Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | NAD(P)H dehydrogenase, quinone 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | Get druggable targets OG5_138113 | All targets in OG5_138113 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | Get druggable targets OG5_138113 | All targets in OG5_138113 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.2916 | 0.278 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0312 | 0.2916 | 0.278 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.0692 | 1 | 0.5 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.0584 | 0.7979 | 0.5 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0165 | 0.0188 | 0.0188 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.0692 | 1 | 0.5 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.0584 | 0.7979 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0312 | 0.2916 | 1 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.0692 | 1 | 0.5 |
Schistosoma mansoni | serine-type protease inhibitor | 0.043 | 0.5117 | 0.5023 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0168 | 0.0241 | 0.0194 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.0692 | 1 | 0.5 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0302 | 0.2728 | 0.2728 |
Loa Loa (eye worm) | matrixin family protein | 0.0183 | 0.0523 | 0.0342 |
Onchocerca volvulus | Matrilysin homolog | 0.0168 | 0.0241 | 0.0194 |
Echinococcus multilocularis | caspase | 0.0302 | 0.2728 | 0.2728 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.0584 | 0.7979 | 1 |
Echinococcus granulosus | caspase 2 | 0.0312 | 0.2916 | 0.2916 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.0584 | 0.7979 | 0.5 |
Schistosoma mansoni | serine-type protease inhibitor | 0.043 | 0.5117 | 0.5023 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0302 | 0.2728 | 0.2728 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.0692 | 1 | 1 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0165 | 0.0188 | 0.0188 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0276 | 0.2242 | 0.2242 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.0584 | 0.7979 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0168 | 0.0241 | 0.0054 |
Echinococcus multilocularis | caspase 2 | 0.0312 | 0.2916 | 0.2916 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0692 | 1 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.042 | 0.4922 | 0.4825 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.0692 | 1 | 1 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.0692 | 1 | 0.5 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0302 | 0.2728 | 0.2589 |
Echinococcus granulosus | caspase | 0.0302 | 0.2728 | 0.2728 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0302 | 0.2728 | 0.2589 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.0692 | 1 | 1 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.0692 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0276 | 0.2242 | 0.2242 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.0692 | 1 | 0.5 |
Brugia malayi | Cell death protein 3 precursor | 0.0312 | 0.2916 | 0.278 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.0692 | 1 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0183 | 0.0523 | 0.0342 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Growth inhibition of human MIA PaCa2 cells | ChEMBL. | 17999461 |
Activity (functional) | = 2.5 nmol/min | Effect on respiration rate in human MIA PaCa2 cells assessed as oxygen consumption per 10^6 cells at 100 uM | ChEMBL. | 17999461 |
Activity (functional) | = 2.5 nmol/min | Effect on respiration rate in human MIA PaCa2 cells assessed as oxygen consumption per 10^6 cells at 100 uM | ChEMBL. | 17999461 |
IC50 (binding) | = 0.25 uM | Inhibition of human recombinant NQO1 | ChEMBL. | 17999461 |
IC50 (binding) | = 0.25 uM | Inhibition of human recombinant NQO1 | ChEMBL. | 17999461 |
IC50 (binding) | = 0.6 uM | Inhibition of human recombinant NQO1 in presence of BSA | ChEMBL. | 17999461 |
IC50 (binding) | = 0.6 uM | Inhibition of human recombinant NQO1 in presence of BSA | ChEMBL. | 17999461 |
IC50 (functional) | = 140 uM | Cytotoxicity against human MIA PaCa2 cells by MTT assay | ChEMBL. | 17999461 |
IC50 (functional) | = 140 uM | Cytotoxicity against human MIA PaCa2 cells by MTT assay | ChEMBL. | 17999461 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.