Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3413 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3413 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3413 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.008 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.3413 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3413 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.6 uM | Inhibition of Escherichia coli H560 DNA gyrase assessed as DNA cleavage | ChEMBL. | 17196390 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against membrane efflux-pump deficient Escherichia coli Tol C EC-2549 | ChEMBL. | 17196390 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against membrane efflux-pump deficient Escherichia coli Tol C EC-2549 | ChEMBL. | 17196390 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Escherichia coli MC4100 EC-2026 | ChEMBL. | 17196390 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Escherichia coli MC4100 EC-2026 | ChEMBL. | 17196390 |
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against Streptococcus pyogenes C-203 SP1-1 | ChEMBL. | 17196390 |
MIC (functional) | = 32 ug ml-1 | Antibacterial activity against Enterococcus faecalis MGH-2 EF1-1 | ChEMBL. | 17196390 |
MIC (functional) | = 64 ug ml-1 | Antibacterial activity against Staphylococcus aureus UC-76 SA-1 | ChEMBL. | 17196390 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.