Detailed information for compound 450506

Basic information

Technical information
  • TDR Targets ID: 450506
  • Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S)-1- (3,3-dimethyl-2-methylidenebutoxy)propan-2-yl ]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4 -ylidene]ethylidene]-4-methylidenecyclohexane -1,3-diol
  • MW: 442.674 | Formula: C29H46O3
  • H donors: 2 H acceptors: 2 LogP: 6.31 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1C[C@H](O)C(=C)/C(=C\C=C\2/CCC[C@]3([C@H]2CC[C@@H]3[C@@H](COCC(=C)C(C)(C)C)C)C)/C1
  • InChi: 1S/C29H46O3/c1-19(17-32-18-20(2)28(4,5)6)25-12-13-26-22(9-8-14-29(25,26)7)10-11-23-15-24(30)16-27(31)21(23)3/h10-11,19,24-27,30-31H,2-3,8-9,12-18H2,1,4-7H3/b22-10+,23-11-/t19-,24-,25-,26+,27+,29-/m1/s1
  • InChiKey: UAFNLUQZVDRWEB-MOFNPVRRSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1S)-2-(3,3-dimethyl-2-methylene-butoxy)-1-methyl-ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1S)-2-(3,3-dimethyl-2-methylenebutoxy)-1-methylethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylenecyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S)-1-(3,3-dimethyl-2-methylidene-butoxy)propan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1S)-2-(2-tert-butylallyloxy)-1-methyl-ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1S)-2-(2-tert-butylprop-2-enoxy)-1-methyl-ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexane-1,3-diol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tar DNA binding protein 0.0064 0.045 0.0655
Brugia malayi Pre-SET motif family protein 0.0192 0.1482 1
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0067
Brugia malayi cytochrome P450 0.0017 0.0066 0.0443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0025 0.0086
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Echinococcus granulosus jun protein 0.0089 0.0649 0.1003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Brugia malayi nuclear hormone receptor 0.0012 0.0025 0.017
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0025 0.0039
Echinococcus multilocularis Polycystic kidney disease protein 0.0099 0.0728 0.1061
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0096 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0076 0.0111
Loa Loa (eye worm) RecQ helicase 0.0021 0.0096 0.0566
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0041 0.0064
Trichomonas vaginalis set domain proteins, putative 0.0218 0.1696 0.1696
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Plasmodium vivax SET domain protein, putative 0.0029 0.0158 0.0334
Schistosoma mansoni coup transcription factor 0.0012 0.0025 0.0039
Loa Loa (eye worm) doublecortin family protein 0.0099 0.0728 0.4871
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0076 0.0434
Brugia malayi ephrin receptor 1 precursor 0.0028 0.0154 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0013 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0013 0.0027
Brugia malayi hypothetical protein 0.0099 0.0728 0.4915
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0069 0.1472
Brugia malayi TAR-binding protein 0.0064 0.045 0.3033
Schistosoma mansoni cpg binding protein 0.0057 0.0385 0.0596
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0355 0.7525
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0304 0.0471
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0206 0.4358
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0025 0.0086
Brugia malayi Cytochrome P450 family protein 0.0017 0.0066 0.0443
Loa Loa (eye worm) TAR-binding protein 0.0064 0.045 0.2973
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.0038 0.0234 0.0571
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0096 0.0096
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.045 0.3033
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0067
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Brugia malayi hypothetical protein 0.0099 0.0728 0.4915
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0025 0.017
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0069 0.0169
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0158 0.0244
Leishmania major cathepsin L-like protease 0.0067 0.0472 0.1007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0855 0.6863 1
Echinococcus multilocularis geminin 0.0179 0.1376 0.2005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0908 0.1405
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0096 0.2029
Schistosoma mansoni DNA helicase recq5 0.0021 0.0096 0.0148
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0025 0.0086
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0069 0.0147
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0491 0.3912 0.4869
Loa Loa (eye worm) cytochrome P450 family protein 0.0072 0.0512 0.34
Brugia malayi hypothetical protein 0.0038 0.0234 0.1579
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0304 0.0471
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0025 0.0019
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0069 0.0147
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0000000004757
Schistosoma mansoni hypothetical protein 0.0099 0.0728 0.1127
Trichomonas vaginalis conserved hypothetical protein 0.1241 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0022 0.0149
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0069 0.0147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0069 0.0169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0025 0.0037
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0013 0.0268
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0064
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0043 0.0063
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0033 0.0195 0.013
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0206 0.0141
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0201
Brugia malayi Cytochrome P450 family protein 0.0072 0.0512 0.3456
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0025 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Onchocerca volvulus 0.0012 0.0025 0.0019
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Echinococcus granulosus cpg binding protein 0.006 0.0411 0.0636
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Onchocerca volvulus 0.0018 0.0069 0.0283
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0025 0.0039
Loa Loa (eye worm) hypothetical protein 0.0058 0.0399 0.263
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0043 0.0063
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0048 0.0075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0566
Chlamydia trachomatis 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0592 0.4733 1
Echinococcus multilocularis cysteine protease 0.0018 0.0069 0.0101
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0069 0.0101
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0025 0.0039
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0043 0.0293
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0206 0.4358
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0025 0.0039
Mycobacterium ulcerans integral membrane transporter 0.0033 0.0195 0.013
Echinococcus multilocularis GPCR, family 2 0.0014 0.0043 0.0063
Plasmodium vivax 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, putative 0.0592 0.4733 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0066 0.139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0025 0.0086
Mycobacterium leprae Probable transmembrane transport protein 0.024 0.1875 0.4485
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0069 0.0101
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0096 0.014
Echinococcus granulosus cathepsin l1 0.0018 0.0069 0.0107
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0989
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0387
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0472 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0514 0.41 1
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0179 0.121
Schistosoma mansoni hypothetical protein 0.0031 0.0179 0.0277
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0066 0.0102
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0096 0.0202
Brugia malayi Protein kinase domain containing protein 0.0014 0.0041 0.0278
Echinococcus granulosus geminin 0.0179 0.1376 0.2129
Entamoeba histolytica cysteine protease, putative 0.0018 0.0069 0.0169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0025 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0022 0.0022
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0234 0.0362
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0025 0.0037
Loa Loa (eye worm) cysteine protease 0.0018 0.0069 0.0387
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Onchocerca volvulus 0.0099 0.0728 0.4218
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0096 0.0075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0304 0.0443
Schistosoma mansoni rab6-interacting 0.0099 0.0728 0.1127
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0043 0.0209
Schistosoma mansoni hypothetical protein 0.0806 0.6463 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0066 0.139
Schistosoma mansoni DNA helicase recq1 0.0021 0.0096 0.0148
Onchocerca volvulus 0.0018 0.0069 0.0283
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0069 0.0283
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0304 0.2052
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0025 0.0039
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0195 0.4132
Onchocerca volvulus 0.0018 0.0069 0.0283
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0096 0.0202
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0158 0.0244
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0025 0.0039
Schistosoma mansoni hypothetical protein 0.0179 0.1376 0.2129
Schistosoma mansoni hypothetical protein 0.0038 0.0234 0.0362
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.024 0.1875 0.2291
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0069 0.0069
Onchocerca volvulus 0.0099 0.0728 0.4218
Mycobacterium tuberculosis Probable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) 0.0475 0.3781 0.4704
Schistosoma mansoni hypothetical protein 0.0014 0.0041 0.0064
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0048 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0013 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0025 0.017
Plasmodium vivax vivapain-2 0.0018 0.0069 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0096 0.0234
Treponema pallidum hypothetical protein 0.0592 0.4733 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0067
Echinococcus multilocularis lipoxygenase domain containing protein 0.0099 0.0728 0.1061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Brugia malayi ecdysteroid receptor 0.0012 0.0025 0.017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.0649 0.0945
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0158 0.0244
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0022 0.0054
Plasmodium vivax multidomain scavenger receptor, putative 0.0099 0.0728 0.1539
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0025 0.0039
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0025 0.017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0025 0.017
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0096 0.0148
Plasmodium falciparum 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0592 0.4733 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.003 0.003
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0192 0.1482 1
Onchocerca volvulus 0.0058 0.0399 0.2251
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0025 0.017
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0096 0.0183
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0041 0.0278
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0075 0.0503
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0025 0.0039
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Loa Loa (eye worm) ctsf protein 0.0018 0.0069 0.0387
Echinococcus multilocularis RUN 0.0099 0.0728 0.1061
Brugia malayi Cytochrome P450 family protein 0.0034 0.0206 0.1387
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.0649 0.1003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0206 0.1313
Loa Loa (eye worm) hypothetical protein 0.0046 0.0297 0.1932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0069 0.0387
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0206 0.4358
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0041 0.0064
Echinococcus granulosus Polycystic kidney disease protein 0.0099 0.0728 0.1127
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0041 0.0114
Echinococcus granulosus tar DNA binding protein 0.0064 0.045 0.0696
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0064
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0096 0.0646
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0206 0.1313
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0263 0.2064 0.2531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0728 0.4871
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0033 0.0195 0.013
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0385 0.2535
Brugia malayi RNA binding protein 0.0064 0.045 0.3033
Echinococcus granulosus Ankyrin 0.0014 0.0042 0.0065
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0472 1
Leishmania major cytochrome p450-like protein 0.0034 0.0206 0.0347
Brugia malayi hypothetical protein 0.0159 0.1219 0.8223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0048 0.0075
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0991 0.7964 1
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0195 0.4132
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.0297 0.1932
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0804 0.1682
Schistosoma mansoni microtubule-associated protein tau 0.0727 0.5829 0.9019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0096 0.0183
Schistosoma mansoni lipoxygenase 0.0402 0.3189 0.4935
Brugia malayi Uncoordinated protein 44 0.0014 0.0041 0.0278
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0158 0.0244
Entamoeba histolytica hypothetical protein 0.0038 0.0234 0.0571
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0025 0.0039
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0234 0.0362
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0515 0.0751
Echinococcus granulosus ephrin type A receptor 4 A 0.0059 0.0404 0.0626
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0025 0.017
Brugia malayi Doublecortin family protein 0.0099 0.0728 0.4915
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0041 0.0064
Echinococcus multilocularis neuropeptide s receptor 0.0487 0.3882 0.5656
Schistosoma mansoni carbonic anhydrase 0.0514 0.41 0.6344
Brugia malayi Pre-SET motif family protein 0.0029 0.0158 0.1066
Brugia malayi Cathepsin L-like precursor 0.0012 0.0022 0.0149
Schistosoma mansoni hypothetical protein 0.0073 0.0519 0.0802
Schistosoma mansoni loxhd1 0.0099 0.0728 0.1127
Loa Loa (eye worm) hypothetical protein 0.0083 0.0601 0.4004
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0041 0.0195
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0234 0.0341
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0096 0.0566
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0025 0.0037
Onchocerca volvulus 0.0208 0.1614 0.9504
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0025 0.0039
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0022 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0025 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0025 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0025 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0304 0.0471
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0096 0.0646
Echinococcus multilocularis Ankyrin 0.0014 0.0042 0.0061
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0069 0.0469
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.1241 1 1
Plasmodium vivax sulfate transporter, putative 0.0033 0.0195 0.0412
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.0297 0.2001
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0009 0.0014
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0025 0.017
Schistosoma mansoni lipoxygenase 0.0224 0.1745 0.2701
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Toxoplasma gondii cathepsin CPL 0.0018 0.0069 0.0127
Echinococcus granulosus neuropeptide s receptor 0.0487 0.3882 0.6006
Echinococcus granulosus neuropeptide receptor A26 0.0487 0.3882 0.6006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0304 0.0471
Wolbachia endosymbiont of Brugia malayi 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0592 0.4733 0.5
Echinococcus multilocularis jun protein 0.0089 0.0649 0.0945
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0096 0.0646
Schistosoma mansoni hypothetical protein 0.0179 0.1376 0.2129
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0064
Loa Loa (eye worm) TK/EPH protein kinase 0.0075 0.0534 0.3548
Mycobacterium ulcerans carbonic anhydrase 0.0514 0.41 0.4062
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0013 0.0268
Echinococcus multilocularis cysteine protease 0.0018 0.0069 0.0101
Brugia malayi cathepsin L-like precursor 0.0012 0.0022 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0042 0.0065
Onchocerca volvulus 0.0018 0.0069 0.0283
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0066 0.0119
Brugia malayi Cathepsin L-like precursor 0.0012 0.0022 0.0149
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0025 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0025 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus multilocularis 0.0017 0.0066 0.0096
Brugia malayi nuclear receptor NHR-88 0.0012 0.0025 0.017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0048 0.0075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0304 0.0471
Schistosoma mansoni netrin receptor unc5 0.0014 0.0041 0.0064
Echinococcus multilocularis ephrin type A receptor 4 A 0.0059 0.0404 0.0589
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0096 0.0096
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0025 0.0037
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0425 0.8997
Echinococcus granulosus lipoxygenase domain containing protein 0.0099 0.0728 0.1127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Onchocerca volvulus 0.0057 0.0385 0.2168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0069 0.0107
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0515 0.0797
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0025 0.017
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0025 0.0086
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Brugia malayi steroid hormone receptor 0.0012 0.0025 0.017
Echinococcus granulosus dnaJ subfamily B 0.0806 0.6463 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.045 0.2973
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0206 0.1313
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0069 0.0107
Echinococcus granulosus cathepsin l1 0.0012 0.0022 0.0034
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0069 0.0101
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0158 0.023
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0025 0.0019
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0025 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0472 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0025 0.0037
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0013 0.002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0025 0.0039
Brugia malayi CXXC zinc finger family protein 0.0057 0.0385 0.2599
Brugia malayi Cytochrome P450 family protein 0.0034 0.0206 0.1387
Schistosoma mansoni polycystin 1-related 0.0099 0.0728 0.1127
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0025 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Schistosoma mansoni ephrin receptor 0.0059 0.0404 0.0626
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0048 0.0071
Echinococcus granulosus microtubule associated protein 2 0.0727 0.5829 0.9019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0179 0.1134
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0069 0.0283
Entamoeba histolytica recQ family helicase, putative 0.001 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0159 0.1219 0.8208
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus multilocularis neuropeptide receptor A26 0.0487 0.3882 0.5656
Schistosoma mansoni cytochrome P450 0.0017 0.0066 0.0102
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0076 0.0118
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Echinococcus granulosus RUN 0.0099 0.0728 0.1127
Schistosoma mansoni cpg binding protein 0.006 0.0411 0.0636
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0025 0.0039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0025 0.0037
Leishmania major cathepsin L-like protease 0.0067 0.0472 0.1007
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0009 0.002
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0067
Schistosoma mansoni rab6-interacting 0.0099 0.0728 0.1127
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0033 0.0195 0.0393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0025 0.0086
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0041 0.006
Entamoeba histolytica hypothetical protein 0.0038 0.0234 0.0571
Echinococcus multilocularis microtubule associated protein 2 0.0727 0.5829 0.8494
Toxoplasma gondii 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase domain-containing protein 0.0592 0.4733 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0025 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Plasmodium falciparum LCCL domain-containing protein 0.0099 0.0728 0.1539
Loa Loa (eye worm) hypothetical protein 0.0099 0.0728 0.4871
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0209
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0025 0.0039
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0158 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0025 0.017
Loa Loa (eye worm) cytochrome P450 0.0017 0.0066 0.0361
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0025 0.017
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0041 0.006
Echinococcus multilocularis cpg binding protein 0.006 0.0411 0.0599
Echinococcus granulosus GPCR family 2 0.0014 0.0043 0.0067
Mycobacterium ulcerans 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0592 0.4733 0.4699
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.0102
Brugia malayi bZIP transcription factor family protein 0.0089 0.0649 0.4376
Onchocerca volvulus 0.0218 0.1697 1
Echinococcus granulosus bloom syndrome protein 0.0021 0.0096 0.0148
Schistosoma mansoni cpg binding protein 0.006 0.0411 0.0636
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Onchocerca volvulus 0.0159 0.1219 0.7146
Leishmania major cathepsin L-like protease 0.0067 0.0472 0.1007
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0066 0.139
Echinococcus granulosus lipoxygenase domain containing protein 0.0099 0.0728 0.1127
Plasmodium vivax vivapain-2 0.0018 0.0069 0.0147
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.014 0.0216
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0025 0.0039
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0025 0.0039
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0043 0.0293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0025 0.0086
Mycobacterium ulcerans hypothetical protein 0.0111 0.0823 0.0763
Onchocerca volvulus 0.0018 0.0069 0.0283
Onchocerca volvulus 0.0018 0.0069 0.0283
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0096 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0158 0.0244
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0069 0.0283
Leishmania major carbonic anhydrase family protein, putative 0.0514 0.41 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0099 0.0728 0.1061
Loa Loa (eye worm) fibroinase 0.0018 0.0069 0.0387
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0402 0.3189 0.4935
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0025 0.0037
Onchocerca volvulus 0.0067 0.0471 0.2681
Onchocerca volvulus 0.0018 0.0069 0.0283
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0025 0.0037
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0195 0.4132
Echinococcus multilocularis dnaJ subfamily B 0.0806 0.6463 0.9418
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0066 0.139
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0033 0.0195 0.0412
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0158 0.023
Brugia malayi hypothetical protein 0.0067 0.0471 0.3178
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.0297 0.2001
Loa Loa (eye worm) RNA binding protein 0.0064 0.045 0.2973
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0025 0.0039
Onchocerca volvulus Putative sulfate transporter 0.0208 0.1614 0.9504
Entamoeba histolytica carbonic anhydrase, putative 0.0514 0.41 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0043 0.0067
Entamoeba histolytica hypothetical protein 0.0038 0.0234 0.0571
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0069 0.0107
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0069 0.0009
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0069 0.0387
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0096 0.0096
Trichomonas vaginalis helicase, putative 0.0013 0.003 0.003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0304 0.1984
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0096 0.0148
Onchocerca volvulus 0.0029 0.0158 0.0811
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0025 0.0039
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0304 0.0443
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0069 0.0101
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0096 0.2029
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0025 0.017
Schistosoma mansoni jun-related protein 0.0073 0.0519 0.0802
Mycobacterium leprae Probable 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) (MECDP-synthase ) 0.0475 0.3781 0.9207
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0069 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0025 0.017
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0472 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0025 0.0086
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0402 0.3189 0.4647
Echinococcus granulosus death domain containing protein 0.0014 0.0041 0.0064
Brugia malayi Death domain containing protein 0.0014 0.0041 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0096 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0043 0.0067

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Induction of CYP24 mRNA transcriptional activity in C57BL/6 mouse duodenum at 25 ug/kg, ip after 4 hrs ChEMBL. 17924616
Activity (functional) Induction of TRPV6 mRNA transcriptional activity in C57BL/6 mouse duodenum at 25 ug/kg, ip after 4 hrs ChEMBL. 17924616
Activity (functional) 0 Induction of CYP24 mRNA transcriptional activity in C57BL/6 mouse duodenum at 25 ug/kg, ip after 4 hrs ChEMBL. 17924616
Activity (functional) 0 Induction of TRPV6 mRNA transcriptional activity in C57BL/6 mouse duodenum at 25 ug/kg, ip after 4 hrs ChEMBL. 17924616
Activity (functional) < 0.02 Calciuric activity in rat utrine assessed as vitamine D3 level relative to calcitriol ChEMBL. 17924616
ED50 (binding) = 6 nM Activity at human recombinant VDR in ROS 17/2.8 cells transfected with growth hormone fusion gene VDRE assessed as growth hormone level by transcriptional assay ChEMBL. 17924616
ED50 (binding) = 6 nM Activity at human recombinant VDR in ROS 17/2.8 cells transfected with growth hormone fusion gene VDRE assessed as growth hormone level by transcriptional assay ChEMBL. 17924616
IC50 (functional) = 20 nM Antiproliferative activity against mouse keratinocytes ChEMBL. 17924616
IC50 (binding) = 85 nM Displacement of 1alpha, 25-(OH)[3H]D3 from human VDR expressed in COS1 cells ChEMBL. 17924616
IC50 (binding) = 85 nM Displacement of 1alpha, 25-(OH)[3H]D3 from human VDR expressed in COS1 cells ChEMBL. 17924616
LogP = 4.7 Lipophilicity, log D of the compound ChEMBL. 17924616

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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