Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.029 | 0.1148 | 0.8059 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.004 | 0.0064 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.029 | 0.1148 | 0.1148 |
Leishmania major | ecotin, putative | 0.004 | 0.0064 | 1 |
Mycobacterium leprae | Possible lipase LipU | 0.004 | 0.0064 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.029 | 0.1148 | 0.1148 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0168 | 0.0621 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0194 | 0.0731 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.1148 | 0.1148 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.004 | 0.0064 | 0.5 |
Loa Loa (eye worm) | ammd protein | 0.004 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.2333 | 1 | 1 |
Onchocerca volvulus | 0.004 | 0.0064 | 0.5 | |
Trichomonas vaginalis | Esterase, putative | 0.004 | 0.0064 | 0.5 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0354 | 0.1425 | 1 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.004 | 0.0064 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2333 | 1 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0354 | 0.1425 | 0.1425 |
Trichomonas vaginalis | Esterase, putative | 0.004 | 0.0064 | 0.5 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0168 | 0.0621 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.004 | 0.0064 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2333 | 1 | 1 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0054 | 0.0126 | 0.0126 |
Echinococcus granulosus | sodium channel protein | 0.003 | 0.0024 | 0.0024 |
Brugia malayi | Kelch motif family protein | 0.0054 | 0.0126 | 0.0882 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.004 | 0.0064 | 0.0064 |
Echinococcus multilocularis | integrin beta 2 | 0.0262 | 0.1028 | 0.1028 |
Echinococcus multilocularis | hormone sensitive lipase | 0.2333 | 1 | 1 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.004 | 0.0064 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0064 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2333 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.0731 | 0.0731 |
Schistosoma mansoni | voltage-gated potassium channel | 0.029 | 0.1148 | 0.1148 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.029 | 0.1148 | 0.1148 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0064 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.0949 | 0.0949 |
Brugia malayi | aryl-acylamidase | 0.004 | 0.0064 | 0.045 |
Schistosoma mansoni | voltage-gated potassium channel | 0.029 | 0.1148 | 0.1148 |
Trichomonas vaginalis | Esterase, putative | 0.004 | 0.0064 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.004 | 0.0064 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.003 | 0.0024 | 0.0024 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.004 | 0.0064 | 0.5 |
Loa Loa (eye worm) | aryl-acylamidase | 0.004 | 0.0064 | 0.0064 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.003 | 0.0024 | 0.0024 |
Echinococcus granulosus | integrin beta 2 | 0.0262 | 0.1028 | 0.1028 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0126 | 0.0126 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0277 | 0.1094 | 0.1094 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0126 | 0.0882 |
Schistosoma mansoni | integrin beta subunit | 0.0208 | 0.0795 | 0.0795 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 35 uM | Inhibition of Escherichia coli H560 DNA gyrase assessed as DNA cleavage | ChEMBL. | 17196390 |
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against membrane efflux-pump deficient Escherichia coli Tol C EC-2549 | ChEMBL. | 17196390 |
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against membrane efflux-pump deficient Escherichia coli Tol C EC-2549 | ChEMBL. | 17196390 |
MIC (functional) | = 64 ug ml-1 | Antibacterial activity against Escherichia coli MC4100 EC-2026 | ChEMBL. | 17196390 |
MIC (functional) | > 64 ug ml-1 | Antibacterial activity against Enterococcus faecalis MGH-2 EF1-1 | ChEMBL. | 17196390 |
MIC (functional) | > 64 ug ml-1 | Antibacterial activity against Staphylococcus aureus UC-76 SA-1 | ChEMBL. | 17196390 |
MIC (functional) | > 64 ug ml-1 | Antibacterial activity against Streptococcus pyogenes C-203 SP1-1 | ChEMBL. | 17196390 |
MIC (functional) | = 64 ug ml-1 | Antibacterial activity against Escherichia coli MC4100 EC-2026 | ChEMBL. | 17196390 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.