Detailed information for compound 458742

Basic information

Technical information
  • TDR Targets ID: 458742
  • Name: (2R)-3-(3-bromophenyl)sulfonyl-N-(1-cyanocycl opropyl)-2-[[(1S)-2,2,2-trifluoro-1-phenyleth yl]amino]propanamide
  • MW: 530.358 | Formula: C21H19BrF3N3O3S
  • H donors: 2 H acceptors: 4 LogP: 3.58 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#CC1(CC1)NC(=O)[C@H](CS(=O)(=O)c1cccc(c1)Br)N[C@H](C(F)(F)F)c1ccccc1
  • InChi: 1S/C21H19BrF3N3O3S/c22-15-7-4-8-16(11-15)32(30,31)12-17(19(29)28-20(13-26)9-10-20)27-18(21(23,24)25)14-5-2-1-3-6-14/h1-8,11,17-18,27H,9-10,12H2,(H,28,29)/t17-,18-/m0/s1
  • InChiKey: SEBANXBXZIIACF-ROUUACIJSA-N  


Substructure search Similarity search

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Synonyms

  • (2R)-3-(3-bromophenyl)sulfonyl-N-(1-cyanocyclopropyl)-2-[[(1S)-2,2,2-trifluoro-1-phenyl-ethyl]amino]propanamide
  • (2R)-3-(3-bromophenyl)sulfonyl-N-(1-cyanocyclopropyl)-2-[[(1S)-2,2,2-trifluoro-1-phenyl-ethyl]amino]propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cathepsin B Starlite/ChEMBL References
Mus musculus cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Rattus norvegicus Cathepsin L Starlite/ChEMBL References
Mus musculus cathepsin S Starlite/ChEMBL References
Rattus norvegicus Cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References
Mus musculus cathepsin K Starlite/ChEMBL References
Mus musculus cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_129645 All targets in OG5_129645
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis papain family cysteine protease containing protein Get druggable targets OG5_129645 All targets in OG5_129645
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis cysteine protease 2 Get druggable targets OG5_129645 All targets in OG5_129645
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_129645 All targets in OG5_129645
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 282 aa 26.2 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 372 aa 23.7 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 36.4 %
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 273 aa 26.0 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 337 aa 26.1 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 271 aa 26.9 %
Plasmodium vivax serine-repeat antigen 4 (SERA), putative Cathepsin S   330 aa 274 aa 23.4 %
Drosophila melanogaster Cathepsin B1 Cathepsin S   330 aa 305 aa 27.2 %
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Cathepsin L   334 aa 277 aa 24.5 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 341 aa 26.7 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 332 aa 23.5 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 319 aa 25.7 %
Schistosoma mansoni cathepsin F (C01 family) Cathepsin B   339 aa 273 aa 28.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 28.6 %
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin B   339 aa 301 aa 23.6 %
Babesia bovis cathepsin C precursor, putative Cathepsin B   339 aa 304 aa 26.6 %
Plasmodium berghei berghepain-1 Cathepsin L   334 aa 353 aa 29.7 %
Plasmodium knowlesi knowpain-2 Cathepsin B   339 aa 302 aa 24.8 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 275 aa 29.1 %
Schistosoma mansoni cathepsin S (C01 family) Cathepsin L   334 aa 311 aa 35.0 %
Onchocerca volvulus Cathepsin L   334 aa 325 aa 47.4 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 278 aa 26.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 24.8 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin B   339 aa 298 aa 23.8 %
Onchocerca volvulus Cathepsin S   330 aa 289 aa 29.4 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 298 aa 28.9 %
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Cathepsin L   334 aa 290 aa 27.6 %
Echinococcus granulosus cathepsin b Cathepsin S   330 aa 276 aa 26.1 %
Echinococcus multilocularis cathepsin b Cathepsin S   330 aa 278 aa 28.8 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 279 aa 25.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 279 aa 28.3 %
Neospora caninum hypothetical protein Cathepsin L   334 aa 299 aa 28.4 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 277 aa 26.0 %
Plasmodium falciparum cysteine proteinase falcipain 1 Cathepsin L   334 aa 359 aa 29.8 %
Brugia malayi Papain family cysteine protease containing protein Cathepsin L   334 aa 296 aa 31.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 23.4 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 276 aa 25.4 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 38.0 %
Toxoplasma gondii cathepsin B Cathepsin S   330 aa 265 aa 24.9 %
Dictyostelium discoideum cysteine protease Cathepsin B   339 aa 283 aa 24.7 %
Plasmodium vivax dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 271 aa 27.7 %
Loa Loa (eye worm) hypothetical protein Cathepsin S   330 aa 281 aa 28.5 %
Brugia malayi cathepsin B-like cysteine proteinase Cathepsin L   334 aa 303 aa 23.4 %
Giardia lamblia Dipeptidyl-peptidase I precursor Cathepsin L   334 aa 304 aa 28.3 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 325 aa 29.5 %
Schistosoma japonicum ko:K01365 cathepsin L [EC3.4.22.15], putative Cathepsin S   330 aa 309 aa 44.7 %
Schistosoma mansoni SmCB2 peptidase (C01 family) Cathepsin L   334 aa 288 aa 26.7 %
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 277 aa 26.0 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 25.0 %
Plasmodium falciparum serine repeat antigen 8 Cathepsin B   339 aa 272 aa 25.0 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 Cathepsin B   339 aa 367 aa 25.9 %
Plasmodium berghei dipeptidyl aminopeptidase 2 Cathepsin B   339 aa 314 aa 24.5 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Toxoplasma gondii cathepsin CPC1 Cathepsin L   334 aa 295 aa 28.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 295 aa 25.4 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Cathepsin L   334 aa 318 aa 48.4 %
Schistosoma mansoni SmCL2-like peptidase (C01 family) Cathepsin L   334 aa 316 aa 30.1 %
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) Cathepsin B   339 aa 327 aa 30.3 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Babesia bovis preprocathepsin c precursor, putative Cathepsin B   339 aa 282 aa 29.8 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 273 aa 25.3 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 334 aa 367 aa 30.0 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Onchocerca volvulus Cathepsin L   334 aa 311 aa 40.8 %
Schistosoma mansoni cathepsin F (C01 family) Cathepsin B   339 aa 273 aa 28.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Giardia lamblia Encystation-specific protease Cathepsin B   339 aa 272 aa 23.5 %
Trypanosoma cruzi cysteine protease, putative Cathepsin L   334 aa 323 aa 30.3 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 324 aa 34.6 %
Plasmodium vivax vivapain-1 Cathepsin L   334 aa 366 aa 28.4 %
Cryptosporidium hominis preprocathepsin c precursor Cathepsin B   339 aa 282 aa 29.4 %
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase Cathepsin S   330 aa 266 aa 32.0 %
Plasmodium vivax vivapain-3 Cathepsin L   334 aa 345 aa 30.7 %
Theileria parva cathepsin C, putative Cathepsin B   339 aa 295 aa 26.1 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Cathepsin L   334 aa 311 aa 36.0 %
Babesia bovis papain family cysteine protease containing protein Cathepsin L   334 aa 321 aa 32.7 %
Echinococcus granulosus cathepsin b Cathepsin S   330 aa 288 aa 30.2 %
Plasmodium vivax unspecified product Cathepsin L   334 aa 366 aa 28.4 %
Plasmodium knowlesi knowpain-1 Cathepsin L   334 aa 373 aa 27.6 %
Onchocerca volvulus Cathepsin L   334 aa 300 aa 24.3 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Onchocerca volvulus Protein MCM10 homolog Cathepsin L   334 aa 300 aa 41.0 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 274 aa 48.2 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 274 aa 48.5 %
Schistosoma mansoni cathepsin F (C01 family) Cathepsin B   339 aa 273 aa 28.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 276 aa 26.8 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 325 aa 38.1 %
Onchocerca volvulus Cathepsin B   339 aa 319 aa 38.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Onchocerca volvulus Cathepsin B-like cysteine proteinase 6 homolog Cathepsin B   339 aa 326 aa 51.2 %
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin B   339 aa 302 aa 24.5 %
Plasmodium yoelii cysteine proteinase precursor Cathepsin L   334 aa 360 aa 29.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.9 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 347 aa 28.8 %
Schistosoma japonicum Cathepsin C precursor, putative Cathepsin B   339 aa 332 aa 26.8 %
Echinococcus granulosus cathepsin L cysteine protease Cathepsin L   334 aa 323 aa 46.1 %
Plasmodium knowlesi dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 273 aa 27.8 %
Cryptosporidium parvum preprocathepsin c precursor, putative Cathepsin B   339 aa 287 aa 30.3 %
Plasmodium yoelii cathepsin c precursor Cathepsin L   334 aa 292 aa 22.6 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 309 aa 26.5 %
Plasmodium knowlesi cysteine protease, putative Cathepsin S   330 aa 291 aa 23.0 %
Plasmodium berghei serine repeat antigen 1 Cathepsin S   330 aa 287 aa 25.4 %
Echinococcus multilocularis cathepsin b Cathepsin S   330 aa 288 aa 30.2 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 341 aa 375 aa 29.9 %
Plasmodium knowlesi knowpain-4 Cathepsin B   339 aa 304 aa 24.3 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase Cathepsin B   339 aa 287 aa 22.6 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 2b cathepsin K 329 aa 328 aa 34.5 %
Schistosoma japonicum ko:K01275 cathepsin C [EC3.4.14.1], putative Cathepsin B   339 aa 334 aa 29.3 %
Plasmodium yoelii SERA-2 Cathepsin S   330 aa 267 aa 24.3 %
Plasmodium vivax dipeptidyl aminopeptidase 1, putative Cathepsin B   339 aa 304 aa 27.0 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 317 aa 33.8 %
Dictyostelium discoideum cysteine proteinase 5 precursor Cathepsin B   339 aa 303 aa 22.4 %
Plasmodium falciparum dipeptidyl aminopeptidase 2 Cathepsin L   334 aa 294 aa 23.8 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.2 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 303 aa 26.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 309 aa 30.4 %
Plasmodium vivax serine-repeat antigen (SERA), putative Cathepsin S   330 aa 293 aa 22.2 %
Onchocerca volvulus Cathepsin L homolog Cathepsin L   334 aa 322 aa 41.6 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 336 aa 25.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 270 aa 25.6 %
Plasmodium berghei dipeptidyl aminopeptidase 1, putative Cathepsin B   339 aa 319 aa 26.6 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Cathepsin L   334 aa 345 aa 35.4 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 25.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin S   330 aa 319 aa 23.5 %
Echinococcus granulosus cysteine protease Cathepsin L   334 aa 323 aa 44.3 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 333 aa 28.8 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 270 aa 25.6 %
Dictyostelium discoideum cathepsin L-like proteinase Cathepsin L   334 aa 312 aa 42.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cysteine protease 0.0055 0.0653 0.2331
Onchocerca volvulus 0.0012 0.0045 0.0139
Onchocerca volvulus 0.0018 0.0123 0.0402
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0055 0.0653 0.0649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0045 0.0045
Plasmodium vivax unspecified product 0.0055 0.0653 0.1873
Echinococcus multilocularis cathepsin b 0.0537 0.7559 0.7559
Brugia malayi Cathepsin L-like precursor 0.0218 0.2983 0.3943
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0123 0.0123
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0045 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Plasmodium vivax serine-repeat antigen (SERA) 0.0055 0.0653 0.1873
Loa Loa (eye worm) cell death specification protein 2 0.0009 0.0004 0.0005
Brugia malayi isocitrate dehydrogenase 0.0033 0.0342 0.0448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2983 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0123 0.012
Onchocerca volvulus 0.0012 0.0045 0.0139
Giardia lamblia Encystation-specific protease 0.0055 0.0653 0.2331
Schistosoma mansoni cpg binding protein 0.0031 0.0315 0.0312
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Giardia lamblia Cysteine protease 0.0055 0.0653 0.2331
Echinococcus granulosus X box binding protein 1 0.0296 0.4099 0.4099
Brugia malayi hypothetical protein 0.0012 0.0045 0.0055
Giardia lamblia Cathepsin B precursor 0.0055 0.0653 0.2331
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0069 0.0069
Loa Loa (eye worm) glutaminase 2 0.0291 0.4029 0.533
Brugia malayi GnHR receptor homolog 0.0012 0.0045 0.0055
Brugia malayi Cathepsin L-like precursor 0.0218 0.2983 0.3943
Giardia lamblia Cathepsin B precursor 0.0055 0.0653 0.2331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.1962 0.4384
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0071 0.089 0.1173
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0045 0.0045
Onchocerca volvulus 0.0012 0.0045 0.0139
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0045 0.0045
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Brugia malayi cathepsin Z-like cysteine proteinase 0.0055 0.0653 0.0859
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0653 0.0826
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2983 0.7157
Loa Loa (eye worm) hypothetical protein 0.0055 0.0653 0.0864
Giardia lamblia Cathepsin L precursor 0.0055 0.0653 0.2331
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0055 0.0653 0.0826
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0653 0.0864
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0045 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2983 0.7157
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0004 0.0004
Schistosoma mansoni biogenic amine receptor 0.0012 0.0045 0.0042
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0004 0.0000073174
Giardia lamblia Cathepsin L precursor 0.0055 0.0653 0.2331
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0045 0.0055
Onchocerca volvulus 0.0012 0.0045 0.0139
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0387 0.0383
Brugia malayi hypothetical protein 0.0012 0.0045 0.0055
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0123 0.0158
Brugia malayi hypothetical protein 0.0012 0.0045 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.0055 0.0653 0.2179
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.2983 0.3659
Trypanosoma cruzi cysteine proteinase, putative 0.0126 0.1673 0.1845
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0045 0.0042
Toxoplasma gondii cathepsin CPC1 0.0055 0.0653 0.1873
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0.0045 0.0139
Onchocerca volvulus 0.0218 0.2983 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.089 0.1177
Echinococcus granulosus sex peptide receptor 0.0012 0.0045 0.0045
Brugia malayi Protein kinase domain containing protein 0.0014 0.0069 0.0087
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0009 0.0004 0.0004
Brugia malayi nuclear receptor NHR-88 0.0018 0.0123 0.0158
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0123 0.0163
Echinococcus granulosus neuropeptide receptor 0.0012 0.0045 0.0045
Leishmania major pyruvate kinase 0.0033 0.0349 0.0027
Brugia malayi hypothetical protein 0.0012 0.0045 0.0055
Entamoeba histolytica cysteine protease, putative 0.0126 0.1673 0.5604
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0342 0.0338
Echinococcus granulosus neuropeptide receptor 0.0012 0.0045 0.0045
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0055 0.0653 0.1873
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0045 0.0045
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0045 0.0042
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0045 0.0045
Brugia malayi hypothetical protein 0.0012 0.0045 0.0055
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0004 0.0004
Brugia malayi Serotonin receptor 0.0012 0.0045 0.0055
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0045 0.0045
Brugia malayi Death domain containing protein 0.0014 0.0069 0.0087
Entamoeba histolytica cysteine protease, putative 0.0055 0.0653 0.2179
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0218 0.2983 1
Plasmodium falciparum serine repeat antigen 1 0.0055 0.0653 0.1873
Onchocerca volvulus 0.0012 0.0045 0.0139
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.089 0.0759
Brugia malayi cathepsin F-like cysteine proteinase 0.0071 0.089 0.1173
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0123 0.0158
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0009 0.0004 0.0004
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0045 0.006
Onchocerca volvulus Huntingtin homolog 0.013 0.1734 0.5807
Plasmodium falciparum serine repeat antigen 7 0.0055 0.0653 0.1873
Brugia malayi Cathepsin L-like precursor 0.0218 0.2983 0.3943
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0342 0.0789
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0123 0.012
Echinococcus granulosus neuropeptide s receptor 0.0484 0.6799 0.6799
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0045 0.0042
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0045 0.0042
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0055 0.0653 0.1873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2983 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0094
Echinococcus granulosus cathepsin l1 0.0146 0.1962 0.1962
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0045 0.0045
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0126 0.1673 0.167
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0163
Giardia lamblia Cathepsin L precursor 0.0055 0.0653 0.2331
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0069 0.0069
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0055 0.0653 0.1873
Onchocerca volvulus 0.0012 0.0045 0.0139
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0342 0.0342
Onchocerca volvulus 0.0218 0.2983 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0045 0.006
Schistosoma mansoni cathepsin S (C01 family) 0.0055 0.0653 0.0649
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0342 0.0789
Brugia malayi steroid hormone receptor 0.0018 0.0123 0.0158
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0123 0.0123
Brugia malayi follicle stimulating hormone receptor 0.0012 0.0045 0.0055
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0045 0.0045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0123 0.0123
Echinococcus multilocularis cysteine protease 0.0218 0.2983 0.2983
Entamoeba histolytica cysteine protease, putative 0.0126 0.1673 0.5604
Echinococcus granulosus allatostatin A receptor 0.0012 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.0055 0.0653 0.2179
Brugia malayi hypothetical protein 0.0012 0.0045 0.0055
Onchocerca volvulus 0.0218 0.2983 1
Giardia lamblia Cathepsin L-like protease 0.0055 0.0653 0.2331
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0349 0.0814
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.1037 0.1037
Echinococcus multilocularis pyruvate kinase 0.0033 0.0349 0.0349
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0055 0.0653 0.0649
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0055 0.0653 0.0649
Onchocerca volvulus 0.0012 0.0045 0.0139
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0045 0.006
Brugia malayi hypothetical protein 0.013 0.1734 0.229
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2983 0.7157
Plasmodium vivax serine-repeat antigen (SERA) 0.0055 0.0653 0.1873
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0045 0.0042
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0349 0.0457
Echinococcus multilocularis cathepsin L 0.0055 0.0653 0.0653
Onchocerca volvulus 0.0012 0.0045 0.0139
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0009 0.0004 0.0004
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.013 0.1734 0.2293
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0342 0.0342
Brugia malayi neuropeptide F receptor 0.0012 0.0045 0.0055
Plasmodium falciparum serine repeat antigen 8 0.0055 0.0653 0.1873
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0045 0.0045
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0123 0.0158
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0045 0.0045
Echinococcus multilocularis pyruvate kinase 0.0026 0.0248 0.0248
Schistosoma mansoni cpg binding protein 0.0031 0.0315 0.0312
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0163
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0055 0.0653 0.1873
Echinococcus granulosus cathepsin L cysteine proteinase 0.0218 0.2983 0.2983
Giardia lamblia Hypothetical protein 0.0055 0.0653 0.2331
Entamoeba histolytica cysteine proteinase 1, putative 0.0126 0.1673 0.5604
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0342 0.0342
Echinococcus multilocularis pyruvate kinase 0.0017 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0342 0.0789
Brugia malayi G-protein coupled receptor 0.0012 0.0045 0.0055
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0341 0.0341
Plasmodium falciparum cysteine proteinase falcipain 3 0.0218 0.2983 1
Brugia malayi hypothetical protein 0.0012 0.0045 0.0055
Plasmodium falciparum serine repeat antigen 4 0.0055 0.0653 0.1873
Brugia malayi Cathepsin L-like precursor 0.0218 0.2983 0.3943
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0218 0.2983 0.2983
Schistosoma mansoni hypothetical protein 0.042 0.5874 0.5873
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0045 0.0055
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0045 0.0045
Leishmania major cathepsin L-like protease 0.0218 0.2983 1
Plasmodium vivax vivapain-1 0.0126 0.1673 0.5433
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0123 0.0123
Brugia malayi Dopamine receptor protein 1 0.0012 0.0045 0.0055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0123 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Onchocerca volvulus Huntingtin homolog 0.013 0.1734 0.5807
Loa Loa (eye worm) hypothetical protein 0.013 0.1734 0.2293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2983 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.1673 0.3598
Brugia malayi Cathepsin L-like precursor 0.0218 0.2983 0.3943
Echinococcus granulosus pyruvate kinase 0.0017 0.0116 0.0116
Echinococcus multilocularis neuropeptide receptor A26 0.0484 0.6799 0.6799
Schistosoma mansoni hypothetical protein 0.0071 0.0888 0.0885
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0045 0.0045
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0045 0.006
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.0004 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0653 0.0826
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0045 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2983 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0123 0.0158
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0045 0.0055
Echinococcus multilocularis microtubule associated protein 2 0.0708 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0066 0.0818 0.0815
Giardia lamblia Cathepsin B precursor 0.0204 0.2789 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0045 0.0045
Schistosoma mansoni amine GPCR 0.0012 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0653 0.0826
Onchocerca volvulus 0.0012 0.0045 0.0139
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0055 0.0653 0.0859
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0123 0.0123
Schistosoma mansoni cathepsin F (C01 family) 0.0218 0.2983 0.298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0069 0.0087
Schistosoma mansoni amine GPCR 0.0012 0.0045 0.0042
Echinococcus granulosus hypothetical protein 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0055 0.0653 0.0864
Loa Loa (eye worm) hypothetical protein 0.0218 0.2983 0.3946
Giardia lamblia Cathepsin B precursor 0.0055 0.0653 0.2331
Schistosoma mansoni opsin-like receptor 0.0012 0.0045 0.0042
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0123 0.012
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0291 0.0385
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0045 0.0045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0218 0.2983 0.3946
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0123 0.0158
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Loa Loa (eye worm) hypothetical protein 0.0146 0.1962 0.2596
Plasmodium vivax vivapain-2 0.0218 0.2983 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0349 0.0462
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0204 0.027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0341 0.0447
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0055 0.0653 0.2331
Onchocerca volvulus 0.0064 0.0786 0.2627
Entamoeba histolytica cysteine protease, putative 0.0126 0.1673 0.5604
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0123 0.0158
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0123 0.0123
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0055 0.0653 0.0649
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0.0045 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2983 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0653 0.0864
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Echinococcus granulosus cathepsin L cysteine protease 0.0126 0.1673 0.1673
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Onchocerca volvulus 0.0055 0.0653 0.2179
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0123 0.012
Brugia malayi Papain family cysteine protease containing protein 0.0126 0.1673 0.221
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0653 0.2179
Brugia malayi hypothetical protein 0.0012 0.0045 0.0055
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.136 0.1795
Entamoeba histolytica cysteine proteinase, putative 0.0146 0.1962 0.6575
Brugia malayi ecdysteroid receptor 0.0018 0.0123 0.0158
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0045 0.0045
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0349 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0204 0.2789 0.2786
Loa Loa (eye worm) hypothetical protein 0.0023 0.0204 0.027
Echinococcus granulosus cathepsin L 0.0126 0.1673 0.1673
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0045 0.0045
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0204 0.2789 0.663
Loa Loa (eye worm) hypothetical protein 0.0071 0.089 0.1177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2983 0.7157
Echinococcus granulosus pyruvate kinase 0.0017 0.0116 0.0116
Brugia malayi hypothetical protein 0.0009 0.0004 0.0000073174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0123 0.0163
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.1673 0.5604
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0537 0.7559 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0045 0.0045
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0342 0.0342
Plasmodium falciparum serine repeat antigen 5 0.0055 0.0653 0.1873
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0126 0.1673 0.167
Echinococcus granulosus pyruvate kinase 0.0033 0.0349 0.0349
Onchocerca volvulus 0.0218 0.2983 1
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0349 0.1159
Toxoplasma gondii preprocathepsin c precursor, putative 0.0055 0.0653 0.1873
Schistosoma mansoni cathepsin B (C01 family) 0.0055 0.0653 0.0649
Schistosoma mansoni pyruvate kinase 0.0017 0.0116 0.0112
Echinococcus granulosus cathepsin l1 0.0218 0.2983 0.2983
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2983 0.7157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0653 0.0826
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Echinococcus granulosus Ankyrin 0.0014 0.0071 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2983 1
Leishmania major pyruvate kinase 0.0033 0.0349 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0045 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0045 0.0045
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0653 0.0649
Brugia malayi CXXC zinc finger family protein 0.0029 0.0291 0.0381
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0045 0.0045
Plasmodium falciparum serine repeat antigen 2 0.0055 0.0653 0.1873
Brugia malayi nuclear receptor RXR 0.0009 0.0004 0.0000073174
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0045 0.0042
Echinococcus multilocularis protocadherin 11 0.0009 0.0004 0.0004
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0126 0.1673 0.1845
Echinococcus granulosus death domain containing protein 0.0014 0.0069 0.0069
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.1037 0.1037
Loa Loa (eye worm) hypothetical protein 0.0071 0.0888 0.1175
Echinococcus multilocularis neuropeptide s receptor 0.0484 0.6799 0.6799
Brugia malayi cathepsin L-like precursor 0.0146 0.1962 0.2592
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0055 0.0653 0.2331
Mycobacterium ulcerans glutaminase 0.0291 0.4029 1
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0349 0.0814
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0893 0.0893
Echinococcus multilocularis cysteine protease 0.0218 0.2983 0.2983
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0653 0.0649
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2983 0.7157
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0045 0.0042
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0045 0.0042
Echinococcus multilocularis jun protein 0.0082 0.1037 0.1037
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0045 0.0045
Toxoplasma gondii cathepsin B 0.0204 0.2789 0.9324
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0123 0.0123
Leishmania major cathepsin L-like protease 0.0218 0.2983 1
Entamoeba histolytica cysteine protease, putative 0.0126 0.1673 0.5604
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0055 0.0653 0.2331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0123 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0653 0.0826
Echinococcus multilocularis dnaJ subfamily B 0.042 0.5874 0.5874
Loa Loa (eye worm) bZIP transcription factor family protein 0.0009 0.0004 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0045 0.006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.136 0.1795
Brugia malayi neuropeptide F receptor 0.0012 0.0045 0.0055
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0045 0.0045
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Brugia malayi cathepsin F-like cysteine proteinase 0.0055 0.0653 0.0859
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0045 0.0045
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0069 0.0092
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0341 0.0447
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0045 0.0045
Onchocerca volvulus 0.0012 0.0045 0.0139
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0126 0.1673 0.167
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.0009 0.0004 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0004 0.0000055306
Brugia malayi Cathepsin L-like precursor 0.0218 0.2983 0.3943
Leishmania major cathepsin L-like protease 0.0218 0.2983 1
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0123 0.0163
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0123 0.0158
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0055 0.0653 0.2331
Echinococcus multilocularis serotonin receptor 0.0012 0.0045 0.0045
Brugia malayi Cathepsin L-like precursor 0.0146 0.1962 0.2592
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0218 0.2983 0.2983
Entamoeba histolytica cysteine protease, putative 0.0126 0.1673 0.5604
Entamoeba histolytica cysteine protease, putative 0.0055 0.0653 0.2179
Giardia lamblia Cathepsin L precursor 0.0055 0.0653 0.2331
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0055 0.0653 0.0864
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0055 0.0653 0.0826
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0045 0.0045
Trypanosoma cruzi cysteine protease, putative 0.0126 0.1673 0.1845
Echinococcus granulosus GPCR family 2 0.0033 0.0341 0.0341
Entamoeba histolytica hypothetical protein 0.0036 0.0387 0.1286
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0092
Echinococcus granulosus somatostatin receptor 0.0012 0.0045 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.2983 0.3659
Schistosoma mansoni neuropeptide receptor 0.0012 0.0045 0.0042
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0045 0.0055
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0653 0.0649
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0055 0.0653 0.1873
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0123 0.012
Schistosoma mansoni hypothetical protein 0.0033 0.0341 0.0338
Trypanosoma cruzi cruzipain precursor, putative 0.0218 0.2983 0.3659
Echinococcus granulosus cpg binding protein 0.0031 0.0315 0.0315
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0.0045 0.0139
Giardia lamblia Cathepsin L precursor 0.0055 0.0653 0.2331
Giardia lamblia Cathepsin L-like protease 0.0055 0.0653 0.2331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0653 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0055 0.0653 0.1873
Echinococcus granulosus ccaat enhancer binding protein delta 0.0009 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0653 0.0826
Echinococcus granulosus cathepsin b 0.0537 0.7559 0.7559
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0204 0.0673
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0045 0.0042
Schistosoma mansoni jun-related protein 0.0066 0.0818 0.0815
Brugia malayi cathepsin Z-like cysteine proteinase 0.0055 0.0653 0.0859
Brugia malayi Dopamine receptor 0.0012 0.0045 0.0055
Entamoeba histolytica cysteine protease, putative 0.0055 0.0653 0.2179
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.0009 0.0004 0.0004
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0218 0.2983 0.3946
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0653 0.0649
Schistosoma mansoni hypothetical protein 0.0296 0.4099 0.4097
Loa Loa (eye worm) fibroinase 0.0218 0.2983 0.3946
Brugia malayi Dopamine receptor protein 2 0.0012 0.0045 0.0055
Echinococcus granulosus protocadherin 11 0.0009 0.0004 0.0004
Echinococcus granulosus g protein coupled receptor 0.0012 0.0045 0.0045
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.0126 0.1673 0.5604
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0123 0.0158
Loa Loa (eye worm) glutaminase 0.0291 0.4029 0.533
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0045 0.0045
Echinococcus granulosus protocadherin 11 0.0009 0.0004 0.0004
Schistosoma mansoni amine GPCR 0.0012 0.0045 0.0042
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0123 0.0158
Echinococcus multilocularis cathepsin L cysteine protease 0.0218 0.2983 0.2983
Giardia lamblia Hypothetical protein 0.0055 0.0653 0.2331
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0349 0.1159
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0123 0.0123
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0005
Echinococcus multilocularis X box binding protein 1 0.0296 0.4099 0.4099
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0123 0.0158
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0012 0.0045 0.0042
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0537 0.7559 0.7558
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0069 0.0221
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.136 0.1799
Schistosoma mansoni hypothetical protein 0.0036 0.0387 0.0383
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0653 0.0826
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Echinococcus granulosus pyruvate kinase 0.0017 0.0116 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Plasmodium falciparum serine repeat antigen 6 0.0055 0.0653 0.1873
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0349 0.5
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0055 0.0653 0.1873
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0123 0.0163
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0071 0.089 0.1177
Echinococcus multilocularis cathepsin b 0.0537 0.7559 0.7559
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0349 0.0462
Plasmodium falciparum cysteine proteinase falcipain 1 0.0126 0.1673 0.5433
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0071 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0653 0.0826
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0045 0.0042
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0341 0.0451
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0349 0.0462
Plasmodium falciparum serine repeat antigen 9 0.0055 0.0653 0.1873
Toxoplasma gondii cathepsin CPL 0.0218 0.2983 1
Echinococcus multilocularis sex peptide receptor 0.0012 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2983 0.7157
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0069 0.0066
Entamoeba histolytica hypothetical protein 0.0036 0.0387 0.1286
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0537 0.7559 0.7558
Schistosoma mansoni hypothetical protein 0.0012 0.0045 0.0042
Schistosoma mansoni amine GPCR 0.0012 0.0045 0.0042
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0342 0.0452
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0653 0.0826
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0055 0.0653 0.1873
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0123 0.0402
Schistosoma mansoni adenoreceptor 0.0012 0.0045 0.0042
Schistosoma mansoni amine GPCR 0.0012 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0163
Toxoplasma gondii cathepsin CPC2 0.0055 0.0653 0.1873
Giardia lamblia Cathepsin B precursor 0.0055 0.0653 0.2331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0045 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2983 1
Schistosoma mansoni microtubule-associated protein tau 0.0708 1 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0342 0.0789
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0055 0.0653 0.1873
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0653 0.0826
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Brugia malayi Serotonin receptor 0.0012 0.0045 0.0055
Onchocerca volvulus 0.0012 0.0045 0.0139
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.089 0.0759
Schistosoma mansoni biogenic amine receptor 0.0012 0.0045 0.0042
Entamoeba histolytica cysteine protease, putative 0.0126 0.1673 0.5604
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0204 0.2789 0.9266
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0764 0.0761
Entamoeba histolytica hypothetical protein 0.0036 0.0387 0.1286
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0342 0.0448
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0341 0.0341
Onchocerca volvulus 0.0012 0.0045 0.0139
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Onchocerca volvulus 0.0012 0.0045 0.0139
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0015 0.0015
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0055 0.0653 0.2179
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Brugia malayi putative neuropeptide receptor 0.0012 0.0045 0.0055
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0893 0.0893
Brugia malayi nuclear hormone receptor 0.0018 0.0123 0.0158
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0653 0.0864
Loa Loa (eye worm) hypothetical protein 0.0146 0.1962 0.2596
Entamoeba histolytica cysteine protease, putative 0.0126 0.1673 0.5604
Schistosoma mansoni hypothetical protein 0.0012 0.0045 0.0042
Brugia malayi Papain family cysteine protease containing protein 0.0126 0.1673 0.221
Loa Loa (eye worm) hypothetical protein 0.0071 0.089 0.1177
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0055 0.0653 0.2179
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.1673 0.5604
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0009 0.0004 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Entamoeba histolytica cysteine proteinase, putative 0.0218 0.2983 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0653 0.0864
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Onchocerca volvulus 0.0218 0.2983 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0055 0.0653 0.0826
Schistosoma mansoni myosin xvIII 0.0012 0.0045 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0045 0.0042
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0341 0.0341
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0045 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0653 0.0826
Giardia lamblia Cathepsin B precursor 0.0204 0.2789 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0163
Brugia malayi RE15519p 0.0012 0.0045 0.0055
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0653 0.0859
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0123 0.0123
Leishmania major cathepsin L-like protease 0.0218 0.2983 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0146 0.1962 0.2245
Trypanosoma cruzi cysteine proteinase, putative 0.0126 0.1673 0.1845
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0005
Echinococcus multilocularis cpg binding protein 0.0031 0.0315 0.0315
Schistosoma mansoni hypothetical protein 0.0033 0.0341 0.0338
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0045 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0123 0.0163
Leishmania major cathepsin L-like protease 0.0218 0.2983 1
Trichomonas vaginalis glutaminase, putative 0.0291 0.4029 1
Onchocerca volvulus 0.0012 0.0045 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0123 0.0158
Schistosoma mansoni netrin receptor unc5 0.0014 0.0069 0.0066
Entamoeba histolytica cysteine protease, putative 0.0218 0.2983 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0123 0.0123
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0888 0.1171
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0349 0.1159
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0537 0.7559 0.7558
Schistosoma mansoni hypothetical protein 0.0014 0.0069 0.0066
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.2983 0.3659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1673 0.5041
Schistosoma mansoni cathepsin s 0.0071 0.089 0.0887
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0123 0.0123
Schistosoma mansoni histamine h1 receptor 0.0012 0.0045 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0123 0.0158
Echinococcus granulosus cathepsin l cysteine peptidase 0.0218 0.2983 0.2983
Entamoeba histolytica hypothetical protein 0.0036 0.0387 0.1286
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.0004 0.0000055306
Schistosoma mansoni cpg binding protein 0.0029 0.0291 0.0288
Brugia malayi ORL1-like opioid receptor 0.0012 0.0045 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2983 1
Echinococcus granulosus cathepsin L 0.0055 0.0653 0.0653
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0055 0.0653 0.1873
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0045 0.006
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0123 0.012
Loa Loa (eye worm) hypothetical protein 0.0146 0.1962 0.2596
Echinococcus granulosus g protein coupled receptor 0.0012 0.0045 0.0045
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0668 0.1928
Schistosoma mansoni opsin-like receptor 0.0012 0.0045 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Schistosoma mansoni neuropeptide receptor 0.0012 0.0045 0.0042
Echinococcus multilocularis Ankyrin 0.0014 0.0071 0.0071
Brugia malayi G-protein coupled receptor 0.0012 0.0045 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0653 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0218 0.2983 0.7157
Brugia malayi cathepsin L precursor 0.0055 0.0653 0.0859
Echinococcus granulosus jun protein 0.0082 0.1037 0.1037
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0537 0.7559 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.1962 0.4384
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Schistosoma mansoni hypothetical protein 0.0012 0.0045 0.0042
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0045 0.006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0163
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Onchocerca volvulus 0.0012 0.0045 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0123 0.0163
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0045 0.0045
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0045 0.0045
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0537 0.7559 0.7558
Plasmodium vivax unspecified product 0.0071 0.089 0.2701
Onchocerca volvulus Cathepsin L homolog 0.0218 0.2983 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0123 0.0123
Brugia malayi Cathepsin L-like precursor 0.0146 0.1962 0.2592
Onchocerca volvulus 0.0012 0.0045 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Schistosoma mansoni hypothetical protein 0.0033 0.0341 0.0338
Echinococcus multilocularis cathepsin L 0.0126 0.1673 0.1673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Schistosoma mansoni neuropeptide receptor 0.0012 0.0045 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0045 0.0042
Plasmodium vivax vivapain-3 0.0126 0.1673 0.5433
Echinococcus multilocularis serotonin receptor 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0033 0.0341 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0045 0.0055
Echinococcus granulosus fmrfamide receptor 0.0012 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.0126 0.1673 0.5604
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0653 0.0431
Schistosoma mansoni pyruvate kinase 0.0033 0.0349 0.0346
Brugia malayi Cathepsin L-like cysteine proteinase 0.0146 0.1962 0.2592
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0123 0.012
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0069 0.0069
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0387 0.0387
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0045 0.0042
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.1673 0.1845
Entamoeba histolytica cysteine proteinase, putative 0.0218 0.2983 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0055 0.0653 0.0826
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Schistosoma mansoni neuropeptide receptor 0.0012 0.0045 0.0042
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0045 0.0045
Chlamydia trachomatis pyruvate kinase 0.0033 0.0349 0.5
Schistosoma mansoni pyruvate kinase 0.0033 0.0349 0.0346
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0123 0.0123
Onchocerca volvulus 0.0146 0.1962 0.6575
Echinococcus granulosus dnaJ subfamily B 0.042 0.5874 0.5874
Echinococcus granulosus neuropeptide receptor A26 0.0484 0.6799 0.6799
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0104 0.136 0.1799
Leishmania major cysteine peptidase A (CPA) 0.0218 0.2983 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0653 0.0864
Loa Loa (eye worm) cysteine protease 0.0218 0.2983 0.3946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2983 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0055 0.0653 0.1873
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0653 0.0859
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0055 0.0653 0.0864
Brugia malayi cathepsin L-like cysteine proteinase 0.0055 0.0653 0.0859
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0349 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0123 0.0158
Entamoeba histolytica cysteine protease, putative 0.0126 0.1673 0.5604
Brugia malayi Papain family cysteine protease containing protein 0.0218 0.2983 0.3943
Schistosoma mansoni biogenic amine receptor 0.0012 0.0045 0.0042
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0045 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.2983 0.3659
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0123 0.0123
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0123 0.0158
Brugia malayi AKH receptor 0.0012 0.0045 0.0055
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0045 0.0042
Brugia malayi glutaminase DH11.1 0.0291 0.4029 0.5328
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Brugia malayi hypothetical protein 0.0012 0.0045 0.0055
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0045 0.0055
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0055 0.0653 0.1873
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0349 0.001
Giardia lamblia Pyruvate kinase 0.0017 0.0116 0.0402
Plasmodium falciparum serine repeat antigen 3 0.0055 0.0653 0.1873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0653 0.0826
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1673 0.5041
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0218 0.2983 0.7157
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0204 0.2789 0.339
Plasmodium vivax vivapain-2 0.0218 0.2983 1
Brugia malayi hypothetical protein 0.0012 0.0045 0.0055
Brugia malayi bZIP transcription factor family protein 0.0082 0.1037 0.1368
Brugia malayi larval opioid receptor 0.0012 0.0045 0.0055
Entamoeba histolytica cysteine protease, putative 0.0126 0.1673 0.5604
Loa Loa (eye worm) hypothetical protein 0.0033 0.0349 0.0462
Brugia malayi sulfakinin receptor protein 0.0012 0.0045 0.0055
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Schistosoma mansoni coup transcription factor 0.0018 0.0123 0.012
Loa Loa (eye worm) hypothetical protein 0.0079 0.1005 0.1329
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0123 0.012
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0349 0.0457
Plasmodium vivax unspecified product 0.0126 0.1673 0.5433
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0123 0.012
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0005
Trypanosoma brucei cysteine peptidase C (CPC) 0.0204 0.2789 0.9266
Onchocerca volvulus 0.0012 0.0045 0.0139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2983 0.7157
Echinococcus multilocularis pyruvate kinase 0.0033 0.0349 0.0349
Brugia malayi cathepsin B-like cysteine proteinase 0.0537 0.7559 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0123 0.0123
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0123 0.012
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0045 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2983 1
Schistosoma mansoni cathepsin C 0.0055 0.0653 0.0649
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0163
Brugia malayi Uncoordinated protein 44 0.0014 0.0069 0.0087
Giardia lamblia Pyruvate kinase 0.0033 0.0349 0.124
Brugia malayi Cathepsin L-like precursor 0.0071 0.089 0.1173
Schistosoma mansoni cathepsin F (C01 family) 0.0146 0.1962 0.1959
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0387 0.0387
Onchocerca volvulus 0.0218 0.2983 1
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0045 0.006
Entamoeba histolytica cysteine protease, putative 0.0126 0.1673 0.5604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0045 0.0045
Entamoeba histolytica cysteine proteinase 2 0.0126 0.1673 0.5604
Echinococcus granulosus g protein coupled receptor 0.0012 0.0045 0.0045
Onchocerca volvulus Cathepsin L homolog 0.0218 0.2983 1
Leishmania major cathepsin L-like protease 0.0218 0.2983 1
Onchocerca volvulus 0.0218 0.2983 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0123 0.0158
Entamoeba histolytica cysteine protease, putative 0.0055 0.0653 0.2179
Giardia lamblia Cysteine protease 0.0055 0.0653 0.2331
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0653 0.0649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0045 0.0055
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0045 0.0042
Echinococcus multilocularis cathepsin L cysteine protease 0.0218 0.2983 0.2983
Brugia malayi fibroinase precursor 0.0055 0.0653 0.0859
Echinococcus granulosus serotonin receptor 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0005
Brugia malayi Melatonin receptor type 1A 0.0012 0.0045 0.0055
Leishmania major cathepsin L-like protease 0.0218 0.2983 1
Schistosoma mansoni glutaminase 0.0291 0.4029 0.4027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.1673 0.3598
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2983 0.7157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0653 0.0826
Loa Loa (eye worm) ctsf protein 0.0218 0.2983 0.3946
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0004 0.0000073174
Schistosoma mansoni cathepsin F (C01 family) 0.0218 0.2983 0.298
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0653 0.0431
Echinococcus multilocularis somatostatin receptor 0.0012 0.0045 0.0045
Echinococcus multilocularis pyruvate kinase 0.0017 0.0116 0.0116
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0009 0.0004 0.0004
Onchocerca volvulus Cathepsin F homolog 0.0218 0.2983 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0341 0.0341
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0045 0.0045
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0045 0.0045
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2983 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Leishmania major cathepsin L-like protease 0.0218 0.2983 1
Giardia lamblia Cathepsin L precursor 0.0055 0.0653 0.2331
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0045 0.0045
Giardia lamblia Cysteine protease 0.0055 0.0653 0.2331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2983 0.7157
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0069 0.0069
Echinococcus multilocularis pyruvate kinase 0.0017 0.0116 0.0116
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0123 0.012
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0045 0.0045
Giardia lamblia Cathepsin B precursor 0.0055 0.0653 0.2331
Brugia malayi G protein-coupled receptor 0.0012 0.0045 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0045 0.0042
Entamoeba histolytica hypothetical protein 0.0055 0.0653 0.2179
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0349 0.0027
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0123 0.0402
Echinococcus granulosus cathepsin b 0.0537 0.7559 0.7559
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0163
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.1673 0.5604
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0123 0.0163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0033 0.0341 0.0338
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0045 0.0055
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0045 0.0045
Plasmodium falciparum pyruvate kinase 0.0033 0.0349 0.0814
Brugia malayi hypothetical protein 0.0064 0.0786 0.1036
Giardia lamblia Cathepsin B precursor 0.0204 0.2789 1
Brugia malayi hypothetical protein 0.0036 0.0387 0.0507
Loa Loa (eye worm) cathepsin B 0.0204 0.2789 0.3689
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0349 0.0027
Onchocerca volvulus 0.0029 0.0291 0.0965
Schistosoma mansoni opsin-like receptor 0.0012 0.0045 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0045 0.0045
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0123 0.0123
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0045 0.0045
Echinococcus multilocularis protocadherin 11 0.0009 0.0004 0.0004
Entamoeba histolytica cysteine protease, putative 0.0126 0.1673 0.5604
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0653 0.0859
Brugia malayi hypothetical protein 0.0009 0.0004 0.0000073174
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0045 0.0045
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.1673 0.5604
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0055 0.0653 0.1873
Echinococcus granulosus cysteine protease 0.0126 0.1673 0.1673
Echinococcus granulosus orexin receptor type 2 0.0012 0.0045 0.0045
Echinococcus multilocularis GPCR, family 2 0.0033 0.0341 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0123 0.0158
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0045 0.006
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.0009 0.0004 0.0004
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0123 0.0402
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0218 0.2983 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.2 nM Inhibition of human cathepsin S ChEMBL. 17590332
IC50 (binding) < 0.2 nM Inhibition of mouse recombinant cathepsin S ChEMBL. 17590332
IC50 (binding) = 0.2 nM Inhibition of human cathepsin S ChEMBL. 17590332
IC50 (binding) < 0.2 nM Inhibition of mouse recombinant cathepsin S ChEMBL. 17590332
IC50 (binding) = 23 nM Inhibition of human cathepsin L ChEMBL. 17590332
IC50 (binding) = 23 nM Inhibition of human cathepsin L ChEMBL. 17590332
IC50 (binding) = 44 nM Inhibition of rat spleen cathepsin S ChEMBL. 17590332
IC50 (binding) = 44 nM Inhibition of rat spleen cathepsin S ChEMBL. 17590332
IC50 (binding) = 90 nM Inhibition of mouse recombinant cathepsin L ChEMBL. 17590332
IC50 (binding) = 90 nM Inhibition of mouse recombinant cathepsin L ChEMBL. 17590332
IC50 (binding) = 132 nM Inhibition of rat liver lysosomal cathepsin L ChEMBL. 17590332
IC50 (binding) = 132 nM Inhibition of rat liver lysosomal cathepsin L ChEMBL. 17590332
IC50 (binding) = 269 nM Inhibition of human cathepsin K ChEMBL. 17590332
IC50 (binding) = 269 nM Inhibition of human cathepsin K ChEMBL. 17590332
IC50 (binding) = 2553 nM Inhibition of mouse recombinant cathepsin K ChEMBL. 17590332
IC50 (binding) = 2553 nM Inhibition of mouse recombinant cathepsin K ChEMBL. 17590332
IC50 (binding) = 4013 nM Inhibition of mouse recombinant cathepsin B ChEMBL. 17590332
IC50 (binding) = 4013 nM Inhibition of mouse recombinant cathepsin B ChEMBL. 17590332
IC50 (binding) = 4702 nM Inhibition of rat liver lysosomal cathepsin B ChEMBL. 17590332
IC50 (binding) = 4702 nM Inhibition of rat liver lysosomal cathepsin B ChEMBL. 17590332
IC50 (binding) = 6629 nM Inhibition of human cathepsin B ChEMBL. 17590332
IC50 (binding) = 6629 nM Inhibition of human cathepsin B ChEMBL. 17590332

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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