0.0013 0.0005 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0166 0.1253
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0017 0.0024 0.0132
Loa Loa (eye worm) hypothetical protein 0.0044 0.0166 0.0906
Schistosoma mansoni hypothetical protein 0.0039 0.014 0.0399
Trypanosoma brucei hypothetical protein, conserved 0.0044 0.0166 0.1379
Brugia malayi hypothetical protein 0.0032 0.0101 0.0571
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0215 0.105 0.1421
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0038 0.0133
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.021
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0044 0.0166 0.1338
Schistosoma mansoni hypothetical protein 0.0039 0.014 0.0399
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0641 0.1887
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.002 0.0038 0.0049
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0038 0.0213
Schistosoma mansoni smad 0.0024 0.0061 0.0173
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0044 0.0166 0.0487
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0017 0.0024 0.0132
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Giardia lamblia NADH oxidase lateral transfer candidate 0.0074 0.0322 0.1626
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0058 0.0237 0.0698
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0017 0.0024 0.0071
Schistosoma mansoni hypothetical protein 0.0066 0.0279 0.0799
Trypanosoma brucei unspecified product 0.004 0.0143 0.1163
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0044 0.0166 0.0487
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0257 0.0756
Loa Loa (eye worm) thioredoxin reductase 0.0215 0.105 0.5744
Loa Loa (eye worm) hypothetical protein 0.0104 0.0474 0.2595
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0038 0.0216
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1391 0.7163 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0147 0.1092
Brugia malayi glutamate synthase 0.002 0.0038 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.051 0.1459
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0044 0.0166 0.0474
Brugia malayi ImpB/MucB/SamB family protein 0.0058 0.0237 0.1336
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0544 0.2762 0.3824
Echinococcus multilocularis serine threonine protein kinase 0.0099 0.0447 0.1316
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0024 0.0069
Loa Loa (eye worm) hypothetical protein 0.0084 0.0373 0.2038
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0166 0.1253
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0017 0.0024 0.0071
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0237 0.2077
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0061 0.0331
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1338
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0147 0.0433
Brugia malayi MH2 domain containing protein 0.0354 0.1775 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0143 0.1163
Brugia malayi Protein kinase c protein 2 0.0094 0.0423 0.2384
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0074 0.0322 0.0398
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0044 0.0166 0.0487
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0074 0.0322 0.2899
Mycobacterium ulcerans glutamate synthase subunit beta 0.002 0.0038 0.0009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0038 0.021
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.002 0.0038 0.0086
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0192 0.1601
Loa Loa (eye worm) RNA binding protein 0.0062 0.0257 0.1406
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.032 0.1598 0.874
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Leishmania major hypothetical protein, conserved 0.002 0.0038 0.0086
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0038 0.0216
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0192 0.1601
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0166 0.1338
Brugia malayi Hr1 repeat family protein 0.0017 0.0024 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0257 0.0735
Giardia lamblia Thioredoxin reductase 0.002 0.0038 0.0049
Echinococcus multilocularis smad 0.0024 0.0061 0.0178
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0058 0.0237 0.028
Brugia malayi polk-prov protein 0.0018 0.0029 0.0163
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.021
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0429 0.1263
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0132 0.0962
Echinococcus granulosus dna polymerase kappa 0.0058 0.0237 0.0698
Echinococcus granulosus protein kinase c iota type 0.0029 0.0087 0.0256
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0038 0.0213
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.002 0.0038 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0143 0.1163
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.002 0.0038 0.0133
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.002 0.0038 0.0086
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0166 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0038 0.0216
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0166 0.0487
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0237 0.2077
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0038 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0038 0.0216
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0364 0.1828 0.5378
Loa Loa (eye worm) AGC/NDR protein kinase 0.0017 0.0024 0.0132
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0546 0.2773 0.2752
Loa Loa (eye worm) hypothetical protein 0.0041 0.0147 0.0806
Echinococcus granulosus unc 13 munc13 0.0015 0.0011 0.0033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0038 0.011
Echinococcus multilocularis RNA directed DNA polymerase 0.0079 0.0345 0.1016
Echinococcus granulosus NDR protein kinase 0.0017 0.0024 0.0071
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0166 0.1253
Brugia malayi ImpB/MucB/SamB family protein 0.0084 0.0373 0.2099
Brugia malayi Pre-SET motif family protein 0.003 0.0093 0.0526
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0025
Brugia malayi ecdysteroid receptor 0.002 0.0038 0.0216
Brugia malayi hypothetical protein 0.007 0.0299 0.1682
Echinococcus granulosus sulfide:quinone oxidoreductase 0.002 0.0038 0.0111
Schistosoma mansoni hypothetical protein 0.0022 0.0051 0.0145
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0038 0.0136
Onchocerca volvulus Huntingtin homolog 0.0118 0.055 0.3741
Echinococcus granulosus protein kinase c epsilon type 0.0032 0.01 0.0294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0038 0.021
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0044 0.0166 0.0933
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Plasmodium vivax phosphodiesterase gamma, putative 0.0044 0.0166 0.1338
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0038 0.011
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0061 0.0178
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0051 0.0149
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Schistosoma mansoni sulfide quinone reductase 0.002 0.0038 0.0108
Echinococcus multilocularis protein dispatched 1 0.0047 0.0177 0.0521
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.002 0.0038 0.0336
Leishmania major hypothetical protein, conserved 0.0044 0.0166 0.1338
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.002 0.0038 0.0336
Trypanosoma cruzi DNA polymerase eta, putative 0.0084 0.0373 0.3365
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0364 0.1828 0.5378
Onchocerca volvulus 0.0029 0.0084 0.0507
Schistosoma mansoni hypothetical protein 0.0039 0.014 0.0399
Loa Loa (eye worm) hypothetical protein 0.0031 0.0094 0.0517
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0192 0.1641
Echinococcus multilocularis unc 13 (munc13) 0.0015 0.0011 0.0033
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0166 0.1379
Onchocerca volvulus 0.0292 0.1452 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0058 0.0237 0.5258
Onchocerca volvulus 0.0237 0.1167 0.8022
Echinococcus granulosus protein kinase C gamma type 0.0099 0.0447 0.1316
Brugia malayi glutathione reductase 0.0215 0.105 0.5915
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.002 0.0038 0.0086
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0044 0.0166 0.0487
Plasmodium falciparum glutathione reductase 0.0074 0.0322 0.2865
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0074 0.0322 0.2865
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0489 0.2478 0.3425
Brugia malayi protein kinase C II. 0.0032 0.01 0.0564
Plasmodium vivax ferrodoxin reductase, putative 0.002 0.0038 0.0086
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.002 0.0038 0.0111
Schistosoma mansoni serine/threonine kinase 0.0017 0.0024 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0038 0.021
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.002 0.0038 0.0009
Loa Loa (eye worm) Smad1 0.0024 0.0061 0.0331
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0166 0.1338
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0074 0.0322 0.0946
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0038 0.0111
Leishmania major trypanothione reductase 0.0215 0.105 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0044 0.0166 0.1379
Echinococcus multilocularis cpg binding protein 0.003 0.0093 0.0273
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1391 0.7163 1
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0038 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0257 0.0735
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0051 0.0149
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0038 0.0133
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0237 0.204
Schistosoma mansoni hypothetical protein 0.007 0.0299 0.0854
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0038 0.0113
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus multilocularis protein kinase c iota type 0.0029 0.0087 0.0256
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0038 0.0113
Trichomonas vaginalis MYB3r3, putative 0.0038 0.0132 0.0962
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0322 0.2865
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0038 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0237 0.2077
Mycobacterium ulcerans monoxygenase 0.002 0.0038 0.0009
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0132 0.2671
Echinococcus granulosus FTZ F1 alpha 0.002 0.0038 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.01 0.0286
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0166 0.1338
Echinococcus granulosus microtubule associated protein 2 0.0667 0.3399 1
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0024 0.0017
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0074 0.0322 0.2899
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0093 0.0267
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0038 0.0216
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0094 0.0532
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0166 0.0474
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0544 0.2762 0.3824
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0038 0.0113
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0029 0.0083
Loa Loa (eye worm) MH2 domain-containing protein 0.0354 0.1775 0.9711
Loa Loa (eye worm) AGC/PKN protein kinase 0.0017 0.0024 0.0132
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0093 0.0275
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0166 0.0487
Leishmania major NADH dehydrogenase, putative 0.002 0.0038 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0024 0.0069
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1937 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0237 0.0209
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0038 0.021
Trichomonas vaginalis mercuric reductase, putative 0.0074 0.0322 0.2615
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0029 0.0047
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0147 0.0806
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0132 0.2671
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0038 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0038 0.021
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0166 0.1338
Entamoeba histolytica hypothetical protein 0.007 0.0299 0.6771
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0029 0.0047
Trichomonas vaginalis glutathione reductase, putative 0.0074 0.0322 0.2615
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0038 0.0133
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.002 0.0038 0.0336
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.002 0.0038 0.0111
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0489 0.2478 0.3425
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0058 0.0237 0.204
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.0237 0.028
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.002 0.0038 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0093 0.0267
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0223 0.0724
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0257 0.0735
Schistosoma mansoni unc-13 (munc13) 0.0015 0.0011 0.0032
Toxoplasma gondii NADPH-glutathione reductase 0.0074 0.0322 0.1082
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0299 0.0854
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0074 0.0322 0.0293
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0044 0.0166 0.0487
Mycobacterium ulcerans hypothetical protein 0.002 0.0038 0.0009
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0015 0.0011 0.0033
Schistosoma mansoni coup transcription factor 0.002 0.0038 0.011
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0546 0.2773 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0044 0.0166 0.0474
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0038 0.0113
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.027
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0038 0.0086
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0166 0.0933
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0093 0.0275
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0437 0.125
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0192 0.1601
Schistosoma mansoni hypothetical protein 0.0503 0.2547 0.7286
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0038 0.0136
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0237 0.204
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0166 0.0474
Trichomonas vaginalis pc-MYB2, putative 0.0038 0.0132 0.0962
Mycobacterium tuberculosis Probable oxidoreductase 0.0544 0.2762 0.3824
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0322 0.2865
Brugia malayi steroid hormone receptor 0.002 0.0038 0.0216
Brugia malayi TAR-binding protein 0.0062 0.0257 0.1447
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0166 0.0474
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0439 0.2471
Brugia malayi nuclear hormone receptor 0.002 0.0038 0.0216
Brugia malayi MH1 domain containing protein 0.0013 0.0005 0.0026
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0164 0.1326
Mycobacterium ulcerans NADH dehydrogenase 0.002 0.0038 0.0009
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0279 0.1574
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0147 0.0433
Echinococcus multilocularis geminin 0.0503 0.2547 0.7493
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.002 0.0038 0.0213
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.021
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.1067
Echinococcus granulosus GPCR family 2 0.0031 0.0094 0.0278
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.0024 0.0071
Brugia malayi RNA binding protein 0.0062 0.0257 0.1447
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0061 0.0173
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0166 0.0487
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1937 1 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0044 0.0166 0.1338
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0074 0.0322 0.2865
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.0038 0.0336
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0132 0.0962
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.0038 0.0086
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.002 0.0038 0.005
Toxoplasma gondii thioredoxin reductase 0.0215 0.105 0.3733
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0074 0.0322 0.2865
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.002 0.0038 0.0111
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0257 0.0735
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0164 0.051
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0257 0.0735
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0094 0.0278
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0166 0.1379
Echinococcus granulosus Smad4 0.0024 0.0061 0.0178
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0166 0.0487
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0032 0.01 0.0547
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0024 0.0017
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0044 0.0166 0.0474
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0038 0.0136
Onchocerca volvulus 0.002 0.0038 0.0189
Plasmodium falciparum phosphodiesterase delta, putative 0.0044 0.0166 0.1338
Schistosoma mansoni thyroid hormone receptor 0.002 0.0038 0.011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0322 0.2865
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0061 0.0178
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0094 0.0278
Echinococcus granulosus serine:threonine protein kinase N2 0.0017 0.0024 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0237 0.2077
Schistosoma mansoni DNA polymerase eta 0.0084 0.0373 0.1066
Brugia malayi MH2 domain containing protein 0.0024 0.0061 0.0341
Trichomonas vaginalis pc-MYB2, putative 0.0038 0.0132 0.0962
Echinococcus granulosus dna polymerase eta 0.0084 0.0373 0.1096
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0038 0.0113
Giardia lamblia DINP protein human, muc B family 0.0058 0.0237 0.1158
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0104 0.0474 0.2595
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0237 0.2077
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0038 0.0111
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0058 0.0237 0.1298
Trypanosoma brucei trypanothione reductase 0.0215 0.105 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0093 0.0267
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.027
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0017 0.0024 0.0071
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.002 0.0038 0.0133
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0038 0.011
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0038 0.0136
Trichomonas vaginalis MYB72, putative 0.0038 0.0132 0.0962
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0237 0.2077
Entamoeba histolytica hypothetical protein 0.007 0.0299 0.6771
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.3399 0.9723
Trichomonas vaginalis apoptosis inducing factor, putative 0.002 0.0038 0.0136
Trypanosoma cruzi trypanothione reductase, putative 0.0215 0.105 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0074 0.0322 0.0285
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0044 0.0166 0.0906
Loa Loa (eye worm) hypothetical protein 0.0097 0.0439 0.2399
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0038 0.011
Leishmania major hypothetical protein, conserved 0.002 0.0038 0.0086
Brugia malayi Protein kinase domain containing protein 0.0017 0.0024 0.0136
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1338
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0038 0.0113
Schistosoma mansoni cpg binding protein 0.003 0.0093 0.0265
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0158
Trichomonas vaginalis C-MYB, putative 0.0038 0.0132 0.0962
Schistosoma mansoni disulfide oxidoreductase 0.002 0.0038 0.0108
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Leishmania major DNA polymerase kappa, putative 0.0058 0.0237 0.204
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0038 0.011
Loa Loa (eye worm) hypothetical protein 0.0091 0.0408 0.2233
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0166 0.0933
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1018 0.5568
Schistosoma mansoni patched 1 0.0041 0.0147 0.0421
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.002 0.0038 0.0086
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.032 0.1598 0.4701
Echinococcus multilocularis glutamate synthase 0.002 0.0038 0.0111
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0017 0.0024 0.0132
Echinococcus multilocularis protein kinase c epsilon type 0.0032 0.01 0.0294
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0132 0.2671
Loa Loa (eye worm) hypothetical protein 0.0044 0.0166 0.0906
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0094 0.0278
Schistosoma mansoni glutamate synthase 0.002 0.0038 0.0108
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0074 0.0322 0.2865
Schistosoma mansoni atypical protein kinase C 0.0029 0.0087 0.0249
Mycobacterium ulcerans dehydrogenase 0.002 0.0038 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0038 0.021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0094 0.0278
Leishmania major cAMP-specific phosphodiesterase, putative 0.0044 0.0166 0.1338
Echinococcus multilocularis transcription factor eb 0.0104 0.0477 0.1403
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0024 0.0017
Echinococcus multilocularis thioredoxin glutathione reductase 0.0216 0.1055 0.3105
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0038 0.0216
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0044 0.0166 0.1338
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1338
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0038 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0038 0.0086
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0038 0.0136
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0429 1
Schistosoma mansoni hypothetical protein 0.002 0.0038 0.0108
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0132 0.0962
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.002 0.0038 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0024 0.0069
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0038 0.0111
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0024 0.0017
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0237 0.2077
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0166 0.1338
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0017 0.0024 0.0071
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.002 0.0038 0.0136
Brugia malayi Smad1 0.0024 0.0061 0.0341
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0166 0.0487
Giardia lamblia Glutamate synthase 0.002 0.0038 0.0049
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0364 0.1828 0.5378
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.032 0.1598 0.4701
Schistosoma mansoni unc-13 (munc13) 0.0015 0.0011 0.0032
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0074 0.0322 0.0293
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0082 0.036 0.1971
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0093 0.0267
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0058 0.0237 0.0698
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0038 0.0216
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0029 0.0018
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus granulosus RNA directed DNA polymerase 0.0079 0.0345 0.1016
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0029 0.0047
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0429 0.2419
Entamoeba histolytica hypothetical protein 0.007 0.0299 0.6771
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0133 0.097
Brugia malayi hypothetical protein 0.0292 0.1452 0.818
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0237 0.204
Echinococcus multilocularis dna polymerase eta 0.0084 0.0373 0.1096
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.002 0.0038 0.0009
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0546 0.2773 0.3838
Brugia malayi CXXC zinc finger family protein 0.0029 0.0084 0.0474
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.002 0.0038 0.0111
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.021
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0024 0.0017
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0079 0.0345 0.1016
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.002 0.0038 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0237 0.2077
Onchocerca volvulus Huntingtin homolog 0.0118 0.055 0.3741
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1338
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0641 0.1887
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0038 0.0189
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0038 0.0113
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0429 0.1263
Schistosoma mansoni terminal deoxycytidyl transferase 0.0058 0.0237 0.0679
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0364 0.1828 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0364 0.1828 0.5378
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0055 0.0219 0.1234
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0093 0.0252
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0038 0.0113
Schistosoma mansoni Smad4 0.0024 0.0061 0.0173
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0489 0.2478 0.3425
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0299 0.0878
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0074 0.0322 0.2865
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0322 0.2865
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0038 0.0216
Schistosoma mansoni smad1 5 8 and 0.0024 0.0061 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0143 0.1163
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0058 0.0237 0.0679
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.0364 0.1828 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0237 0.2077
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0038 0.011
Loa Loa (eye worm) programmed cell death 8 0.002 0.0038 0.0207
Brugia malayi Pre-SET motif family protein 0.0208 0.1018 0.5734
Echinococcus multilocularis serine:threonine protein kinase 38 0.0017 0.0024 0.0071
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0017 0.0024 0.0132
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0132 0.2671
Giardia lamblia Myb 1-like protein 0.0038 0.0133 0.058
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0017 0.0024 0.0071
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0237 0.0209
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0044 0.0166 0.0474
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0237 0.2077
Mycobacterium ulcerans ferredoxin reductase 0.002 0.0038 0.0009
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0166 0.0474
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0044 0.0166 0.1338
Schistosoma mansoni glutamate synthase 0.002 0.0038 0.0108
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0038 0.0086
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0038 0.0136
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0166 0.1253
Trypanosoma brucei NADH dehydrogenase 0.002 0.0038 0.0133
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0133 0.097
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0166 0.0474
Loa Loa (eye worm) hypothetical protein 0.0095 0.0429 0.2349
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.002 0.0038 0.0111
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0038 0.0136
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0132 0.2671
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0074 0.0322 0.0293
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.0024 0.0071
Echinococcus granulosus cpg binding protein 0.003 0.0093 0.0273
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0038 0.0216
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.002 0.0038 0.0086
Plasmodium vivax SET domain protein, putative 0.003 0.0093 0.063
Schistosoma mansoni smad1 5 8 and 0.0024 0.0061 0.0173
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0029 0.0047
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0257 0.1406
Brugia malayi MH1 domain containing protein 0.0013 0.0005 0.0026
Leishmania major hypothetical protein, conserved 0.002 0.0038 0.0086
Schistosoma mansoni nuclear hormone receptor 0.002 0.0038 0.011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0074 0.0322 0.2865
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0439 0.2399
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0074 0.0322 0.2865
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0192 0.1601
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0074 0.0322 0.2865
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0044 0.0166 0.0487
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0038 0.011
Echinococcus granulosus Protein kinase C brain isozyme 0.0111 0.051 0.1501
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0038 0.011
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0024 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0237 0.2077
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0489 0.2478 0.3425
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0257 0.1447
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0166 0.0474
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0093 0.0275
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.0038 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0166 0.1338
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0029 0.0018
Brugia malayi Pax transcription factor protein 2 0.0233 0.1143 0.644
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Schistosoma mansoni cpg binding protein 0.003 0.0093 0.0265
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0038 0.0113
Loa Loa (eye worm) hypothetical protein 0.0292 0.1452 0.7943
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus granulosus transcription factor eb 0.0104 0.0477 0.1403
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0237 0.204
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0166 0.0515
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0074 0.0322 0.2865
Loa Loa (eye worm) hypothetical protein 0.0066 0.0279 0.1528
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0074 0.0322 0.0946
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0038 0.0113
Entamoeba histolytica hypothetical protein 0.007 0.0299 0.6771
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0111 0.051 0.1501
Plasmodium falciparum thioredoxin reductase 0.0215 0.105 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0166 0.1253
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0257 0.1406
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0364 0.1828 0.5229
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.021
Schistosoma mansoni smad1 5 8 and 0.0024 0.0061 0.0173
Echinococcus multilocularis GPCR, family 2 0.0031 0.0094 0.0278
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0147 0.0433
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1937 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0166 0.1338
Schistosoma mansoni glutamate synthase 0.002 0.0038 0.0108
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Schistosoma mansoni thyroid hormone receptor 0.002 0.0038 0.011
Echinococcus granulosus smad 0.0024 0.0061 0.0178
Loa Loa (eye worm) glutathione reductase 0.0215 0.105 0.5744
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0029 0.0047
Leishmania major DNA polymerase eta, putative 0.0044 0.0164 0.1326
Treponema pallidum NADH oxidase 0.0074 0.0322 0.0285
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0038 0.0133 0.0397
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0024 0.0017
Schistosoma mansoni cpg binding protein 0.0029 0.0084 0.0241
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0038 0.0136
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0074 0.0322 0.1082
Trypanosoma brucei unspecified product 0.0058 0.0237 0.2077
Plasmodium falciparum ferrodoxin reductase-like protein 0.002 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.021
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0166 0.1338
Plasmodium falciparum glutathione reductase 0.0215 0.105 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0044 0.0166 0.1338
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0094 0.0517
Brugia malayi Protein kinase domain containing protein 0.0017 0.0024 0.0136
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0038 0.0113
Echinococcus granulosus thioredoxin glutathione reductase 0.0216 0.1055 0.3105
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.002 0.0038 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0322 0.2865
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0074 0.0322 0.1811
Brugia malayi Thioredoxin reductase 0.0215 0.105 0.5915
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.002 0.0038 0.0111
Plasmodium vivax thioredoxin reductase, putative 0.0215 0.105 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.002 0.0038 0.0009
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.002 0.0038 0.0086
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.002 0.0038 0.0207
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.002 0.0038 0.0111
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0489 0.2478 0.3425
Trypanosoma cruzi trypanothione reductase, putative 0.0074 0.0322 0.2865
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0192 0.0612
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0017 0.0024 0.0071
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0038 0.0113
Echinococcus multilocularis dna polymerase kappa 0.0058 0.0237 0.0698
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0024 0.0069
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0439 0.2471
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0104 0.0477 0.2687
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0166 0.0933
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.0038 0.0336
Schistosoma mansoni hypothetical protein 0.0503 0.2547 0.7286
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0038 0.0216
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0074 0.0322 0.2865
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0166 0.1253
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0038 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0237 0.2077

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) = 80 uM Cytotoxicity against Vero cells ChEMBL. 17234303
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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