Detailed information for compound 440494

Basic information

Technical information
  • TDR Targets ID: 440494
  • Name: 1-cyclopropyl-3-[[1-[3-(1-hydroxycyclopropyl) propyl]benzimidazol-2-yl]methyl]imidazo[4,5-c ]pyridin-2-one
  • MW: 403.477 | Formula: C23H25N5O2
  • H donors: 1 H acceptors: 4 LogP: 1.8 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1n(Cc2nc3c(n2CCCC2(O)CC2)cccc3)c2c(n1C1CC1)ccnc2
  • InChi: 1S/C23H25N5O2/c29-22-27(20-14-24-12-8-19(20)28(22)16-6-7-16)15-21-25-17-4-1-2-5-18(17)26(21)13-3-9-23(30)10-11-23/h1-2,4-5,8,12,14,16,30H,3,6-7,9-11,13,15H2
  • InChiKey: UOYODLLSYQHHED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-cyclopropyl-3-[[1-[3-(1-hydroxycyclopropyl)propyl]-2-benzimidazolyl]methyl]-2-imidazo[4,5-c]pyridinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0191 0.6529 0.668
Loa Loa (eye worm) ShTK domain-containing protein 0.0191 0.6529 0.668
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0037 0.0794 0.0813
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.4576 1
Brugia malayi TAR-binding protein 0.0061 0.1694 0.1733
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.1336 0.4271
Giardia lamblia Cathepsin B precursor 0.0097 0.3023 0.3023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0794 0.0813
Entamoeba histolytica cysteine proteinase 1, putative 0.0031 0.0542 0.0542
Onchocerca volvulus 0.0191 0.6529 1
Loa Loa (eye worm) fibroinase 0.0052 0.1336 0.1367
Loa Loa (eye worm) RNA binding protein 0.0061 0.1694 0.1733
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.1336 0.1336
Onchocerca volvulus 0.0052 0.1336 0.2046
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0542 0.0542
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0078 0.008
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0078 0.008
Brugia malayi Cathepsin L-like precursor 0.0052 0.1336 0.1367
Entamoeba histolytica cysteine protease, putative 0.0031 0.0542 0.0542
Giardia lamblia Cathepsin B precursor 0.0097 0.3023 0.3023
Trypanosoma brucei cysteine peptidase C (CPC) 0.0097 0.3023 1
Loa Loa (eye worm) ctsf protein 0.0052 0.1336 0.1367
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0078 0.0078
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0278 0.9774 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0794 0.0794
Echinococcus granulosus cathepsin L 0.0031 0.0542 0.0554
Toxoplasma gondii exonuclease III APE 0.0018 0.0078 0.0257
Leishmania major cysteine peptidase A (CPA) 0.0052 0.1336 0.4271
Leishmania major cathepsin L-like protease 0.0052 0.1336 0.4271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0794 0.0794
Entamoeba histolytica cysteine protease, putative 0.0031 0.0542 0.0542
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1694 0.1733
Trypanosoma cruzi cysteine protease, putative 0.0031 0.0542 0.0554
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.1336 0.1336
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0078 0.008
Brugia malayi Cathepsin L-like precursor 0.0052 0.1336 0.1367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0542 0.0542
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0278 0.9774 1
Onchocerca volvulus 0.0052 0.1336 0.2046
Leishmania major cathepsin L-like protease 0.0052 0.1336 0.4271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.1336 0.4271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.1336 0.1367
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0078 0.5
Onchocerca volvulus 0.0052 0.1336 0.2046
Schistosoma mansoni tyrosinase precursor 0.0191 0.6529 0.668
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.1336 0.1336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.1336 0.4271
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.1336 0.1367
Loa Loa (eye worm) hypothetical protein 0.0037 0.0794 0.0813
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.1336 0.1336
Echinococcus multilocularis cathepsin b 0.0278 0.9774 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Onchocerca volvulus 0.0052 0.1336 0.2046
Onchocerca volvulus 0.0191 0.6529 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.1336 0.1336
Leishmania major cathepsin L-like protease 0.0052 0.1336 0.4271
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.1336 0.1367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.1336 0.1336
Leishmania major cathepsin L-like protease 0.0052 0.1336 0.4271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Giardia lamblia Cathepsin B precursor 0.0097 0.3023 0.3023
Loa Loa (eye worm) cysteine protease 0.0052 0.1336 0.1367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Onchocerca volvulus Cathepsin L homolog 0.0052 0.1336 0.2046
Onchocerca volvulus Cathepsin F homolog 0.0052 0.1336 0.2046
Entamoeba histolytica cysteine protease, putative 0.0031 0.0542 0.0542
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0542 0.0554
Echinococcus granulosus tar DNA binding protein 0.0061 0.1694 0.1733
Echinococcus granulosus cysteine protease 0.0031 0.0542 0.0554
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0191 0.6529 0.668
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.1336 0.1367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0542 0.1575
Plasmodium vivax vivapain-2 0.0052 0.1336 1
Brugia malayi cathepsin L-like precursor 0.0037 0.0794 0.0813
Loa Loa (eye worm) cathepsin B 0.0097 0.3023 0.3093
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.1336 0.1367
Treponema pallidum fructose-bisphosphate aldolase 0.0284 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Brugia malayi ShTK domain containing protein 0.0191 0.6529 0.668
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.1336 0.1336
Echinococcus granulosus cathepsin L cysteine protease 0.0031 0.0542 0.0554
Brugia malayi RNA binding protein 0.0061 0.1694 0.1733
Brugia malayi Cathepsin L-like precursor 0.0052 0.1336 0.1367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.1336 0.4271
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0542 0.0542
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0097 0.3023 0.3093
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.1336 0.1367
Entamoeba histolytica cysteine protease, putative 0.0031 0.0542 0.0542
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0078 0.008
Entamoeba histolytica cysteine protease, putative 0.0031 0.0542 0.0542
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.1336 0.1367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.1336 0.1367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.1336 0.1336
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1694 0.1733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.1336 0.1336
Brugia malayi Cathepsin L-like precursor 0.0037 0.0794 0.0813
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.1336 0.1367
Loa Loa (eye worm) hypothetical protein 0.0052 0.1336 0.1367
Plasmodium vivax vivapain-2 0.0052 0.1336 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.1336 0.4271
Onchocerca volvulus 0.0052 0.1336 0.2046
Loa Loa (eye worm) hypothetical protein 0.0037 0.0794 0.0813
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.1336 0.4271
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.1336 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0078 0.008
Brugia malayi Cathepsin L-like precursor 0.0037 0.0794 0.0813
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0542 0.0554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.1336 0.1367
Brugia malayi Cathepsin L-like precursor 0.0052 0.1336 0.1367
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0278 0.9774 1
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.1336 0.1367
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0542 0.0554
Brugia malayi Common central domain of tyrosinase family protein 0.0191 0.6529 0.668
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0031 0.0542 0.0554
Leishmania major cathepsin L-like protease 0.0052 0.1336 0.4271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.1336 0.4271
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.1336 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0278 0.9774 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Echinococcus multilocularis cathepsin b 0.0278 0.9774 1
Onchocerca volvulus 0.0191 0.6529 1
Echinococcus granulosus cathepsin l1 0.0037 0.0794 0.0813
Entamoeba histolytica cysteine protease, putative 0.0031 0.0542 0.0542
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1694 0.1733
Entamoeba histolytica cysteine protease, putative 0.0031 0.0542 0.0542
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0542 0.0554
Echinococcus multilocularis cysteine protease 0.0052 0.1336 0.1367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Plasmodium vivax unspecified product 0.0031 0.0542 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0542 0.0554
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0078 0.0078
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0794 0.0813
Entamoeba histolytica cysteine protease, putative 0.0031 0.0542 0.0542
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Loa Loa (eye worm) ShTK domain-containing protein 0.0191 0.6529 0.668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0542 0.0542
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0542 0.1575
Loa Loa (eye worm) hypothetical protein 0.0278 0.9774 1
Leishmania major cathepsin L-like protease 0.0052 0.1336 0.4271
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0078 0.0078
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0542 0.0554
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0542 0.0554
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0078 0.0582
Onchocerca volvulus 0.0052 0.1336 0.2046
Schistosoma mansoni tyrosinase precursor 0.0191 0.6529 0.668
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.1336 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.1336 0.4271
Plasmodium falciparum cysteine proteinase falcipain 1 0.0031 0.0542 0.4054
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0078 0.0582
Entamoeba histolytica cysteine protease, putative 0.0031 0.0542 0.0542
Toxoplasma gondii cathepsin CPL 0.0052 0.1336 0.4419
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0078 0.008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.3023 0.3093
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.1336 0.1367
Schistosoma mansoni ap endonuclease 0.0018 0.0078 0.008
Echinococcus multilocularis cysteine protease 0.0052 0.1336 0.1367
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0191 0.6529 0.668
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0542 0.0542
Entamoeba histolytica cysteine protease, putative 0.0031 0.0542 0.0542
Onchocerca volvulus Cathepsin L homolog 0.0052 0.1336 0.2046
Loa Loa (eye worm) hypothetical protein 0.0191 0.6529 0.668
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.1336 0.1336
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0542 0.0554
Brugia malayi Cathepsin L-like cysteine proteinase 0.0037 0.0794 0.0813
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.1336 0.1367
Echinococcus multilocularis cathepsin L 0.0031 0.0542 0.0554
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1694 0.1733
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0794 0.0794
Echinococcus granulosus cathepsin l1 0.0052 0.1336 0.1367
Entamoeba histolytica cysteine protease, putative 0.0031 0.0542 0.0542
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.1336 0.1367
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1694 0.1733
Leishmania major cathepsin L-like protease 0.0052 0.1336 0.4271
Brugia malayi Cathepsin L-like precursor 0.0052 0.1336 0.1367
Toxoplasma gondii cathepsin B 0.0097 0.3023 1
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0191 0.6529 0.668
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1694 0.1733
Plasmodium vivax vivapain-3 0.0031 0.0542 0.4054
Brugia malayi Cathepsin L-like precursor 0.0052 0.1336 0.1367
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 1 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1694 0.1733
Onchocerca volvulus 0.0052 0.1336 0.2046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Entamoeba histolytica cysteine protease, putative 0.0031 0.0542 0.0542
Schistosoma mansoni ap endonuclease 0.0018 0.0078 0.008
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0097 0.3023 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.1336 0.1336
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.1336 0.1367
Entamoeba histolytica cysteine protease, putative 0.0052 0.1336 0.1336
Loa Loa (eye worm) tyrosinase 1 0.0191 0.6529 0.668
Plasmodium vivax vivapain-1 0.0031 0.0542 0.4054
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 1 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0278 0.9774 1
Entamoeba histolytica cysteine proteinase 2 0.0031 0.0542 0.0542
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1694 0.1733
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.1336 0.4271
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0191 0.6529 0.668
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0078 0.0078
Echinococcus granulosus cathepsin b 0.0278 0.9774 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0278 0.9774 1
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0542 0.0542
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.1336 0.1336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.1336 0.4271
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0097 0.3023 0.3023
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.4576 1
Entamoeba histolytica cysteine protease, putative 0.0031 0.0542 0.0542
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.1336 0.1367
Leishmania major cathepsin L-like protease 0.0052 0.1336 0.4271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.1336 0.1336
Echinococcus granulosus cathepsin b 0.0278 0.9774 1
Onchocerca volvulus 0.0191 0.6529 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.1336 0.1336
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1694 0.1733
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.4576 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.1336 0.4271
Onchocerca volvulus 0.0037 0.0794 0.1217

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 130.7 uM Cytotoxicity against HEp2 cells ChEMBL. 17169560
EC50 (functional) = 0.008 uM Antiviral activity against RSV Long in HEp2 cells assessed as reduction of virus-induced cytopathic effect ChEMBL. 17169560
permeability (ADMET) = 233 nm/s Permeability across human Caco2 cells ChEMBL. 17169560
permeability (ADMET) = 233 nm/s Permeability across human Caco2 cells ChEMBL. 17169560
Ratio CC50/EC50 (functional) = 16337 Therapeutic index, ratio of CC50 for HEp2 cells to EC50 for RSV Long ChEMBL. 17169560
t1/2 (ADMET) = 4.5 min Metabolic stability human liver microsomes ChEMBL. 17169560

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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