Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | spleen tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Echinococcus multilocularis | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma japonicum | ko:K05855 spleen tyrosine kinase, putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Echinococcus granulosus | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3134 | 0.5169 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0094 | 0.2147 | 0.1843 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0152 | 0.483 | 0.8451 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0152 | 0.483 | 0.8343 |
Leishmania major | adenine aminohydrolase | 0.0171 | 0.5716 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0171 | 0.5716 | 0.555 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0094 | 0.2147 | 0.1843 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3134 | 0.5169 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0171 | 0.5716 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0171 | 0.5716 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0258 | 0.972 | 0.9709 |
Mycobacterium ulcerans | adenosine deaminase | 0.0171 | 0.5716 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0171 | 0.5716 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0094 | 0.2147 | 0.1843 |
Echinococcus granulosus | adenosine deaminase | 0.0171 | 0.5716 | 0.555 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0152 | 0.483 | 0.4631 |
Brugia malayi | Adenosylhomocysteinase | 0.0152 | 0.483 | 0.8343 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0152 | 0.483 | 0.4631 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0152 | 0.483 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0152 | 0.483 | 0.8451 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0152 | 0.483 | 0.8343 |
Echinococcus multilocularis | adenosine deaminase | 0.0171 | 0.5716 | 0.555 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0171 | 0.5716 | 1 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0171 | 0.5716 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0152 | 0.483 | 0.4631 |
Treponema pallidum | adenosine deaminase | 0.0171 | 0.5716 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0171 | 0.5716 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0152 | 0.483 | 0.8343 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3134 | 0.5169 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0152 | 0.483 | 0.8343 |
Plasmodium falciparum | adenosine deaminase | 0.0171 | 0.5716 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0171 | 0.5716 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0171 | 0.5716 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0171 | 0.5716 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0171 | 0.5716 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0152 | 0.483 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3134 | 0.5169 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0171 | 0.5716 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0152 | 0.483 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0152 | 0.483 | 0.8343 |
Schistosoma mansoni | tyrosine kinase | 0.0264 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0094 | 0.2147 | 0.1843 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.5716 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0171 | 0.5716 | 0.555 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0152 | 0.483 | 0.8343 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0152 | 0.483 | 0.8343 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0264 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 71 nM | Inhibition of recombinant Syk | ChEMBL. | 19254842 |
IC50 (binding) | = 0.071 uM | Inhibitory activity against spleen tyrosine kinase (SYK) | ChEMBL. | 12668002 |
IC50 (binding) | = 0.071 uM | Inhibitory activity against spleen tyrosine kinase (SYK) | ChEMBL. | 12668002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.