Detailed information for compound 458522

Basic information

Technical information
  • TDR Targets ID: 458522
  • Name: (2R)-N-(1-cyanocyclopropyl)-3-methylsulfonyl- 2-[[(1S)-2,2,2-trifluoro-1-(3-fluorophenyl)et hyl]amino]propanamide
  • MW: 407.383 | Formula: C16H17F4N3O3S
  • H donors: 2 H acceptors: 4 LogP: 1.43 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1(CC1)NC(=O)[C@H](CS(=O)(=O)C)N[C@H](C(F)(F)F)c1cccc(c1)F
  • InChi: 1S/C16H17F4N3O3S/c1-27(25,26)8-12(14(24)23-15(9-21)5-6-15)22-13(16(18,19)20)10-3-2-4-11(17)7-10/h2-4,7,12-13,22H,5-6,8H2,1H3,(H,23,24)/t12-,13-/m0/s1
  • InChiKey: OOVJOXGELNYKFE-STQMWFEESA-N  


Substructure search Similarity search

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Synonyms

  • (2R)-N-(1-cyanocyclopropyl)-3-mesyl-2-[[(1S)-2,2,2-trifluoro-1-(3-fluorophenyl)ethyl]amino]propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.41 0.41
Echinococcus multilocularis cysteine protease 0.0086 0.41 0.41
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.2438 0.2438
Schistosoma mansoni hypothetical protein 0.0033 0.0824 0.0824
Entamoeba histolytica cysteine protease, putative 0.0047 0.1662 0.4054
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0048 0.173 0.173
Entamoeba histolytica cysteine protease, putative 0.0047 0.1662 0.4054
Onchocerca volvulus 0.0086 0.41 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0052 0.1975 0.1975
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.41 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0425 0.0425
Brugia malayi Metabotropic glutamate receptor precursor. 0.0042 0.1372 0.1372
Leishmania major cathepsin L-like protease 0.0086 0.41 1
Echinococcus granulosus cathepsin b 0.0181 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.41 0.41
Echinococcus multilocularis cathepsin b 0.0181 1 1
Leishmania major cathepsin L-like protease 0.0086 0.41 1
Onchocerca volvulus 0.0059 0.2438 0.5946
Plasmodium vivax vivapain-1 0.0047 0.1662 0.4054
Echinococcus granulosus cathepsin l1 0.0059 0.2438 0.2438
Entamoeba histolytica cysteine protease, putative 0.0047 0.1662 0.4054
Schistosoma mansoni metabotropic glutamate receptor 0.0035 0.0949 0.0949
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.1662 0.1662
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.41 0.41
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.2438 0.2438
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1662 0.1662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0425 0.0425
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0425 0.0425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.41 1
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.41 0.41
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1662 0.4054
Plasmodium vivax vivapain-2 0.0086 0.41 1
Plasmodium vivax unspecified product 0.0027 0.0425 0.1037
Brugia malayi Cathepsin L-like precursor 0.0086 0.41 0.41
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.1778 0.1778
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.41 0.41
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0035 0.0949 0.0949
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Trypanosoma cruzi cysteine protease, putative 0.0047 0.1662 0.1662
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.41 0.41
Brugia malayi Cathepsin L-like precursor 0.0086 0.41 0.41
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0035 0.0035
Entamoeba histolytica cysteine protease, putative 0.0047 0.1662 0.4054
Onchocerca volvulus 0.0086 0.41 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0027 0.0425 0.0425
Onchocerca volvulus 0.0086 0.41 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1662 0.4054
Toxoplasma gondii cathepsin B 0.007 0.3093 0.7543
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Plasmodium vivax vivapain-2 0.0086 0.41 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.41 1
Toxoplasma gondii cathepsin CPL 0.0086 0.41 1
Echinococcus multilocularis cysteine protease 0.0086 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1662 0.1662
Echinococcus multilocularis cathepsin L 0.0047 0.1662 0.1662
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.41 0.41
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.41 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.1662 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1662 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Schistosoma mansoni cathepsin s 0.0027 0.0425 0.0425
Entamoeba histolytica cysteine protease, putative 0.0047 0.1662 0.4054
Echinococcus granulosus metabotropic glutamate receptor 5 0.0052 0.1975 0.1975
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.1778 0.1778
Loa Loa (eye worm) ctsf protein 0.0086 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.2438 0.5946
Leishmania major cathepsin L-like protease 0.0086 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.41 1
Echinococcus granulosus cathepsin b 0.0181 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.41 0.41
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.41 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1662 0.4054
Entamoeba histolytica cysteine protease, putative 0.0086 0.41 1
Leishmania major cathepsin L-like protease 0.0086 0.41 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 1 1
Echinococcus granulosus cysteine protease 0.0047 0.1662 0.1662
Brugia malayi Cathepsin L-like precursor 0.0086 0.41 0.41
Entamoeba histolytica cysteine protease, putative 0.0047 0.1662 0.4054
Loa Loa (eye worm) hypothetical protein 0.0027 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0086 0.41 0.41
Entamoeba histolytica cysteine protease, putative 0.0047 0.1662 0.4054
Echinococcus multilocularis cathepsin b 0.0181 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.41 1
Brugia malayi Cathepsin L-like precursor 0.0059 0.2438 0.2438
Brugia malayi Cathepsin L-like precursor 0.0086 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.41 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.1662 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.1778 0.1778
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.3093 0.3093
Loa Loa (eye worm) hypothetical protein 0.0059 0.2438 0.2438
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1662 0.4054
Leishmania major cathepsin L-like protease 0.0086 0.41 1
Plasmodium vivax unspecified product 0.0047 0.1662 0.4054
Echinococcus granulosus cathepsin L 0.0047 0.1662 0.1662
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.41 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.41 0.41
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.41 0.41
Plasmodium vivax vivapain-3 0.0047 0.1662 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.41 1
Onchocerca volvulus 0.0086 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.41 0.41
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.1662 0.1662
Onchocerca volvulus 0.0086 0.41 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.0425 0.0425
Echinococcus granulosus cathepsin l1 0.0086 0.41 0.41
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.1662 0.1662
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.3093 0.7543
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.41 0.41
Loa Loa (eye worm) hypothetical protein 0.0181 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 1 1
Leishmania major cathepsin L-like protease 0.0086 0.41 1
Onchocerca volvulus 0.0086 0.41 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0824 0.0824
Loa Loa (eye worm) hypothetical protein 0.0027 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0059 0.2438 0.2438
Onchocerca volvulus Cathepsin L homolog 0.0086 0.41 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.3093 0.3093
Onchocerca volvulus 0.0086 0.41 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1662 0.1662
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.1662 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.41 1
Onchocerca volvulus Cathepsin F homolog 0.0086 0.41 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0824 0.0824
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.2438 0.2438
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0038 0.1127 0.1127
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.3093 0.5868
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.0425 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.2438 0.5946
Brugia malayi cathepsin L-like precursor 0.0059 0.2438 0.2438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Giardia lamblia Cathepsin B precursor 0.007 0.3093 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.1662 0.1662
Brugia malayi Cathepsin L-like precursor 0.0086 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.1662 0.4054
Loa Loa (eye worm) hypothetical protein 0.0048 0.1778 0.1778
Entamoeba histolytica cysteine proteinase 2 0.0047 0.1662 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.41 1
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.2438 0.5946
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.1662 0.1662
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.41 1
Leishmania major cathepsin L-like protease 0.0086 0.41 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0027 0.0425 0.0425
Entamoeba histolytica cysteine protease, putative 0.0047 0.1662 0.4054
Giardia lamblia Cathepsin B precursor 0.007 0.3093 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.41 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1975 0.1975
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.41 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1662 0.4054
Leishmania major cysteine peptidase A (CPA) 0.0086 0.41 1
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.41 0.41
Brugia malayi Cathepsin L-like precursor 0.0059 0.2438 0.2438
Entamoeba histolytica cysteine protease, putative 0.0047 0.1662 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0086 0.41 1
Loa Loa (eye worm) cathepsin B 0.007 0.3093 0.3093
Leishmania major cathepsin L-like protease 0.0086 0.41 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0035 0.0949 0.0949
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.41 0.41
Loa Loa (eye worm) glutamate receptor 0.0042 0.1372 0.1372
Brugia malayi Cathepsin L-like precursor 0.0086 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.41 1
Giardia lamblia Cathepsin B precursor 0.007 0.3093 1
Loa Loa (eye worm) fibroinase 0.0086 0.41 0.41
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.1662 0.1662
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.41 0.41
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.1662 0.1662
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1662 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.41 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.41 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1662 0.4054
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.2438 0.2438
Loa Loa (eye worm) cysteine protease 0.0086 0.41 0.41

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.4 nM Inhibition of human cathepsin S ChEMBL. 17590332
IC50 (binding) = 6.4 nM Inhibition of human cathepsin S ChEMBL. 17590332
IC50 (binding) = 314 nM Inhibition of human cathepsin K ChEMBL. 17590332
IC50 (binding) = 314 nM Inhibition of human cathepsin K ChEMBL. 17590332
IC50 (binding) = 911 nM Inhibition of human cathepsin L ChEMBL. 17590332
IC50 (binding) = 911 nM Inhibition of human cathepsin L ChEMBL. 17590332
IC50 (binding) = 3854 nM Inhibition of human cathepsin B ChEMBL. 17590332
IC50 (binding) = 3854 nM Inhibition of human cathepsin B ChEMBL. 17590332

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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