Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0697 | 0.9122 | 0.9122 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0067 | 0.0703 | 0.4112 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0067 | 0.0703 | 0.1583 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.0139 | 0.1667 | 0.1667 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0697 | 0.9122 | 0.9122 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0067 | 0.0703 | 0.0703 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0067 | 0.0703 | 0.4112 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0762 | 1 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0067 | 0.0703 | 0.1583 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.0139 | 0.1667 | 1 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0017 | 0.003 | 0.5 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0139 | 0.1667 | 1 |
Brugia malayi | eukaryotic translation initiation factor 4E-1 | 0.0017 | 0.003 | 0.003 |
Schistosoma mansoni | alpha-glucosidase | 0.0697 | 0.9122 | 0.9108 |
Schistosoma mansoni | alpha-glucosidase | 0.0697 | 0.9122 | 0.9108 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0697 | 0.9122 | 0.9108 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 0.3851 |
Plasmodium vivax | hypothetical protein, conserved | 0.0017 | 0.003 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Onchocerca volvulus | 0.0027 | 0.0166 | 0.0224 | |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0762 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E-1 | 0.0017 | 0.003 | 0.003 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0067 | 0.0703 | 0.1583 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0067 | 0.0703 | 0.4112 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0166 | 0.0166 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0.0703 | 0.4112 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0017 | 0.003 | 0.5 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 0.3851 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0139 | 0.1667 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0.0703 | 0.4112 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.0139 | 0.1667 | 0.1641 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 0.3851 |
Giardia lamblia | Hypothetical protein | 0.0017 | 0.003 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0067 | 0.0703 | 0.1583 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.0139 | 0.1667 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0067 | 0.0703 | 0.4112 |
Brugia malayi | Eukaryotic translation initiation factor 4E type 3, putative | 0.0017 | 0.003 | 0.003 |
Leishmania major | glycosyl hydrolase-like protein | 0.0067 | 0.0703 | 0.4112 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0067 | 0.0703 | 0.4112 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0067 | 0.0703 | 0.1583 |
Onchocerca volvulus | 0.0468 | 0.6067 | 1 | |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0067 | 0.0703 | 0.4112 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0762 | 1 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0067 | 0.0703 | 0.1583 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.0139 | 0.1667 | 0.1526 |
Giardia lamblia | Translation elongation factor | 0.0017 | 0.003 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0697 | 0.9122 | 0.9108 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 0.3851 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E type 3 | 0.0017 | 0.003 | 0.003 |
Onchocerca volvulus | 0.0027 | 0.0166 | 0.0224 | |
Leishmania major | eukaryotic translation initiation factor-like | 0.0139 | 0.1667 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0697 | 0.9122 | 0.912 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0762 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0166 | 0.0136 |
Giardia lamblia | Hypothetical protein | 0.0017 | 0.003 | 0.5 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.0139 | 0.1667 | 0.1526 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0067 | 0.0703 | 0.0547 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0017 | 0.003 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0067 | 0.0703 | 0.0703 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0067 | 0.0703 | 0.0675 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0159 | 0.0159 |
Mycobacterium tuberculosis | Arylamine N-acetyltransferase Nat (arylamine acetylase) | 0.0625 | 0.8168 | 0.5 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0703 | 0.0703 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0166 | 0.0166 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0166 | 0.0136 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0762 | 1 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0067 | 0.0703 | 0.4112 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0334 | 0.428 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0139 | 0.1667 | 1 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.0139 | 0.1667 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0067 | 0.0703 | 0.4112 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0067 | 0.0703 | 0.0703 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0067 | 0.0703 | 0.1114 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0067 | 0.0703 | 0.4112 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0166 | 0.0166 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0334 | 0.428 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0067 | 0.0703 | 0.0547 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0166 | 0.0166 |
Brugia malayi | translation initiation factor 4E | 0.0139 | 0.1667 | 0.1667 |
Giardia lamblia | hypothetical protein | 0.0017 | 0.003 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0067 | 0.0703 | 0.1583 |
Echinococcus granulosus | lamin | 0.0027 | 0.0166 | 0.0136 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (ADMET) | = 135 uM | Antiproliferative activity against human HFL1 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (ADMET) | = 135 uM | Antiproliferative activity against human HFL1 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (functional) | = 320 uM | Antiproliferative activity against human T24 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (functional) | = 320 uM | Antiproliferative activity against human T24 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.