Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0059 | 0.047 | 0.0275 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0135 | 0.1679 | 0.1513 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0086 | 0.0894 | 0.605 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0302 | 0.4333 | 0.7691 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0018 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.0613 | 0.4178 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0059 | 0.047 | 0.113 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0254 | 0.357 | 0.6211 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0086 | 0.0894 | 0.2188 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0202 | 0.2858 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.038 | 0.5573 | 0.2188 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0126 | 0.153 | 0.2122 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0656 | 0.9962 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Trypanosoma brucei | unspecified product | 0.0036 | 0.0094 | 0.0969 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0302 | 0.4333 | 0.7691 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.0613 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0658 | 1 | 1 |
Onchocerca volvulus | 0.0245 | 0.3422 | 1 | |
Schistosoma mansoni | lipoxygenase | 0.0085 | 0.0883 | 0.216 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.038 | 0.5573 | 1 |
Brugia malayi | polk-prov protein | 0.0032 | 0.0038 | 0.0051 |
Trichomonas vaginalis | glutaminase, putative | 0.0282 | 0.4022 | 0.7113 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0122 | 0.1466 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0059 | 0.047 | 0.3124 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.038 | 0.5573 | 0.5502 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0302 | 0.4333 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0282 | 0.4022 | 0.3914 |
Brugia malayi | glutaminase DH11.1 | 0.0282 | 0.4022 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0135 | 0.1679 | 0.2422 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0055 | 0.0407 | 0.0971 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0148 | 0.1875 | 0.1714 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0122 | 0.1466 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.0613 | 0.1485 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0302 | 0.4333 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0302 | 0.4333 | 0.7691 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0086 | 0.0894 | 0.2188 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0018 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0202 | 0.2858 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0254 | 0.357 | 0.3451 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0235 | 0.3272 | 0.5612 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0215 | 0.2949 | 0.7321 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.0613 | 0.1485 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0068 | 0.0613 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0059 | 0.047 | 0.0275 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Echinococcus granulosus | dna polymerase kappa | 0.0042 | 0.0202 | 0.138 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0302 | 0.4333 | 0.7691 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.0613 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0148 | 0.1875 | 0.0502 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0235 | 0.3272 | 0.409 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0302 | 0.4333 | 0.7691 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0302 | 0.4333 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.038 | 0.5573 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0068 | 0.0613 | 0.1485 |
Trichomonas vaginalis | set domain proteins, putative | 0.0245 | 0.3422 | 0.5995 |
Loa Loa (eye worm) | glutaminase | 0.0282 | 0.4022 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.0155 | 0.106 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0373 | 0.5461 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0215 | 0.2949 | 0.7321 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.0613 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0059 | 0.047 | 0.3208 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0658 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0122 | 0.1466 | 0.3617 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0148 | 0.1875 | 0.2814 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0894 | 0.2188 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0373 | 0.5461 | 0.9714 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0373 | 0.5461 | 0.5388 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0302 | 0.4333 | 0.7691 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0018 | 0.0123 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0086 | 0.0894 | 0.6098 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0656 | 0.9962 | 0.9933 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0038 | 0.0051 |
Onchocerca volvulus | 0.0086 | 0.0894 | 0.2574 | |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0254 | 0.357 | 0.4857 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0202 | 0.2858 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0059 | 0.047 | 0.113 |
Echinococcus multilocularis | dna polymerase kappa | 0.0042 | 0.0202 | 0.1273 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.0155 | 0.0949 |
Loa Loa (eye worm) | glutaminase 2 | 0.0282 | 0.4022 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0302 | 0.4333 | 0.7691 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.0613 | 0.4105 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0036 | 0.0094 | 0.0969 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0302 | 0.4333 | 0.7691 |
Schistosoma mansoni | glutaminase | 0.0282 | 0.4022 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 20 uM | Antiparasitic activity against Trypanosoma brucei 221 blood stream form at pH 7.4 | ChEMBL. | 17588747 |
IC50 (functional) | > 20 uM | Antiparasitic activity against Trypanosoma brucei 221 blood stream form at pH 7.4 | ChEMBL. | 17588747 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.