Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0185 | 0.0746 | 0.0469 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0501 | 0.3322 | 1 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0459 | 0.2974 | 0.8045 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0459 | 0.2974 | 0.2764 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0185 | 0.0746 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0185 | 0.0746 | 0.0469 |
Trypanosoma brucei | glucosidase, putative | 0.0185 | 0.0746 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0954 | 0.7007 | 0.6918 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0185 | 0.0746 | 0.0469 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0185 | 0.0746 | 0.0469 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0154 | 0.0498 | 0.4554 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1322 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0874 | 0.6349 | 0.624 |
Brugia malayi | Ceramide glucosyltransferase | 0.0501 | 0.3322 | 0.3122 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0501 | 0.3322 | 1 |
Echinococcus granulosus | beta galactosidase | 0.0278 | 0.1505 | 0.3641 |
Trichomonas vaginalis | beta-glucosidase, putative | 0.0131 | 0.0306 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.1505 | 0.1251 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0201 | 0.088 | 0.0607 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0185 | 0.0746 | 0.0469 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0954 | 0.7007 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0539 | 0.3627 | 0.3436 |
Schistosoma mansoni | alpha-glucosidase | 0.0471 | 0.3075 | 0.9258 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1322 | 1 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0185 | 0.0746 | 0.1364 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0227 | 0.1093 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.1322 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0539 | 0.3627 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1322 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0185 | 0.0746 | 0.0469 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0185 | 0.0746 | 0.5 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0459 | 0.2974 | 0.8045 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1322 | 1 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0501 | 0.3322 | 0.9087 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0185 | 0.0746 | 0.1364 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0185 | 0.0746 | 0.5 |
Echinococcus multilocularis | beta galactosidase | 0.0278 | 0.1505 | 0.3641 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0954 | 0.7007 | 0.6918 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0185 | 0.0746 | 0.0469 |
Trichomonas vaginalis | glycoside hydrolases, putative | 0.0131 | 0.0306 | 0.0016 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0185 | 0.0746 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0471 | 0.3075 | 0.9258 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.059 | 0.1775 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0539 | 0.3627 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0501 | 0.3322 | 0.3122 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0185 | 0.0746 | 0.0469 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0874 | 0.6349 | 0.624 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0501 | 0.3322 | 0.9087 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.1505 | 0.1251 |
Schistosoma mansoni | alpha glucosidase | 0.0185 | 0.0746 | 0.2245 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0954 | 0.7007 | 0.6918 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0954 | 0.7007 | 0.6918 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0539 | 0.3627 | 0.3436 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0185 | 0.0746 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1322 | 1 | 1 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0459 | 0.2974 | 0.2764 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0501 | 0.3322 | 0.0627 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0954 | 0.7007 | 0.6918 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0459 | 0.2974 | 0.8953 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0185 | 0.0746 | 0.0469 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0154 | 0.0498 | 0.0213 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1322 | 1 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0201 | 0.088 | 0.0607 |
Schistosoma mansoni | beta-galactosidase | 0.0278 | 0.1505 | 0.4531 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0459 | 0.2974 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0954 | 0.7007 | 0.6918 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0954 | 0.7007 | 0.6918 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0539 | 0.3627 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0185 | 0.0746 | 0.0469 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.5 nM | Antiviral acativity against HIV1 LAI assessed as inhibition of viral-induced cytopathicity in MT4 cells by MTT method | ChEMBL. | 17157017 |
IC50 (functional) | = 31.6 nM | Antiviral activity against HIV1 RT 100I mutant assessed as inhibition of viral-induced cytopathicity in MT4 cells by MTT method | ChEMBL. | 17157017 |
IC50 (functional) | = 79.4 nM | Antiviral activity against HIV1 with RT 103N mutant assessed as inhibition of viral-induced cytopathicity in MT4 cells by MTT method | ChEMBL. | 17157017 |
IC50 (functional) | = 158 nM | Antiviral activity against HIV1 RT 181C mutant assessed as inhibition of viral-induced cytopathicity in MT4 cells by MTT method | ChEMBL. | 17157017 |
IC50 (functional) | = 316 nM | Antiviral activity against HIV1 RT 100I/103N mutant assessed as inhibition of viral-induced cytopathicity in MT4 cells by MTT method | ChEMBL. | 17157017 |
IC50 (functional) | = 501 nM | Antiviral activity against HIV1 RT 103N/181C mutant assessed as inhibition of viral-induced cytopathicity in MT4 cells by MTT method | ChEMBL. | 17157017 |
IC50 (functional) | = 794 nM | Antiviral activity against HIV1 RT 188L mutant assessed as inhibition of viral-induced cytopathicity in MT4 cells by MTT method | ChEMBL. | 17157017 |
Ratio CC50/IC50 (functional) | = 39811 | Selectivity index, ratio of CC50 for MT4 cells to IC50 for HIV1 LAI | ChEMBL. | 17157017 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.