Detailed information for compound 44569

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 269.146 | Formula: C13H12Cl2NO-
  • H donors: 2 H acceptors: 1 LogP: 4.03 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCc1cc(Cl)cc(c1O)c1ccccc1.[Cl-]
  • InChi: 1S/C13H12ClNO.ClH/c14-11-6-10(8-15)13(16)12(7-11)9-4-2-1-3-5-9;/h1-7,16H,8,15H2;1H/p-1
  • InChiKey: TYMADPAKYNFBEU-UHFFFAOYSA-M  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni pyruvate kinase 0.0066 0.0233 0.0293
Echinococcus multilocularis musashi 0.0027 0.0043 0.0043
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0138 0.0127
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0014 0.0061
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0064 0.007
Chlamydia trachomatis pyruvate kinase 0.0066 0.0233 0.0089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0153 0.0679
Schistosoma mansoni survival motor neuron protein 0.0048 0.0145 0.0177
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0309
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0217 0.0272
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0384 0.0493
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0153 0.0679
Mycobacterium leprae Probable pyruvate kinase PykA 0.0066 0.0233 0.0977
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.007 0.0252 0.0319
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.1598 0.7574 0.5
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0014 0.0004
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.1598 0.7574 1
Brugia malayi hypothetical protein 0.0122 0.0498 0.0644
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0064 0.007
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1598 0.7574 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0014 0.0005
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0121 0.0493 0.0634
Entamoeba histolytica hypothetical protein 0.0036 0.0086 0.0099
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0014 0.0003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0086 0.0099
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Schistosoma mansoni DNA polymerase eta 0.0047 0.0138 0.0168
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0121 0.0493 0.0638
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0014 0.0004
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0233 0.4515
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0077 0.0087
Echinococcus multilocularis protein dispatched 1 0.0048 0.0144 0.0176
Onchocerca volvulus 0.0048 0.0145 0.2698
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0585 0.0759
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.1598 0.7574 1
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0121 0.0493 0.0634
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0252 0.0319
Echinococcus granulosus expressed conserved protein 0.0092 0.0355 0.0455
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1013 0.4771 0.6294
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0488 0.2253 1
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0064 0.0067
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0014 0.0061
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0014 0.0004
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0014 0.0004
Loa Loa (eye worm) hypothetical protein 0.0051 0.0161 0.0298
Mycobacterium ulcerans hypothetical protein 0.007 0.0252 0.0319
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0014 0.0003
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.1598 0.7574 0.5
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0014 0.0061
Loa Loa (eye worm) oxidoreductase 0.0021 0.0014 0.0005
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.1598 0.7574 1
Echinococcus granulosus lamin dm0 0.0027 0.0043 0.0043
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Schistosoma mansoni hypothetical protein 0.004 0.0109 0.0129
Schistosoma mansoni glutaminase 0.0271 0.1212 0.1588
Schistosoma mansoni lamin 0.0027 0.0043 0.0043
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0121 0.0493 0.0638
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0217 0.0272
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1598 0.7574 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0014 0.0061
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0014 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0152 0.0187
Echinococcus multilocularis lamin dm0 0.0027 0.0043 0.0043
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1013 0.4771 0.6294
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0043 0.0064
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0014 0.0003
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0145 0.0177
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0309
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0121 0.0493 0.0638
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0014 0.0004
Echinococcus multilocularis lamin 0.0027 0.0043 0.0043
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1013 0.4771 0.9436
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0064 0.007
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.1598 0.7574 1
Schistosoma mansoni patched 1 0.0042 0.0116 0.0139
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0005
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0478
Loa Loa (eye worm) glutaminase 2 0.0271 0.1212 0.238
Plasmodium falciparum pyruvate kinase 2 0.0034 0.0078 0.0085
Loa Loa (eye worm) hypothetical protein 0.0098 0.0384 0.0739
Trypanosoma brucei pyruvate kinase 1 0.0066 0.0233 0.0222
Trichomonas vaginalis pyruvate kinase, putative 0.0066 0.0233 0.0293
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0252 0.0319
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0121 0.0493 0.0638
Mycobacterium ulcerans glutaminase 0.0271 0.1212 0.1588
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.1598 0.7574 0.7571
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0252 0.0319
Brugia malayi TAR-binding protein 0.0063 0.0217 0.0272
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.1598 0.7574 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0252 0.0319
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0525 0.2432 0.3202
Echinococcus granulosus tumor protein p63 0.0336 0.1524 0.2001
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0384 0.0493
Brugia malayi hypothetical protein 0.0036 0.0086 0.0099
Echinococcus granulosus tar DNA binding protein 0.0063 0.0217 0.0272
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0014 0.0003
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0525 0.2432 0.2424
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0011 0.0049
Schistosoma mansoni pyruvate kinase 0.0066 0.0233 0.0293
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0252 0.0241
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 0.7571
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0014 0.0061
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0014 0.0061
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0086 0.0099
Entamoeba histolytica hypothetical protein 0.0036 0.0086 0.0099
Giardia lamblia Pyruvate kinase 0.0066 0.0233 0.0293
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0116 0.0139
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.007 0.0252 0.1118
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0384 0.0493
Onchocerca volvulus 0.0027 0.0043 0.0608
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.1598 0.7574 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.1598 0.7574 0.7571
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0233 0.4515
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1013 0.4771 0.6294
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0153 0.0679
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.1041 0.1362
Loa Loa (eye worm) hypothetical protein 0.0122 0.0498 0.0966
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.1598 0.7574 1
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.0078 0.0085
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0121 0.0493 0.0483
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0014 0.0003
Echinococcus granulosus intermediate filament protein 0.0027 0.0043 0.0043
Echinococcus granulosus lamin 0.0027 0.0043 0.0043
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0121 0.0493 0.0956
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0391 0.0502
Giardia lamblia Pyruvate kinase 0.0034 0.0078 0.0088
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0478
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 0.7571
Trichomonas vaginalis pyruvate kinase, putative 0.0066 0.0233 0.0293
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0064 0.007
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.0078 0.0085
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0072 0.0061
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0167 0.0202
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0252 0.0319
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0525 0.2432 0.2424
Schistosoma mansoni hypothetical protein 0.0036 0.0086 0.0099
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0252 0.0319
Schistosoma mansoni hypothetical protein 0.004 0.0109 0.0129
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0252 0.1063
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Entamoeba histolytica hypothetical protein 0.0036 0.0086 0.0099
Echinococcus granulosus dna polymerase eta 0.0047 0.0138 0.0168
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.1598 0.7574 0.7571
Trypanosoma cruzi pyruvate kinase 2, putative 0.0066 0.0233 0.0222
Loa Loa (eye worm) hypothetical protein 0.005 0.0152 0.028
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0252 0.0241
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0121 0.0493 0.0638
Mycobacterium ulcerans pyruvate kinase 0.0066 0.0233 0.0293
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0152 0.0187
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.1598 0.7574 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0525 0.2432 0.2424
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0488 0.2253 1
Onchocerca volvulus Huntingtin homolog 0.0122 0.0498 1
Onchocerca volvulus Huntingtin homolog 0.0122 0.0498 1
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0121 0.0493 0.0483
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0014 0.0005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0086 0.0099
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1013 0.4771 0.6294
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0233 0.0439
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Brugia malayi RNA binding protein 0.0063 0.0217 0.0272
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.2104 1 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.3777 0.498
Echinococcus multilocularis pyruvate kinase 0.0066 0.0233 0.0293
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 0.7571
Plasmodium falciparum pyruvate kinase 0.0066 0.0233 0.0289
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0064 0.0067
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0064 0.0053
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0014 0.0004
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0116 0.0139
Leishmania major pyruvate kinase 0.0066 0.0233 0.0222
Loa Loa (eye worm) RNA binding protein 0.0063 0.0217 0.0407
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.2104 1 1
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.1598 0.7574 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0233 0.0439
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Entamoeba histolytica pyruvate kinase, putative 0.0046 0.0136 0.0166
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1598 0.7574 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.1598 0.7574 0.7571
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 0.7571
Loa Loa (eye worm) hypothetical protein 0.0235 0.1041 0.2042
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0064 0.0053
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0121 0.0493 0.0638
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0064 0.007
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0014 0.0004
Echinococcus granulosus pyruvate kinase 0.0034 0.0078 0.0088
Loa Loa (eye worm) pyruvate kinase-PB 0.0046 0.0136 0.0249
Brugia malayi isocitrate dehydrogenase 0.0031 0.0064 0.007
Echinococcus multilocularis pyruvate kinase 0.0034 0.0078 0.0088
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0121 0.0493 0.0483
Trichomonas vaginalis glutaminase, putative 0.0271 0.1212 0.1588
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0014 0.0004
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.1598 0.7574 0.7571
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.1041 0.1362
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0309
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0525 0.2432 0.2424
Echinococcus multilocularis pyruvate kinase 0.0034 0.0078 0.0088
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0138 0.0168
Brugia malayi glutaminase DH11.1 0.0271 0.1212 0.1588
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1598 0.7574 1
Echinococcus multilocularis tumor protein p63 0.0336 0.1524 0.2001
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0014 0.0004
Echinococcus granulosus pyruvate kinase 0.0066 0.0233 0.0293
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0249
Schistosoma mansoni lamin 0.0027 0.0043 0.0043
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0064 0.0067
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0014 0.0004
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0066 0.0233 0.1032
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0217 0.0272
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0043 0.0064
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1013 0.4771 0.9436
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0167 0.0202
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0153 0.0679
Plasmodium vivax pyruvate kinase, putative 0.0066 0.0233 0.0289
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0217 0.0407
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0585 0.0759
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0064 0.0053
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0121 0.0493 0.0956
Echinococcus multilocularis pyruvate kinase 0.0066 0.0233 0.0293
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0217 0.0272
Echinococcus granulosus pyruvate kinase 0.0034 0.0078 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0217 0.0272
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0014 0.0004
Brugia malayi hypothetical protein 0.0235 0.1041 0.1362
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0014 0.0004
Echinococcus multilocularis expressed conserved protein 0.0092 0.0355 0.0455
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0217 0.0407
Schistosoma mansoni microtubule-associated protein tau 0.0718 0.3357 0.4425
Trypanosoma brucei pyruvate kinase 1, putative 0.0066 0.0233 0.0222
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.1598 0.7574 0.7571
Brugia malayi CHE-14 protein 0.0042 0.0116 0.0139
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0252 0.0241
Brugia malayi AMP-binding enzyme family protein 0.007 0.0252 0.0319
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0041 0.0059
Onchocerca volvulus 0.007 0.0252 0.4915
Onchocerca volvulus 0.0049 0.015 0.2819
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.1598 0.7574 0.7571
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0138 0.0127
Schistosoma mansoni hypothetical protein 0.004 0.0109 0.0129
Schistosoma mansoni hypothetical protein 0.0034 0.0077 0.0087
Loa Loa (eye worm) glutaminase 0.0271 0.1212 0.238
Echinococcus granulosus pyruvate kinase 0.0034 0.0078 0.0088
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0064 0.0105
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0064
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0252 0.1063
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.015 0.0276
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0014 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0014 0.0004
Schistosoma mansoni pyruvate kinase 0.0034 0.0078 0.0088
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0014 0.0004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0077 0.0131
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0217 0.0272
Brugia malayi Pyruvate kinase, muscle isozyme 0.0066 0.0233 0.0293
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0064 0.0285
Onchocerca volvulus 0.0027 0.0043 0.0608
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0043 0.0043
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0014 0.0004
Entamoeba histolytica hypothetical protein 0.0036 0.0086 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0217 0.0272
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0121 0.0493 0.0638
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0014 0.0004
Brugia malayi Pyruvate kinase, M2 isozyme 0.0066 0.0233 0.0293
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0384 0.0493
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0072 0.0077
Brugia malayi AMP-binding enzyme family protein 0.007 0.0252 0.0319
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0309
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0309
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0014 0.0061
Leishmania major DNA polymerase eta, putative 0.0047 0.0138 0.0127
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0011 0.0049
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1073 0.5056 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0014 0.0003
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0233 0.0439
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0014 0.0004
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0014 0.0061
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.1598 0.7574 1
Echinococcus multilocularis dna polymerase eta 0.0047 0.0138 0.0168
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.1598 0.7574 0.7571
Leishmania major DNA polymerase eta, putative 0.0033 0.0072 0.0061
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0167 0.074
Brugia malayi intermediate filament protein 0.0027 0.0043 0.0043
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0064 0.0053
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.1598 0.7574 1
Schistosoma mansoni hypothetical protein 0.004 0.0109 0.0129
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0121 0.0493 0.0638
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0116 0.0139
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0585 0.2717 0.3579
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0152 0.028
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0064 0.007
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0252 0.0319
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0478
Echinococcus multilocularis pyruvate kinase 0.0034 0.0078 0.0088
Entamoeba histolytica acyl-coA synthetase, putative 0.007 0.0252 0.0319
Echinococcus granulosus microtubule associated protein 2 0.0718 0.3357 0.4425
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0014 0.0003
Brugia malayi AMP-binding enzyme family protein 0.007 0.0252 0.0319
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0014 0.0003
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.111 0.5235 0.6908
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0116 0.0208
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0064 0.0053
Loa Loa (eye worm) hypothetical protein 0.0122 0.0498 0.0966
Echinococcus multilocularis protein patched 0.0042 0.0116 0.0139
Loa Loa (eye worm) hypothetical protein 0.0047 0.0138 0.0252
Echinococcus multilocularis microtubule associated protein 2 0.0718 0.3357 0.4425
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0064 0.007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0167 0.0206
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0014 0.0004
Schistosoma mansoni hypothetical protein 0.0048 0.0145 0.0177
Echinococcus multilocularis pyruvate kinase 0.0052 0.0166 0.0204
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0014 0.0061
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1073 0.5056 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0121 0.0493 0.0483
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.015 0.0184
Loa Loa (eye worm) hypothetical protein 0.1013 0.4771 0.9436
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0064 0.007
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0116 0.0139
Leishmania major pyruvate kinase 0.0066 0.0233 0.0222
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0121 0.0493 0.0634
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.1598 0.7574 1
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.2104 1 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0585 0.2717 0.3578
Schistosoma mansoni intermediate filament proteins 0.0027 0.0043 0.0043
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0233 0.4515
Trypanosoma cruzi pyruvate kinase 2, putative 0.0066 0.0233 0.0222
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0233 0.0439
Echinococcus granulosus pyruvate kinase 0.0066 0.0233 0.0293
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0014 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0252 0.1118
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0014 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0116 0.0208
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0014 0.0004
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.007 0.0252 0.0319
Toxoplasma gondii pyruvate kinase PyK1 0.0066 0.0233 0.0289
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0525 0.2432 0.2424
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0064 0.0067

Activities

Activity type Activity value Assay description Source Reference
Diuretic activity (functional) = 250 Salidiuretic activity in dog following i.v. dosing at 5 mg/kg ChEMBL. 7452697

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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