TDR Targets

Basic information

Technical information

TDR Targets ID: 453508
Name: 2-[2-(3-chlorophenyl)ethynyl]-6-methylpyridin e
MW: 227.689 | Formula: C14H10ClN
H donors: 0 H acceptors: 1 LogP: 3.94 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)C#Cc1cccc(n1)C
InChi: 1S/C14H10ClN/c1-11-4-2-7-14(16-11)9-8-12-5-3-6-13(15)10-12/h2-7,10H,1H3
InChiKey: PHMIEAGFDRJBOP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[2-(3-chlorophenyl)ethynyl]-6-methyl-pyridine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, metabotropic 5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	metabotropic glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	Metabotropic glutamate receptor precursor, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	Metabotropic glutamate receptor precursor.	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	ko:K04606 glutamate receptor, metabotropic 3, putative	Get druggable targets OG5_127095	All targets in OG5_127095

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Melatonin receptor type 1A	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Echinococcus granulosus	neuropeptide Y receptor	0.0202	0.0642	0.595
Schistosoma mansoni	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	dna polymerase eta	0.0019	0.002	0.0006
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0259	0.3854
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.0259	0.0923
Schistosoma mansoni	amine GPCR	0.0202	0.0642	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0074	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0202	0.0642	0.595
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0074	1
Mycobacterium tuberculosis	Isocitrate lyase Icl (isocitrase) (isocitratase)	0.2955	1	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.016	0.2259
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	TYRA-2 protein	0.0202	0.0642	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0202	0.0642	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.002	0.001
Schistosoma mansoni	myosin xvIII	0.0202	0.0642	1
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	g-protein coupled receptor	0.0202	0.0642	0.2394
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0074	0.087
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0074	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	neuropeptide receptor A26	0.0202	0.0642	0.595
Brugia malayi	G-protein coupled receptor	0.0202	0.0642	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0202	0.0642	0.2394
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.087
Brugia malayi	metabotropic glutamate receptor type 2	0.0024	0.0036	0.0272
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0202	0.0642	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0202	0.0642	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.0292	0.4386
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.002	0.0001
Echinococcus granulosus	7TM GPCR rhodopsin	0.0202	0.0642	0.595
Schistosoma mansoni	biogenic amine receptor	0.0202	0.0642	1
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.002	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0202	0.0642	0.595
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.002	0.2727
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0202	0.0642	0.2394
Onchocerca volvulus		0.0048	0.0118	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.002	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.002	0.0001
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0202	0.0642	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0062	0.0684
Echinococcus granulosus	dro:myosuppressin receptor	0.0202	0.0642	0.595
Echinococcus granulosus	neuropeptides capa receptor	0.0202	0.0642	0.595
Schistosoma mansoni	amine GPCR	0.0202	0.0642	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Echinococcus multilocularis	somatostatin receptor	0.0202	0.0642	0.2394
Brugia malayi	putative neuropeptide receptor	0.0202	0.0642	1
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0062	0.0684
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0202	0.0642	1
Schistosoma mansoni	hypothetical protein	0.0164	0.0512	0.7914
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0202	0.0642	0.2394
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0202	0.0642	0.2394
Echinococcus multilocularis	neuropeptides capa receptor	0.0202	0.0642	0.2394
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0074	0.0054
Echinococcus granulosus	neuropeptide Y receptor	0.0202	0.0642	0.595
Brugia malayi	beta-lactamase family protein	0.0035	0.0074	0.087
Echinococcus multilocularis	neuropeptide Y receptor	0.0202	0.0642	0.2394
Onchocerca volvulus		0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0202	0.0642	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0202	0.0642	0.2394
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0202	0.0642	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0019	0.5
Echinococcus granulosus	g protein coupled receptor	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	fmrfamide receptor	0.0202	0.0642	0.2394
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0202	0.0642	0.2394
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0074	0.087
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.087
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0202	0.0642	0.2394
Mycobacterium tuberculosis	Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl)	0.2955	1	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0222	0.0711	0.0693
Echinococcus multilocularis	serotonin receptor	0.0202	0.0642	0.2394
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0062	0.0164
Schistosoma mansoni	neuropeptide receptor	0.0202	0.0642	1
Brugia malayi	AKH receptor	0.0202	0.0642	1
Loa Loa (eye worm)	glutamate receptor	0.0019	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.002	0.0001
Onchocerca volvulus		0.0202	0.0642	1
Echinococcus granulosus	neuropeptides capa receptor	0.0202	0.0642	0.595
Echinococcus multilocularis	g protein coupled receptor	0.0202	0.0642	0.2394
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Echinococcus granulosus	allatostatin A receptor	0.0202	0.0642	0.595
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.002	0.0109
Echinococcus granulosus	neuropeptide FF receptor 2	0.0202	0.0642	0.595
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Brugia malayi	Dopamine receptor	0.0202	0.0642	1
Echinococcus granulosus	neuropeptide s receptor	0.0202	0.0642	0.595
Schistosoma mansoni	hypothetical protein	0.0031	0.0062	0.0684
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0202	0.0642	0.2394
Schistosoma mansoni	hypothetical protein	0.0031	0.0062	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.002	0.001
Brugia malayi	putative neuropeptide receptor NPR1	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.002	0.0109
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0202	0.0642	0.2394
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0259	0.3854
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.002	0.001
Echinococcus granulosus	dna polymerase kappa	0.0019	0.002	0.0006
Echinococcus multilocularis	geminin	0.0164	0.0512	0.1895
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0074	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0202	0.0642	1
Mycobacterium tuberculosis	Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl)	0.2955	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0074	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0074	0.0054
Onchocerca volvulus		0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.002	0.001
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0202	0.0642	1
Echinococcus granulosus	g protein coupled receptor	0.0202	0.0642	0.595
Schistosoma mansoni	histamine h1 receptor	0.0202	0.0642	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0019	0.5
Mycobacterium ulcerans	lipase LipD	0.0035	0.0074	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Schistosoma mansoni	neuropeptide receptor	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0202	0.0642	1
Schistosoma mansoni	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	metabotropic glutamate receptor	0.0024	0.0036	0.0272
Echinococcus granulosus	orexin receptor type 2	0.0202	0.0642	0.595
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	g protein coupled receptor	0.0202	0.0642	0.595
Onchocerca volvulus		0.0202	0.0642	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0202	0.0642	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0202	0.0642	0.2394
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0202	0.0642	0.595
Schistosoma mansoni	neuropeptide receptor	0.0202	0.0642	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Echinococcus multilocularis	allatostatin A receptor	0.0202	0.0642	0.2394
Echinococcus multilocularis	fmrfamide receptor	0.0202	0.0642	0.2394
Onchocerca volvulus		0.0202	0.0642	1
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0074	0.0054
Onchocerca volvulus		0.0202	0.0642	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.087
Echinococcus multilocularis	g protein coupled receptor	0.0202	0.0642	0.2394
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0041	0.0095	0.0289
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0202	0.0642	0.595
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0074	0.0518
Brugia malayi	neuropeptide F receptor	0.0202	0.0642	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0202	0.0642	1
Echinococcus granulosus	serotonin receptor	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Mycobacterium ulcerans	isocitrate lyase Icl	0.2955	1	1
Echinococcus multilocularis	orexin receptor type 2	0.0202	0.0642	0.2394
Schistosoma mansoni	hypothetical protein	0.0164	0.0512	0.7914
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.002	0.0109
Schistosoma mansoni	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0202	0.0642	0.595
Mycobacterium ulcerans	isocitrate lyase AceAb	0.2955	1	1
Schistosoma mansoni	hypothetical protein	0.0068	0.0186	0.2672
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0202	0.0642	0.595
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.158
Brugia malayi	G protein-coupled receptor F59B2.13	0.0202	0.0642	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0259	0.3854
Schistosoma mansoni	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.002	0.0002
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0074	0.0054
Brugia malayi	G-protein coupled receptor	0.0202	0.0642	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0202	0.0642	0.2394
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0062	0.0684
Echinococcus granulosus	tm gpcr rhodopsin	0.0202	0.0642	0.595
Echinococcus multilocularis	neuropeptides capa receptor	0.0202	0.0642	0.2394
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0074	0.0054
Onchocerca volvulus		0.0202	0.0642	1
Brugia malayi	RE15519p	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.002	0.2727
Loa Loa (eye worm)	glutamate receptor	0.0049	0.0122	0.1642
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0292	0.4386
Echinococcus multilocularis	neuropeptide s receptor	0.0202	0.0642	0.2394
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0202	0.0642	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0074	0.0054
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0062	0.0164
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0202	0.0642	1
Echinococcus multilocularis	neuropeptide receptor	0.0202	0.0642	0.2394
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0062	0.0407
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0202	0.0642	0.595
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0074	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0074	0.087
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0202	0.0642	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.0259	0.2293
Schistosoma mansoni	amine GPCR	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	amine GPCR	0.0202	0.0642	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.002	0.0001
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0202	0.0642	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0202	0.0642	0.2394
Schistosoma mansoni	adenoreceptor	0.0202	0.0642	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0202	0.0642	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0202	0.0642	1
Brugia malayi	beta-lactamase	0.0035	0.0074	0.087
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0202	0.0642	1
Brugia malayi	Dopamine receptor protein 1	0.0202	0.0642	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0062	0.0684
Leishmania major	DNA polymerase kappa, putative	0.0019	0.002	0.0109
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0041	0.0095	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0202	0.0642	0.2394
Brugia malayi	beta-lactamase family protein	0.0035	0.0074	0.087
Brugia malayi	Dopamine receptor protein 2	0.0202	0.0642	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.002	0.0006
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0074	0.0208
Onchocerca volvulus		0.0202	0.0642	1
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0062	0.0164
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.002	0.2727
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0062	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0074	1
Leishmania major	DNA polymerase eta, putative	0.0019	0.002	0.0109
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0074	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0202	0.0642	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Onchocerca volvulus		0.0202	0.0642	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0202	0.0642	0.595
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.0292	0.4386
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0074	1
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0074	0.087
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Brugia malayi	G protein-coupled receptor	0.0202	0.0642	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0089	0.0259	0.3854
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0062	0.0407
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.0259	0.2293
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0074	0.087
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Brugia malayi	larval opioid receptor	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.002	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	metabotropic glutamate receptor 5	0.006	0.016	0.1344
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	hypothetical protein	0.0202	0.0642	0.595
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0186	0.2672
Echinococcus multilocularis	sex peptide receptor	0.0202	0.0642	0.2394
Trichomonas vaginalis	esterase, putative	0.0035	0.0074	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0783	0.2619	1
Brugia malayi	sulfakinin receptor protein	0.0202	0.0642	1
Schistosoma mansoni	DNA polymerase eta	0.0019	0.002	0.001
Echinococcus multilocularis	g protein coupled receptor	0.0202	0.0642	0.2394
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0202	0.0642	1
Schistosoma mansoni	neuropeptide receptor	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Onchocerca volvulus		0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0074	0.0054
Loa Loa (eye worm)	melatonin receptor type 1A	0.0202	0.0642	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0202	0.0642	0.2394
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	geminin	0.0164	0.0512	0.4709
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0118	0.158
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.0259	0.0923
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Echinococcus granulosus	GPCR family 2	0.0031	0.0062	0.0407
Trypanosoma brucei	unspecified product	0.0019	0.002	0.2727
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0044	0.0106	0.139
Schistosoma mansoni	biogenic amine receptor	0.0202	0.0642	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0202	0.0642	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0202	0.0642	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	metabotropic glutamate receptor	0.0041	0.0095	0.1208
Schistosoma mansoni	opsin-like receptor	0.0202	0.0642	1
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	somatostatin receptor	0.0202	0.0642	0.595
Loa Loa (eye worm)	neuropeptide F receptor	0.0202	0.0642	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0074	0.0054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.0292	0.4386
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0202	0.0642	0.595
Schistosoma mansoni	amine GPCR	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.087
Toxoplasma gondii	ABC1 family protein	0.0035	0.0074	1
Brugia malayi	Serotonin receptor	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0056	0.0144	0.2008
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0202	0.0642	0.2394
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0202	0.0642	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0202	0.0642	1
Echinococcus granulosus	G protein coupled receptor 139	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.002	0.0109
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0074	0.0054
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.006	0.016	0.0541
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.002	0.001
Brugia malayi	ORL1-like opioid receptor	0.0202	0.0642	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0074	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.087
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.002	0.001
Brugia malayi	Serotonin receptor	0.0202	0.0642	1
Onchocerca volvulus		0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0074	0.0054
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0074	0.0054
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0019	0.2646
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Echinococcus multilocularis	neuropeptide receptor	0.0202	0.0642	0.2394
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0202	0.0642	0.2394
Schistosoma mansoni	opsin-like receptor	0.0202	0.0642	1
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0049	0.0122	0.1642
Echinococcus granulosus	neuropeptide receptor	0.0202	0.0642	0.595
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0202	0.0642	1
Mycobacterium leprae	Isocitrate lyase	0.1385	0.4664	0.4624
Onchocerca volvulus		0.0202	0.0642	1
Brugia malayi	neuropeptide F receptor	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Brugia malayi	follicle stimulating hormone receptor	0.0202	0.0642	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0089	0.0259	0.3854
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0202	0.0642	0.2394
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Giardia lamblia	DINP protein human, muc B family	0.0019	0.002	1
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	g-protein coupled receptor	0.0202	0.0642	0.595
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.002	0.0002
Loa Loa (eye worm)	neuropeptide F receptor	0.0202	0.0642	1
Echinococcus multilocularis	dna polymerase eta	0.0019	0.002	0.0002
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0202	0.0642	0.2394
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0202	0.0642	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.002	0.0109
Onchocerca volvulus		0.0202	0.0642	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0202	0.0642	0.595
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0202	0.0642	0.2394
Brugia malayi	GnHR receptor homolog	0.0202	0.0642	1
Echinococcus granulosus	tumor protein p63	0.0326	0.1065	1
Onchocerca volvulus		0.0202	0.0642	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0074	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0186	0.2672
Schistosoma mansoni	opsin-like receptor	0.0202	0.0642	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0202	0.0642	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0074	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Onchocerca volvulus		0.0202	0.0642	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0202	0.0642	0.595
Leishmania major	hypothetical protein, conserved	0.0035	0.0074	1
Echinococcus multilocularis	serotonin receptor	0.0202	0.0642	0.2394
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.002	0.0109
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0019	0.5
Schistosoma mansoni	biogenic amine receptor	0.0202	0.0642	1
Echinococcus granulosus	sex peptide receptor	0.0202	0.0642	0.595
Echinococcus granulosus	neuropeptide receptor	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.087
Echinococcus multilocularis	tumor protein p63	0.0326	0.1065	0.4023
Schistosoma mansoni	hypothetical protein	0.0031	0.0062	0.0684
Echinococcus multilocularis	G protein coupled receptor 139	0.0202	0.0642	0.2394
Onchocerca volvulus		0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Onchocerca volvulus		0.0202	0.0642	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.002	0.0109
Echinococcus granulosus	tm gpcr rhodopsin	0.0202	0.0642	0.595
Echinococcus granulosus	fmrfamide receptor	0.0202	0.0642	0.595

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3 nM	Displacement of [3H]MPEP from mGlu5 receptor	ChEMBL.	17196387
IC50 (binding)	= 3 nM	Displacement of [3H]MPEP from mGlu5 receptor	ChEMBL.	17196387
IC50 (functional)	= 7 nM	Antagonist activity at mGluR5 by FLIPR	ChEMBL.	17196387
IC50 (functional)	= 7 nM	Antagonist activity at mGluR5 by FLIPR	ChEMBL.	17196387

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL245404
PubChem: 18763270

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 453508