Detailed information for compound 43896

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 151.189 | Formula: C6H5N3S
  • H donors: 1 H acceptors: 2 LogP: 0.53 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Sc1[nH]ccc2c1ncn2
  • InChi: 1S/C6H5N3S/c10-6-5-4(1-2-7-6)8-3-9-5/h1-3,7,10H
  • InChiKey: JKDNLVRKUCJJNW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0043 0.0108 0.1794
Schistosoma mansoni integrin beta subunit 0.0179 0.1753 0.1736
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0043 0.0108 0.0114
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni neuropeptide receptor 0.0043 0.0108 0.0087
Loa Loa (eye worm) integrin beta-2 0.0304 0.3264 0.4631
Loa Loa (eye worm) aspartyl protease 6 0.0051 0.0202 0.0259
Echinococcus granulosus g-protein coupled receptor 0.0043 0.0108 0.0115
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Brugia malayi ORL1-like opioid receptor 0.0043 0.0108 0.0124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0108 0.0114
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0201 0.2022 0.41
Loa Loa (eye worm) hypothetical protein 0.0429 0.4774 0.6789
Schistosoma mansoni hypothetical protein 0.0043 0.0108 0.0087
Brugia malayi putative neuropeptide receptor 0.0043 0.0108 0.0124
Brugia malayi G protein-coupled receptor 0.0043 0.0108 0.0124
Brugia malayi hypothetical protein 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.0108 0.0087
Echinococcus multilocularis neuropeptide s receptor 0.0043 0.0108 0.0114
Loa Loa (eye worm) hypothetical protein 0.0051 0.0202 0.0259
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0202 0.0182
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0201 0.2022 0.5
Brugia malayi Cell death protein 3 precursor 0.0057 0.0278 0.0366
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0043 0.0108 0.0114
Onchocerca volvulus 0.0043 0.0108 0.1794
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0201 0.2022 0.41
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni adenoreceptor 0.0043 0.0108 0.0087
Schistosoma mansoni cathepsin D (A01 family) 0.0051 0.0202 0.0182
Brugia malayi Eukaryotic aspartyl protease family protein 0.0051 0.0202 0.0259
Brugia malayi hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0202 0.0182
Schistosoma mansoni hypothetical protein 0.0195 0.1942 0.1925
Brugia malayi GnHR receptor homolog 0.0043 0.0108 0.0124
Echinococcus granulosus dro:myosuppressin receptor 0.0043 0.0108 0.0115
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0043 0.0108 0.0114
Loa Loa (eye worm) hypothetical protein 0.0051 0.0202 0.0259
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0043 0.0108 0.0087
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Brugia malayi Integrin beta pat-3 precursor 0.0304 0.3264 0.4631
Echinococcus granulosus integrin alpha ps 0.0134 0.1205 0.1562
Echinococcus multilocularis kelch ECH associated protein 1 0.0662 0.7599 0.9971
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Echinococcus multilocularis integrin beta 2 0.0225 0.2312 0.3014
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.0108 0.0124
Echinococcus granulosus peptide allatostatin:somatostatin 0.0043 0.0108 0.0115
Onchocerca volvulus 0.0043 0.0108 0.1794
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0177 0.1724 0.2432
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0524 0.5925 0.5
Echinococcus multilocularis Kelch repeat type 1 0.0664 0.7621 1
Schistosoma mansoni hypothetical protein 0.0195 0.1942 0.1925
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0108 0.0115
Echinococcus granulosus g protein coupled receptor 0.0043 0.0108 0.0115
Brugia malayi Kelch motif family protein 0.0046 0.0148 0.0181
Schistosoma mansoni hypothetical protein 0.004 0.0071 0.005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.0108 0.0114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0108 0.0114
Schistosoma mansoni amine GPCR 0.0043 0.0108 0.0087
Schistosoma mansoni alpha-1 adrenergic receptor 0.0043 0.0108 0.0087
Echinococcus multilocularis neuropeptide receptor A26 0.0043 0.0108 0.0114
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Onchocerca volvulus 0.0043 0.0108 0.1794
Echinococcus granulosus allatostatin A receptor 0.0043 0.0108 0.0115
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.0108 0.0115
Echinococcus granulosus hypothetical protein 0.0043 0.0108 0.0115
Onchocerca volvulus 0.0051 0.0202 0.6361
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0108 0.0114
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0108 0.0115
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.0108 0.0124
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.0108 0.0115
Echinococcus multilocularis protein patched 0.0177 0.1724 0.2241
Loa Loa (eye worm) hypothetical protein 0.0064 0.0364 0.049
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0202 0.0182
Schistosoma mansoni neuropeptide f receptor 76f 0.0043 0.0108 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0108 0.0115
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0108 0.0114
Onchocerca volvulus 0.0043 0.0108 0.1794
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.0108 0.0114
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0524 0.5925 1
Schistosoma mansoni hypothetical protein 0.0043 0.0108 0.0087
Brugia malayi Serotonin receptor 0.0043 0.0108 0.0124
Echinococcus multilocularis g protein coupled receptor 0.0043 0.0108 0.0114
Onchocerca volvulus 0.0043 0.0108 0.1794
Echinococcus multilocularis g protein coupled receptor 0.0043 0.0108 0.0114
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0429 0.4774 0.6254
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0108 0.0115
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.0108 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0108 0.0087
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0524 0.5925 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0043 0.0108 0.1794
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0524 0.5925 1
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0159 0.151 0.2132
Brugia malayi G-protein coupled receptor 0.0043 0.0108 0.0124
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0043 0.0108 0.0124
Brugia malayi Serotonin receptor 0.0043 0.0108 0.0124
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni opsin-like receptor 0.0043 0.0108 0.0087
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.0108 0.0114
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Echinococcus granulosus biogenic amine 5HT receptor 0.0043 0.0108 0.0115
Schistosoma mansoni integrin alpha 0.0298 0.3193 0.3178
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0071
Loa Loa (eye worm) latrophilin receptor protein 2 0.0195 0.1942 0.2743
Echinococcus granulosus kelch ECH associated protein 1 like 0.0662 0.7599 1
Echinococcus granulosus sex peptide receptor 0.0043 0.0108 0.0115
Echinococcus multilocularis fmrfamide receptor 0.0043 0.0108 0.0114
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.0108 0.0087
Echinococcus granulosus neuropeptide receptor 0.0043 0.0108 0.0115
Echinococcus multilocularis g-protein coupled receptor 0.0043 0.0108 0.0114
Schistosoma mansoni biogenic amine (5HT) receptor 0.0043 0.0108 0.0087
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.0108 0.0114
Schistosoma mansoni hypothetical protein 0.0043 0.0108 0.0087
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0043 0.0108 0.0124
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0195 0.1942 0.2527
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Brugia malayi Integrin alpha pat-2 precursor 0.0298 0.3193 0.453
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0108 0.0087
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Onchocerca volvulus 0.0043 0.0108 0.1794
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Brugia malayi sulfakinin receptor protein 0.0043 0.0108 0.0124
Echinococcus granulosus serotonin receptor 0.0043 0.0108 0.0115
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0442 0.4932 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0182 0.1786 0.2322
Echinococcus multilocularis G-protein coupled receptor, putative 0.0043 0.0108 0.0114
Loa Loa (eye worm) hypothetical protein 0.007 0.0431 0.0585
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0108 0.0087
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0043 0.0108 0.0114
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0429 0.4774 0.7549
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Brugia malayi hypothetical protein 0.0182 0.1786 0.2521
Brugia malayi hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.0108 0.0087
Schistosoma mansoni hypothetical protein 0.0195 0.1942 0.1925
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0043 0.0108 0.0124
Brugia malayi G protein-coupled receptor F59B2.13 0.0043 0.0108 0.0124
Echinococcus granulosus tachykinin peptides receptor 99D 0.0043 0.0108 0.0115
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0182 0.1786 0.2329
Echinococcus multilocularis integrin alpha ps 0.0134 0.1205 0.1558
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0043 0.0108 0.0114
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0524 0.5925 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.0108 0.0115
Echinococcus granulosus biogenic amine 5HT receptor 0.0043 0.0108 0.0115
Schistosoma mansoni hypothetical protein 0.042 0.4671 0.466
Schistosoma mansoni cathepsin D (A01 family) 0.0051 0.0202 0.0182
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0043 0.0108 0.0115
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0524 0.5925 0.7769
Loa Loa (eye worm) TYRA-2 protein 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni amine GPCR 0.0043 0.0108 0.0087
Brugia malayi hypothetical protein 0.0043 0.0108 0.0124
Onchocerca volvulus 0.0043 0.0108 0.1794
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0195 0.1942 0.2527
Echinococcus multilocularis neuropeptide receptor 0.0043 0.0108 0.0114
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Onchocerca volvulus 0.0043 0.0108 0.1794
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0108 0.0114
Brugia malayi hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni integrin alpha-ps 0.007 0.0431 0.041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0108 0.0114
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Echinococcus multilocularis somatostatin receptor 0.0043 0.0108 0.0114
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.0108 0.0114
Schistosoma mansoni hypothetical protein 0.0182 0.1786 0.1769
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0429 0.4774 0.7549
Echinococcus multilocularis serotonin receptor 0.0043 0.0108 0.0114
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0043 0.0108 0.0124
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0201 0.2022 0.41
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.0108 0.0114
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0043 0.0108 0.0087
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0051 0.0202 0.0259
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0202 0.0182
Schistosoma mansoni biogenic amine receptor 0.0043 0.0108 0.0087
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0043 0.0108 0.0124
Schistosoma mansoni neuropeptide receptor 0.0043 0.0108 0.0087
Echinococcus multilocularis caspase 2 0.0057 0.0278 0.0337
Entamoeba histolytica hypothetical protein 0.0182 0.1786 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0108 0.0087
Schistosoma mansoni integrin alpha-ps 0.0134 0.1205 0.1186
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0043 0.0108 0.0124
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.0108 0.0114
Echinococcus granulosus integrin alpha 3 0.0228 0.2352 0.3076
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0043 0.0108 0.0114
Brugia malayi Calcitonin receptor-like protein seb-1 0.0615 0.7023 1
Echinococcus multilocularis fmrfamide receptor 0.0043 0.0108 0.0114
Echinococcus granulosus kelch ECH associated protein 1 0.0662 0.7599 1
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0225 0.2315 0.3276
Onchocerca volvulus 0.0043 0.0108 0.1794
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0043 0.0108 0.0124
Echinococcus multilocularis orexin receptor type 2 0.0043 0.0108 0.0114
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0429 0.4774 0.9638
Schistosoma mansoni amine GPCR 0.0043 0.0108 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0108 0.0114
Onchocerca volvulus 0.0043 0.0108 0.1794
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0524 0.5925 0.8432
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0442 0.4932 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni hypothetical protein 0.0195 0.1942 0.1925
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0177 0.1724 0.1707
Loa Loa (eye worm) hypothetical protein 0.0195 0.1942 0.2743
Schistosoma mansoni neuropeptide receptor 0.0043 0.0108 0.0087
Echinococcus granulosus Protein patched homolog 1 0.0177 0.1724 0.2247
Brugia malayi aspartic protease BmAsp-2, identical 0.0051 0.0202 0.0259
Echinococcus multilocularis sterol regulatory element binding protein 0.0177 0.1724 0.2241
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0043 0.0108 0.0124
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0036 0.0021 0.0043
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.0108 0.0115
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0043 0.0108 0.0114
Brugia malayi latrophilin 2 splice variant baaae 0.042 0.4671 0.6641
Brugia malayi hypothetical protein 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0071 0.0066
Schistosoma mansoni neuropeptide receptor 0.0043 0.0108 0.0087
Echinococcus multilocularis G protein coupled receptor 139 0.0043 0.0108 0.0114
Echinococcus multilocularis serotonin receptor 0.0043 0.0108 0.0114
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Brugia malayi hypothetical protein 0.0051 0.0202 0.0259
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.0108 0.0087
Echinococcus granulosus G protein coupled receptor 139 0.0043 0.0108 0.0115
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0429 0.4774 0.6273
Onchocerca volvulus 0.0043 0.0108 0.1794
Onchocerca volvulus Neuropeptide F receptor homolog 0.0043 0.0108 0.1794
Schistosoma mansoni hypothetical protein 0.0664 0.7621 0.7616
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0524 0.5925 1
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0046 0.0148 0.0181
Brugia malayi Dopamine receptor 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0234 0.2419 0.3424
Entamoeba histolytica hypothetical protein 0.0182 0.1786 0.5
Echinococcus granulosus caspase 2 0.0057 0.0278 0.0338
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0442 0.4932 0.5
Loa Loa (eye worm) integrin alpha pat-2 0.0459 0.5144 0.7316
Schistosoma mansoni myosin xvIII 0.0043 0.0108 0.0087
Echinococcus granulosus sterol regulatory element binding protein 0.0177 0.1724 0.2247
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0043 0.0108 0.0087
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0043 0.0108 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0108 0.0115
Brugia malayi hypothetical protein 0.004 0.0071 0.0071
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0524 0.5925 0.8432
Brugia malayi CHE-14 protein 0.0177 0.1724 0.2432
Echinococcus multilocularis dro:myosuppressin receptor 0.0043 0.0108 0.0114
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.0108 0.0115
Schistosoma mansoni hypothetical protein 0.0043 0.0108 0.0087
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0043 0.0108 0.0087
Schistosoma mansoni biogenic amine receptor 0.0043 0.0108 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0108 0.0114
Echinococcus multilocularis neuropeptide receptor 0.0043 0.0108 0.0114
Echinococcus granulosus neuropeptide receptor A26 0.0043 0.0108 0.0115
Schistosoma mansoni amine GPCR 0.0043 0.0108 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0181
Echinococcus granulosus neuropeptide receptor 0.0043 0.0108 0.0115
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.0108 0.0114
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0202 0.0182
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0051 0.0202 0.0259
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0195 0.1942 0.2534
Loa Loa (eye worm) hypothetical protein 0.0057 0.0278 0.0366
Onchocerca volvulus 0.0043 0.0108 0.1794
Brugia malayi hypothetical protein 0.0051 0.0202 0.0259
Echinococcus multilocularis neuropeptide FF receptor 2 0.0043 0.0108 0.0114
Echinococcus multilocularis g protein coupled receptor 0.0043 0.0108 0.0114
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0202 0.0182
Echinococcus multilocularis kelch ECH associated protein 1 0.0662 0.7599 0.9971
Echinococcus granulosus somatostatin receptor 0.0043 0.0108 0.0115
Echinococcus granulosus Niemann Pick C1 protein 0.0177 0.1724 0.2247
Echinococcus multilocularis integrin alpha ps 0.0064 0.0364 0.0451
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.0108 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.0108 0.0114
Echinococcus granulosus fmrfamide receptor 0.0043 0.0108 0.0115
Onchocerca volvulus 0.0043 0.0108 0.1794
Brugia malayi hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0108 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0108 0.0115
Schistosoma mansoni hypothetical protein 0.0064 0.0364 0.0343
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0202 0.0182
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0043 0.0108 0.0114
Schistosoma mansoni opsin-like receptor 0.0043 0.0108 0.0087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0615 0.7023 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0043 0.0108 0.0087
Brugia malayi aspartic protease BmAsp-1, identical 0.0051 0.0202 0.0259
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Echinococcus multilocularis allatostatin A receptor 0.0043 0.0108 0.0114
Loa Loa (eye worm) hypothetical protein 0.0177 0.1724 0.2432
Onchocerca volvulus 0.0051 0.0202 0.6361
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0036 0.0021 0.0043
Entamoeba histolytica hypothetical protein 0.0182 0.1786 0.5
Brugia malayi neuropeptide F receptor 0.0043 0.0108 0.0124
Echinococcus granulosus neuropeptide s receptor 0.0043 0.0108 0.0115
Echinococcus multilocularis integrin alpha 3 0.0228 0.2352 0.3067
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0043 0.0108 0.0115
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0202 0.0182
Brugia malayi Latrophilin receptor protein 2 0.0195 0.1942 0.2743
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0524 0.5925 0.7792
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0043 0.0108 0.0114
Schistosoma mansoni amine GPCR 0.0043 0.0108 0.0087
Echinococcus granulosus g protein coupled receptor 0.0043 0.0108 0.0115
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0108 0.0087
Onchocerca volvulus Cell death protein 3 homolog 0.0057 0.0278 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Brugia malayi larval opioid receptor 0.0043 0.0108 0.0124
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0051 0.0202 0.0411
Loa Loa (eye worm) hypothetical protein 0.0615 0.7023 1
Onchocerca volvulus 0.0043 0.0108 0.1794
Brugia malayi hypothetical protein 0.0043 0.0108 0.0124
Loa Loa (eye worm) melatonin receptor type 1A 0.0043 0.0108 0.0124
Echinococcus granulosus GPCR family 2 0.0195 0.1942 0.2534
Schistosoma mansoni growth hormone secretagogue receptor 0.0043 0.0108 0.0087
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0202 0.0182
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0615 0.7023 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0195 0.1942 0.2534
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0195 0.1942 0.2743
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0051 0.0202 0.0238
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni histamine h1 receptor 0.0043 0.0108 0.0087
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.0108 0.0087
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0043 0.0108 0.0087
Schistosoma mansoni biogenic amine (5HT) receptor 0.0043 0.0108 0.0087
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0071 0.0065
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0524 0.5925 1
Brugia malayi putative neuropeptide receptor NPR1 0.0043 0.0108 0.0124
Echinococcus multilocularis protein dispatched 1 0.0177 0.1724 0.2241
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0051 0.0202 0.0239
Schistosoma mansoni caspase-7 (C14 family) 0.0057 0.0278 0.0257
Echinococcus granulosus integrin beta 2 0.0225 0.2312 0.3023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0429 0.4774 0.6789
Schistosoma mansoni transcription factor LCR-F1 0.0182 0.1786 0.1769
Echinococcus multilocularis GPCR, family 2 0.0195 0.1942 0.2527
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0043 0.0108 0.0115
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.0108 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0108 0.0115
Loa Loa (eye worm) hypothetical protein 0.0225 0.2315 0.3276
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0108 0.0087
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1724 0.3496
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Brugia malayi Melatonin receptor type 1A 0.0043 0.0108 0.0124
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.0108 0.0115
Echinococcus granulosus 7TM GPCR rhodopsin 0.0043 0.0108 0.0115
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0442 0.4932 1
Entamoeba histolytica hypothetical protein 0.0182 0.1786 0.5
Onchocerca volvulus 0.0043 0.0108 0.1794
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0524 0.5925 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0043 0.0108 0.0115
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0043 0.0108 0.0124
Echinococcus granulosus kelch ECH associated protein 1 like 0.0662 0.7599 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0043 0.0108 0.0115
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0043 0.0108 0.0087
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.0108 0.0115
Loa Loa (eye worm) hypothetical protein 0.0164 0.1578 0.2223
Brugia malayi neuropeptide F receptor 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0051 0.0202 0.0259
Loa Loa (eye worm) hypothetical protein 0.042 0.4671 0.6641
Brugia malayi hypothetical protein 0.0043 0.0108 0.0124
Echinococcus granulosus integrin alpha ps 0.0064 0.0364 0.0452
Brugia malayi Dopamine receptor protein 1 0.0043 0.0108 0.0124
Schistosoma mansoni opsin-like receptor 0.0043 0.0108 0.0087
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0524 0.5925 0.5917
Echinococcus granulosus g protein coupled receptor 0.0043 0.0108 0.0115
Brugia malayi G-protein coupled receptor 0.0043 0.0108 0.0124
Brugia malayi RE15519p 0.0043 0.0108 0.0124
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.0108 0.0115
Brugia malayi Dopamine receptor protein 2 0.0043 0.0108 0.0124
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0108 0.0087
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Brugia malayi AKH receptor 0.0043 0.0108 0.0124
Brugia malayi Pepsin A precursor 0.0051 0.0202 0.0259
Echinococcus multilocularis integrin alpha ps 0.0134 0.1205 0.1558
Brugia malayi follicle stimulating hormone receptor 0.0043 0.0108 0.0124
Onchocerca volvulus 0.0043 0.0108 0.1794
Echinococcus granulosus orexin receptor type 2 0.0043 0.0108 0.0115
Brugia malayi hypothetical protein 0.0046 0.0148 0.0181
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0043 0.0108 0.0115
Schistosoma mansoni biogenic amine receptor 0.0043 0.0108 0.0087
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0442 0.4932 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0108 0.0087
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0429 0.4774 0.4763
Schistosoma mansoni patched 1 0.0177 0.1724 0.1707
Echinococcus multilocularis Niemann Pick C1 protein 0.0177 0.1724 0.2241
Echinococcus granulosus 7tm_1 domain containing protein 0.0043 0.0108 0.0115
Echinococcus multilocularis sex peptide receptor 0.0043 0.0108 0.0114
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0043 0.0108 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0108 0.0124
Brugia malayi hypothetical protein 0.0043 0.0108 0.0124

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 8 mg kg-1 Dose required to produce an acute inflammatory response of the algal poly saccharide carrageenan into the pleural cavity of rat. ChEMBL. 3941408
Inhibition (functional) < 5 % Inhibition of lymphocyte-mediated cytolysis at a concentratioon of 100 uM in [51Cr]- labelled EL4 leukemia cells ChEMBL. 3941408
Inhibition (functional) < 5 % Inhibition of lymphocyte-mediated cytolysis at a concentratioon of 100 uM in [51Cr]- labelled EL4 leukemia cells ChEMBL. 3941408
Inhibition (functional) = 26 % Compound was tested for inhibition of human sternal marrow cell (D98) growth at a concentration of 100 uM ChEMBL. 3941408
Inhibition (functional) = 38 % Compound was tested for inhibition of mouse connective tissue cell (L) growth at a concentration of 100 uM ChEMBL. 3941408
Inhibition (functional) = 38 % Compound was tested for inhibition of mouse connective tissue cell (L) growth at a concentration of 100 uM ChEMBL. 3941408

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.