Detailed information for compound 434977

Basic information

Technical information
  • TDR Targets ID: 434977
  • Name: N-(2-benzyl-1,3-benzoxazol-5-yl)-2-(4-fluorop henyl)acetamide
  • MW: 360.381 | Formula: C22H17FN2O2
  • H donors: 1 H acceptors: 2 LogP: 4.59 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccc(cc1)F)Nc1ccc2c(c1)nc(o2)Cc1ccccc1
  • InChi: 1S/C22H17FN2O2/c23-17-8-6-16(7-9-17)12-21(26)24-18-10-11-20-19(14-18)25-22(27-20)13-15-4-2-1-3-5-15/h1-11,14H,12-13H2,(H,24,26)
  • InChiKey: IUGCFYKGNPZQEI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-fluorophenyl)-N-[2-(phenylmethyl)-1,3-benzoxazol-5-yl]ethanamide
  • 2-(4-fluorophenyl)-N-[2-(phenylmethyl)-1,3-benzoxazol-5-yl]acetamide
  • N-[2-(benzyl)-1,3-benzoxazol-5-yl]-2-(4-fluorophenyl)acetamide
  • AIDS-222969
  • AIDS222969
  • N-(2-Benzyl-benzooxazol-5-yl)-2-(4-fluoro-phenyl)-acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Integrin alpha pat-2 precursor 0.0034 0.0304 0.2402
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.011 0.011
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0186 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0091 0.1264 0.1264
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Echinococcus multilocularis tar DNA binding protein 0.0035 0.0312 0.0312
Brugia malayi RNA recognition motif domain containing protein 0.0035 0.0312 0.2467
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.011 0.011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0024 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0023 0.0115 0.0115
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.011 0.011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0025 0.0147 0.0147
Brugia malayi neuropeptide F receptor 0.0023 0.011 0.0871
Brugia malayi beta-lactamase 0.0027 0.0186 0.1471
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0045 0.0492 0.0492
Schistosoma mansoni hypothetical protein 0.0023 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.011 0.011
Schistosoma mansoni neuropeptide receptor 0.0023 0.011 0.011
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Schistosoma mansoni opsin-like receptor 0.0023 0.011 0.011
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Schistosoma mansoni opsin-like receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.011 0.011
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.011 0.011
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.011 0.011
Echinococcus multilocularis tumor protein p63 0.0485 0.7988 0.7988
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.011 0.0871
Echinococcus granulosus serotonin receptor 0.0023 0.011 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0186 0.5
Schistosoma mansoni hypothetical protein 0.0024 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Brugia malayi ORL1-like opioid receptor 0.0023 0.011 0.0871
Echinococcus multilocularis somatostatin receptor 0.0023 0.011 0.011
Brugia malayi hypothetical protein 0.0023 0.011 0.0871
Brugia malayi hypothetical protein 0.0023 0.011 0.0871
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Entamoeba histolytica hypothetical protein 0.0024 0.0136 0.5
Brugia malayi hypothetical protein 0.0023 0.011 0.0871
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Schistosoma mansoni integrin alpha-4 0.0146 0.2214 0.2214
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Schistosoma mansoni adenoreceptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0025 0.0147 0.0147
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0027 0.0186 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.011 0.011
Brugia malayi Melatonin receptor type 1A 0.0023 0.011 0.0871
Loa Loa (eye worm) integrin alpha pat-2 0.0034 0.0304 0.0304
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Mycobacterium ulcerans lipase LipD 0.0027 0.0186 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.011 0.011
Brugia malayi Serotonin receptor 0.0023 0.011 0.0871
Echinococcus granulosus g protein coupled receptor 0.0023 0.011 0.011
Toxoplasma gondii MAPEG family protein 0.0045 0.0492 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0175 0.2694 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0024
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Schistosoma mansoni biogenic amine receptor 0.0023 0.011 0.011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0186 0.0186
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0093 0.1302 0.1302
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0186 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0186 0.0186
Echinococcus multilocularis orexin receptor type 2 0.0023 0.011 0.011
Echinococcus granulosus g-protein coupled receptor 0.0023 0.011 0.011
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.011 0.011
Echinococcus multilocularis sex peptide receptor 0.0023 0.011 0.011
Schistosoma mansoni histamine h1 receptor 0.0023 0.011 0.011
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.011 0.011
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0093 0.1302 0.1302
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.011 0.011
Schistosoma mansoni lipoxygenase 0.0028 0.019 0.019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0025 0.0147 0.0147
Echinococcus multilocularis neuropeptide receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0027 0.0186 0.0186
Loa Loa (eye worm) RNA binding protein 0.0035 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0027 0.0186 0.0186
Brugia malayi neuropeptide F receptor 0.0023 0.011 0.0871
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0028 0.019 0.019
Echinococcus granulosus g protein coupled receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.011 0.011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0025 0.0147 0.1167
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.011 0.011
Loa Loa (eye worm) TAR-binding protein 0.0035 0.0312 0.0312
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0186 0.0186
Schistosoma mansoni microsomal glutathione s-transferase 0.0045 0.0492 0.0492
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.011 0.011
Echinococcus granulosus hypothetical protein 0.0023 0.011 0.011
Echinococcus granulosus tumor protein p63 0.0485 0.7988 0.7988
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.011 0.011
Echinococcus granulosus orexin receptor type 2 0.0023 0.011 0.011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0025 0.0147 0.0147
Schistosoma mansoni integrin alpha-ps 0.0034 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.011 0.011
Schistosoma mansoni transcription factor LCR-F1 0.0024 0.0136 0.0136
Echinococcus multilocularis g protein coupled receptor 0.0023 0.011 0.011
Echinococcus multilocularis g protein coupled receptor 0.0023 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.011 0.011
Schistosoma mansoni cellular tumor antigen P53 0.0071 0.0931 0.0931
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.011 0.011
Echinococcus granulosus somatostatin receptor 0.0023 0.011 0.011
Brugia malayi GnHR receptor homolog 0.0023 0.011 0.0871
Brugia malayi hypothetical protein 0.0023 0.011 0.0871
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.011 0.011
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.011 0.011
Echinococcus multilocularis serotonin receptor 0.0023 0.011 0.011
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Entamoeba histolytica hypothetical protein 0.0024 0.0136 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.011 0.011
Schistosoma mansoni myosin xvIII 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Echinococcus granulosus neuropeptide receptor 0.0023 0.011 0.011
Schistosoma mansoni tar DNA-binding protein 0.0035 0.0312 0.0312
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0025 0.0147 0.0147
Brugia malayi larval opioid receptor 0.0023 0.011 0.0871
Schistosoma mansoni tar DNA-binding protein 0.0035 0.0312 0.0312
Mycobacterium leprae Probable lipase LipE 0.0027 0.0186 0.5
Schistosoma mansoni amine GPCR 0.0023 0.011 0.011
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.011 0.011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.011 0.011
Schistosoma mansoni neuropeptide receptor 0.0023 0.011 0.011
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.011 0.011
Onchocerca volvulus 0.0027 0.0186 0.0925
Brugia malayi latrophilin 2 splice variant baaae 0.0023 0.0115 0.0908
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.011 0.011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0034 0.0297 0.2352
Schistosoma mansoni neuropeptide receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Schistosoma mansoni amine GPCR 0.0023 0.011 0.011
Brugia malayi G protein-coupled receptor 0.0023 0.011 0.0871
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.011 0.011
Schistosoma mansoni integrin alpha 0.0034 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.011 0.011
Schistosoma mansoni amine GPCR 0.0023 0.011 0.011
Trichomonas vaginalis penicillin-binding protein, putative 0.0027 0.0186 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.011 0.011
Brugia malayi hypothetical protein 0.0023 0.011 0.0871
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.011 0.011
Loa Loa (eye worm) beta-lactamase 0.0027 0.0186 0.0186
Brugia malayi AKH receptor 0.0023 0.011 0.0871
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0023 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0023 0.011 0.011
Trichomonas vaginalis esterase, putative 0.0027 0.0186 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.011 0.011
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.011 0.011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0186 0.0186
Brugia malayi G-protein coupled receptor 0.0023 0.011 0.0871
Brugia malayi Serotonin receptor 0.0023 0.011 0.0871
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.011 0.011
Echinococcus granulosus neuropeptide receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0028 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0034 0.0297 0.0297
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0603 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0025 0.0147 0.0147
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.011 0.011
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0186 0.5
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0603 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0186 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.011 0.011
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0045 0.0492 0.0492
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.011 0.0871
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.011 0.011
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.011 0.011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.011 0.011
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.011 0.011
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.011 0.0871
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.011 0.011
Brugia malayi G-protein coupled receptor 0.0023 0.011 0.0871
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Entamoeba histolytica hypothetical protein 0.0024 0.0136 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0023 0.011 0.011
Brugia malayi beta-lactamase family protein 0.0027 0.0186 0.1471
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.011 0.011
Brugia malayi hypothetical protein 0.0023 0.011 0.0871
Echinococcus multilocularis serotonin receptor 0.0023 0.011 0.011
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.011 0.011
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.011 0.011
Brugia malayi follicle stimulating hormone receptor 0.0023 0.011 0.0871
Onchocerca volvulus 0.0071 0.0931 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0024
Echinococcus granulosus allatostatin A receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.011 0.011
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.011 0.0871
Brugia malayi RNA binding protein 0.0035 0.0312 0.2467
Echinococcus granulosus fmrfamide receptor 0.0023 0.011 0.011
Echinococcus multilocularis geminin 0.0093 0.1302 0.1302
Schistosoma mansoni amine GPCR 0.0023 0.011 0.011
Echinococcus granulosus microsomal glutathione S transferase 3 0.0045 0.0492 0.0492
Schistosoma mansoni biogenic amine receptor 0.0023 0.011 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0025 0.0147 0.0147
Brugia malayi hypothetical protein 0.0023 0.011 0.0871
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0115 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.011 0.011
Echinococcus granulosus g protein coupled receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0034 0.0297 0.2352
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.011 0.011
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.011 0.011
Brugia malayi hypothetical protein 0.0023 0.011 0.0871
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.011 0.011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0186 0.0186
Echinococcus multilocularis hormone sensitive lipase 0.0603 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Schistosoma mansoni neuropeptide receptor 0.0023 0.011 0.011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0027 0.0186 0.1471
Brugia malayi hypothetical protein 0.0023 0.011 0.0871
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.011 0.011
Echinococcus granulosus integrin alpha ps 0.0034 0.0304 0.0304
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.011 0.011
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.011 0.011
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.011 0.011
Entamoeba histolytica hypothetical protein 0.0024 0.0136 0.5
Echinococcus granulosus sex peptide receptor 0.0023 0.011 0.011
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.011 0.011
Brugia malayi sulfakinin receptor protein 0.0023 0.011 0.0871
Onchocerca volvulus 0.0027 0.0186 0.0925
Schistosoma mansoni tar DNA-binding protein 0.0035 0.0312 0.0312
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.011 0.0871
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0035 0.0312 0.0312
Mycobacterium ulcerans hypothetical protein 0.0027 0.0186 0.5
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0186 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.011 0.011
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.011 0.0871
Brugia malayi hypothetical protein 0.0024 0.0136 0.1075
Mycobacterium ulcerans beta-lactamase 0.0027 0.0186 0.5
Brugia malayi MH2 domain containing protein 0.0091 0.1264 1
Schistosoma mansoni opsin-like receptor 0.0023 0.011 0.011
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.011 0.011
Brugia malayi RE15519p 0.0023 0.011 0.0871
Brugia malayi Dopamine receptor protein 2 0.0023 0.011 0.0871
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.011 0.011
Echinococcus multilocularis integrin alpha ps 0.0034 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.011 0.011
Loa Loa (eye worm) MH2 domain-containing protein 0.0091 0.1264 0.1264
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Brugia malayi hypothetical protein 0.0023 0.011 0.0871
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0027 0.0186 0.0186
Brugia malayi putative neuropeptide receptor 0.0023 0.011 0.0871
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.011 0.011
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.011 0.0871
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0024 0.0136 0.0136
Brugia malayi Dopamine receptor protein 1 0.0023 0.011 0.0871
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.011 0.011
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.011 0.011
Brugia malayi beta-lactamase family protein 0.0027 0.0186 0.1471
Echinococcus multilocularis fmrfamide receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0186 0.0186
Echinococcus granulosus tar DNA binding protein 0.0035 0.0312 0.0312
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.011 0.011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.011 0.011
Schistosoma mansoni amine GPCR 0.0023 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.011 0.011
Mycobacterium ulcerans esterase/lipase LipP 0.0027 0.0186 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.011 0.011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.011 0.011
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.011 0.011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.011 0.011
Schistosoma mansoni biogenic amine receptor 0.0023 0.011 0.011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0034 0.0297 0.0297
Echinococcus multilocularis allatostatin A receptor 0.0023 0.011 0.011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0025 0.0147 0.0147
Echinococcus granulosus neuropeptide s receptor 0.0023 0.011 0.011
Echinococcus granulosus geminin 0.0093 0.1302 0.1302
Trichomonas vaginalis penicillin-binding protein, putative 0.0027 0.0186 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0603 1 1
Echinococcus multilocularis neuropeptide receptor 0.0023 0.011 0.011
Echinococcus multilocularis fmrfamide receptor 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.011 0.011
Schistosoma mansoni integrin alpha-ps 0.0018 0.0024 0.0024
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.011 0.011
Brugia malayi TAR-binding protein 0.0035 0.0312 0.2467
Onchocerca volvulus 0.0027 0.0186 0.0925
Echinococcus granulosus beta LACTamase domain containing family member 0.0027 0.0186 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0186 0.5
Schistosoma mansoni tar DNA-binding protein 0.0035 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0071 0.0931 0.0931
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0186 0.5
Leishmania major hypothetical protein, conserved 0.0027 0.0186 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.011 0.011
Echinococcus multilocularis g protein coupled receptor 0.0023 0.011 0.011
Echinococcus multilocularis integrin alpha ps 0.0034 0.0304 0.0304
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.011 0.011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.011 0.011
Brugia malayi Dopamine receptor 0.0023 0.011 0.0871
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.011 0.0871
Schistosoma mansoni tar DNA-binding protein 0.0035 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0603 1 1

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 12.5 ug ml-1 Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by serial dilution method ChEMBL. 17337097
MIC (functional) = 12.5 ug ml-1 Antifungal activity against Candida glabrata after 48 hrs by serial dilution method ChEMBL. 17337097
MIC (functional) = 25 ug ml-1 Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by serial dilution method ChEMBL. 17337097
MIC (functional) = 25 ug ml-1 Antibacterial activity against Escherichia coli ATCC 23556 after 24 hrs by serial dilution method ChEMBL. 17337097
MIC (functional) = 25 ug ml-1 Antibacterial activity against Pseudomonas aeruginosa ATCC 10145 after 24 hrs by serial dilution method ChEMBL. 17337097
MIC (functional) = 25 ug ml-1 Antibacterial activity against Escherichia coli ATCC 23556 after 24 hrs by serial dilution method ChEMBL. 17337097
MIC (functional) = 50 ug ml-1 Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by serial dilution method ChEMBL. 17337097
MIC (functional) = 50 ug ml-1 Antifungal activity against Candida albicans after 48 hrs by serial dilution method ChEMBL. 17337097
MIC (functional) = 50 ug ml-1 Antifungal activity against Candida albicans after 48 hrs by serial dilution method ChEMBL. 17337097

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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