Detailed information for compound 449390

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 636.647 | Formula: C36H40BrN6-
  • H donors: 0 H acceptors: 0 LogP: 9.49 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: N=c1cc2ccc3c(c2nn1CCCCCCCCCCCCn1nc2c(cc1=N)ccc1c2cccc1)cccc3.[Br-]
  • InChi: 1S/C36H40N6.BrH/c37-33-25-29-21-19-27-15-9-11-17-31(27)35(29)39-41(33)23-13-7-5-3-1-2-4-6-8-14-24-42-34(38)26-30-22-20-28-16-10-12-18-32(28)36(30)40-42;/h9-12,15-22,25-26,37-38H,1-8,13-14,23-24H2;1H/p-1
  • InChiKey: IAEFMOBDTWXPKR-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0559 0.5044 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0034 0.0239 0.1647
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0239 0.5254
Onchocerca volvulus 0.0023 0.014 0.0967
Echinococcus granulosus ubiquitin specific protease 41 0.003 0.0201 0.0201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0388 0.0793
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0199 0.0861
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0038 0.0271 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0044 0.0331 1
Schistosoma mansoni hypothetical protein 0.0043 0.0317 0.0647
Trichomonas vaginalis chromobox protein, putative 0.0056 0.0444 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0043 0.0317 0.0317
Brugia malayi Associated with TFs and helicases family protein 0.0009 0.0012 0.0051
Schistosoma mansoni cpg binding protein 0.0023 0.014 0.0286
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0201 0.5702
Brugia malayi hypothetical protein 0.0009 0.0012 0.0051
Schistosoma mansoni chromobox protein 0.0009 0.0012 0.0024
Echinococcus granulosus cpg binding protein 0.0025 0.0152 0.0152
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0239 0.5254
Trichomonas vaginalis chromobox protein, putative 0.0056 0.0444 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.003 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0014 0.0053 0.0231
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0134 0.1158 0.5013
Schistosoma mansoni lipoxygenase 0.0231 0.2038 0.4163
Onchocerca volvulus 0.0009 0.0012 0.0081
Brugia malayi Valyl-tRNA synthetase 0.0009 0.0012 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.4746
Schistosoma mansoni rab6-interacting 0.006 0.0474 0.0968
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.003 0.0201 0.0411
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0038 0.0271 0.5615
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.0559 0.5044 1
Onchocerca volvulus 0.0166 0.145 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0051
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0043 0.0317 0.0317
Schistosoma mansoni hypothetical protein 0.0009 0.0009 0.0018
Brugia malayi CXXC zinc finger family protein 0.0023 0.014 0.0607
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.0474 0.0474
Brugia malayi CHD4 protein 0.0011 0.0024 0.0104
Brugia malayi TAR-binding protein 0.007 0.0566 0.2448
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0038 0.0271 0.0271
Brugia malayi hypothetical protein 0.002 0.0109 0.0471
Echinococcus multilocularis microtubule associated protein 2 0.0543 0.4896 0.4896
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.003 0.0201 0.0201
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.0474 0.0474
Brugia malayi hypothetical protein 0.006 0.0474 0.2052
Echinococcus multilocularis Polycystic kidney disease protein 0.006 0.0474 0.0474
Brugia malayi isocitrate dehydrogenase 0.0038 0.0271 0.1174
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0132 0.2789
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0132 0.2789
Echinococcus granulosus microtubule associated protein 2 0.0543 0.4896 0.4896
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0024 0.0049
Loa Loa (eye worm) latrophilin receptor protein 2 0.0043 0.0317 0.1371
Brugia malayi SET domain containing protein 0.001 0.0016 0.0071
Loa Loa (eye worm) helicase 0.0009 0.0012 0.0051
Brugia malayi Doublecortin family protein 0.006 0.0474 0.2052
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0109 0.2097
Schistosoma mansoni tar DNA-binding protein 0.007 0.0566 0.1155
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0166 0.145 0.6276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0388 0.0793
Loa Loa (eye worm) hypothetical protein 0.026 0.2311 1
Brugia malayi intermediate filament protein 0.003 0.0199 0.0861
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0009 0.0012 0.0012
Onchocerca volvulus 0.006 0.0474 0.3269
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0058 0.0058
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0413 0.1789
Onchocerca volvulus 0.0053 0.0413 0.285
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0038 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0134 0.1158 0.5013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0134 0.1158 0.5013
Loa Loa (eye worm) isocitrate dehydrogenase 0.0038 0.0271 0.1174
Schistosoma mansoni tar DNA-binding protein 0.007 0.0566 0.1155
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.003 0.0201 1
Brugia malayi Isocitrate dehydrogenase 0.0038 0.0271 0.1174
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0038 0.0271 1
Loa Loa (eye worm) doublecortin family protein 0.006 0.0474 0.2052
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0872
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0009 0.0009 0.0009
Echinococcus multilocularis RUN 0.006 0.0474 0.0474
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.4746
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0051
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.006 0.1117
Echinococcus multilocularis Chromo domain 0.0009 0.0012 0.0012
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0009 0.0012 0.0024
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0038 0.0271 1
Onchocerca volvulus 0.0009 0.0012 0.0081
Loa Loa (eye worm) hypothetical protein 0.006 0.0474 0.2052
Brugia malayi chromobox protein homolog 3 0.0032 0.0217 0.0938
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0051
Echinococcus multilocularis isocitrate dehydrogenase 0.0038 0.0271 0.0271
Echinococcus multilocularis lamin dm0 0.003 0.0199 0.0199
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0009 0.0009 0.0009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0038 0.0271 0.0271
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0038 0.0271 0.0271
Schistosoma mansoni hypothetical protein 0.006 0.0474 0.0968
Echinococcus multilocularis musashi 0.003 0.0199 0.0199
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.003 0.0201 0.4389
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.003 0.0201 0.5702
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0388 0.0793
Onchocerca volvulus 0.003 0.0199 0.1372
Brugia malayi Calcitonin receptor-like protein seb-1 0.0134 0.1158 0.5013
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0109 0.2097
Echinococcus multilocularis neuropeptide receptor A26 0.11 1 1
Echinococcus granulosus RUN 0.006 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.003 0.0199 0.0861
Echinococcus granulosus intermediate filament protein 0.003 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0051
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0566 0.2448
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0043 0.0317 0.0317
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0559 0.5044 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0058 0.0253
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0038 0.0271 0.0554
Mycobacterium ulcerans isocitrate lyase Icl 0.0559 0.5044 0.5
Onchocerca volvulus 0.006 0.0474 0.3269
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0388 0.0388
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0073 0.0315
Schistosoma mansoni hypothetical protein 0.0043 0.0317 0.0647
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0231 0.2038 0.2038
Schistosoma mansoni microtubule-associated protein tau 0.0543 0.4896 1
Echinococcus multilocularis cpg binding protein 0.0025 0.0152 0.0152
Echinococcus multilocularis neuropeptide s receptor 0.11 1 1
Schistosoma mansoni loxhd1 0.006 0.0474 0.0968
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0201 0.5702
Toxoplasma gondii isocitrate dehydrogenase 0.0038 0.0271 0.8139
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0201 0.5702
Schistosoma mansoni tar DNA-binding protein 0.007 0.0566 0.1155
Brugia malayi Latrophilin receptor protein 2 0.0043 0.0317 0.1371
Schistosoma mansoni cpg binding protein 0.0025 0.0152 0.0311
Brugia malayi Protein cec-1. 0.0009 0.0012 0.0051
Schistosoma mansoni polycystin 1-related 0.006 0.0474 0.0968
Echinococcus granulosus GPCR family 2 0.0043 0.0317 0.0317
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.006 0.1117
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.003 0.0201 0.0872
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.006 0.1117
Schistosoma mansoni lipoxygenase 0.0123 0.1054 0.2153
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0231 0.2038 0.2038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.006 0.1117
Echinococcus granulosus Polycystic kidney disease protein 0.006 0.0474 0.0474
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0038 0.0599
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0388 0.0388
Brugia malayi hypothetical protein 0.006 0.0474 0.2052
Plasmodium vivax ataxin-2 like protein, putative 0.002 0.0109 0.2097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0938
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0388 0.168
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.003 0.0201 0.0201
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.003 0.0201 0.4389
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0051
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.0024 0.0024
Loa Loa (eye worm) RNA binding protein 0.007 0.0566 0.2448
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0201 0.4389
Schistosoma mansoni lamin 0.003 0.0199 0.0407
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.006 0.1117
Echinococcus multilocularis Chromobox protein 3 0.0009 0.0012 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0034 0.0518
Echinococcus granulosus lamin 0.003 0.0199 0.0199
Echinococcus granulosus Chromo domain 0.0009 0.0012 0.0012
Brugia malayi RNA binding protein 0.007 0.0566 0.2448
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0043 0.0317 0.0317
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.003 0.0201 0.5
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.0024 0.0104
Echinococcus multilocularis tar DNA binding protein 0.007 0.0566 0.0566
Schistosoma mansoni chromobox protein 0.0009 0.0012 0.0024
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.003 0.0201 0.0201
Echinococcus granulosus neuropeptide receptor A26 0.11 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.014 0.0607
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0009 0.0012 0.0012
Brugia malayi latrophilin 2 splice variant baaae 0.0092 0.0769 0.3327
Echinococcus granulosus chromobox protein 2 0.0009 0.0012 0.0012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0566 0.2448
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0043 0.0317 0.1371
Loa Loa (eye worm) intermediate filament protein 0.003 0.0199 0.0861
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0388 0.168
Plasmodium vivax multidomain scavenger receptor, putative 0.006 0.0474 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.006 0.1117
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.0109 0.3039
Echinococcus multilocularis ubiquitin specific protease 41 0.003 0.0201 0.0201
Echinococcus granulosus survival motor neuron protein 1 0.026 0.2311 0.2311
Schistosoma mansoni lamin 0.003 0.0199 0.0407
Schistosoma mansoni cpg binding protein 0.0025 0.0152 0.0311
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0559 0.5044 1
Echinococcus granulosus chromobox protein 1 0.0056 0.0444 0.0444
Onchocerca volvulus 0.003 0.0199 0.1372
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0038 0.0271 0.5615
Echinococcus multilocularis chromobox protein 2 0.0009 0.0012 0.0012
Onchocerca volvulus 0.001 0.0016 0.0113
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.006 0.1117
Echinococcus granulosus chromobox protein 1 0.0056 0.0444 0.0444
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.0474 0.0474
Echinococcus multilocularis chromobox protein 1 0.0056 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0471
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0051
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0009 0.0012 0.0051
Schistosoma mansoni chromobox protein 0.0056 0.0444 0.0907
Schistosoma mansoni hypothetical protein 0.0043 0.0317 0.0647
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.0024
Brugia malayi hypothetical protein 0.026 0.2311 1
Echinococcus multilocularis chromobox protein 1 0.0056 0.0444 0.0444
Schistosoma mansoni hypothetical protein 0.0092 0.0769 0.157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0388 0.0388
Toxoplasma gondii isocitrate dehydrogenase 0.0038 0.0271 0.8139
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0038 0.0271 1
Schistosoma mansoni hypothetical protein 0.0043 0.0317 0.0647
Loa Loa (eye worm) hypothetical protein 0.006 0.0474 0.2052
Brugia malayi hypothetical protein 0.0013 0.0044 0.0192
Schistosoma mansoni tar DNA-binding protein 0.007 0.0566 0.1155
Echinococcus granulosus tar DNA binding protein 0.007 0.0566 0.0566
Schistosoma mansoni survival motor neuron protein 0.0053 0.0413 0.0844
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0073 0.0315
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0049 0.0379 0.0774
Schistosoma mansoni chromobox protein 0.0056 0.0444 0.0907
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0009 0.0012 0.0024
Brugia malayi M-phase phosphoprotein, mpp8 0.0009 0.0012 0.0051
Echinococcus granulosus Chromobox protein 3 0.0009 0.0012 0.0012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0038 0.0599
Schistosoma mansoni tar DNA-binding protein 0.007 0.0566 0.1155
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0032 0.0217 0.1495
Plasmodium falciparum LCCL domain-containing protein 0.006 0.0474 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0053 0.0231
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.2311 0.2311
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.001 0.0016 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.006 0.1117
Schistosoma mansoni intermediate filament proteins 0.003 0.0199 0.0407
Mycobacterium ulcerans isocitrate lyase AceAb 0.0559 0.5044 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0154 0.0668
Loa Loa (eye worm) TAR-binding protein 0.007 0.0566 0.2448
Onchocerca volvulus 0.0025 0.0154 0.1064
Schistosoma mansoni rab6-interacting 0.006 0.0474 0.0968
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0051
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0038 0.0271 0.0271
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.003 0.0201 0.0411
Loa Loa (eye worm) hypothetical protein 0.0029 0.0194 0.084
Echinococcus multilocularis GPCR, family 2 0.0043 0.0317 0.0317
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0038 0.0271 1
Brugia malayi Heterochromatin protein 1 0.0056 0.0444 0.1921
Loa Loa (eye worm) hypothetical protein 0.0043 0.0317 0.1371
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0199 0.0861
Echinococcus granulosus lamin dm0 0.003 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0092 0.0769 0.3327
Loa Loa (eye worm) heterochromatin protein 1 0.0056 0.0444 0.1921
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0009 0.0012 0.0024
Brugia malayi hypothetical protein 0.0166 0.145 0.6276
Echinococcus multilocularis lamin 0.003 0.0199 0.0199
Schistosoma mansoni hypothetical protein 0.0053 0.0413 0.0844

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 50 nM Antimalarial activity against Plasmodium falciparum Nigerian in human erythrocytes after 48 hrs ChEMBL. 18004799
pKa = 11.7 Dissociation constant, pKa of the compound by potentiometric titration ChEMBL. 18004799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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