Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | EPH receptor B4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | ephrin type A receptor 4 A | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Echinococcus multilocularis | ephrin type A receptor 4 A | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Schistosoma japonicum | ko:K05109 Eph receptor A8, putative | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Brugia malayi | ephrin receptor 1 precursor | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Onchocerca volvulus | Get druggable targets OG5_126715 | All targets in OG5_126715 | |
Schistosoma mansoni | ephrin receptor | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Loa Loa (eye worm) | TK/EPH protein kinase | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126715 | All targets in OG5_126715 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible esterase LipW | 0.0043 | 0.0045 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0043 | 0.0045 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2544 | 1 | 1 |
Mycobacterium ulcerans | lipase LipI | 0.0043 | 0.0045 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0043 | 0.0045 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.0043 | 0.0045 | 1 |
Loa Loa (eye worm) | TK/EPH protein kinase | 0.0085 | 0.0211 | 0.0204 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0045 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0043 | 0.0045 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0043 | 0.0045 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2544 | 1 | 1 |
Mycobacterium ulcerans | lipase LipU | 0.0043 | 0.0045 | 0.5 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0043 | 0.0045 | 0.5 |
Schistosoma mansoni | ephrin receptor | 0.0067 | 0.0139 | 0.0094 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2544 | 1 | 1 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0043 | 0.0045 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0043 | 0.0045 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0043 | 0.0045 | 0.5 |
Loa Loa (eye worm) | ammd protein | 0.0043 | 0.0045 | 0.0038 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0043 | 0.0045 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0043 | 0.0045 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0043 | 0.0045 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0043 | 0.0045 | 0.5 |
Onchocerca volvulus | 0.0066 | 0.0136 | 1 | |
Leishmania major | ecotin, putative | 0.0043 | 0.0045 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0043 | 0.0045 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0043 | 0.0045 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0043 | 0.0045 | 0.5 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0043 | 0.0045 | 0.0038 |
Mycobacterium leprae | Possible lipase LipU | 0.0043 | 0.0045 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0043 | 0.0045 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0043 | 0.0045 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0043 | 0.0045 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0043 | 0.0045 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0043 | 0.0045 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0043 | 0.0045 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0043 | 0.0045 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0043 | 0.0045 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0043 | 0.0045 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0043 | 0.0045 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.2544 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0043 | 0.0045 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0043 | 0.0045 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0045 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0043 | 0.0045 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2544 | 1 | 1 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0043 | 0.0045 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0043 | 0.0045 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0136 | 0.0129 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0045 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0043 | 0.0045 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0043 | 0.0045 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.