TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 449.486 | Formula: C23H22F3NO3S
H donors: 0 H acceptors: 3 LogP: 3.97 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CCC2(C(=C1)CCN(C2)S(=O)(=O)c1ccccc1C(F)(F)F)Cc1ccccc1
InChi: 1S/C23H22F3NO3S/c24-23(25,26)20-8-4-5-9-21(20)31(29,30)27-13-11-18-14-19(28)10-12-22(18,16-27)15-17-6-2-1-3-7-17/h1-9,14H,10-13,15-16H2
InChiKey: TYWKLNWWKKALNZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0381	0.0341
Echinococcus granulosus	G protein coupled receptor 139	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus multilocularis	calpain 7 (C02 family)	0.0106	0.1472	0.144
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0051	0.0399	0.0363
Trypanosoma brucei	caltractin, putative	0.0036	0.0123	0.0285
Schistosoma mansoni	neuropeptide F-like receptor	0.0051	0.0399	0.0363
Echinococcus multilocularis	expressed conserved protein	0.01	0.1345	0.1312
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Onchocerca volvulus		0.0051	0.0399	0.1424
Echinococcus multilocularis	cathepsin b	0.0549	1	1
Echinococcus granulosus	g-protein coupled receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0399	0.0363
Brugia malayi	sulfakinin receptor protein	0.0051	0.0399	0.0363
Toxoplasma gondii	ABC1 family protein	0.0074	0.0848	0.2806
Echinococcus granulosus	Protein patched homolog 1	0.0046	0.0303	0.0266
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0399	0.0363
Onchocerca volvulus		0.0051	0.0399	0.1424
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0106	0.1473	0.4982
Echinococcus multilocularis	neuropeptide Y receptor	0.0051	0.0399	0.0363
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0106	0.1473	0.1441
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0283	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0037	0.0037
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0399	0.0363
Brugia malayi	larval opioid receptor	0.0051	0.0399	0.0363
Leishmania major	peptidylprolyl isomerase-like protein	0.0106	0.1473	0.4982
Echinococcus granulosus	hypothetical protein	0.0051	0.0399	0.0363
Schistosoma mansoni	hypothetical protein	0.0069	0.0747	0.0712
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Onchocerca volvulus		0.0074	0.0848	0.3024
Brugia malayi	Dopamine receptor	0.0051	0.0399	0.0363
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0381	0.0341
Entamoeba histolytica	hypothetical protein	0.007	0.0777	0.514
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0399	0.0363
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0106	0.1473	1
Echinococcus granulosus	allatostatin A receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0051	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Schistosoma mansoni	immunophilin	0.0106	0.1473	0.1441
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0106	0.1473	0.1441
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.007	0.0777	0.0743
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0106	0.1472	0.1437
Loa Loa (eye worm)	hypothetical protein	0.0056	0.05	0.05
Brugia malayi	RE15519p	0.0051	0.0399	0.0363
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0399	0.0363
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0092	0.1192	0.1159
Echinococcus multilocularis	hypothetical protein	0.0106	0.1472	0.144
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0848	0.081
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0106	0.1473	0.1438
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0051	0.0399	0.0363
Trypanosoma brucei	centrin-3	0.0036	0.0123	0.0285
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0039	0.0174	0.0137
Schistosoma mansoni	immunophilin	0.0106	0.1473	0.1441
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Echinococcus granulosus	laminin	0.0039	0.0174	0.0137
Schistosoma mansoni	hypothetical protein	0.0051	0.0399	0.0363
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0106	0.1473	1
Trypanosoma brucei	calpain-like protein, putative	0.0106	0.1472	0.4978
Echinococcus multilocularis	neuropeptides capa receptor	0.0051	0.0399	0.0363
Giardia lamblia	Cathepsin B precursor	0.0181	0.2916	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0106	0.1468	0.9965
Schistosoma mansoni	patched 1	0.0046	0.0303	0.0266
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0051	0.0399	0.1424
Brugia malayi	gamma-secretase subunit aph-1	0.0243	0.4104	0.4081
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0106	0.1472	0.1437
Brugia malayi	neuropeptide F receptor	0.0051	0.0399	0.0363
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0848	0.2806
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Schistosoma mansoni	calpain C (C02 family)	0.0106	0.1472	0.144
Trichomonas vaginalis	immunophilin, putative	0.0106	0.1473	0.4982
Echinococcus multilocularis	serotonin receptor	0.0051	0.0399	0.0363
Echinococcus granulosus	geminin	0.0177	0.283	0.2803
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.1358	0.1326
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0243	0.4104	0.4104
Brugia malayi	hypothetical protein	0.0051	0.0399	0.0363
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0283	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus multilocularis	somatostatin receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	beta-lactamase	0.0074	0.0848	0.0848
Loa Loa (eye worm)	hypothetical protein	0.025	0.4235	0.4235
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0174	0.0174
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	opsin-like receptor	0.0051	0.0399	0.0363
Echinococcus granulosus	sterol regulatory element binding protein	0.0046	0.0303	0.0266
Echinococcus granulosus	7TM GPCR rhodopsin	0.0051	0.0399	0.0363
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0106	0.1473	0.4982
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0381	0.0345
Mycobacterium leprae	Probable lipase LipE	0.0074	0.0848	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0051	0.0399	0.0363
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0181	0.2916	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0499	0.9021	0.9018
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0106	0.1473	1
Trypanosoma brucei	protein kinase, putative	0.005	0.0381	0.1183
Echinococcus granulosus	calpain A	0.0106	0.1472	0.144
Schistosoma mansoni	chromobox protein	0.0068	0.0732	0.0697
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0051	0.0399	0.0363
Brugia malayi	RNA binding protein	0.0068	0.074	0.0705
Brugia malayi	beta-lactamase family protein	0.0074	0.0848	0.0813
Schistosoma mansoni	egf-like domain protein	0.0039	0.0174	0.0137
Brugia malayi	ORL1-like opioid receptor	0.0051	0.0399	0.0363
Echinococcus granulosus	calpain A	0.0298	0.5157	0.5139
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0298	0.5157	0.5139
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0092	0.1192	0.1159
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0381	0.1183
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0106	0.1473	0.4309
Brugia malayi	Heterochromatin protein 1	0.0068	0.0732	0.0697
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0399	0.0363
Schistosoma mansoni	adenoreceptor	0.0051	0.0399	0.0363
Schistosoma mansoni	hypothetical protein	0.0044	0.0271	0.0234
Schistosoma mansoni	hypothetical protein	0.0051	0.0399	0.0363
Brugia malayi	calpain 5	0.0074	0.0857	0.0823
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Echinococcus multilocularis	fk506 binding protein	0.0106	0.1473	0.1441
Entamoeba histolytica	hypothetical protein	0.007	0.0777	0.514
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0381	0.1183
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0074	0.0857	0.5697
Schistosoma mansoni	amine GPCR	0.0051	0.0399	0.0363
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0106	0.1472	0.1437
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0381	0.0345
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0051	0.0399	0.0363
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0106	0.1473	0.1441
Schistosoma mansoni	transcription factor LCR-F1	0.007	0.0777	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0174	0.0174
Brugia malayi	putative neuropeptide receptor	0.0051	0.0399	0.0363
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Trichomonas vaginalis	fk506-binding protein, putative	0.0106	0.1473	0.4982
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0051	0.0399	0.0363
Onchocerca volvulus		0.0176	0.2804	1
Entamoeba histolytica	protein kinase, putative	0.0075	0.0866	0.5757
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0549	1	1
Plasmodium vivax	calpain, putative	0.0106	0.1472	0.998
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0051	0.0399	0.0399
Onchocerca volvulus		0.0051	0.0399	0.1424
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0732	0.0697
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0283	0.0247
Onchocerca volvulus		0.0051	0.0399	0.1424
Onchocerca volvulus		0.0051	0.0399	0.1424
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0848	0.0813
Loa Loa (eye worm)	calpain family protein 1	0.0207	0.3419	0.3419
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0848	0.081
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0106	0.1473	0.1441
Brugia malayi	AKH receptor	0.0051	0.0399	0.0363
Trypanosoma cruzi	Aph-1 protein, putative	0.0095	0.1249	0.1213
Echinococcus granulosus	calpain 7 C02 family	0.0106	0.1472	0.144
Brugia malayi	beta-lactamase family protein	0.0074	0.0848	0.0813
Brugia malayi	hypothetical protein	0.0051	0.0399	0.0363
Echinococcus multilocularis	calpain family protein 1, d	0.0207	0.3419	0.3394
Echinococcus granulosus	chromobox protein 1	0.0068	0.0732	0.0697
Echinococcus multilocularis	neuropeptide s receptor	0.0499	0.9021	0.9018
Leishmania major	fk506-binding protein 1-like protein	0.0106	0.1473	0.4982
Echinococcus multilocularis	protein patched	0.0046	0.0303	0.0266
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0174	0.0174
Schistosoma mansoni	amine GPCR	0.0051	0.0399	0.0363
Brugia malayi	neuropeptide F receptor	0.0051	0.0399	0.0363
Echinococcus granulosus	neuropeptide Y receptor	0.0051	0.0399	0.0363
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0106	0.1472	0.1437
Schistosoma mansoni	opsin-like receptor	0.0051	0.0399	0.0363
Trypanosoma cruzi	kinesin, putative	0.0074	0.0857	0.0819
Brugia malayi	hypothetical protein	0.007	0.0777	0.0743
Brugia malayi	G-protein coupled receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.1358	0.1326
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0051	0.0399	0.0363
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0106	0.1473	0.1438
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0381	0.1183
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Trypanosoma brucei	calpain-like protein, putative	0.0106	0.1472	0.4978
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0158	0.0158
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0051	0.0399	0.0363
Brugia malayi	GnHR receptor homolog	0.0051	0.0399	0.0363
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0106	0.1472	0.1437
Echinococcus granulosus	neuropeptide FF receptor 2	0.0051	0.0399	0.0363
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0381	0.0345
Schistosoma mansoni	hypothetical protein	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0207	0.3419	0.3419
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0041	0.0041
Echinococcus granulosus	cathepsin b	0.0549	1	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0106	0.1468	0.1436
Schistosoma mansoni	hypothetical protein	0.0044	0.0271	0.0234
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0732	0.2403
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0381	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0848	0.0848
Echinococcus granulosus	gamma secretase subunit aph 1	0.0243	0.4104	0.4081
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0108	0.15	0.1468
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0283	0.0283
Echinococcus granulosus	neuropeptide Y receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	chromobox protein	0.0068	0.0732	0.0697
Onchocerca volvulus		0.0074	0.0848	0.3024
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus granulosus	expressed conserved protein	0.01	0.1345	0.1312
Echinococcus multilocularis	fmrfamide receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0399	0.0363
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0158	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.074	0.0705
Echinococcus granulosus	dro:myosuppressin receptor	0.0051	0.0399	0.0363
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0051	0.0399	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0549	1	1
Echinococcus multilocularis	fibrillin 1	0.0039	0.0174	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1468	0.1468
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0051	0.0399	0.0399
Echinococcus multilocularis	serotonin receptor	0.0051	0.0399	0.0363
Brugia malayi	Serotonin receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0039	0.0174	0.0174
Echinococcus granulosus	sex peptide receptor	0.0051	0.0399	0.0363
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0732	0.0697
Onchocerca volvulus		0.0051	0.0399	0.1424
Schistosoma mansoni	hypothetical protein	0.0032	0.0041	0.0004
Entamoeba histolytica	hypothetical protein	0.007	0.0777	0.514
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0747	0.0712
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0106	0.1473	0.1441
Trypanosoma cruzi	centrin, putative	0.0036	0.0123	0.0082
Leishmania major	hypothetical protein, conserved	0.0074	0.0848	0.2806
Schistosoma mansoni	immunophilin	0.0092	0.1192	0.1159
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0051	0.0399	0.0363
Onchocerca volvulus		0.0051	0.0399	0.1424
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0051	0.0399	0.0363
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.074	0.0705
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0399	0.0363
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0399	0.0363
Onchocerca volvulus		0.0051	0.0399	0.1424
Echinococcus multilocularis	calpain A	0.0298	0.5157	0.5139
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0381	0.0381
Echinococcus granulosus	orexin receptor type 2	0.0051	0.0399	0.0363
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0106	0.1473	0.4982
Echinococcus granulosus	neuropeptides capa receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	calpain-2 (C02 family)	0.0032	0.0041	0.0004
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0399	0.0363
Giardia lamblia	Cathepsin B precursor	0.0181	0.2916	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0152	0.2345	0.2316
Echinococcus granulosus	neuropeptide s receptor	0.0499	0.9021	0.9018
Schistosoma mansoni	growth hormone secretagogue receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0283	0.0247
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0848	0.0813
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0399	0.0363
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0214	0.06
Brugia malayi	hypothetical protein	0.0051	0.0399	0.0363
Brugia malayi	putative neuropeptide receptor NPR1	0.0051	0.0399	0.0363
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0243	0.4104	0.4081
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0051	0.0399	0.0363
Echinococcus granulosus	cathepsin b	0.0549	1	1
Brugia malayi	Serotonin receptor	0.0051	0.0399	0.0363
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.074	0.0705
Echinococcus granulosus	neuropeptides capa receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.074	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0174	0.0174
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0549	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0158	0.0407
Loa Loa (eye worm)	G-protein coupled receptor	0.0051	0.0399	0.0399
Echinococcus multilocularis	sterol regulatory element binding protein	0.0046	0.0303	0.0266
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0106	0.1473	0.1438
Entamoeba histolytica	grainin 2	0.0036	0.0123	0.0572
Brugia malayi	hypothetical protein	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Onchocerca volvulus		0.0051	0.0399	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0051	0.0399	0.0399
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0381	0.1183
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	neuropeptide F-like receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0848	0.0848
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0214	0.0762
Schistosoma mansoni	calpain-7 (C02 family)	0.0106	0.1472	0.144
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Loa Loa (eye worm)	TYRA-2 protein	0.0051	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0399	0.0363
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0399	0.0363
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.007	0.0777	0.0743
Brugia malayi	calpain family protein 1	0.0282	0.485	0.4831
Schistosoma mansoni	neuropeptide f receptor 76f	0.0051	0.0399	0.0363
Toxoplasma gondii	cathepsin B	0.0181	0.2916	1
Brugia malayi	calpain family protein 1	0.0282	0.485	0.4831
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus multilocularis	geminin	0.0177	0.283	0.2803
Schistosoma mansoni	calpain (C02 family)	0.0106	0.1472	0.144
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0549	1	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus multilocularis	laminin	0.0039	0.0174	0.0137
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0039	0.0174	0.0462
Schistosoma mansoni	hypothetical protein	0.0177	0.283	0.2803
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0298	0.5157	0.5139
Brugia malayi	TAR-binding protein	0.0068	0.074	0.0705
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.1358	0.1358
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0381	0.0345
Mycobacterium leprae	conserved hypothetical protein	0.0074	0.0848	0.5
Brugia malayi	Niemann-Pick C1 protein precursor	0.0106	0.1468	0.1436
Echinococcus multilocularis	sex peptide receptor	0.0051	0.0399	0.0363
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0106	0.1472	0.4978
Trypanosoma brucei	hypothetical protein, conserved	0.0074	0.0848	0.2806
Echinococcus multilocularis	calpain 5	0.0106	0.1472	0.144
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0399	0.0363
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0106	0.1472	0.1437
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Echinococcus multilocularis	neuropeptide receptor	0.0051	0.0399	0.0363
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0848	0.2806
Brugia malayi	G protein-coupled receptor F59B2.13	0.0051	0.0399	0.0363
Onchocerca volvulus		0.0074	0.0848	0.3024
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0283	0.0247
Brugia malayi	Melatonin receptor type 1A	0.0051	0.0399	0.0363
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0106	0.1472	0.1437
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0051	0.0399	0.0363
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0399	0.0363
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0106	0.1473	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0051	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Schistosoma mansoni	amine GPCR	0.0051	0.0399	0.0363
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0181	0.2916	1
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0106	0.1472	0.144
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0046	0.0303	0.0303
Brugia malayi	calpain 5	0.0032	0.0041	0.0004
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0549	1	1
Schistosoma mansoni	opsin-like receptor	0.0051	0.0399	0.0363
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0074	0.0848	0.0813
Schistosoma mansoni	myosin xvIII	0.0051	0.0399	0.0363
Brugia malayi	CHE-14 protein	0.0046	0.0303	0.0266
Echinococcus granulosus	serotonin receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.0732	0.0732
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Brugia malayi	calpain 7	0.0106	0.1472	0.144
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.074	0.074
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0282	0.485	0.485
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.074	0.074
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0051	0.0399	0.0363
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0106	0.1472	0.4978
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0283	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0747	0.0747
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.074	0.0705
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0298	0.5157	0.5139
Trypanosoma cruzi	Aph-1 protein, putative	0.0095	0.1249	0.1213
Echinococcus granulosus	tar DNA binding protein	0.0068	0.074	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus multilocularis	neuropeptide receptor	0.0051	0.0399	0.0363
Echinococcus multilocularis	dro:myosuppressin receptor	0.0051	0.0399	0.0363
Leishmania major	kinesin, putative	0.0074	0.0857	0.2838
Brugia malayi	hypothetical protein	0.0051	0.0399	0.0363
Brugia malayi	G-protein coupled receptor	0.0051	0.0399	0.0363
Brugia malayi	hypothetical protein	0.0051	0.0399	0.0363
Brugia malayi	chromobox protein homolog 3	0.0038	0.0158	0.0121
Echinococcus granulosus	neuropeptide receptor	0.0051	0.0399	0.0363
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0051	0.0399	0.0363
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0848	0.2806
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0181	0.2916	1
Loa Loa (eye worm)	cathepsin B	0.0181	0.2916	0.2916
Trypanosoma cruzi	centrin-3	0.0036	0.0123	0.0082
Echinococcus multilocularis	Niemann Pick C1 protein	0.0152	0.2345	0.2316
Trypanosoma brucei	calpain-like protein, putative	0.0106	0.1472	0.4978
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.074	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Trichomonas vaginalis	esterase, putative	0.0074	0.0848	0.2806
Loa Loa (eye worm)	RNA binding protein	0.0068	0.074	0.074
Loa Loa (eye worm)	hypothetical protein	0.01	0.1358	0.1358
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0399	0.0363
Trypanosoma brucei	Aph-1 protein, putative	0.0095	0.1249	0.4201
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0381	0.1183
Echinococcus granulosus	biogenic amine 5HT receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0848	0.0848
Schistosoma mansoni	calpain-7 (C02 family)	0.0106	0.1472	0.144
Trichomonas vaginalis	calcium binding protein, putative	0.0036	0.0123	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus multilocularis	programmed cell death protein	0.0036	0.0123	0.0086
Echinococcus granulosus	beta LACTamase domain containing family member	0.0074	0.0848	0.0813
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Echinococcus multilocularis	g-protein coupled receptor	0.0051	0.0399	0.0363
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0381	0.0341
Echinococcus granulosus	somatostatin receptor	0.0051	0.0399	0.0363
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0399	0.0363
Echinococcus granulosus	neuropeptide receptor A26	0.0499	0.9021	0.9018
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.074	0.0705
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0074	0.0848	0.0848
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0848	0.0848
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0106	0.1473	0.4982
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0303	0.0303
Schistosoma mansoni	hypothetical protein	0.007	0.0777	0.0743
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0106	0.1473	1
Brugia malayi	Fibulin-1 precursor	0.0039	0.0174	0.0137
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0298	0.5157	0.5139
Trypanosoma brucei	calpain-like protein, putative	0.0106	0.1472	0.4978
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0106	0.1473	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0848	0.2806
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0381	0.1183
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	amine GPCR	0.0051	0.0399	0.0363
Trypanosoma cruzi	centrin, putative	0.0036	0.0123	0.0082
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0283	0.0247
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0106	0.1472	0.4978
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0051	0.0399	0.0363
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0106	0.1472	0.4978
Brugia malayi	Dopamine receptor protein 1	0.0051	0.0399	0.0363
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	hypothetical protein	0.0177	0.283	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0051	0.0399	0.0363
Onchocerca volvulus	Arrow homolog	0.0039	0.0174	0.0621
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0106	0.1472	0.1437
Loa Loa (eye worm)	calpain D	0.0032	0.0041	0.0041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Echinococcus granulosus	neuropeptide receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0214	0.06
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0181	0.2916	0.2886
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0106	0.1473	0.1438
Loa Loa (eye worm)	G-protein coupled receptor	0.0051	0.0399	0.0399
Echinococcus multilocularis	cathepsin b	0.0549	1	1
Brugia malayi	hypothetical protein	0.0051	0.0399	0.0363
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0051	0.0399	0.0363
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0106	0.1473	0.4309
Echinococcus multilocularis	fmrfamide receptor	0.0051	0.0399	0.0363
Brugia malayi	follicle stimulating hormone receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0039	0.0174	0.0174
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0074	0.0848	0.0813
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0106	0.1472	0.1437
Onchocerca volvulus		0.0051	0.0399	0.1424
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0381	0.1183
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0051	0.0399	0.0363
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0106	0.1472	0.1437
Echinococcus multilocularis	neuropeptide Y receptor	0.0051	0.0399	0.0363
Echinococcus multilocularis	Tolloid protein 1	0.0039	0.0174	0.0137
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0381	0.0345
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0051	0.0399	0.0363
Brugia malayi	hypothetical protein	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1192	0.1192
Echinococcus granulosus	Tolloid protein 1	0.0039	0.0174	0.0137
Brugia malayi	beta-lactamase	0.0074	0.0848	0.0813
Onchocerca volvulus		0.0051	0.0399	0.1424
Schistosoma mansoni	histamine h1 receptor	0.0051	0.0399	0.0363
Echinococcus multilocularis	allatostatin A receptor	0.0051	0.0399	0.0363
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0283	0.0247
Onchocerca volvulus		0.0051	0.0399	0.1424
Echinococcus granulosus	calpain	0.0106	0.1472	0.144
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Trypanosoma brucei	kinesin, putative	0.0074	0.0857	0.2838
Brugia malayi	hypothetical protein	0.0051	0.0399	0.0363
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0381	0.1183
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0051	0.0399	0.0363
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0039	0.0174	0.0462
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0051	0.0399	0.0363
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0848	0.2806
Brugia malayi	Dopamine receptor protein 2	0.0051	0.0399	0.0363
Brugia malayi	G protein-coupled receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0051	0.0399	0.0363
Echinococcus multilocularis	G protein coupled receptor 139	0.0051	0.0399	0.0363
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0399	0.0363
Echinococcus multilocularis	neuropeptides capa receptor	0.0051	0.0399	0.0363
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus granulosus	chromobox protein 1	0.0068	0.0732	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2804	0.2804
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0848	0.0848
Onchocerca volvulus		0.0051	0.0399	0.1424
Schistosoma mansoni	amine GPCR	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Schistosoma mansoni	hypothetical protein	0.0044	0.0271	0.0234
Schistosoma mansoni	hypothetical protein	0.0051	0.0399	0.0363
Echinococcus granulosus	biogenic amine 5HT receptor	0.0051	0.0399	0.0363
Entamoeba histolytica	hypothetical protein	0.007	0.0777	0.514
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0399	0.0363
Onchocerca volvulus		0.0051	0.0399	0.1424
Trypanosoma cruzi	kinesin, putative	0.0074	0.0857	0.0819
Loa Loa (eye worm)	calpain	0.0106	0.1472	0.1472
Onchocerca volvulus		0.0051	0.0399	0.1424
Echinococcus granulosus	calpain 5	0.0106	0.1472	0.144
Echinococcus multilocularis	programmed cell death protein	0.0036	0.0123	0.0086
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0732	0.2403
Brugia malayi	Calcium binding EGF domain containing protein	0.0039	0.0174	0.0137
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0051	0.0399	0.0363
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0106	0.1473	0.1441
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0848	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0174	0.0174
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0039	0.0174	0.0174
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0051	0.0399	0.0363
Loa Loa (eye worm)	FKBP5 protein	0.0106	0.1473	0.1473
Echinococcus granulosus	fmrfamide receptor	0.0051	0.0399	0.0363
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0472	0.8509	1
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0243	0.4104	0.4081
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0051	0.0399	0.0363
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0158	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus granulosus	7tm_1 domain containing protein	0.0051	0.0399	0.0363
Echinococcus multilocularis	protein dispatched 1	0.0052	0.0426	0.039
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0039	0.0174	0.0137
Loa Loa (eye worm)	calpain family protein 1	0.0282	0.485	0.485
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0106	0.1473	0.1473
Loa Loa (eye worm)	calpain 5	0.0074	0.0857	0.0857
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0051	0.0399	0.0399
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0282	0.485	0.4831
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Trichomonas vaginalis	calmodulin, putative	0.0036	0.0123	0.0285
Schistosoma mansoni	hypothetical protein	0.0044	0.0271	0.0234
Loa Loa (eye worm)	melatonin receptor type 1A	0.0051	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Trypanosoma brucei	antigen, putative	0.0106	0.1472	0.4978
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0051	0.0399	0.0363
Brugia malayi	MAP kinase sur-1	0.005	0.0381	0.0345
Giardia lamblia	Cathepsin B precursor	0.0181	0.2916	1
Brugia malayi	calpain D	0.0032	0.0041	0.0004
Loa Loa (eye worm)	neuropeptide F receptor	0.0051	0.0399	0.0399
Brugia malayi	hypothetical protein	0.0051	0.0399	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0399	0.0363
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0303	0.0909
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.2916	0.2889
Echinococcus multilocularis	orexin receptor type 2	0.0051	0.0399	0.0363
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0106	0.1472	0.4978
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0051	0.0399	0.0363
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0549	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0051	0.0399	0.0363
Echinococcus multilocularis	calpain	0.0106	0.1472	0.144
Onchocerca volvulus		0.0051	0.0399	0.1424
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0051	0.0399	0.0363
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0399	0.0363
Echinococcus granulosus	Niemann Pick C1 protein	0.0106	0.1468	0.1436
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0051	0.0399	0.0363
Onchocerca volvulus		0.0051	0.0399	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399
Echinococcus granulosus	programmed cell death protein	0.0036	0.0123	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0399	0.0399

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 4450 nM	Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus	ChEMBL.	17822897
Ki (binding)	= 4450 nM	Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus	ChEMBL.	17822897

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 460324