Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0803 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.008 | 0.0803 | 0.0803 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0803 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.008 | 0.0803 | 0.0803 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0803 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.008 | 0.0803 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0253 | 1 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.008 | 0.0803 | 1 |
Echinococcus granulosus | geminin | 0.0173 | 0.5732 | 0.5732 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0803 | 0.0803 |
Echinococcus multilocularis | geminin | 0.0173 | 0.5732 | 0.5732 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.008 | 0.0803 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.008 | 0.0803 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0803 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.5732 | 0.5732 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0803 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0803 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0803 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.008 | 0.0803 | 0.0803 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.5732 | 0.5732 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.008 | 0.0803 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 5 uM | Inhibition of recombinant human hormone-sensitive lipase | ChEMBL. | 17918819 |
IC50 (binding) | > 5 uM | Inhibition of recombinant human hormone-sensitive lipase | ChEMBL. | 17918819 |
IC50 (binding) | > 50 uM | Inhibition of acetylcholine esterase | ChEMBL. | 17918819 |
IC50 (binding) | > 50 uM | Inhibition of butyrylcholine esterase | ChEMBL. | 17918819 |
IC50 (binding) | > 50 uM | Inhibition of acetylcholine esterase | ChEMBL. | 17918819 |
IC50 (binding) | > 50 uM | Inhibition of butyrylcholine esterase | ChEMBL. | 17918819 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.