Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.0465 | 0.0437 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0132 | 0.0783 | 0.0737 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1195 | 1 | 1 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0797 | 0.6549 | 0.648 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.2219 | 1 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0797 | 0.6549 | 0.6256 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.111 | 0.1117 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0175 | 0.1154 | 0.5201 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 0.1658 | 0.095 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.035 | 0.2669 | 1 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0123 | 0.0703 | 0.3167 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0123 | 0.0703 | 0.0657 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0123 | 0.0703 | 0.3167 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0298 | 0.2219 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0175 | 0.1154 | 0.38 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.0859 | 0.3871 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0175 | 0.1154 | 0.38 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0123 | 0.0703 | 0.1953 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.1658 | 0.095 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0797 | 0.6549 | 0.6532 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0797 | 0.6549 | 0.6256 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0175 | 0.1154 | 0.111 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0175 | 0.1154 | 0.0978 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1195 | 1 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0175 | 0.1154 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0175 | 0.1154 | 0.38 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0123 | 0.0703 | 0.1953 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0123 | 0.0703 | 0.1953 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0797 | 0.6549 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0175 | 0.1154 | 0.38 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0175 | 0.1154 | 0.38 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0797 | 0.6549 | 0.6842 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.2219 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0175 | 0.1154 | 0.1163 |
Entamoeba histolytica | glycogen debranching enzyme, putative | 0.0132 | 0.0783 | 0.1783 |
Trypanosoma brucei | glucosidase, putative | 0.0175 | 0.1154 | 0.5201 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0123 | 0.0703 | 0.1953 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0175 | 0.1154 | 0.2977 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0175 | 0.1154 | 0.38 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.1658 | 0.1493 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0175 | 0.1154 | 0.0402 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0123 | 0.0703 | 0.0927 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.035 | 0.2669 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.1143 | 0.9549 | 1 |
Mycobacterium ulcerans | arylamine N-acetyltransferase Nat | 0.0615 | 0.4974 | 0.7163 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0079 | 0.0358 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0132 | 0.0783 | 0.2283 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0132 | 0.0783 | 0.2283 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0123 | 0.0703 | 0.3167 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0123 | 0.0703 | 0.1953 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0175 | 0.1154 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0175 | 0.1154 | 0.0402 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.0859 | 0.1031 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0175 | 0.1154 | 0.38 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0123 | 0.0703 | 0.1953 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0123 | 0.0703 | 0.1953 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0123 | 0.0703 | 0.1953 |
Mycobacterium tuberculosis | Arylamine N-acetyltransferase Nat (arylamine acetylase) | 0.0615 | 0.4974 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0783 | 0.06 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0175 | 0.1154 | 0.5201 |
Giardia lamblia | 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase | 0.0132 | 0.0783 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1195 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0233 | 0.1658 | 0.1617 |
Toxoplasma gondii | Amylo-alpha-1,6-glucosidase | 0.0132 | 0.0783 | 0.663 |
Onchocerca volvulus | 0.086 | 0.7094 | 1 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0175 | 0.1154 | 0.38 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0298 | 0.2219 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0703 | 0.0518 |
Schistosoma mansoni | alpha-glucosidase | 0.1143 | 0.9549 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0141 | 0.0859 | 0.3871 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0175 | 0.1154 | 0.38 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1195 | 1 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0175 | 0.1154 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (ADMET) | = 120 uM | Antiproliferative activity against human HFL1 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (ADMET) | = 120 uM | Antiproliferative activity against human HFL1 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (functional) | = 225 uM | Antiproliferative activity against human T24 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (functional) | = 225 uM | Antiproliferative activity against human T24 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.