Detailed information for compound 460323

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 406.497 | Formula: C23H22N2O3S
  • H donors: 0 H acceptors: 4 LogP: 2.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccccc1S(=O)(=O)N1CCC2=CC(=O)CCC2(C1)Cc1ccccc1
  • InChi: 1S/C23H22N2O3S/c24-16-19-8-4-5-9-22(19)29(27,28)25-13-11-20-14-21(26)10-12-23(20,17-25)15-18-6-2-1-3-7-18/h1-9,14H,10-13,15,17H2
  • InChiKey: TWVFKAUSUVXHPA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0295 0.5184 0.5139
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0898 0.0813
Trypanosoma brucei calpain-like protein, putative 0.0105 0.1519 0.3015
Schistosoma mansoni opsin-like receptor 0.0053 0.0516 0.0427
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.1546 0.1468
Loa Loa (eye worm) calpain 5 0.0074 0.0908 0.0857
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0798 0.0712
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0053 0.0516 0.0427
Brugia malayi hypothetical protein 0.0053 0.0516 0.0427
Echinococcus multilocularis prolyl endopeptidase 0.004 0.0252 0.0162
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0434 0.0673
Trypanosoma cruzi centrin-3 0.0036 0.0178 0.0082
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0356 0.0266
Echinococcus granulosus gamma secretase subunit aph 1 0.0241 0.4137 0.4083
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0053 0.0516 0.0427
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0252 0.0158
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.004 0.0252 0.0546
Loa Loa (eye worm) hypothetical protein 0.0091 0.124 0.1191
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.1515 0.1436
Mycobacterium ulcerans hypothetical protein 0.0073 0.0898 0.5094
Loa Loa (eye worm) hypothetical protein 0.0174 0.2844 0.2804
Echinococcus granulosus serotonin receptor 0.0053 0.0516 0.0427
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0106 0.152 0.1441
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Trichomonas vaginalis calcium binding protein, putative 0.0036 0.0178 0.0602
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0105 0.1519 0.1437
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1405 0.1325
Echinococcus multilocularis G protein coupled receptor 139 0.0053 0.0516 0.0427
Onchocerca volvulus 0.0053 0.0516 0.0953
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0434 0.0341
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0106 0.152 0.3016
Schistosoma mansoni hypothetical protein 0.0068 0.0798 0.0712
Brugia malayi putative neuropeptide receptor 0.0053 0.0516 0.0427
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0053 0.0516 0.0427
Loa Loa (eye worm) melatonin receptor type 1A 0.0053 0.0516 0.0463
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0106 0.152 0.1438
Schistosoma mansoni opsin-like receptor 0.0053 0.0516 0.0427
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0337 0.0283
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0791 0.074
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0053 0.0516 0.0427
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0053 0.0516 0.0427
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0791 0.0705
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0791 0.0705
Brugia malayi gamma-secretase subunit aph-1 0.0241 0.4137 0.4083
Echinococcus granulosus geminin 0.0175 0.2868 0.2802
Loa Loa (eye worm) hypothetical protein 0.0055 0.0552 0.05
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0053 0.0516 0.0463
Echinococcus granulosus cathepsin b 0.0545 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0053 0.0516 0.0427
Schistosoma mansoni hypothetical protein 0.007 0.0828 0.0743
Trypanosoma cruzi prolyl endopeptidase 0.004 0.0252 0.0158
Loa Loa (eye worm) calpain family protein 1 0.028 0.4878 0.485
Echinococcus granulosus neuropeptide receptor 0.0053 0.0516 0.0427
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0898 0.0781
Loa Loa (eye worm) hypothetical protein 0.0032 0.0092 0.0037
Onchocerca volvulus 0.0053 0.0516 0.0953
Echinococcus multilocularis calpain A 0.0295 0.5184 0.5139
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0276 0.4816 0.4768
Echinococcus granulosus fmrfamide receptor 0.0053 0.0516 0.0427
Schistosoma mansoni hypothetical protein 0.0044 0.0325 0.0234
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0276 0.4816 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0105 0.1519 0.1437
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0053 0.0516 0.0427
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0276 0.4816 1
Trypanosoma brucei caltractin, putative 0.0036 0.0178 0.0172
Onchocerca volvulus 0.0053 0.0516 0.0953
Entamoeba histolytica hypothetical protein 0.007 0.0828 0.5141
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0898 0.304
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0053 0.0516 0.0427
Schistosoma mansoni amine GPCR 0.0053 0.0516 0.0427
Echinococcus multilocularis neuropeptides capa receptor 0.0053 0.0516 0.0427
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0268 0.044
Schistosoma mansoni hypothetical protein 0.0044 0.0325 0.0234
Brugia malayi G protein-coupled receptor F59B2.13 0.0053 0.0516 0.0427
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0106 0.152 1
Trypanosoma cruzi Aph-1 protein, putative 0.0094 0.1298 0.1213
Echinococcus multilocularis sex peptide receptor 0.0053 0.0516 0.0427
Schistosoma mansoni amine GPCR 0.0053 0.0516 0.0427
Echinococcus granulosus g protein coupled receptor 0.0053 0.0516 0.0427
Schistosoma mansoni alpha-1 adrenergic receptor 0.0053 0.0516 0.0427
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0516 0.0427
Schistosoma mansoni hypothetical protein 0.0044 0.0325 0.0234
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0096 0.0326
Echinococcus multilocularis calpain 7 (C02 family) 0.0105 0.1519 0.144
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0898 0.1699
Loa Loa (eye worm) hypothetical protein 0.0206 0.3455 0.3419
Echinococcus multilocularis serotonin receptor 0.0053 0.0516 0.0427
Trypanosoma brucei Aph-1 protein, putative 0.0094 0.1298 0.2545
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0898 0.0813
Echinococcus multilocularis hypothetical protein 0.0105 0.1519 0.144
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0053 0.0516 0.0427
Echinococcus granulosus peptide allatostatin:somatostatin 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.004 0.0252 0.0198
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.1515 0.1436
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0091 0.124 0.1158
Echinococcus granulosus g protein coupled receptor 0.0053 0.0516 0.0427
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0545 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0096 0.0041
Trichomonas vaginalis calpain, putative 0.0032 0.0096 0.0326
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0053 0.0516 0.0463
Onchocerca volvulus 0.0053 0.0516 0.0953
Brugia malayi calpain 5 0.0074 0.0908 0.0823
Brugia malayi AKH receptor 0.0053 0.0516 0.0427
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0516 0.0427
Loa Loa (eye worm) beta-lactamase 0.0073 0.0898 0.0848
Brugia malayi hypothetical protein 0.007 0.0828 0.0743
Brugia malayi putative neuropeptide receptor NPR1 0.0053 0.0516 0.0427
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0053 0.0516 0.0427
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0106 0.152 0.5145
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0213 0.0326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Schistosoma mansoni calpain (C02 family) 0.0105 0.1519 0.144
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.0516 0.0427
Onchocerca volvulus Neuropeptide F receptor homolog 0.0053 0.0516 0.0953
Schistosoma mansoni biogenic amine (5HT) receptor 0.0053 0.0516 0.0427
Brugia malayi prolyl oligopeptidase family protein 0.0276 0.4816 0.4768
Echinococcus multilocularis geminin 0.0175 0.2868 0.2802
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0268 0.0906
Loa Loa (eye worm) hypothetical protein 0.0073 0.0898 0.0848
Brugia malayi G protein-coupled receptor 0.0053 0.0516 0.0427
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0898 0.0813
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0365 0.6529 0.6496
Loa Loa (eye worm) calpain 0.0105 0.1519 0.1472
Mycobacterium tuberculosis Conserved protein 0.0073 0.0898 0.0781
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0053 0.0516 0.0427
Onchocerca volvulus 0.0053 0.0516 0.0953
Toxoplasma gondii cathepsin B 0.018 0.2955 1
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0898 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0096 0.0326
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0295 0.5184 0.5139
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0053 0.0516 0.0427
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0898 0.081
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0106 0.152 0.1441
Entamoeba histolytica prolyl oligopeptidase family protein 0.004 0.0252 0.1097
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Trypanosoma brucei antigen, putative 0.0105 0.1519 0.3015
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0434 0.147
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.0516 0.0427
Brugia malayi Dopamine receptor protein 2 0.0053 0.0516 0.0427
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0434 0.1182
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0105 0.1519 0.1437
Trypanosoma cruzi kinesin, putative 0.0074 0.0908 0.0819
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.004 0.0252 0.0158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0516 0.0427
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0791 0.0705
Brugia malayi hypothetical protein 0.0053 0.0516 0.0427
Brugia malayi ORL1-like opioid receptor 0.0053 0.0516 0.0427
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0105 0.1519 0.3015
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0516 0.0427
Brugia malayi hypothetical protein 0.0053 0.0516 0.0427
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0434 0.147
Brugia malayi neuropeptide F receptor 0.0053 0.0516 0.0427
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0898 0.0813
Loa Loa (eye worm) hypothetical protein 0.0068 0.0798 0.0747
Schistosoma mansoni calpain-7 (C02 family) 0.0105 0.1519 0.144
Loa Loa (eye worm) G-protein coupled receptor 0.0053 0.0516 0.0463
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0252 0.0854
Onchocerca volvulus 0.0053 0.0516 0.0953
Onchocerca volvulus 0.0073 0.0898 0.1745
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus multilocularis neuropeptide FF receptor 2 0.0053 0.0516 0.0427
Loa Loa (eye worm) prolyl oligopeptidase 0.004 0.0252 0.0198
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1405 0.1358
Echinococcus multilocularis calpain family protein 1, d 0.0206 0.3455 0.3394
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0147 0.2327 0.2285
Brugia malayi Heterochromatin protein 1 0.0067 0.0783 0.0697
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0783 0.0732
Onchocerca volvulus 0.0073 0.0898 0.1745
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0053 0.0516 0.0427
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1405 0.1325
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0053 0.0516 0.0427
Brugia malayi hypothetical protein 0.0053 0.0516 0.0427
Schistosoma mansoni biogenic amine receptor 0.0053 0.0516 0.0427
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0434 0.0341
Echinococcus granulosus neuropeptide FF receptor 2 0.0053 0.0516 0.0427
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0106 0.152 0.1441
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0434 0.0381
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0295 0.5184 0.5139
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0106 0.152 0.1438
Schistosoma mansoni immunophilin 0.0091 0.124 0.1158
Schistosoma mansoni biogenic amine receptor 0.0053 0.0516 0.0427
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0516 0.0427
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.004 0.0252 0.0331
Schistosoma mansoni hypothetical protein 0.0053 0.0516 0.0427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0337 0.0247
Loa Loa (eye worm) neuropeptide F receptor 0.0053 0.0516 0.0463
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0053 0.0516 0.0463
Trichomonas vaginalis calmodulin, putative 0.0036 0.0178 0.0602
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0105 0.1519 0.3015
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0106 0.152 0.1473
Echinococcus granulosus neuropeptide s receptor 0.0498 0.909 0.9081
Brugia malayi beta-lactamase 0.0073 0.0898 0.0813
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.004 0.0252 0.0331
Loa Loa (eye worm) hypothetical protein 0.01 0.1405 0.1358
Loa Loa (eye worm) hypothetical protein 0.0105 0.1515 0.1468
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0106 0.152 0.3016
Loa Loa (eye worm) hypothetical protein 0.0073 0.0898 0.0848
Schistosoma mansoni hypothetical protein 0.0175 0.2868 0.2802
Schistosoma mansoni adenoreceptor 0.0053 0.0516 0.0427
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0105 0.1519 0.3015
Brugia malayi MAP kinase sur-1 0.0049 0.0434 0.0345
Trypanosoma brucei oligopeptidase b 0.004 0.0252 0.0331
Entamoeba histolytica prolyl oligopeptidase family protein 0.004 0.0252 0.1097
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0434 0.0716
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0276 0.4816 0.4768
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0106 0.152 0.4691
Schistosoma mansoni neuropeptide F-like receptor 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0545 1 1
Echinococcus multilocularis programmed cell death protein 0.0036 0.0178 0.0086
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0828 0.0743
Echinococcus granulosus hypothetical protein 0.0053 0.0516 0.0427
Brugia malayi larval opioid receptor 0.0053 0.0516 0.0427
Schistosoma mansoni gamma-secretase subunit aph-1 0.0241 0.4137 0.4083
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0791 0.0705
Echinococcus granulosus 7tm_1 domain containing protein 0.0053 0.0516 0.0427
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0276 0.4816 0.4766
Schistosoma mansoni immunophilin 0.0106 0.152 0.1441
Schistosoma mansoni neuropeptide receptor 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.004 0.0252 0.0162
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus granulosus biogenic amine 5HT receptor 0.0053 0.0516 0.0427
Brugia malayi hypothetical protein 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.004 0.0252 0.0198
Onchocerca volvulus 0.0053 0.0516 0.0953
Echinococcus granulosus Dipeptidyl peptidase 9 0.0276 0.4816 0.4768
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0516 0.0427
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.004 0.0252 0.0331
Echinococcus multilocularis g-protein coupled receptor 0.0053 0.0516 0.0427
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0545 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0053 0.0516 0.0427
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0106 0.152 0.1438
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.028 0.4885 1
Giardia lamblia Cathepsin B precursor 0.018 0.2955 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0105 0.1519 0.1437
Brugia malayi neuropeptide F receptor 0.0053 0.0516 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0213 0.0719
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0295 0.5184 0.5139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0337 0.0247
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0791 0.0705
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0434 0.0341
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0252 0.0158
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Schistosoma mansoni hypothetical protein 0.0044 0.0325 0.0234
Entamoeba histolytica hypothetical protein 0.007 0.0828 0.5141
Loa Loa (eye worm) calpain D 0.0032 0.0096 0.0041
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.004 0.0252 0.0162
Entamoeba histolytica prolyl oligopeptidase family protein 0.004 0.0252 0.1097
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0053 0.0516 0.0463
Trypanosoma brucei cysteine peptidase C (CPC) 0.018 0.2955 0.6056
Brugia malayi TAR-binding protein 0.0068 0.0791 0.0705
Giardia lamblia Cathepsin B precursor 0.018 0.2955 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Brugia malayi sulfakinin receptor protein 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus granulosus acylamino acid releasing enzyme 0.004 0.0252 0.0162
Loa Loa (eye worm) hypothetical protein 0.0038 0.0213 0.0158
Loa Loa (eye worm) G-protein coupled receptor 0.0053 0.0516 0.0463
Trichomonas vaginalis esterase, putative 0.0073 0.0898 0.304
Leishmania major peptidylprolyl isomerase-like protein 0.0106 0.152 0.3016
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0337 0.0247
Schistosoma mansoni Mername-AA248 (C02 family) 0.0105 0.1519 0.144
Brugia malayi beta-lactamase family protein 0.0073 0.0898 0.0813
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0434 0.147
Onchocerca volvulus 0.0053 0.0516 0.0953
Echinococcus multilocularis acylamino acid releasing enzyme 0.004 0.0252 0.0162
Echinococcus granulosus neuropeptide receptor 0.0053 0.0516 0.0427
Trichomonas vaginalis calpain, putative 0.0032 0.0096 0.0326
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0783 0.265
Loa Loa (eye worm) TYRA-2 protein 0.0053 0.0516 0.0463
Brugia malayi calpain D 0.0032 0.0096 0.0004
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0434 0.0716
Brugia malayi Tachykinin-like peptides receptor 99D 0.0053 0.0516 0.0427
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0053 0.0516 0.0427
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0053 0.0516 0.0427
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0898 0.304
Echinococcus multilocularis neuropeptide Y receptor 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.028 0.4878 0.485
Trypanosoma cruzi centrin, putative 0.0036 0.0178 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0337 0.0247
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0898 0.0781
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0898 0.081
Schistosoma mansoni myosin xvIII 0.0053 0.0516 0.0427
Toxoplasma gondii prolyl endopeptidase 0.004 0.0252 0.0546
Trypanosoma brucei prolyl endopeptidase 0.004 0.0252 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0791 0.0705
Trypanosoma brucei protein kinase, putative 0.0049 0.0434 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0096 0.0326
Echinococcus multilocularis neuropeptides capa receptor 0.0053 0.0516 0.0427
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0106 0.152 0.1438
Loa Loa (eye worm) hypothetical protein 0.0045 0.0356 0.0302
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0105 0.1519 0.1437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.1515 0.9964
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0356 0.0266
Echinococcus granulosus g protein coupled receptor 0.0053 0.0516 0.0427
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0468 0.8515 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0898 0.0813
Echinococcus multilocularis neuropeptide receptor 0.0053 0.0516 0.0427
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0053 0.0516 0.0953
Trypanosoma brucei calpain-like protein, putative 0.0105 0.1519 0.3015
Leishmania major oligopeptidase b 0.004 0.0252 0.0331
Leishmania major kinesin, putative 0.0074 0.0908 0.1719
Schistosoma mansoni calpain C (C02 family) 0.0105 0.1519 0.144
Onchocerca volvulus 0.0174 0.2844 0.5773
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0252 0.0854
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0053 0.0516 0.0427
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0434 0.147
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0169 0.2742 0.9254
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0337 0.0247
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0434 0.0345
Echinococcus granulosus tachykinin peptides receptor 99D 0.0053 0.0516 0.0427
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0105 0.1519 0.3015
Schistosoma mansoni neuropeptide receptor 0.0053 0.0516 0.0427
Loa Loa (eye worm) neuropeptide F receptor 0.0053 0.0516 0.0463
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.018 0.2955 1
Echinococcus granulosus tar DNA binding protein 0.0068 0.0791 0.0705
Onchocerca volvulus 0.0053 0.0516 0.0953
Toxoplasma gondii hypothetical protein 0.004 0.0252 0.0546
Plasmodium falciparum peptidase, putative 0.004 0.0252 0.1097
Loa Loa (eye worm) hypothetical protein 0.0073 0.0898 0.0848
Brugia malayi calpain 5 0.0032 0.0096 0.0004
Trypanosoma brucei calpain-like protein, putative 0.0105 0.1519 0.3015
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0106 0.152 1
Trichomonas vaginalis immunophilin, putative 0.0106 0.152 0.5145
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.028 0.4885 0.4837
Echinococcus multilocularis expressed conserved protein 0.0099 0.1392 0.1312
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.0516 0.0427
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.0516 0.0427
Giardia lamblia Cathepsin B precursor 0.018 0.2955 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.1515 0.1436
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0096 0.0326
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Brugia malayi G-protein coupled receptor 0.0053 0.0516 0.0427
Entamoeba histolytica hypothetical protein, conserved 0.004 0.0252 0.1097
Loa Loa (eye worm) FKBP5 protein 0.0106 0.152 0.1473
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0106 0.152 0.1441
Brugia malayi RE15519p 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0248 0.4267 0.4235
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Brugia malayi prolyl oligopeptidase family protein 0.004 0.0252 0.0162
Schistosoma mansoni chromobox protein 0.0067 0.0783 0.0697
Echinococcus granulosus calpain 7 C02 family 0.0105 0.1519 0.144
Brugia malayi Melatonin receptor type 1A 0.0053 0.0516 0.0427
Echinococcus granulosus orexin receptor type 2 0.0053 0.0516 0.0427
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0096 0.0326
Leishmania major fk506-binding protein 1-like protein 0.0106 0.152 0.3016
Schistosoma mansoni chromobox protein 0.0067 0.0783 0.0697
Brugia malayi prolyl oligopeptidase family protein 0.004 0.0252 0.0162
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus multilocularis Niemann Pick C1 protein 0.015 0.2386 0.2315
Schistosoma mansoni neuropeptide receptor 0.0053 0.0516 0.0427
Schistosoma mansoni neuropeptide f receptor 76f 0.0053 0.0516 0.0427
Brugia malayi Dopamine receptor protein 1 0.0053 0.0516 0.0427
Echinococcus multilocularis somatostatin receptor 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0337 0.0247
Schistosoma mansoni calpain-7 (C02 family) 0.0105 0.1519 0.144
Onchocerca volvulus 0.0053 0.0516 0.0953
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0828 0.0743
Echinococcus multilocularis calpain 0.0105 0.1519 0.144
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0053 0.0516 0.0427
Loa Loa (eye worm) RNA binding protein 0.0068 0.0791 0.074
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0783 0.265
Echinococcus granulosus G protein coupled receptor 139 0.0053 0.0516 0.0427
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Schistosoma mansoni biogenic amine (5HT) receptor 0.0053 0.0516 0.0427
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0545 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0898 0.5094
Loa Loa (eye worm) hypothetical protein 0.0073 0.0898 0.0848
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Trypanosoma cruzi kinesin, putative 0.0074 0.0908 0.0819
Echinococcus granulosus neuropeptide Y receptor 0.0053 0.0516 0.0427
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0096 0.0326
Schistosoma mansoni neuropeptide receptor 0.0053 0.0516 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0213 0.0719
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0898 0.304
Brugia malayi RNA binding protein 0.0068 0.0791 0.0705
Echinococcus granulosus allatostatin A receptor 0.0053 0.0516 0.0427
Trypanosoma brucei prolyl oligopeptidase, putative 0.004 0.0252 0.0331
Echinococcus granulosus g-protein coupled receptor 0.0053 0.0516 0.0427
Schistosoma mansoni opsin-like receptor 0.0053 0.0516 0.0427
Schistosoma mansoni immunophilin 0.0106 0.152 0.1441
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0434 0.0345
Onchocerca volvulus 0.0053 0.0516 0.0953
Mycobacterium tuberculosis Conserved protein 0.0073 0.0898 0.0781
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.018 0.2955 0.6056
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus multilocularis chromobox protein 1 0.0067 0.0783 0.0697
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0898 0.0848
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0516 0.0427
Schistosoma mansoni neuropeptide F-like receptor 0.0053 0.0516 0.0427
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0105 0.1519 0.1437
Schistosoma mansoni hypothetical protein 0.0053 0.0516 0.0427
Echinococcus multilocularis calpain 5 0.0105 0.1519 0.144
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0365 0.6529 0.6496
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0365 0.6529 0.6496
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0898 0.5094
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0106 0.152 0.5
Brugia malayi chromobox protein homolog 3 0.0038 0.0213 0.0121
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus multilocularis orexin receptor type 2 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0356 0.1205
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0053 0.0516 0.0463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0106 0.152 1
Brugia malayi G-protein coupled receptor 0.0053 0.0516 0.0427
Echinococcus multilocularis gamma secretase subunit aph 1 0.0241 0.4137 0.4083
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0053 0.0516 0.0427
Echinococcus granulosus prolyl endopeptidase 0.004 0.0252 0.0162
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0106 0.152 0.4691
Brugia malayi hypothetical protein 0.0053 0.0516 0.0427
Echinococcus granulosus sex peptide receptor 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0073 0.0898 0.0848
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.018 0.2955 0.2889
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.028 0.4885 0.4837
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0434 0.0345
Echinococcus granulosus chromobox protein 1 0.0067 0.0783 0.0697
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0516 0.0427
Entamoeba histolytica dipeptidyl-peptidase, putative 0.004 0.0252 0.1097
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0241 0.4137 0.4105
Trypanosoma brucei calpain-like protein, putative 0.0105 0.1519 0.3015
Loa Loa (eye worm) prolyl oligopeptidase 0.028 0.4885 0.4857
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0516 0.0427
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0053 0.0516 0.0427
Echinococcus multilocularis G-protein coupled receptor, putative 0.0053 0.0516 0.0427
Echinococcus granulosus expressed conserved protein 0.0099 0.1392 0.1312
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0129 0.1974 0.1929
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0053 0.0516 0.0427
Mycobacterium leprae Probable lipase LipE 0.0073 0.0898 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0053 0.0516 0.0427
Brugia malayi hypothetical protein 0.0053 0.0516 0.0427
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0898 0.0781
Mycobacterium ulcerans beta-lactamase 0.0073 0.0898 0.5094
Echinococcus multilocularis serotonin receptor 0.0053 0.0516 0.0427
Echinococcus multilocularis protein patched 0.0045 0.0356 0.0266
Schistosoma mansoni amine GPCR 0.0053 0.0516 0.0427
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0053 0.0516 0.0427
Trichomonas vaginalis fk506-binding protein, putative 0.0106 0.152 0.5145
Brugia malayi Serotonin receptor 0.0053 0.0516 0.0427
Entamoeba histolytica protein kinase, putative 0.0074 0.0916 0.5758
Plasmodium vivax calpain, putative 0.0105 0.1519 0.9993
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0276 0.4816 1
Echinococcus granulosus neuropeptide receptor A26 0.0498 0.909 0.9081
Trypanosoma cruzi oligopeptidase b 0.004 0.0252 0.0158
Echinococcus multilocularis fmrfamide receptor 0.0053 0.0516 0.0427
Echinococcus multilocularis allatostatin A receptor 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0053 0.0516 0.0427
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0105 0.1519 0.3015
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0053 0.0516 0.0427
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0106 0.152 0.5145
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus granulosus calpain 0.0105 0.1519 0.144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0337 0.0247
Brugia malayi follicle stimulating hormone receptor 0.0053 0.0516 0.0427
Schistosoma mansoni hypothetical protein 0.0032 0.0096 0.0004
Echinococcus granulosus somatostatin receptor 0.0053 0.0516 0.0427
Echinococcus multilocularis neuropeptide Y receptor 0.0053 0.0516 0.0427
Schistosoma mansoni growth hormone secretagogue receptor 0.0053 0.0516 0.0427
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0106 0.152 1
Brugia malayi calpain 7 0.0105 0.1519 0.144
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0898 0.304
Entamoeba histolytica dipeptidyl-peptidase, putative 0.004 0.0252 0.1097
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0545 1 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0434 0.0345
Echinococcus granulosus calpain 5 0.0105 0.1519 0.144
Trypanosoma cruzi Aph-1 protein, putative 0.0094 0.1298 0.1213
Schistosoma mansoni hypothetical protein 0.0053 0.0516 0.0427
Brugia malayi beta-lactamase family protein 0.0073 0.0898 0.0813
Brugia malayi calpain family protein 1 0.028 0.4878 0.4831
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.004 0.0252 0.0331
Brugia malayi Dopamine receptor 0.0053 0.0516 0.0427
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0516 0.0427
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.018 0.2955 0.2886
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0516 0.0427
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0898 0.0781
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0053 0.0516 0.0427
Onchocerca volvulus Prolyl endopeptidase homolog 0.004 0.0252 0.0408
Echinococcus multilocularis fk506 binding protein 0.0106 0.152 0.1441
Brugia malayi hypothetical protein 0.0053 0.0516 0.0427
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.028 0.4885 0.4837
Echinococcus multilocularis neuropeptide receptor 0.0053 0.0516 0.0427
Trypanosoma cruzi centrin, putative 0.0036 0.0178 0.0082
Echinococcus multilocularis protein dispatched 1 0.0052 0.0479 0.039
Echinococcus granulosus chromobox protein 1 0.0067 0.0783 0.0697
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus granulosus neuropeptides capa receptor 0.0053 0.0516 0.0427
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0105 0.1519 0.1437
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0828 0.0743
Brugia malayi prolyl oligopeptidase family protein 0.028 0.4885 0.4837
Echinococcus granulosus cathepsin b 0.0545 1 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0105 0.1519 0.1437
Echinococcus granulosus programmed cell death protein 0.0036 0.0178 0.0086
Echinococcus granulosus Niemann Pick C1 protein 0.015 0.2386 0.2315
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Entamoeba histolytica hypothetical protein 0.007 0.0828 0.5141
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0898 0.304
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0092 0.0037
Echinococcus multilocularis neuropeptide s receptor 0.0498 0.909 0.9081
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0898 0.0781
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0106 0.152 0.1441
Schistosoma mansoni amine GPCR 0.0053 0.0516 0.0427
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0516 0.0427
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0356 0.0266
Schistosoma mansoni amine GPCR 0.0053 0.0516 0.0427
Entamoeba histolytica calpain large subunit domain III containing protein 0.0074 0.0908 0.5698
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.004 0.0252 0.0162
Echinococcus granulosus dro:myosuppressin receptor 0.0053 0.0516 0.0427
Schistosoma mansoni hypothetical protein 0.0175 0.2868 0.2802
Trypanosoma brucei centrin-3 0.0036 0.0178 0.0172
Trichomonas vaginalis calpain, putative 0.0032 0.0096 0.0326
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0105 0.1519 0.1437
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.004 0.0252 0.0162
Brugia malayi calpain family protein 1 0.028 0.4878 0.4831
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.0516 0.0427
Trypanosoma brucei kinesin, putative 0.0074 0.0908 0.1719
Loa Loa (eye worm) cathepsin B 0.018 0.2955 0.2916
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0791 0.0705
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0053 0.0516 0.0427
Echinococcus granulosus calpain A 0.0295 0.5184 0.5139
Trichomonas vaginalis hypothetical protein 0.0032 0.0096 0.0326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0516 0.0427
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.004 0.0252 0.0158
Echinococcus granulosus alpha 1A adrenergic receptor 0.0053 0.0516 0.0427
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0106 0.152 1
Onchocerca volvulus 0.0053 0.0516 0.0953
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.028 0.4878 0.4831
Onchocerca volvulus 0.0053 0.0516 0.0953
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Brugia malayi GnHR receptor homolog 0.0053 0.0516 0.0427
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0545 1 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0898 0.0781
Schistosoma mansoni hypothetical protein 0.0053 0.0516 0.0427
Echinococcus multilocularis cathepsin b 0.0545 1 1
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0434 0.0345
Mycobacterium ulcerans lipase LipD 0.0073 0.0898 0.5094
Onchocerca volvulus 0.0053 0.0516 0.0953
Brugia malayi hypothetical protein 0.0053 0.0516 0.0427
Brugia malayi CHE-14 protein 0.0045 0.0356 0.0266
Schistosoma mansoni biogenic amine receptor 0.0053 0.0516 0.0427
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0276 0.4816 0.4766
Onchocerca volvulus 0.0053 0.0516 0.0953
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0268 0.0906
Loa Loa (eye worm) calpain family protein 1 0.0206 0.3455 0.3419
Echinococcus multilocularis neuropeptide receptor A26 0.0498 0.909 0.9081
Onchocerca volvulus 0.0053 0.0516 0.0953
Brugia malayi Serotonin receptor 0.0053 0.0516 0.0427
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0091 0.124 0.1158
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0434 0.0716
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0053 0.0516 0.0427
Echinococcus granulosus biogenic amine 5HT receptor 0.0053 0.0516 0.0427
Schistosoma mansoni histamine h1 receptor 0.0053 0.0516 0.0427
Brugia malayi hypothetical protein 0.0053 0.0516 0.0427
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0791 0.074
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0434 0.0341
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0106 0.152 0.1441
Echinococcus multilocularis cathepsin b 0.0545 1 1
Entamoeba histolytica grainin 2 0.0036 0.0178 0.0572
Echinococcus granulosus neuropeptide Y receptor 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0516 0.0427
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0356 0.0302
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0516 0.0427
Schistosoma mansoni calpain-2 (C02 family) 0.0032 0.0096 0.0004
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0898 0.0781
Echinococcus granulosus calpain A 0.0105 0.1519 0.144
Entamoeba histolytica hypothetical protein 0.007 0.0828 0.5141
Echinococcus multilocularis fmrfamide receptor 0.0053 0.0516 0.0427
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0053 0.0516 0.0427
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Schistosoma mansoni patched 1 0.0045 0.0356 0.0266
Echinococcus multilocularis programmed cell death protein 0.0036 0.0178 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0898 0.5094
Brugia malayi prolyl oligopeptidase family protein 0.004 0.0252 0.0162
Echinococcus multilocularis chromobox protein 1 0.0067 0.0783 0.0697
Leishmania major hypothetical protein, conserved 0.0073 0.0898 0.1699
Echinococcus granulosus 7TM GPCR rhodopsin 0.0053 0.0516 0.0427
Onchocerca volvulus 0.0053 0.0516 0.0953
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Trypanosoma cruzi oligopeptidase b 0.004 0.0252 0.0158
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0096 0.0326
Mycobacterium tuberculosis Conserved protein 0.0073 0.0898 0.0781
Loa Loa (eye worm) hypothetical protein 0.0073 0.0898 0.0848
Echinococcus multilocularis dro:myosuppressin receptor 0.0053 0.0516 0.0427
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.004 0.0252 0.0854
Toxoplasma gondii ABC1 family protein 0.0073 0.0898 0.2805
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0337 0.0247
Brugia malayi hypothetical protein 0.0129 0.1974 0.1899
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0463
Onchocerca volvulus 0.0073 0.0898 0.1745
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0105 0.1519 0.1437

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1000 nM Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus ChEMBL. 17822897
Ki (binding) = 1000 nM Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus ChEMBL. 17822897

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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