Detailed information for compound 446592

Basic information

Technical information
  • TDR Targets ID: 446592
  • Name: [4-[[5-(trifluoromethyl)pyridin-2-yl]amino]ph enyl] N-methyl-N-phenylcarbamate
  • MW: 387.355 | Formula: C20H16F3N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.93 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccccc1)C(=O)Oc1ccc(cc1)Nc1ccc(cn1)C(F)(F)F
  • InChi: 1S/C20H16F3N3O2/c1-26(16-5-3-2-4-6-16)19(27)28-17-10-8-15(9-11-17)25-18-12-7-14(13-24-18)20(21,22)23/h2-13H,1H3,(H,24,25)
  • InChiKey: IXQRSRUXRGXCCW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[[5-(trifluoromethyl)-2-pyridyl]amino]phenyl] N-methyl-N-phenyl-carbamate
  • N-methyl-N-phenylcarbamic acid [4-[[5-(trifluoromethyl)-2-pyridyl]amino]phenyl] ester
  • [4-[[5-(trifluoromethyl)pyridin-2-yl]amino]phenyl] N-methyl-N-phenyl-carbamate
  • N-methyl-N-phenyl-carbamic acid [4-[[5-(trifluoromethyl)-2-pyridyl]amino]phenyl] ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lipase, hormone-sensitive Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus hormone sensitive lipase Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma mansoni hormone-sensitive lipase (S09 family) Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma mansoni hormone-sensitive lipase (S09 family) Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma mansoni hormone-sensitive lipase (S09 family) Get druggable targets OG5_132840 All targets in OG5_132840
Echinococcus multilocularis hormone sensitive lipase Get druggable targets OG5_132840 All targets in OG5_132840
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma japonicum Hormone-sensitive lipase, putative Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma japonicum ko:K07188 hormone-sensitive lipase [EC3.1.1.79], putative Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma japonicum Hormone-sensitive lipase, putative Get druggable targets OG5_132840 All targets in OG5_132840
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cpg binding protein 0.0031 0.0309 0.0309
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1296 0.3495
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.1114 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2388 0.6291
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0549 0.1378
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.3707 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0159 0.0225
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0232 0.0226
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0232 0.0232
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.3707 1
Schistosoma mansoni tar DNA-binding protein 0.0201 0.2717 0.2605
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1136
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0642 0.0642
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.03 0.1544
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0552 0.0406
Schistosoma mansoni lamin 0.0027 0.0255 0.0105
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0077 0.0208
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0088 0.1114 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0549 0.0549
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0232 0.0833
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0159 0.0159
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.2594 0.2594
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0272 0.3707 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0537 0.5501
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0255 0.0489
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.1114 0.5
Onchocerca volvulus 0.0029 0.0285 0.0142
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.0134
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0152 0.1043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0057 0.0153
Schistosoma mansoni tar DNA-binding protein 0.0201 0.2717 0.2605
Echinococcus granulosus dna polymerase kappa 0.002 0.0159 0.0159
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0253 0.3448 0.3347
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0537 0.1267
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2388 0.6291
Loa Loa (eye worm) hypothetical protein 0.0047 0.0537 0.1449
Echinococcus granulosus lamin 0.0027 0.0255 0.0255
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.3707 1
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0537 0.597
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0686 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0549 0.148
Onchocerca volvulus 0.0048 0.0549 0.1378
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0088 0.1114 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0285 0.0769
Echinococcus multilocularis musashi 0.0027 0.0255 0.0255
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0852 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0339 0.2681
Echinococcus granulosus intermediate filament protein 0.0027 0.0255 0.0255
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0159 0.0021
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0549 0.0549
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0057 0.0057
Schistosoma mansoni microtubule-associated protein tau 0.0717 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1296 0.3357
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0323 0.0323
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.03 0.1544
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0748 0.0605
Schistosoma mansoni tar DNA-binding protein 0.0201 0.2717 0.2605
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0232 0.0081
Brugia malayi intermediate filament protein 0.0027 0.0255 0.0489
Trypanosoma brucei unspecified product 0.002 0.0159 0.1136
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0159 0.0104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0552 0.0406
Loa Loa (eye worm) hypothetical protein 0.0129 0.1691 0.4563
Schistosoma mansoni hypothetical protein 0.0295 0.4041 0.3949
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2388 0.6291
Loa Loa (eye worm) MBCTL1 0.0055 0.0642 0.1733
Echinococcus granulosus dnaJ subfamily B 0.0416 0.5751 0.5751
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0232 0.1144
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0852 0.0712
Loa Loa (eye worm) hypothetical protein 0.0055 0.0642 0.1733
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.1114 1
Leishmania major DNA polymerase eta, putative 0.0047 0.0537 0.5501
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0552 0.1488
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1136
Brugia malayi mbt repeat family protein 0.0048 0.0549 0.1299
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0159 0.0104
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.03 0.1544
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0159 0.0076
Brugia malayi mbt repeat family protein 0.0048 0.0549 0.1299
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0088 0.1114 1
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0549 0.0549
Toxoplasma gondii hypothetical protein 0.003 0.03 0.1544
Loa Loa (eye worm) hypothetical protein 0.0032 0.0323 0.087
Leishmania major DNA polymerase eta, putative 0.0033 0.0339 0.2681
Echinococcus multilocularis transcription factor Dp 1 0.004 0.044 0.044
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0549 0.0403
Brugia malayi hypothetical protein 0.0129 0.1691 0.4447
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0549 0.148
Schistosoma mansoni DNA polymerase eta 0.0047 0.0537 0.0391
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0159 0.1136
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0232 0.0625
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1136
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0101 0.1296 0.3495
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0159 0.0076
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0159 0.0159
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0232 1
Echinococcus multilocularis geminin 0.0191 0.2563 0.2563
Leishmania major DNA polymerase kappa, putative 0.002 0.0159 0.0104
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0686 0.4744
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0159 0.0137
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0159 0.1136
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1296 0.3357
Schistosoma mansoni tar DNA-binding protein 0.0201 0.2717 0.2605
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0852 0.0852
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0852 0.2136
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0159 0.0007
Onchocerca volvulus Glucosylceramidase homolog 0.0178 0.2388 1
Schistosoma mansoni hypothetical protein 0.0069 0.0845 0.0704
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0253 0.3448 0.3347
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0159 0.0429
Schistosoma mansoni hypothetical protein 0.0032 0.0323 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0201 0.2717 0.2605
Echinococcus granulosus tar DNA binding protein 0.0201 0.2717 0.2717
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2388 0.6291
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0549 0.0403
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0552 0.0552
Schistosoma mansoni hypothetical protein 0.0191 0.2563 0.2449
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0152 0.0205
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0152 0.0409
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0323 0.087
Echinococcus multilocularis dna polymerase kappa 0.002 0.0159 0.0159
Echinococcus granulosus lamin dm0 0.0027 0.0255 0.0255
Echinococcus multilocularis microtubule associated protein 2 0.0717 1 1
Echinococcus multilocularis tar DNA binding protein 0.0201 0.2717 0.2717
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0686 0.0686
Brugia malayi RNA recognition motif domain containing protein 0.0201 0.2717 0.7273
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0159 0.1136
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0323 0.0323
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0852 0.0852
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0159 0.0104
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.0134
Schistosoma mansoni hypothetical protein 0.0032 0.0323 0.0174
Echinococcus granulosus geminin 0.0191 0.2563 0.2563
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1136
Schistosoma mansoni cpg binding protein 0.0031 0.0309 0.0159
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0642 0.0498
Loa Loa (eye worm) hypothetical protein 0.0088 0.1114 0.3005
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0852 1
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0232 0.0426
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0852 0.23
Brugia malayi TAR-binding protein 0.0201 0.2717 0.7273
Echinococcus multilocularis hormone sensitive lipase 0.0253 0.3448 0.3448
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0232 0.2068
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0232 0.1144
Schistosoma mansoni peptidase Clp (S14 family) 0.0088 0.1114 0.0977
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0152 0.0152
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0339 0.1952
Echinococcus multilocularis dna polymerase eta 0.0047 0.0537 0.0537
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0852 1
Echinococcus granulosus cpg binding protein 0.0031 0.0309 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1136
Echinococcus multilocularis GPCR, family 2 0.0032 0.0323 0.0323
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0323 0.0676
Trichomonas vaginalis chaperonin, putative 0.0025 0.0232 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1136
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0152 0.0152
Loa Loa (eye worm) RNA binding protein 0.0201 0.2717 0.733
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.3707 1
Loa Loa (eye worm) hypothetical protein 0.0253 0.3448 0.93
Onchocerca volvulus Huntingtin homolog 0.0129 0.1691 0.6734
Schistosoma mansoni hypothetical protein 0.0032 0.0323 0.0174
Schistosoma mansoni lamin 0.0027 0.0255 0.0105
Schistosoma mansoni hypothetical protein 0.0416 0.5751 0.5686
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.2524 0.6672
Schistosoma mansoni hypothetical protein 0.0032 0.0323 0.0174
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0552 0.1307
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1136
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0549 0.0549
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2388 0.6291
Brugia malayi CXXC zinc finger family protein 0.0029 0.0285 0.0573
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0232 0.0833
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0642 0.1557
Schistosoma mansoni intermediate filament proteins 0.0027 0.0255 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0552 0.0406
Echinococcus granulosus transcription factor Dp 1 0.004 0.044 0.044
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.3707 1
Echinococcus multilocularis lamin dm0 0.0027 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0027 0.0248 0.0668
Onchocerca volvulus Huntingtin homolog 0.0129 0.1691 0.6734
Brugia malayi RNA binding protein 0.0201 0.2717 0.7273
Schistosoma mansoni cpg binding protein 0.0029 0.0285 0.0136
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0159 0.0104
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0552 0.0552
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0642 0.0642
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.1114 1
Echinococcus multilocularis lamin 0.0027 0.0255 0.0255
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0201 0.2717 0.733
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0088 0.1114 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0159 0.0021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0323 0.0323
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0654 0.5223
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0255 0.0687
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0852 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0253 0.3448 0.3347
Loa Loa (eye worm) hypothetical protein 0.0027 0.0255 0.0687
Brugia malayi Probable ClpP-like protease 0.0088 0.1114 0.2857
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0686 1
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0232 0.0833
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1136
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0159 0.0104
Giardia lamblia DINP protein human, muc B family 0.002 0.0159 0.0911
Loa Loa (eye worm) hypothetical protein 0.0129 0.1691 0.4563
Echinococcus granulosus dna polymerase eta 0.0047 0.0537 0.0537
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.2524 0.6672
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1136
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.3707 1
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0232 0.0232
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0088 0.1114 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.1114 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0852 1
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0232 0.0426
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0642 0.0642
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.1114 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0057 0.0057
Echinococcus granulosus hormone sensitive lipase 0.0253 0.3448 0.3448
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0159 0.0104
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0642 0.0642
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0552 0.0552
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2388 0.6291
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0686 0.0686
Loa Loa (eye worm) hypothetical protein 0.0069 0.0845 0.228
Loa Loa (eye worm) TAR-binding protein 0.0201 0.2717 0.733
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0552 0.0552
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0159 0.0137
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.2594 0.2594
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0845 0.2116
Schistosoma mansoni hypothetical protein 0.0191 0.2563 0.2449
Schistosoma mansoni cpg binding protein 0.0031 0.0309 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2388 0.6291
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0232 0.0081
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0232 0.0081
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0255 0.0687
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0323 0.0676
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0272 0.3707 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0159 0.0007
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0549 0.0403
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0088 0.1114 0.1114
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.5751 0.5751
Echinococcus granulosus GPCR family 2 0.0032 0.0323 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0159 0.1136
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0088 0.1114 0.1114
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0232 0.1144

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.23 uM Inhibition of recombinant human hormone-sensitive lipase ChEMBL. 17918819
IC50 (binding) = 1.23 uM Inhibition of recombinant human hormone-sensitive lipase ChEMBL. 17918819
IC50 (binding) > 50 uM Inhibition of acetylcholine esterase ChEMBL. 17918819
IC50 (binding) > 50 uM Inhibition of butyrylcholine esterase ChEMBL. 17918819
IC50 (binding) > 50 uM Inhibition of acetylcholine esterase ChEMBL. 17918819
IC50 (binding) > 50 uM Inhibition of butyrylcholine esterase ChEMBL. 17918819

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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