Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.209 | 1 | 1 |
Mycobacterium ulcerans | lipase LipU | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0035 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.209 | 1 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0035 | 0 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0035 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0035 | 0 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0035 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.209 | 1 | 1 |
Leishmania major | ecotin, putative | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.209 | 1 | 1 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Brugia malayi | aryl-acylamidase | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.209 | 1 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0035 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 21 uM | Inhibition of Escherichia coli H560 DNA gyrase assessed as DNA cleavage | ChEMBL. | 17196390 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against membrane efflux-pump deficient Escherichia coli Tol C EC-2549 | ChEMBL. | 17196390 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against membrane efflux-pump deficient Escherichia coli Tol C EC-2549 | ChEMBL. | 17196390 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Escherichia coli MC4100 EC-2026 | ChEMBL. | 17196390 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Escherichia coli MC4100 EC-2026 | ChEMBL. | 17196390 |
MIC (functional) | = 32 ug ml-1 | Antibacterial activity against Streptococcus pyogenes C-203 SP1-1 | ChEMBL. | 17196390 |
MIC (functional) | = 32 ug ml-1 | Antibacterial activity against Staphylococcus aureus UC-76 SA-1 | ChEMBL. | 17196390 |
MIC (functional) | = 64 ug ml-1 | Antibacterial activity against Enterococcus faecalis MGH-2 EF1-1 | ChEMBL. | 17196390 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.