TDR Targets

Basic information

Technical information

TDR Targets ID: 458512
Name: (2R)-2-[[(1S)-1-(4-bromophenyl)-2,2,2-trifluo roethyl]amino]-N-(1-cyanocyclopropyl)-3-methy lsulfinylpropanamide
MW: 452.289 | Formula: C16H17BrF3N3O2S
H donors: 2 H acceptors: 3 LogP: 2.74 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: N#CC1(CC1)NC(=O)[C@@H](N[C@H](C(F)(F)F)c1ccc(cc1)Br)C[S+](C)[O-]
InChi: 1S/C16H17BrF3N3O2S/c1-26(25)8-12(14(24)23-15(9-21)6-7-15)22-13(16(18,19)20)10-2-4-11(17)5-3-10/h2-5,12-13,22H,6-8H2,1H3,(H,23,24)/t12-,13-,26?/m0/s1
InChiKey: WKOXXQWORKCMDZ-GXXHEZNASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2R)-2-[[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]amino]-N-(1-cyanocyclopropyl)-3-methylsulfinyl-propanamide
(2R)-2-[[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]amino]-N-(1-cyanocyclopropyl)-3-methylsulfinyl-propionamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2996	0.2996
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0739	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1132	0.1132
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2278	0.4606
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2278	0.4606
Entamoeba histolytica	acyl-coA synthetase, putative	0.0017	0.0548	0.0472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.4536	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0739	0.0928
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0739	0.0739
Entamoeba histolytica	cysteine protease, putative	0.002	0.0739	0.0928
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0017	0.0548	1
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0739	0.0928
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0086	0.4536	1
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.4536	1
Onchocerca volvulus		0.002	0.0739	0.1629
Giardia lamblia	Hypothetical protein	0.002	0.0739	0.1194
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0548	0.0548
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Plasmodium falciparum	serine repeat antigen 7	0.002	0.0739	0.1022
Loa Loa (eye worm)	hypothetical protein	0.002	0.0739	0.0739
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0739	0.0739
Toxoplasma gondii	cathepsin CPC2	0.002	0.0739	0.0928
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.002	0.0739	0.1022
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1132	0.1132
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0739	0.0739
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0027	0.1132	0.1132
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0739	0.0739
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.2996	0.2742
Plasmodium falciparum	serine repeat antigen 2	0.002	0.0739	0.1022
Schistosoma mansoni	ap endonuclease	0.0013	0.035	0.035
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0017	0.0548	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.002	0.0739	0.1022
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.1132	0.081
Leishmania major	cathepsin L-like protease	0.0086	0.4536	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.002	0.0739	0.0739
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.002	0.0739	0.1022
Entamoeba histolytica	hypothetical protein	0.002	0.0739	0.0928
Onchocerca volvulus	Cathepsin F homolog	0.0086	0.4536	1
Echinococcus multilocularis	cathepsin b	0.0181	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.002	0.0739	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2996	0.2996
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.002	0.0739	0.1022
Giardia lamblia	Cysteine protease	0.002	0.0739	0.1194
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.4536	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.2278	0.2278
Giardia lamblia	Cathepsin L precursor	0.002	0.0739	0.1194
Giardia lamblia	Cathepsin B precursor	0.002	0.0739	0.1194
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.4536	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.4536	1
Giardia lamblia	Cathepsin L precursor	0.002	0.0739	0.1194
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0306	0.0306
Schistosoma mansoni	cathepsin B (C01 family)	0.002	0.0739	0.0739
Echinococcus multilocularis	geminin	0.0119	0.6417	0.6417
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0181	1	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.002	0.0739	0.0739
Loa Loa (eye worm)	hypothetical protein	0.002	0.0739	0.0739
Plasmodium falciparum	serine repeat antigen 8	0.002	0.0739	0.1022
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0017	0.0548	1
Entamoeba histolytica	cysteine protease, putative	0.002	0.0739	0.0928
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.002	0.0739	0.0928
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0013	0.035	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	1	1
Plasmodium falciparum	serine repeat antigen 6	0.002	0.0739	0.1022
Giardia lamblia	Cathepsin L-like protease	0.002	0.0739	0.1194
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.002	0.0739	0.1022
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.4536	1
Brugia malayi	Cathepsin L-like precursor	0.0086	0.4536	0.4536
Entamoeba histolytica	cysteine proteinase 2	0.0047	0.2278	0.4606
Giardia lamblia	Cysteine protease	0.002	0.0739	0.1194
Echinococcus granulosus	cathepsin l1	0.0086	0.4536	0.4536
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0306	0.0306
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.002	0.0739	0.1194
Echinococcus multilocularis	cathepsin b	0.0181	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0086	0.4536	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0017	0.0548	0.5
Leishmania major	cathepsin L-like protease	0.0086	0.4536	1
Brugia malayi	Cathepsin L-like precursor	0.0086	0.4536	0.4536
Entamoeba histolytica	cysteine protease, putative	0.0086	0.4536	1
Entamoeba histolytica	cysteine protease, putative	0.002	0.0739	0.0928
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.002	0.0739	0.0928
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.4536	0.4337
Giardia lamblia	Cathepsin B precursor	0.002	0.0739	0.1194
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.4536	1
Echinococcus multilocularis	cathepsin L	0.0047	0.2278	0.2278
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.4536	1
Toxoplasma gondii	cathepsin CPC1	0.002	0.0739	0.0928
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2278	0.4606
Plasmodium vivax	vivapain-2	0.0086	0.4536	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0739	0.0739
Echinococcus granulosus	cysteine protease	0.0047	0.2278	0.2278
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.4536	1
Echinococcus granulosus	cathepsin b	0.0181	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0017	0.0548	1
Leishmania major	cathepsin L-like protease	0.0086	0.4536	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0739	0.0739
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.002	0.0739	0.1022
Echinococcus granulosus	cathepsin l1	0.0059	0.2996	0.2996
Plasmodium vivax	vivapain-2	0.0086	0.4536	1
Echinococcus multilocularis	cysteine protease	0.0086	0.4536	0.4536
Plasmodium vivax	serine-repeat antigen (SERA)	0.002	0.0739	0.1022
Trypanosoma cruzi	major cysteine proteinase, putative	0.002	0.0739	0.0402
Echinococcus granulosus	geminin	0.0119	0.6417	0.6417
Plasmodium falciparum	serine repeat antigen 1	0.002	0.0739	0.1022
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2278	0.4606
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.2278	0.4606
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.4536	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0739	0.0928
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0739	0.0928
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0739	0.0928
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.4536	1
Leishmania major	cathepsin L-like protease	0.0086	0.4536	1
Plasmodium falciparum	serine repeat antigen 3	0.002	0.0739	0.1022
Schistosoma mansoni	hypothetical protein	0.0119	0.6417	0.6417
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0181	1	1
Echinococcus granulosus	cathepsin L	0.0047	0.2278	0.2278
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.002	0.0739	0.1022
Giardia lamblia	Cathepsin B precursor	0.002	0.0739	0.1194
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0548	0.0548
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2996	0.6322
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0739	0.0928
Leishmania major	cathepsin L-like protease	0.0086	0.4536	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.4536	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2278	0.4606
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2278	0.4606
Onchocerca volvulus		0.0086	0.4536	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0086	0.4536	0.4337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.2278	0.1998
Brugia malayi	Papain family cysteine protease containing protein	0.0086	0.4536	0.4536
Mycobacterium ulcerans	acyl-CoA synthetase	0.0017	0.0548	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.002	0.0739	0.1194
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.4536	0.4536
Giardia lamblia	Cysteine protease	0.002	0.0739	0.1194
Onchocerca volvulus		0.0086	0.4536	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1132	0.1132
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.002	0.0739	0.1022
Brugia malayi	AMP-binding enzyme family protein	0.0017	0.0548	0.0548
Schistosoma mansoni	ap endonuclease	0.0013	0.035	0.035
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.002	0.0739	0.0739
Plasmodium vivax	serine-repeat antigen (SERA)	0.002	0.0739	0.1022
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2278	0.4606
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.002	0.0739	0.0739
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.2278	0.4606
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0739	0.1629
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2996	0.6322
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0047	0.2278	0.1998
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.1132	0.081
Trypanosoma brucei	cysteine peptidase C (CPC)	0.007	0.3603	0.7771
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0739	0.0739
Brugia malayi	cathepsin F-like cysteine proteinase	0.0027	0.1132	0.1132
Giardia lamblia	Cathepsin B precursor	0.007	0.3603	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.4536	0.4337
Giardia lamblia	Cathepsin B precursor	0.002	0.0739	0.1194
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0047	0.2278	0.4662
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.3603	0.3603
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0739	0.0739
Plasmodium vivax	vivapain-1	0.0047	0.2278	0.4662
Leishmania major	4-coumarate:coa ligase-like protein	0.0017	0.0548	0.0472
Toxoplasma gondii	preprocathepsin c precursor, putative	0.002	0.0739	0.0928
Schistosoma mansoni	cathepsin C	0.002	0.0739	0.0739
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.002	0.0739	0.0739
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.007	0.3603	0.7771
Loa Loa (eye worm)	hypothetical protein	0.0086	0.4536	0.4536
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2996	0.2996
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0548	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0017	0.0548	0.0472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0739	0.0928
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0017	0.0548	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.4536	0.4337
Brugia malayi	cathepsin L-like precursor	0.0059	0.2996	0.2996
Schistosoma mansoni	hypothetical protein	0.0119	0.6417	0.6417
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.4536	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.4536	0.4536
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2278	0.4606
Echinococcus multilocularis	cysteine protease	0.0086	0.4536	0.4536
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0013	0.035	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.4536	0.4337
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0739	0.0739
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0739	0.0928
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0017	0.0548	0.0472
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2278	0.4606
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0086	0.4536	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0739	0.0928
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.4536	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2278	0.4606
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0739	0.0928
Brugia malayi	cathepsin Z-like cysteine proteinase	0.002	0.0739	0.0739
Brugia malayi	cathepsin L precursor	0.002	0.0739	0.0739
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.4536	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.4536	1
Giardia lamblia	Cathepsin B precursor	0.007	0.3603	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0013	0.035	0.035
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0548	0.0548
Giardia lamblia	Cathepsin L precursor	0.002	0.0739	0.1194
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.2278	0.1998
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0013	0.035	0.1822
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0059	0.2996	0.2996
Brugia malayi	fibroinase precursor	0.002	0.0739	0.0739
Toxoplasma gondii	cathepsin CPL	0.0086	0.4536	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0013	0.035	0.035
Loa Loa (eye worm)	ctsf protein	0.0086	0.4536	0.4536
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Plasmodium falciparum	serine repeat antigen 4	0.002	0.0739	0.1022
Brugia malayi	Cathepsin L-like precursor	0.0086	0.4536	0.4536
Loa Loa (eye worm)	hypothetical protein	0.0181	1	1
Entamoeba histolytica	cysteine protease, putative	0.002	0.0739	0.0928
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.2278	0.2278
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0306	0.0306
Plasmodium falciparum	serine repeat antigen 5	0.002	0.0739	0.1022
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0013	0.035	0.0104
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.2278	0.4606
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0739	0.0928
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.2278	0.2278
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0086	0.4536	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.2278	0.1998
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.2996	0.2996
Brugia malayi	Cathepsin L-like precursor	0.0086	0.4536	0.4536
Brugia malayi	cathepsin Z-like cysteine proteinase	0.002	0.0739	0.0739
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.2996	0.6322
Onchocerca volvulus		0.0086	0.4536	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.4536	0.4536
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0739	0.0739
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0013	0.035	0.0104
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0013	0.035	0.035
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0017	0.0548	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0739	0.0739
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2278	0.4606
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0739	0.0739
Onchocerca volvulus		0.0086	0.4536	1
Brugia malayi	AMP-binding enzyme family protein	0.0017	0.0548	0.0548
Giardia lamblia	Cathepsin B precursor	0.002	0.0739	0.1194
Plasmodium vivax	unspecified product	0.0027	0.1132	0.1953
Echinococcus granulosus	cathepsin L cysteine protease	0.0047	0.2278	0.2278
Giardia lamblia	Cysteine protease	0.002	0.0739	0.1194
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.4536	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.002	0.0739	0.1022
Brugia malayi	Cathepsin L-like precursor	0.0086	0.4536	0.4536
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0739	0.0928
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0086	0.4536	0.4536
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Echinococcus granulosus	cathepsin L	0.002	0.0739	0.0739
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0739	0.0928
Trypanosoma cruzi	cysteine protease, putative	0.0047	0.2278	0.1998
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.4536	0.4536
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0739	0.0928
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0086	0.4536	0.4536
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2278	0.4606
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2278	0.4606
Brugia malayi	Cathepsin L-like precursor	0.0086	0.4536	0.4536
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0086	0.4536	0.4536
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0012	0.0306	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.4536	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.1132	0.1132
Leishmania major	cathepsin L-like protease	0.0086	0.4536	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.002	0.0739	0.0739
Giardia lamblia	Cathepsin L-like protease	0.002	0.0739	0.1194
Echinococcus granulosus	cathepsin b	0.0181	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.4536	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.002	0.0739	0.0928
Schistosoma mansoni	cathepsin s	0.0027	0.1132	0.1132
Loa Loa (eye worm)	hypothetical protein	0.002	0.0739	0.0739
Mycobacterium ulcerans	acyl-CoA synthetase	0.0017	0.0548	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0017	0.0548	0.0472
Brugia malayi	cathepsin F-like cysteine proteinase	0.002	0.0739	0.0739
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.002	0.0739	0.0928
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.2278	0.2278
Brugia malayi	exodeoxyribonuclease III family protein	0.0013	0.035	0.035
Giardia lamblia	Cathepsin L precursor	0.002	0.0739	0.1194
Entamoeba histolytica	cysteine protease, putative	0.002	0.0739	0.0928
Plasmodium vivax	unspecified product	0.0047	0.2278	0.4662
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.002	0.0739	0.1022
Echinococcus multilocularis	cathepsin L	0.002	0.0739	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2996	0.2996
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0012	0.0306	0.139
Onchocerca volvulus		0.0086	0.4536	1
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0548	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2278	0.4606
Entamoeba histolytica	cysteine protease, putative	0.002	0.0739	0.0928
Onchocerca volvulus		0.0017	0.0548	0.1208
Giardia lamblia	Encystation-specific protease	0.002	0.0739	0.1194
Giardia lamblia	Cathepsin L precursor	0.002	0.0739	0.1194
Leishmania major	cathepsin L-like protease	0.0086	0.4536	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.002	0.0739	0.0928
Giardia lamblia	Hypothetical protein	0.002	0.0739	0.1194
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.4536	0.4536
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.002	0.0739	0.1194
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.002	0.0739	0.0928
Plasmodium vivax	vivapain-3	0.0047	0.2278	0.4662
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0306	0.0306
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.4536	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0086	0.4536	0.4536
Leishmania major	cathepsin L-like protease	0.0086	0.4536	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0017	0.0548	0.0472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.4536	1
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.2278	0.4606
Giardia lamblia	Cathepsin L precursor	0.002	0.0739	0.1194
Giardia lamblia	Cathepsin B precursor	0.007	0.3603	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.002	0.0739	0.1022
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.4536	0.4536
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.007	0.3603	0.3371
Onchocerca volvulus		0.0086	0.4536	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.1132	0.1132
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.002	0.0739	0.1022
Loa Loa (eye worm)	cathepsin B	0.007	0.3603	0.3603
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.2278	0.2278
Entamoeba histolytica	cysteine proteinase 1, putative	0.0047	0.2278	0.4606
Loa Loa (eye worm)	cysteine protease	0.0086	0.4536	0.4536
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.4536	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.002	0.0739	0.1022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.4536	1
Loa Loa (eye worm)	fibroinase	0.0086	0.4536	0.4536
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.002	0.0739	0.0739
Onchocerca volvulus		0.0059	0.2996	0.6606
Plasmodium vivax	unspecified product	0.002	0.0739	0.1022
Toxoplasma gondii	cathepsin B	0.007	0.3603	0.7771
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0013	0.035	0.2958
Schistosoma mansoni	cathepsin S (C01 family)	0.002	0.0739	0.0739
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.4536	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.4536	1
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2996	0.2996
Brugia malayi	AMP-binding enzyme family protein	0.0017	0.0548	0.0548
Plasmodium falciparum	serine repeat antigen 9	0.002	0.0739	0.1022
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0548	1
Onchocerca volvulus		0.0086	0.4536	1
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.2278	0.4606
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0306	0.0306
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.2278	0.4606
Loa Loa (eye worm)	hypothetical protein	0.002	0.0739	0.0739
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.002	0.0739	0.1194
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.007	0.3603	0.7771
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2278	0.4606
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.4536	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.4536	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 639 nM	Inhibition of human cathepsin K	ChEMBL.	17590332
IC50 (binding)	= 639 nM	Inhibition of human cathepsin K	ChEMBL.	17590332
IC50 (binding)	= 2173 nM	Inhibition of human cathepsin S	ChEMBL.	17590332
IC50 (binding)	= 2173 nM	Inhibition of human cathepsin S	ChEMBL.	17590332
IC50 (binding)	= 8029 nM	Inhibition of human cathepsin B	ChEMBL.	17590332
IC50 (binding)	= 8029 nM	Inhibition of human cathepsin B	ChEMBL.	17590332
IC50 (binding)	> 10000 nM	Inhibition of human cathepsin L	ChEMBL.	17590332
IC50 (binding)	> 10000 nM	Inhibition of human cathepsin L	ChEMBL.	17590332

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL436636
PubChem: 23648279

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 458512