TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 332.439 | Formula: C22H24N2O
H donors: 0 H acceptors: 2 LogP: 2.7 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CCC2(C(=C1)CCN(C2)Cc1ccncc1)Cc1ccccc1
InChi: 1S/C22H24N2O/c25-21-6-10-22(15-18-4-2-1-3-5-18)17-24(13-9-20(22)14-21)16-19-7-11-23-12-8-19/h1-5,7-8,11-12,14H,6,9-10,13,15-17H2
InChiKey: DRYZKLPUYCZNQQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Dopamine receptor	0.0048	0.0704	0.0704
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0046	0.0642	0.0509
Echinococcus granulosus	neuropeptide receptor A26	0.0048	0.0704	0.0572
Echinococcus multilocularis	calpain 7 (C02 family)	0.0069	0.1245	0.112
Schistosoma mansoni	hypothetical protein	0.0174	0.3949	0.3949
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0053	0.083	0.07
Onchocerca volvulus		0.0048	0.0704	0.2492
Onchocerca volvulus		0.0114	0.2403	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.0704	0.0704
Brugia malayi	calpain 5	0.0048	0.071	0.071
Echinococcus granulosus	calpain A	0.0069	0.1245	0.112
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0135	0.2942	0.2942
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.0704	0.0572
Schistosoma mansoni	amine GPCR	0.0048	0.0704	0.0704
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0048	0.0704	0.0704
Brugia malayi	ORL1-like opioid receptor	0.0048	0.0704	0.0704
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.1197	0.1197
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Brugia malayi	Melatonin receptor type 1A	0.0048	0.0704	0.0704
Echinococcus granulosus	sex peptide receptor	0.0048	0.0704	0.0572
Brugia malayi	calpain family protein 1	0.0183	0.4183	0.4183
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0409	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0271	0.0271
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0449	0.0449
Trypanosoma brucei	calpain-like protein, putative	0.0069	0.1245	0.4231
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Schistosoma mansoni	hypothetical protein	0.0031	0.0271	0.0271
Echinococcus multilocularis	expressed conserved protein	0.0098	0.1993	0.1879
Brugia malayi	G protein-coupled receptor	0.0048	0.0704	0.0704
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0053	0.083	0.07
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Giardia lamblia	Cathepsin B precursor	0.0135	0.2942	1
Brugia malayi	gamma-secretase subunit aph-1	0.0239	0.5635	0.5635
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1206	0.1206
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0048	0.0704	0.0704
Echinococcus granulosus	neuropeptide receptor	0.0048	0.0704	0.0572
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0048	0.0704	0.0572
Loa Loa (eye worm)	calpain family protein 1	0.0183	0.4183	0.4183
Brugia malayi	hypothetical protein	0.0048	0.0704	0.0704
Echinococcus granulosus	gamma secretase subunit aph 1	0.0239	0.5635	0.5573
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0048	0.0704	0.2492
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0053	0.083	0.4792
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0048	0.0704	0.0572
Echinococcus multilocularis	G protein coupled receptor 139	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0449	0.0449
Echinococcus multilocularis	neuropeptide s receptor	0.0048	0.0704	0.0572
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0048	0.0704	0.0572
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0069	0.1245	0.4231
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0271	0.0132
Echinococcus granulosus	neuropeptide Y receptor	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.0704	0.0572
Leishmania major	kinesin, putative	0.0048	0.071	0.2412
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0048	0.0704	0.0572
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0069	0.1245	0.4231
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	FKBP5 protein	0.0053	0.083	0.083
Schistosoma mansoni	amine GPCR	0.0048	0.0704	0.0704
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0141	0.0141
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0191	0.4396	0.4316
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0191	0.4396	0.4396
Echinococcus multilocularis	neuropeptide receptor A26	0.0048	0.0704	0.0572
Echinococcus granulosus	7tm_1 domain containing protein	0.0048	0.0704	0.0572
Echinococcus granulosus	neuropeptides capa receptor	0.0048	0.0704	0.0572
Echinococcus granulosus	orexin receptor type 2	0.0048	0.0704	0.0572
Schistosoma mansoni	adenoreceptor	0.0048	0.0704	0.0704
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.062	0.2107
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2011	0.2011
Schistosoma mansoni	neuropeptide f receptor 76f	0.0048	0.0704	0.0704
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0053	0.083	0.5
Giardia lamblia	Cathepsin B precursor	0.0135	0.2942	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Brugia malayi	hypothetical protein	0.0048	0.0704	0.0704
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0449	0.1527
Echinococcus granulosus	neuropeptide s receptor	0.0048	0.0704	0.0572
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0271	0.0132
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0053	0.083	0.2823
Toxoplasma gondii	cathepsin B	0.0135	0.2942	1
Echinococcus multilocularis	somatostatin receptor	0.0048	0.0704	0.0572
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0271	0.0271
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0048	0.0704	0.0572
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0053	0.083	0.083
Echinococcus multilocularis	Niemann Pick C1 protein	0.0104	0.2156	0.2044
Trypanosoma brucei	antigen, putative	0.0069	0.1245	0.4231
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Loa Loa (eye worm)	G-protein coupled receptor	0.0048	0.0704	0.0704
Schistosoma mansoni	patched 1	0.0045	0.062	0.062
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.2011	0.2011
Schistosoma mansoni	hypothetical protein	0.0031	0.0271	0.0271
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0053	0.083	0.083
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.0704	0.0704
Onchocerca volvulus		0.0038	0.0449	0.1364
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0053	0.083	0.07
Echinococcus multilocularis	serotonin receptor	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Brugia malayi	follicle stimulating hormone receptor	0.0048	0.0704	0.0704
Brugia malayi	putative neuropeptide receptor	0.0048	0.0704	0.0704
Brugia malayi	beta-lactamase family protein	0.0038	0.0449	0.0449
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0704	0.0704
Schistosoma mansoni	opsin-like receptor	0.0048	0.0704	0.0704
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0048	0.0704	0.0704
Schistosoma mansoni	myosin xvIII	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	calpain (C02 family)	0.0069	0.1245	0.1245
Schistosoma mansoni	amine GPCR	0.0048	0.0704	0.0704
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0449	0.0449
Brugia malayi	intermediate filament protein	0.0026	0.0141	0.0141
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0106	0.2198	0.2198
Trypanosoma brucei	calpain-like protein, putative	0.0069	0.1245	0.4231
Echinococcus multilocularis	allatostatin A receptor	0.0048	0.0704	0.0572
Brugia malayi	G-protein coupled receptor	0.0048	0.0704	0.0704
Echinococcus granulosus	g protein coupled receptor	0.0048	0.0704	0.0572
Schistosoma mansoni	hypothetical protein	0.0048	0.0704	0.0704
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0053	0.083	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	biogenic amine receptor	0.0048	0.0704	0.0704
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0048	0.0704	0.0704
Schistosoma mansoni	immunophilin	0.0046	0.0642	0.0642
Echinococcus granulosus	fmrfamide receptor	0.0048	0.0704	0.0572
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0048	0.0704	0.0572
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0053	0.083	0.083
Brugia malayi	hypothetical protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0271	0.0271
Schistosoma mansoni	lamin	0.0026	0.0141	0.0141
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0069	0.1245	0.1245
Echinococcus granulosus	serotonin receptor	0.0048	0.0704	0.0572
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0048	0.0704	0.2492
Toxoplasma gondii	ABC1 family protein	0.0038	0.0449	0.1527
Echinococcus granulosus	somatostatin receptor	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0409	1	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0449	0.1527
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0141	0.0141
Brugia malayi	hypothetical protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	TYRA-2 protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	hypothetical protein	0.0043	0.0578	0.0578
Echinococcus granulosus	calpain 5	0.0069	0.1245	0.112
Loa Loa (eye worm)	neuropeptide F receptor	0.0048	0.0704	0.0704
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.0704	0.0572
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0048	0.0704	0.0704
Echinococcus granulosus	calpain 7 C02 family	0.0069	0.1245	0.112
Schistosoma mansoni	neuropeptide F-like receptor	0.0048	0.0704	0.0704
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0048	0.0704	0.0704
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0048	0.0704	0.0704
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0069	0.1245	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Echinococcus granulosus	tar DNA binding protein	0.0067	0.1197	0.1071
Schistosoma mansoni	hypothetical protein	0.0043	0.0578	0.0578
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0183	0.4183	0.4183
Echinococcus granulosus	G protein coupled receptor 139	0.0048	0.0704	0.0572
Schistosoma mansoni	hypothetical protein	0.0043	0.0578	0.0578
Brugia malayi	calpain family protein 1	0.0183	0.4183	0.4183
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0135	0.2942	0.2942
Brugia malayi	AKH receptor	0.0048	0.0704	0.0704
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0135	0.2942	1
Onchocerca volvulus		0.0048	0.0704	0.2492
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0048	0.0704	0.0704
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	G-protein coupled receptor	0.0048	0.0704	0.0704
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Echinococcus multilocularis	neuropeptide Y receptor	0.0048	0.0704	0.0572
Entamoeba histolytica	protein kinase, putative	0.0048	0.071	0.3291
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.062	0.0486
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0141	0.0141
Echinococcus multilocularis	cathepsin b	0.0409	1	1
Trypanosoma brucei	calpain-like protein, putative	0.0069	0.1245	0.4231
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0642	0.0642
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0048	0.0704	0.0572
Echinococcus granulosus	expressed conserved protein	0.0098	0.1993	0.1879
Brugia malayi	Dopamine receptor protein 1	0.0048	0.0704	0.0704
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0449	0.0449
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.1197	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2403	0.2403
Trypanosoma brucei	calpain-like protein, putative	0.0069	0.1245	0.4231
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Trichomonas vaginalis	immunophilin, putative	0.0053	0.083	0.2823
Schistosoma mansoni	opsin-like receptor	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	RNA binding protein	0.0067	0.1197	0.1197
Echinococcus multilocularis	sex peptide receptor	0.0048	0.0704	0.0572
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0069	0.1245	0.4231
Echinococcus multilocularis	calpain A	0.0191	0.4396	0.4316
Brugia malayi	sulfakinin receptor protein	0.0048	0.0704	0.0704
Leishmania major	fk506-binding protein 1-like protein	0.0053	0.083	0.2823
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Onchocerca volvulus		0.0048	0.0704	0.2492
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0048	0.0704	0.0704
Schistosoma mansoni	hypothetical protein	0.0043	0.0578	0.0578
Onchocerca volvulus		0.0038	0.0449	0.1364
Brugia malayi	Serotonin receptor	0.0048	0.0704	0.0704
Echinococcus granulosus	calpain	0.0069	0.1245	0.112
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Echinococcus multilocularis	calpain 5	0.0069	0.1245	0.112
Brugia malayi	RE15519p	0.0048	0.0704	0.0704
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0053	0.083	0.083
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0069	0.1245	0.1245
Echinococcus granulosus	neuropeptide Y receptor	0.0048	0.0704	0.0572
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.1197	0.1197
Schistosoma mansoni	immunophilin	0.0053	0.083	0.083
Loa Loa (eye worm)	neuropeptide F receptor	0.0048	0.0704	0.0704
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.1197	0.1197
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0135	0.2942	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0704	0.0704
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0069	0.1245	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0449	0.0449
Leishmania major	hypothetical protein, conserved	0.0038	0.0449	0.1527
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0704	0.0704
Schistosoma mansoni	hypothetical protein	0.0068	0.1206	0.1206
Schistosoma mansoni	calpain-7 (C02 family)	0.0069	0.1245	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0449	0.0449
Trypanosoma cruzi	Aph-1 protein, putative	0.0093	0.1869	0.1869
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0704	0.0704
Brugia malayi	calpain 7	0.0069	0.1245	0.1245
Schistosoma mansoni	hypothetical protein	0.0174	0.3949	0.3949
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	opsin-like receptor	0.0048	0.0704	0.0704
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Brugia malayi	TAR-binding protein	0.0067	0.1197	0.1197
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0053	0.083	0.3851
Echinococcus granulosus	biogenic amine 5HT receptor	0.0048	0.0704	0.0572
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0048	0.0704	0.0572
Echinococcus multilocularis	neuropeptide receptor	0.0048	0.0704	0.0572
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0048	0.071	0.3291
Echinococcus granulosus	hypothetical protein	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Onchocerca volvulus		0.0048	0.0704	0.2492
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0449	0.1527
Schistosoma mansoni	amine GPCR	0.0048	0.0704	0.0704
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0449	0.5
Onchocerca volvulus		0.0048	0.0704	0.2492
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0048	0.0704	0.0572
Plasmodium vivax	calpain, putative	0.0069	0.1245	1
Onchocerca volvulus		0.0048	0.0704	0.2492
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0409	1	1
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0053	0.083	0.083
Echinococcus multilocularis	fmrfamide receptor	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0069	0.1245	0.1245
Onchocerca volvulus		0.0048	0.0704	0.2492
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0449	0.0313
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0449	0.0449
Brugia malayi	hypothetical protein	0.0048	0.0704	0.0704
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.062	0.0486
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0048	0.0704	0.0704
Brugia malayi	G protein-coupled receptor F59B2.13	0.0048	0.0704	0.0704
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0069	0.1245	0.1245
Schistosoma mansoni	calpain C (C02 family)	0.0069	0.1245	0.1245
Echinococcus multilocularis	g-protein coupled receptor	0.0048	0.0704	0.0572
Trypanosoma cruzi	kinesin, putative	0.0048	0.071	0.071
Echinococcus multilocularis	orexin receptor type 2	0.0048	0.0704	0.0572
Loa Loa (eye worm)	calpain 5	0.0048	0.071	0.071
Echinococcus multilocularis	fmrfamide receptor	0.0048	0.0704	0.0572
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0239	0.5635	0.5635
Echinococcus multilocularis	protein patched	0.0045	0.062	0.0486
Echinococcus granulosus	dro:myosuppressin receptor	0.0048	0.0704	0.0572
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0053	0.083	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0704	0.0704
Leishmania major	peptidylprolyl isomerase-like protein	0.0053	0.083	0.2823
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0783	0.0652
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Brugia malayi	neuropeptide F receptor	0.0048	0.0704	0.0704
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0449	0.1527
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0048	0.0704	0.0572
Echinococcus granulosus	GPCR family 2	0.0031	0.0271	0.0132
Onchocerca volvulus		0.0048	0.0704	0.2492
Onchocerca volvulus		0.0048	0.0704	0.2492
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Brugia malayi	G-protein coupled receptor	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3648	0.3648
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Echinococcus granulosus	7TM GPCR rhodopsin	0.0048	0.0704	0.0572
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0048	0.0704	0.0572
Brugia malayi	neuropeptide F receptor	0.0048	0.0704	0.0704
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0704	0.0704
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0053	0.083	0.083
Trypanosoma brucei	Aph-1 protein, putative	0.0093	0.1869	0.6354
Loa Loa (eye worm)	hypothetical protein	0.0183	0.4183	0.4183
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0704	0.0704
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0191	0.4396	0.4396
Onchocerca volvulus		0.0038	0.0449	0.1364
Echinococcus granulosus	neuropeptides capa receptor	0.0048	0.0704	0.0572
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0704	0.0704
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0191	0.4396	0.4316
Giardia lamblia	Cathepsin B precursor	0.0135	0.2942	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.0704	0.0572
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0069	0.1245	0.1245
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0141	0.0141
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0409	1	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0271	0.0271
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.1197	0.1197
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0449	0.5
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0069	0.1245	0.1245
Brugia malayi	hypothetical protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	calpain family protein 1	0.0135	0.2938	0.2938
Brugia malayi	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0704	0.0704
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0048	0.0704	0.0704
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0244	0.5753	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.2011	0.2011
Brugia malayi	larval opioid receptor	0.0048	0.0704	0.0704
Echinococcus granulosus	Niemann Pick C1 protein	0.0104	0.2156	0.2044
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0704	0.0704
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0135	0.2942	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0048	0.0704	0.0704
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0048	0.0704	0.0572
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0048	0.0704	0.0572
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0048	0.0704	0.0704
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0104	0.2156	0.2156
Schistosoma mansoni	growth hormone secretagogue receptor	0.0048	0.0704	0.0704
Schistosoma mansoni	biogenic amine receptor	0.0048	0.0704	0.0704
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0271	0.0132
Echinococcus granulosus	g protein coupled receptor	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0409	1	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0048	0.0704	0.0572
Schistosoma mansoni	biogenic amine receptor	0.0048	0.0704	0.0704
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0048	0.0704	0.0704
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0048	0.0704	0.0572
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0048	0.0704	0.0572
Brugia malayi	hypothetical protein	0.0048	0.0704	0.0704
Echinococcus granulosus	geminin	0.0174	0.3949	0.3863
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0048	0.0704	0.0704
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0409	1	1
Brugia malayi	Dopamine receptor protein 2	0.0048	0.0704	0.0704
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.0704	0.0572
Onchocerca volvulus		0.0048	0.0704	0.2492
Echinococcus granulosus	cathepsin b	0.0409	1	1
Trichomonas vaginalis	fk506-binding protein, putative	0.0053	0.083	0.2823
Onchocerca volvulus		0.0048	0.0704	0.2492
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0239	0.5635	0.5573
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.0704	0.0572
Echinococcus multilocularis	neuropeptides capa receptor	0.0048	0.0704	0.0572
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0069	0.1245	0.4231
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.1206	0.1206
Onchocerca volvulus		0.0048	0.0704	0.2492
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Echinococcus multilocularis	serotonin receptor	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Echinococcus multilocularis	hypothetical protein	0.0069	0.1245	0.112
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0271	0.0132
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0141	0.0141
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0048	0.0704	0.0704
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0069	0.1245	0.4231
Echinococcus granulosus	calpain A	0.0191	0.4396	0.4316
Echinococcus multilocularis	calpain	0.0069	0.1245	0.112
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0053	0.083	0.2823
Onchocerca volvulus		0.0048	0.0704	0.2492
Trypanosoma cruzi	kinesin, putative	0.0048	0.071	0.071
Echinococcus granulosus	Niemann Pick C1 protein	0.0149	0.3311	0.3216
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.1197	0.1197
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0053	0.083	0.2823
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.062	0.062
Echinococcus granulosus	allatostatin A receptor	0.0048	0.0704	0.0572
Echinococcus granulosus	g-protein coupled receptor	0.0048	0.0704	0.0572
Echinococcus multilocularis	neuropeptides capa receptor	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	histamine h1 receptor	0.0048	0.0704	0.0704
Trypanosoma cruzi	Aph-1 protein, putative	0.0093	0.1869	0.1869
Loa Loa (eye worm)	melatonin receptor type 1A	0.0048	0.0704	0.0704
Brugia malayi	CHE-14 protein	0.0045	0.062	0.062
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0135	0.2938	0.2938
Echinococcus multilocularis	Niemann Pick C1 protein	0.0149	0.3311	0.3216
Echinococcus granulosus	neuropeptide receptor	0.0048	0.0704	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0704	0.0704
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.2011	0.2011
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0053	0.083	0.2823
Loa Loa (eye worm)	cathepsin B	0.0135	0.2942	0.2942
Brugia malayi	RNA binding protein	0.0067	0.1197	0.1197
Onchocerca volvulus		0.0048	0.0704	0.2492
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0449	0.0313
Onchocerca volvulus		0.0048	0.0704	0.2492
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0239	0.5635	0.5635
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0048	0.0704	0.0704
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0053	0.083	0.083
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0449	0.0449
Echinococcus multilocularis	neuropeptide Y receptor	0.0048	0.0704	0.0572
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0449	0.1527
Echinococcus multilocularis	cathepsin b	0.0409	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0048	0.0704	0.0704
Loa Loa (eye worm)	calpain	0.0069	0.1245	0.1245
Brugia malayi	beta-lactamase family protein	0.0038	0.0449	0.0449
Echinococcus granulosus	g protein coupled receptor	0.0048	0.0704	0.0572
Trichomonas vaginalis	esterase, putative	0.0038	0.0449	0.1527
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0069	0.1245	0.1245
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0048	0.0704	0.0572
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0048	0.0704	0.0704
Schistosoma mansoni	hypothetical protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0055	0.088	0.088
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0271	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.1197	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0053	0.083	0.083
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0128	0.0128
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.062	0.0486
Schistosoma mansoni	hypothetical protein	0.0031	0.0271	0.0271
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0048	0.0704	0.0572
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0069	0.1245	0.1245
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0449	0.1527
Schistosoma mansoni	immunophilin	0.0053	0.083	0.083
Brugia malayi	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	neuropeptide F-like receptor	0.0048	0.0704	0.0704
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0048	0.0704	0.0572
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.1197	0.1197
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.0704	0.0704
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Brugia malayi	Serotonin receptor	0.0048	0.0704	0.0704
Echinococcus multilocularis	neuropeptide receptor	0.0048	0.0704	0.0572
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.1197	0.1071
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0704	0.0704
Echinococcus multilocularis	fk506 binding protein	0.0053	0.083	0.07
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0069	0.1245	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0449	0.0449
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0046	0.0642	0.0509
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0048	0.0704	0.0572
Schistosoma mansoni	calpain-7 (C02 family)	0.0069	0.1245	0.1245
Schistosoma mansoni	amine GPCR	0.0048	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0045	0.062	0.062
Echinococcus multilocularis	calpain family protein 1, d	0.0135	0.2938	0.2837
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0048	0.0704	0.0704
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0048	0.0704	0.0704
Schistosoma mansoni	lamin	0.0026	0.0141	0.0141
Brugia malayi	putative neuropeptide receptor NPR1	0.0048	0.0704	0.0704
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Onchocerca volvulus		0.0048	0.0704	0.2492
Trypanosoma brucei	kinesin, putative	0.0048	0.071	0.2412
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0053	0.083	0.3851
Echinococcus granulosus	cathepsin b	0.0409	1	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0704	0.0704
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0048	0.0704	0.0572
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0048	0.0704	0.0572
Echinococcus multilocularis	dro:myosuppressin receptor	0.0048	0.0704	0.0572
Onchocerca volvulus		0.0048	0.0704	0.2492
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0704	0.0704
Brugia malayi	Niemann-Pick C1 protein precursor	0.0104	0.2156	0.2156
Brugia malayi	beta-lactamase	0.0038	0.0449	0.0449
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0271	0.0271
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0104	0.2156	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0704	0.0572
Echinococcus multilocularis	geminin	0.0174	0.3949	0.3863
Brugia malayi	hypothetical protein	0.0048	0.0704	0.0704
Brugia malayi	GnHR receptor homolog	0.0048	0.0704	0.0704
Echinococcus granulosus	biogenic amine 5HT receptor	0.0048	0.0704	0.0572

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	> 10000 nM	Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus	ChEMBL.	17822897
Ki (binding)	> 10000 nM	Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus	ChEMBL.	17822897

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 460322