Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | prolyl oligopeptidase family protein | 0.0068 | 0.0169 | 0.0169 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0068 | 0.0169 | 0.0386 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0072 | 0.0234 | 0.0304 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0203 | 0.2268 | 0.5185 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.3718 | 0.4835 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 0.3049 | 0.697 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0203 | 0.2268 | 0.2949 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 0.3049 | 0.697 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0203 | 0.2268 | 0.2268 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0068 | 0.0169 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0203 | 0.2268 | 0.5185 |
Plasmodium falciparum | transporter, putative | 0.0057 | 0 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0203 | 0.2268 | 0.5185 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0068 | 0.0169 | 0.0386 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0057 | 0 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0338 | 0.4374 | 1 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.0255 | 0.3078 | 0.7037 |
Echinococcus granulosus | serotonin transporter | 0.0338 | 0.4374 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.3049 | 0.3964 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0338 | 0.4374 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0338 | 0.4374 | 0.5688 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0068 | 0.0169 | 0.5 |
Echinococcus granulosus | hormone sensitive lipase | 0.0253 | 0.3049 | 0.697 |
Plasmodium vivax | amine transporter, putative | 0.0057 | 0 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0338 | 0.4374 | 0.5688 |
Echinococcus multilocularis | serotonin transporter | 0.0338 | 0.4374 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 0.3049 | 0.697 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.4374 | 0.5688 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1409 | 0.1831 |
Brugia malayi | Cytochrome P450 family protein | 0.0072 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0338 | 0.4374 | 0.5688 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0203 | 0.2268 | 0.5185 |
Plasmodium falciparum | amino acid transporter, putative | 0.0057 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.4374 | 0.5688 |
Plasmodium vivax | hypothetical protein, conserved | 0.0057 | 0 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0068 | 0.0169 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.7691 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0211 | 0.2388 | 0.546 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0068 | 0.0169 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.4374 | 0.5688 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0338 | 0.4374 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0068 | 0.0169 | 0.0386 |
Onchocerca volvulus | 0.0338 | 0.4374 | 1 | |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0068 | 0.0169 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0068 | 0.0169 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0253 | 0.3049 | 0.697 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0338 | 0.4374 | 0.4374 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.5 uM | Inhibition of recombinant human hormone-sensitive lipase | ChEMBL. | 17918819 |
IC50 (binding) | = 8.5 uM | Inhibition of recombinant human hormone-sensitive lipase | ChEMBL. | 17918819 |
IC50 (binding) | > 50 uM | Inhibition of acetylcholine esterase | ChEMBL. | 17918819 |
IC50 (binding) | > 50 uM | Inhibition of butyrylcholine esterase | ChEMBL. | 17918819 |
IC50 (binding) | > 50 uM | Inhibition of acetylcholine esterase | ChEMBL. | 17918819 |
IC50 (binding) | > 50 uM | Inhibition of butyrylcholine esterase | ChEMBL. | 17918819 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.