Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidase homolog | 0.0262 | 0.0916 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0262 | 0.0916 | 0.5 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.1111 | 1 | 1 |
Onchocerca volvulus | 0.0262 | 0.0916 | 0.5 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.1331 | 0.7711 |
Schistosoma mansoni | peroxidasin | 0.0262 | 0.0916 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0301 | 0.1331 | 0.7711 |
Onchocerca volvulus | 0.0262 | 0.0916 | 0.5 | |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.1331 | 1 |
Echinococcus granulosus | peroxidasin | 0.0262 | 0.0916 | 0.5 |
Onchocerca volvulus | 0.0262 | 0.0916 | 0.5 | |
Mycobacterium ulcerans | hypothetical protein | 0.1111 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | trans-2-enoyl-ACP reductase, FabK | 0.1111 | 1 | 1 |
Trichomonas vaginalis | 2-nitropropane dioxygenase precursor, putative | 0.1111 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.1316 | 0.9644 |
Echinococcus multilocularis | peroxidasin | 0.0262 | 0.0916 | 1 |
Mycobacterium tuberculosis | Possible alanine rich oxidoreductase | 0.1111 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0262 | 0.0916 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0262 | 0.0916 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0312 | 0.1454 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0262 | 0.0916 | 0.5 |
Mycobacterium ulcerans | 2-nitropropane dioxygenase | 0.1111 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0262 | 0.0916 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0262 | 0.0916 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 74 % | Activity against TRAFalpha1 expressed in CHOK1 cells by alkaline phosphatase reporter gene assay | ChEMBL. | 17543524 |
Activity (binding) | = 88 % | Activity against TRAFbeta expressed in CHOK1 cells by alkaline phosphatse reporter gene assay | ChEMBL. | 17543524 |
EC50 (binding) | = 38 nM | Activity against TRAFbeta expressed in CHOK1 cells by alkaline phosphatse reporter gene assay | ChEMBL. | 17543524 |
EC50 (binding) | = 66 nM | Activity against TRAFalpha1 expressed in CHOK1 cells by alkaline phosphatase reporter gene assay | ChEMBL. | 17543524 |
IC50 (binding) | = 26 nM | Binding affinity at human thyroid hormone receptor beta1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
IC50 (binding) | = 26 nM | Binding affinity at human thyroid hormone receptor beta1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
IC50 (binding) | = 168 nM | Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
IC50 (binding) | = 168 nM | Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
Ratio IC50 (binding) | = 3.8 | Selectivity ratio of IC50 for thyroid hormone receptor alpha1 to IC50 for thyroid hormone receptor beta1 | ChEMBL. | 17543524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.