Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0578 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0108 | 0.086 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.0108 | 0.086 | 1 |
Echinococcus granulosus | cathepsin b | 0.0578 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0108 | 0.086 | 0.3201 |
Onchocerca volvulus | Cathepsin L homolog | 0.0108 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0078 | 0.0274 | 0.0274 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0108 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0078 | 0.0274 | 0.1018 |
Onchocerca volvulus | 0.0108 | 0.086 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0202 | 0.2688 | 0.2688 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0108 | 0.086 | 0.0603 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0108 | 0.086 | 0.086 |
Loa Loa (eye worm) | ctsf protein | 0.0108 | 0.086 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0578 | 1 | 1 |
Onchocerca volvulus | 0.0094 | 0.0581 | 0.5247 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0108 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0108 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0108 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0108 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Giardia lamblia | Cathepsin B precursor | 0.0202 | 0.2688 | 0.5 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0202 | 0.2688 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0202 | 0.2688 | 0.2688 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0108 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0108 | 0.086 | 1 | |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0078 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | cathepsin B | 0.0202 | 0.2688 | 0.2482 |
Toxoplasma gondii | cathepsin B | 0.0202 | 0.2688 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0108 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Schistosoma mansoni | tyrosinase precursor | 0.0094 | 0.0581 | 0.0581 |
Onchocerca volvulus | Cathepsin L homolog | 0.0108 | 0.086 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0108 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0108 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0108 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0108 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0578 | 1 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0094 | 0.0581 | 0.0316 |
Brugia malayi | Cathepsin L-like precursor | 0.0108 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0578 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0108 | 0.086 | 0.086 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0094 | 0.0581 | 0.0581 |
Brugia malayi | cathepsin L-like precursor | 0.0078 | 0.0274 | 0.0274 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0108 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0078 | 0.0274 | 0.3182 |
Loa Loa (eye worm) | cysteine protease | 0.0108 | 0.086 | 0.0603 |
Loa Loa (eye worm) | fibroinase | 0.0108 | 0.086 | 0.0603 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0108 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0094 | 0.0581 | 0.0581 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0078 | 0.0274 | 0.0274 |
Echinococcus granulosus | cathepsin b | 0.0578 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0108 | 0.086 | 1 |
Onchocerca volvulus | 0.0108 | 0.086 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0094 | 0.0581 | 0.0581 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0108 | 0.086 | 0.086 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0108 | 0.086 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0108 | 0.086 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0108 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0108 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0108 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0108 | 0.086 | 0.086 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0094 | 0.0581 | 0.0581 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0108 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0108 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0108 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0094 | 0.0581 | 0.5247 | |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0094 | 0.0581 | 0.0316 |
Brugia malayi | Cathepsin L-like precursor | 0.0108 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0108 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0078 | 0.0274 | 0.0274 |
Giardia lamblia | Cathepsin B precursor | 0.0202 | 0.2688 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0094 | 0.0581 | 0.0581 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.086 | 0.0603 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0108 | 0.086 | 1 |
Brugia malayi | ShTK domain containing protein | 0.0094 | 0.0581 | 0.0581 |
Schistosoma mansoni | tyrosinase precursor | 0.0094 | 0.0581 | 0.0581 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0108 | 0.086 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0581 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0581 | 0.0316 |
Echinococcus multilocularis | cathepsin b | 0.0578 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0578 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0108 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0108 | 0.086 | 0.0603 |
Onchocerca volvulus | 0.0094 | 0.0581 | 0.5247 | |
Giardia lamblia | Cathepsin B precursor | 0.0202 | 0.2688 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0078 | 0.0274 | 0.0274 |
Echinococcus multilocularis | cysteine protease | 0.0108 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0108 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0094 | 0.0581 | 0.5247 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0108 | 0.086 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0078 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0108 | 0.086 | 0.3201 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0094 | 0.0581 | 0.0316 |
Brugia malayi | Cathepsin L-like precursor | 0.0108 | 0.086 | 0.086 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0108 | 0.086 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0108 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0108 | 0.086 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.0108 | 0.086 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0202 | 0.2688 | 1 |
Onchocerca volvulus | 0.0108 | 0.086 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0108 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0578 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0108 | 0.086 | 0.086 |
Echinococcus multilocularis | cathepsin b | 0.0578 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0078 | 0.0274 | 0.1018 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0202 | 0.2688 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0108 | 0.086 | 0.086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 2.4 microg.min/mL | AUC in rat at 5 mg/kg, po | ChEMBL. | 17169560 |
AUC (ADMET) | = 11.1 microg.min/mL | AUC in cynamologous monkey at 0.5 mg/kg, po | ChEMBL. | 17169560 |
AUC (ADMET) | = 18.4 microg.min/mL | AUC in dog at 0.5 mg/kg, po | ChEMBL. | 17169560 |
AUC (ADMET) | = 86 microg.min/mL | AUC in mouse at 10 mg/kg, po | ChEMBL. | 17169560 |
AUC (ADMET) | = 86 microg.min/mL | AUC in mouse at 10 mg/kg, po | ChEMBL. | 17169560 |
CC50 (ADMET) | > 94.6 uM | Cytotoxicity against HEp2 cells | ChEMBL. | 17169560 |
EC50 (functional) | = 0.015 uM | Antiviral activity against RSV Long in HEp2 cells assessed as reduction of virus-induced cytopathic effect | ChEMBL. | 17169560 |
log10 TCID50 (functional) | = 2.77 | Antiviral activity against RSV infected BALB/c mouse per lung at 100 mg/kg/day | ChEMBL. | 17169560 |
permeability (ADMET) | = 36 nm/s | Permeability across human Caco2 cells | ChEMBL. | 17169560 |
permeability (ADMET) | = 36 nm/s | Permeability across human Caco2 cells | ChEMBL. | 17169560 |
Ratio CC50/EC50 (functional) | = 6307 | Therapeutic index, ratio of CC50 for HEp2 cells to EC50 for RSV Long | ChEMBL. | 17169560 |
t1/2 (ADMET) | = 87 min | Metabolic stability human liver microsomes | ChEMBL. | 17169560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.