TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 315.264 | Formula: C13H11N6O4-
H donors: 1 H acceptors: 4 LogP: 4.33 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: [NH-]=[N+]=NC1CC(c2c1cc(cc2)C(=CC(=O)C(=O)[O-])O)N=[N+]=[NH-]
InChi: 1S/C13H10N6O4/c14-18-16-9-4-10(17-19-15)8-3-6(1-2-7(8)9)11(20)5-12(21)13(22)23/h1-3,5,9-10,20H,4H2,(H,22,23)/p-1/b11-5+
InChiKey: ASYURJXIVOBIPS-VZUCSPMQSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0334	0.9525	1
Giardia lamblia	Cathepsin B precursor	0.0069	0.1564	0.3647
Echinococcus multilocularis	cathepsin b	0.0349	1	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1564	0.1564
Entamoeba histolytica	cysteine protease, putative	0.0176	0.4791	0.4996
Plasmodium falciparum	serine repeat antigen 1	0.0069	0.1564	0.1584
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Giardia lamblia	Cathepsin L precursor	0.0069	0.1564	0.3647
Schistosoma mansoni	cathepsin C	0.0069	0.1564	0.1564
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.6297	0.6588
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0334	0.9525	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0176	0.4791	0.4757
Giardia lamblia	Cathepsin B precursor	0.0156	0.4173	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Brugia malayi	Papain family cysteine protease containing protein	0.0069	0.1564	0.1564
Trypanosoma cruzi	Protein kinase B	0.0022	0.0163	0.0097
Brugia malayi	Cathepsin L-like precursor	0.0334	0.9525	0.9525
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0069	0.1564	0.1584
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0334	0.9525	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0066	0.5
Loa Loa (eye worm)	cathepsin B	0.0156	0.4173	0.4173
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.9525	1
Echinococcus multilocularis	nervana 2	0.002	0.0097	0.0097
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0069	0.1564	0.1564
Plasmodium vivax	serine-repeat antigen (SERA)	0.0069	0.1564	0.1584
Schistosoma mansoni	hypothetical protein	0.0036	0.0578	0.0578
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0578	0.0578
Plasmodium vivax	vivapain-1	0.0176	0.4791	0.4996
Loa Loa (eye worm)	hypothetical protein	0.0226	0.6297	0.6297
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0334	0.9525	1
Entamoeba histolytica	cysteine proteinase, putative	0.0176	0.4791	0.4996
Echinococcus granulosus	SAM and MBT domain containing protein	0.005	0.1008	0.1008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.1564	0.1584
Trypanosoma cruzi	cysteine peptidase, putative	0.0334	0.9525	0.9522
Leishmania major	cysteine peptidase A (CPA)	0.0334	0.9525	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.9525	1
Entamoeba histolytica	cysteine protease, putative	0.0176	0.4791	0.4996
Entamoeba histolytica	cysteine proteinase, putative	0.0334	0.9525	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0069	0.1564	0.1564
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0176	0.4791	0.4791
Entamoeba histolytica	cysteine proteinase, putative	0.0176	0.4791	0.4996
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0069	0.1564	0.1584
Leishmania major	cathepsin L-like protease	0.0334	0.9525	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0069	0.1564	0.1584
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.1593	0.1593
Onchocerca volvulus		0.0334	0.9525	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Giardia lamblia	Cathepsin B precursor	0.0069	0.1564	0.3647
Entamoeba histolytica	cysteine protease, putative	0.0176	0.4791	0.4996
Echinococcus multilocularis	cathepsin b	0.0349	1	1
Loa Loa (eye worm)	mbt repeat family protein	0.005	0.1008	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1076	0.1076
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0638	0.0638
Giardia lamblia	Cathepsin B precursor	0.0069	0.1564	0.3647
Echinococcus multilocularis	cysteine protease	0.0334	0.9525	0.9525
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Brugia malayi	Cathepsin L-like precursor	0.0334	0.9525	0.9525
Entamoeba histolytica	cysteine protease, putative	0.0176	0.4791	0.4996
Giardia lamblia	Cysteine protease	0.0069	0.1564	0.3647
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0069	0.1564	0.1584
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0466	0.0423
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0466	0.0423
Plasmodium falciparum	serine repeat antigen 3	0.0069	0.1564	0.1584
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0349	1	1
Entamoeba histolytica	cysteine protease, putative	0.0176	0.4791	0.4996
Giardia lamblia	Cathepsin B precursor	0.0069	0.1564	0.3647
Brugia malayi	chromobox protein homolog 3	0.0039	0.0674	0.0674
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0176	0.4791	0.4996
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0057	0.1217	0.1217
Entamoeba histolytica	cysteine protease, putative	0.0176	0.4791	0.4996
Echinococcus granulosus	serine/threonine protein kinase	0.0022	0.0163	0.0163
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0875	0.0875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0066	0.0066
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0066	0.0066
Onchocerca volvulus	Cathepsin F homolog	0.0334	0.9525	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0069	0.1564	0.1584
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0066	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0069	0.1564	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0107	0.2729	0.2729
Entamoeba histolytica	protein kinase 2, putative	0.002	0.0103	0.0039
Echinococcus multilocularis	cathepsin L cysteine protease	0.0334	0.9525	0.9525
Brugia malayi	Papain family cysteine protease containing protein	0.0176	0.4791	0.4791
Plasmodium falciparum	serine repeat antigen 7	0.0069	0.1564	0.1584
Entamoeba histolytica	cysteine proteinase, putative	0.0226	0.6297	0.6588
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0156	0.4173	0.4134
Plasmodium falciparum	serine repeat antigen 8	0.0069	0.1564	0.1584
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0069	0.1564	0.1584
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0069	0.1564	0.1584
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.0163	0.0163
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.002	0.0103	0.0039
Onchocerca volvulus		0.0226	0.6297	0.6455
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0069	0.1564	0.1584
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0057	0.1217	0.1217
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0069	0.1564	0.3647
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.4791	0.4996
Trypanosoma cruzi	cysteine peptidase, putative	0.0334	0.9525	0.9522
Echinococcus multilocularis	Glutaredoxin protein 5	0.002	0.0097	0.0097
Entamoeba histolytica	cysteine proteinase, putative	0.0176	0.4791	0.4996
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.1564	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0226	0.6297	0.6297
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0107	0.2729	0.2729
Brugia malayi	Cathepsin L-like precursor	0.0107	0.2729	0.2729
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0226	0.6297	0.6297
Echinococcus granulosus	nervana 2	0.002	0.0097	0.0097
Brugia malayi	Papain family cysteine protease containing protein	0.0069	0.1564	0.1564
Entamoeba histolytica	protein kinase, putative	0.003	0.0407	0.036
Leishmania major	cathepsin L-like protease	0.0334	0.9525	1
Entamoeba histolytica	protein kinase, putative	0.0032	0.0466	0.0423
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0674	0.0278
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0638	0.0638
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0466	0.0423
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0069	0.1564	0.1584
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.1076	0.1076
Loa Loa (eye worm)	cysteine protease	0.0334	0.9525	0.9525
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.1564	0.1584
Giardia lamblia	Cathepsin L precursor	0.0069	0.1564	0.3647
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0069	0.1564	0.1564
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.1564	0.1584
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0057	0.1217	0.1217
Plasmodium vivax	unspecified product	0.0107	0.2729	0.2815
Echinococcus multilocularis	cathepsin L	0.0176	0.4791	0.4791
Entamoeba histolytica	cysteine protease, putative	0.0176	0.4791	0.4996
Brugia malayi	cathepsin F-like cysteine proteinase	0.0069	0.1564	0.1564
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0226	0.6297	0.6273
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0638	0.0638
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0334	0.9525	0.9525
Brugia malayi	mbt repeat family protein	0.005	0.1008	0.1008
Schistosoma mansoni	cathepsin B (C01 family)	0.0069	0.1564	0.1564
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0069	0.1564	0.1584
Echinococcus granulosus	chromobox protein 1	0.007	0.1593	0.1593
Schistosoma mansoni	chromobox protein	0.007	0.1593	0.1593
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.9525	1
Onchocerca volvulus		0.0334	0.9525	1
Echinococcus multilocularis	polycomb protein SCMH1	0.005	0.1008	0.1008
Entamoeba histolytica	hypothetical protein	0.0069	0.1564	0.1584
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.002	0.0103	0.0103
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0763	0.0737
Schistosoma mansoni	cathepsin S (C01 family)	0.0069	0.1564	0.1564
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0069	0.1564	0.1564
Plasmodium vivax	unspecified product	0.0069	0.1564	0.1584
Leishmania major	cathepsin L-like protease	0.0334	0.9525	1
Loa Loa (eye worm)	hypothetical protein	0.0107	0.2729	0.2729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.1564	0.1584
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0201	0.5552	0.5552
Loa Loa (eye worm)	hypothetical protein	0.0349	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0069	0.1564	0.3647
Onchocerca volvulus		0.0334	0.9525	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0069	0.1564	0.1564
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0032	0.0466	0.0466
Plasmodium falciparum	serine repeat antigen 2	0.0069	0.1564	0.1584
Giardia lamblia	Cathepsin L precursor	0.0069	0.1564	0.3647
Loa Loa (eye worm)	hypothetical protein	0.0107	0.2729	0.2729
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.002	0.0103	0.0037
Trypanosoma brucei	RNA helicase, putative	0.0125	0.3257	0.3373
Echinococcus multilocularis	cathepsin L	0.0069	0.1564	0.1564
Entamoeba histolytica	cysteine proteinase 2	0.0176	0.4791	0.4996
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0032	0.0466	0.0423
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0069	0.1564	0.1584
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0069	0.1564	0.1564
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0674	0.0643
Onchocerca volvulus	Cathepsin L homolog	0.0069	0.1564	0.1256
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0349	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0069	0.1564	0.1584
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0875	0.0875
Brugia malayi	Cathepsin L-like precursor	0.0334	0.9525	0.9525
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0069	0.1564	0.1564
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0069	0.1564	0.1564
Giardia lamblia	Hypothetical protein	0.0069	0.1564	0.3647
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0674	0.0643
Giardia lamblia	Cathepsin L precursor	0.0069	0.1564	0.3647
Giardia lamblia	Kinase, AGC PKA	0.002	0.0103	0.009
Echinococcus granulosus	cathepsin b	0.0349	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0069	0.1564	0.1564
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0069	0.1564	0.1564
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0334	0.9525	1
Entamoeba histolytica	cysteine protease, putative	0.0176	0.4791	0.4996
Brugia malayi	cathepsin L precursor	0.0069	0.1564	0.1564
Plasmodium falciparum	serine repeat antigen 9	0.0069	0.1564	0.1584
Echinococcus granulosus	serine threonine protein kinase nrc	0.002	0.0103	0.0103
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.002	0.0097	0.0097
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0875	0.0875
Toxoplasma gondii	cathepsin CPC2	0.0069	0.1564	0.1584
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0334	0.9525	0.9525
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0334	0.9525	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.9525	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0763	0.0376
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.1564	0.1584
Giardia lamblia	Cysteine protease	0.0069	0.1564	0.3647
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0875	0.0875
Loa Loa (eye worm)	MBCTL1	0.0057	0.1217	0.1217
Leishmania major	cathepsin L-like protease	0.0334	0.9525	1
Schistosoma mansoni	hypothetical protein	0.0309	0.8774	0.8774
Echinococcus granulosus	cathepsin b	0.0349	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0466	0.0423
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0069	0.1564	0.1564
Giardia lamblia	Cathepsin L precursor	0.0069	0.1564	0.3647
Leishmania major	cathepsin L-like protease	0.0334	0.9525	1
Toxoplasma gondii	cathepsin CPL	0.0334	0.9525	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0334	0.9525	0.9522
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0466	0.0423
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0069	0.1564	0.1584
Echinococcus multilocularis	nervana 2	0.002	0.0097	0.0097
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0334	0.9525	0.9525
Entamoeba histolytica	cysteine protease, putative	0.0069	0.1564	0.1584
Giardia lamblia	Cathepsin L-like protease	0.0069	0.1564	0.3647
Brugia malayi	Cathepsin L-like precursor	0.0334	0.9525	0.9525
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.9525	1
Entamoeba histolytica	cysteine protease, putative	0.0176	0.4791	0.4996
Entamoeba histolytica	cysteine protease, putative	0.0069	0.1564	0.1584
Onchocerca volvulus		0.0334	0.9525	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0066	0.0066
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0349	1	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0066	0.5
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0069	0.1564	0.1584
Plasmodium vivax	serine-repeat antigen (SERA)	0.0069	0.1564	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1564	0.1564
Trypanosoma cruzi	cruzipain precursor, putative	0.0107	0.2729	0.268
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.1564	0.1584
Entamoeba histolytica	cysteine protease, putative	0.0069	0.1564	0.1584
Brugia malayi	Heterochromatin protein 1	0.007	0.1593	0.1593
Echinococcus granulosus	cathepsin L	0.0069	0.1564	0.1564
Giardia lamblia	Cathepsin B precursor	0.0156	0.4173	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0069	0.1564	0.1584
Schistosoma mansoni	cathepsin F (C01 family)	0.0334	0.9525	0.9525
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0875	0.0875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0334	0.9525	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0334	0.9525	1
Echinococcus granulosus	Glutaredoxin protein 5	0.002	0.0097	0.0097
Brugia malayi	cathepsin F-like cysteine proteinase	0.0107	0.2729	0.2729
Brugia malayi	Cathepsin L-like precursor	0.0334	0.9525	0.9525
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.6297	0.6588
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0069	0.1564	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1564	0.1564
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0069	0.1564	0.1508
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0069	0.1564	0.1584
Plasmodium falciparum	serine repeat antigen 4	0.0069	0.1564	0.1584
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0069	0.1564	0.1564
Onchocerca volvulus		0.0334	0.9525	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0674	0.0674
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0875	0.0875
Entamoeba histolytica	cysteine proteinase 1, putative	0.0176	0.4791	0.4996
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.9525	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0069	0.1564	0.1584
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0069	0.1564	0.1584
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.1008	0.1008
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0349	1	1
Giardia lamblia	Cathepsin L-like protease	0.0069	0.1564	0.3647
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0332	0.0281
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0156	0.4173	0.4342
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0466	0.0423
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0334	0.9525	0.9525
Onchocerca volvulus		0.0069	0.1564	0.1256
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0875	0.0875
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0176	0.4791	0.4996
Entamoeba histolytica	hypothetical protein	0.0038	0.0638	0.0604
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0466	0.0423
Schistosoma mansoni	ap endonuclease	0.0019	0.0066	0.0066
Entamoeba histolytica	cysteine protease, putative	0.0069	0.1564	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1564	0.1564
Trypanosoma cruzi	cysteine proteinase, putative	0.0176	0.4791	0.4757
Entamoeba histolytica	hypothetical protein	0.0038	0.0638	0.0604
Giardia lamblia	Hypothetical protein	0.0069	0.1564	0.3647
Schistosoma mansoni	cathepsin F (C01 family)	0.0226	0.6297	0.6297
Brugia malayi	p70 ribosomal S6 kinase beta	0.003	0.0407	0.0407
Toxoplasma gondii	cathepsin CPC1	0.0069	0.1564	0.1584
Entamoeba histolytica	cysteine protease, putative	0.0176	0.4791	0.4996
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0334	0.9525	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0022	0.0163	0.0097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.4791	0.4996
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.9525	1
Onchocerca volvulus		0.0334	0.9525	1
Giardia lamblia	Cysteine protease	0.0069	0.1564	0.3647
Entamoeba histolytica	cysteine proteinase, putative	0.0334	0.9525	1
Leishmania major	cathepsin L-like protease	0.0334	0.9525	1
Loa Loa (eye worm)	fibroinase	0.0334	0.9525	0.9525
Entamoeba histolytica	cysteine protease, putative	0.0069	0.1564	0.1584
Brugia malayi	Cathepsin L-like precursor	0.0226	0.6297	0.6297
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0069	0.1564	0.1584
Plasmodium vivax	vivapain-3	0.0176	0.4791	0.4996
Echinococcus granulosus	cathepsin l1	0.0226	0.6297	0.6297
Schistosoma mansoni	hypothetical protein	0.0038	0.0638	0.0638
Schistosoma mansoni	cathepsin s	0.0107	0.2729	0.2729
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0334	0.9525	1
Echinococcus granulosus	histone acetyltransferase MYST2	0.0057	0.1217	0.1217
Trypanosoma cruzi	cysteine peptidase, putative	0.0176	0.4791	0.4757
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0334	0.9525	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0156	0.4173	0.4173
Onchocerca volvulus	Cathepsin L homolog	0.0334	0.9525	1
Entamoeba histolytica	cysteine protease, putative	0.0069	0.1564	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1564	0.1564
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0069	0.1564	0.3647
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0421	0.0421
Trypanosoma cruzi	cysteine protease, putative	0.0176	0.4791	0.4757
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0875	0.0875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0334	0.9525	1
Echinococcus granulosus	chromobox protein 1	0.007	0.1593	0.1593
Loa Loa (eye worm)	hypothetical protein	0.0226	0.6297	0.6297
Toxoplasma gondii	cathepsin B	0.0156	0.4173	0.4342
Trypanosoma cruzi	major cysteine proteinase, putative	0.0069	0.1564	0.1508
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0201	0.5552	0.5552
Trypanosoma cruzi	cysteine peptidase, putative	0.0107	0.2729	0.268
Trypanosoma cruzi	cysteine peptidase, putative	0.0334	0.9525	0.9522
Loa Loa (eye worm)	hypothetical protein	0.0334	0.9525	0.9525
Brugia malayi	cathepsin L-like precursor	0.0226	0.6297	0.6297
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0069	0.1564	0.1564
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0069	0.1564	0.1584
Onchocerca volvulus		0.005	0.1008	0.0645
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.9525	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0069	0.1564	0.1584
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.1076	0.1076
Schistosoma mansoni	hypothetical protein	0.0125	0.3257	0.3257
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.0163	0.0163
Entamoeba histolytica	cysteine protease, putative	0.0334	0.9525	1
Schistosoma mansoni	chromobox protein	0.007	0.1593	0.1593
Giardia lamblia	Cysteine protease	0.0069	0.1564	0.3647
Giardia lamblia	Encystation-specific protease	0.0069	0.1564	0.3647
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0466	0.0466
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0334	0.9525	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0069	0.1564	0.1584
Trypanosoma cruzi	cysteine proteinase, putative	0.0176	0.4791	0.4757
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0057	0.1217	0.1217
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0069	0.1564	0.1584
Toxoplasma gondii	AGC kinase	0.003	0.0407	0.036
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0156	0.4173	0.4342
Echinococcus multilocularis	cysteine protease	0.0334	0.9525	0.9525
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0163	0.0102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Leishmania major	cathepsin L-like protease	0.0334	0.9525	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0176	0.4791	0.4791
Echinococcus granulosus	polycomb protein SCMH1	0.005	0.1008	0.1008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.9525	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0069	0.1564	0.3647
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Trichomonas vaginalis	chromobox protein, putative	0.007	0.1593	0.1614
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0349	1	1
Brugia malayi	Cathepsin L-like precursor	0.0334	0.9525	0.9525
Entamoeba histolytica	hypothetical protein	0.0038	0.0638	0.0604
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0875	0.0875
Giardia lamblia	Cathepsin B precursor	0.0156	0.4173	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0069	0.1564	0.1584
Loa Loa (eye worm)	hypothetical protein	0.005	0.1008	0.1008
Brugia malayi	Cathepsin L-like precursor	0.0226	0.6297	0.6297
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0057	0.1217	0.1217
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.002	0.0103	0.0103
Entamoeba histolytica	protein kinase, putative	0.0032	0.0466	0.0423
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.002	0.0103	0.0039
Onchocerca volvulus		0.0334	0.9525	1
Plasmodium vivax	vivapain-2	0.0334	0.9525	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.005	0.1008	0.1008
Entamoeba histolytica	cysteine protease, putative	0.0176	0.4791	0.4996
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0069	0.1564	0.1564
Schistosoma mansoni	cathepsin F (C01 family)	0.0334	0.9525	0.9525
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.1564	0.1584
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0176	0.4791	0.4791
Loa Loa (eye worm)	ctsf protein	0.0334	0.9525	0.9525
Echinococcus granulosus	cathepsin l1	0.0334	0.9525	0.9525
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.002	0.0097	0.0097
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0066	0.0066
Brugia malayi	mbt repeat family protein	0.005	0.1008	0.1008
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.005	0.1008	0.0645
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0069	0.1564	0.1564
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0334	0.9525	0.9525
Leishmania major	cathepsin L-like protease	0.0334	0.9525	1
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.1008	0.1008
Brugia malayi	fibroinase precursor	0.0069	0.1564	0.1564
Onchocerca volvulus	Cathepsin L homolog	0.0334	0.9525	1
Plasmodium falciparum	serine repeat antigen 6	0.0069	0.1564	0.1584
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.1076	0.1076
Brugia malayi	Papain family cysteine protease containing protein	0.0176	0.4791	0.4791
Brugia malayi	cathepsin L-like cysteine proteinase	0.0069	0.1564	0.1564
Echinococcus multilocularis	rac serine:threonine kinase	0.0022	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1217	0.1217
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.005	0.1008	0.1008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0176	0.4791	0.4996
Giardia lamblia	Cathepsin B precursor	0.0069	0.1564	0.3647
Echinococcus granulosus	cathepsin L	0.0176	0.4791	0.4791
Echinococcus granulosus	cathepsin L cysteine protease	0.0176	0.4791	0.4791
Echinococcus granulosus	nervana 2	0.002	0.0097	0.0097
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.9525	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0066	0.5
Echinococcus multilocularis	chromobox protein 1	0.007	0.1593	0.1593
Entamoeba histolytica	cysteine protease, putative	0.0176	0.4791	0.4996
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0334	0.9525	0.9525
Entamoeba histolytica	cysteine protease, putative	0.0176	0.4791	0.4996
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1564	0.1564
Brugia malayi	Papain family cysteine protease containing protein	0.0334	0.9525	0.9525
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0069	0.1564	0.1584
Echinococcus multilocularis	chromobox protein 1	0.007	0.1593	0.1593
Plasmodium vivax	vivapain-2	0.0334	0.9525	1
Entamoeba histolytica	cysteine proteinase, putative	0.0176	0.4791	0.4996
Brugia malayi	hypothetical protein	0.0038	0.0638	0.0638
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0763	0.0737
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0332	0.0281
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0156	0.4173	0.4342
Plasmodium vivax	unspecified product	0.0176	0.4791	0.4996
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.9525	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.9525	1
Plasmodium falciparum	serine repeat antigen 5	0.0069	0.1564	0.1584
Schistosoma mansoni	ap endonuclease	0.0019	0.0066	0.0066
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0163	0.0102
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.003	0.0407	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0578	0.0578
Entamoeba histolytica	hypothetical protein	0.0038	0.0638	0.0604
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0069	0.1564	0.1564
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0334	0.9525	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0334	0.9525	0.9525
Echinococcus granulosus	cysteine protease	0.0176	0.4791	0.4791
Giardia lamblia	Cathepsin L precursor	0.0069	0.1564	0.3647
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0107	0.2729	0.2729
Trypanosoma cruzi	cruzipain precursor, putative	0.0334	0.9525	0.9522
Trichomonas vaginalis	chromobox protein, putative	0.007	0.1593	0.1614

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.36 uM	Inhibitory activity against HIV-1 integrase	ChEMBL.	15006380

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 147847

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 45907