Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0125 | 0.153 | 0.2122 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0654 | 0.9962 | 1 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0253 | 0.357 | 0.6211 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0086 | 0.0894 | 0.2188 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0379 | 0.5573 | 0.2188 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0202 | 0.2858 |
Trypanosoma brucei | unspecified product | 0.0035 | 0.0094 | 0.0969 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4333 | 0.7691 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Brugia malayi | polk-prov protein | 0.0032 | 0.0038 | 0.0051 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0379 | 0.5573 | 1 |
Onchocerca volvulus | 0.0244 | 0.3422 | 1 | |
Schistosoma mansoni | lipoxygenase | 0.0085 | 0.0883 | 0.216 |
Trichomonas vaginalis | glutaminase, putative | 0.0282 | 0.4022 | 0.7113 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.0613 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0656 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0135 | 0.1679 | 0.1513 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0086 | 0.0894 | 0.605 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4333 | 0.7691 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0059 | 0.047 | 0.0275 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0059 | 0.047 | 0.113 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0018 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.0613 | 0.4178 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0202 | 0.2858 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0018 | 0.5 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0253 | 0.357 | 0.3451 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0086 | 0.0894 | 0.2188 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0235 | 0.3272 | 0.5612 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0214 | 0.2949 | 0.7321 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0059 | 0.047 | 0.0275 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.0613 | 0.1485 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0068 | 0.0613 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.0613 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0042 | 0.0202 | 0.138 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4333 | 0.7691 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0059 | 0.047 | 0.3124 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0301 | 0.4333 | 1 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0379 | 0.5573 | 0.5502 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0121 | 0.1466 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Mycobacterium ulcerans | glutaminase | 0.0282 | 0.4022 | 0.3914 |
Brugia malayi | glutaminase DH11.1 | 0.0282 | 0.4022 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0055 | 0.0407 | 0.0971 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0135 | 0.1679 | 0.2422 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0121 | 0.1466 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.0613 | 0.1485 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0147 | 0.1875 | 0.1714 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0301 | 0.4333 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4333 | 0.7691 |
Loa Loa (eye worm) | glutaminase | 0.0282 | 0.4022 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0244 | 0.3422 | 0.5995 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.0155 | 0.106 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0372 | 0.5461 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.0613 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0059 | 0.047 | 0.3208 |
Brugia malayi | Pre-SET motif family protein | 0.0214 | 0.2949 | 0.7321 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0656 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0121 | 0.1466 | 0.3617 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0235 | 0.3272 | 0.409 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0147 | 0.1875 | 0.0502 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4333 | 0.7691 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0301 | 0.4333 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0379 | 0.5573 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0068 | 0.0613 | 0.1485 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0253 | 0.357 | 0.4857 |
Onchocerca volvulus | 0.0086 | 0.0894 | 0.2574 | |
Loa Loa (eye worm) | glutaminase 2 | 0.0282 | 0.4022 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4333 | 0.7691 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.0613 | 0.4105 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0059 | 0.047 | 0.113 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.0155 | 0.0949 |
Echinococcus multilocularis | dna polymerase kappa | 0.0042 | 0.0202 | 0.1273 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4333 | 0.7691 |
Schistosoma mansoni | glutaminase | 0.0282 | 0.4022 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0035 | 0.0094 | 0.0969 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0147 | 0.1875 | 0.2814 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0894 | 0.2188 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0372 | 0.5461 | 0.5388 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4333 | 0.7691 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0372 | 0.5461 | 0.9714 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0654 | 0.9962 | 0.9933 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0038 | 0.0051 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0018 | 0.0123 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0086 | 0.0894 | 0.6098 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.33 uM | Antiviral activity against influenza A/Hong Kong/7/87 (H3N2) in MDCK cells assessed as inhibition of virus-induced cytopathic effect by MTS assay | ChEMBL. | 17588747 |
MCC (ADMET) | = 113 uM | Cytotoxicity against MDCK cells assessed as changes in cell morphology | ChEMBL. | 17588747 |
Ratio (functional) | = 342 | Selectivity index, ratio of EC50 for influenza A/Hong Kong/7/87 (H3N2) to MCC for MDCK cells | ChEMBL. | 17588747 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.