Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 1 | 1 |
Brugia malayi | Flap endonuclease-1 | 0.0173 | 0.9988 | 1 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0173 | 0.9988 | 0.9988 |
Schistosoma mansoni | flap endonuclease-1 | 0.0147 | 0.7801 | 0.7801 |
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0173 | 1 | 1 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0173 | 1 | 1 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0173 | 0.9988 | 0.9988 |
Plasmodium falciparum | flap endonuclease 1 | 0.0173 | 0.9988 | 0.9988 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0173 | 0.9988 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0173 | 0.9988 | 1 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0173 | 0.9988 | 1 |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0173 | 1 | 1 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0173 | 1 | 1 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0173 | 1 | 1 |
Brugia malayi | XPG N-terminal domain containing protein | 0.0144 | 0.7561 | 0.757 |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0173 | 1 | 1 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0173 | 0.9988 | 0.9988 |
Echinococcus granulosus | flap endonuclease 1 | 0.0173 | 0.9988 | 0.9988 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0173 | 0.9988 | 1 |
Entamoeba histolytica | Flap nuclease, putative | 0.0173 | 0.9988 | 0.9988 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0173 | 0.9988 | 0.9988 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0173 | 0.9988 | 0.9988 |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0173 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 18.75 ug ml-1 | Antibacterial activity against Staphylococcus aureus MTCC 96 by broth dilution method | ChEMBL. | 17692520 |
MIC (functional) | = 18.75 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 by broth dilution method | ChEMBL. | 17692520 |
MIC (functional) | = 18.75 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 by broth dilution method | ChEMBL. | 17692520 |
MIC (functional) | = 37.5 ug ml-1 | Antibacterial activity against Bacillus subtilis MTCC 441 by broth dilution method | ChEMBL. | 17692520 |
MIC (functional) | = 75 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa MTCC 1688 by broth dilution method | ChEMBL. | 17692520 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv by nitrate reductase assay | ChEMBL. | 17692520 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv by nitrate reductase assay | ChEMBL. | 17692520 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.