Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.074 | 0.074 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0044 | 0.0398 | 0.0398 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.074 | 0.1558 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.074 | 0.074 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0254 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0044 | 0.0398 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0044 | 0.0398 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0044 | 0.0398 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0044 | 0.0398 | 0.0398 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0044 | 0.0398 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0044 | 0.0398 | 0.0838 |
Brugia malayi | Cytochrome P450 family protein | 0.0139 | 0.4753 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0254 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0044 | 0.0398 | 0.0838 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0044 | 0.0398 | 0.0398 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0139 | 0.4753 | 0.4753 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0044 | 0.0398 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.074 | 0.1558 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 | Inhibition of rat intestinal alpha-glucosidase | ChEMBL. | 17188491 |
Inhibition (binding) | = 5.1 % | Inhibition of rat intestinal alpha-glucosidase at 100 uM | ChEMBL. | 17188491 |
Ki (binding) | 0 | Inhibition of rat intestinal alpha-glucosidase | ChEMBL. | 17188491 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.