Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Muscarinic acetylcholine receptor M3 | Starlite/ChEMBL | References |
Rattus norvegicus | Muscarinic acetylcholine receptor M2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0091 | 0.0359 |
Schistosoma mansoni | ets-related | 0.0163 | 0.0668 | 0.1779 |
Onchocerca volvulus | 0.0329 | 0.1574 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0491 | 0.1309 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1574 | 0.6198 |
Leishmania major | hypothetical protein, conserved | 0.0058 | 0.0091 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0044 | 0.0013 | 0.0043 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0058 | 0.0091 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0054 | 0.0069 | 0.0354 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0091 | 0.0243 |
Schistosoma mansoni | gabp alpha | 0.0054 | 0.0069 | 0.0182 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0728 | 0.3755 | 0.5 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0728 | 0.3755 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0044 | 0.0013 | 0.0035 |
Loa Loa (eye worm) | fli-1 protein | 0.0163 | 0.0668 | 0.2629 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.187 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0131 | 0.0491 | 0.1601 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.254 | 1 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0054 | 0.0069 | 0.1156 |
Schistosoma mansoni | jumonji domain containing protein | 0.0044 | 0.0013 | 0.0035 |
Brugia malayi | hypothetical protein | 0.0329 | 0.1574 | 1 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1142 | 0.602 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0044 | 0.0013 | 0.0052 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0058 | 0.0091 | 0.0297 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0058 | 0.0091 | 0.0359 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0026 | 0.0102 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0054 | 0.0069 | 0.027 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.187 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0058 | 0.0091 | 0.5 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1142 | 0.602 | 0.3627 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0491 | 0.1309 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.187 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0044 | 0.0013 | 0.0035 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0058 | 0.0091 | 0.1633 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0058 | 0.0091 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1142 | 0.602 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0044 | 0.0013 | 0.0043 |
Brugia malayi | Kringle domain containing protein | 0.0058 | 0.0091 | 0.05 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1142 | 0.602 | 0.3627 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0603 | 0.307 | 1 |
Brugia malayi | Fli-1 protein | 0.0163 | 0.0668 | 0.4193 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0728 | 0.3755 | 1 |
Echinococcus granulosus | geminin | 0.0131 | 0.0491 | 1 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0054 | 0.0069 | 0.0223 |
Brugia malayi | Ets-domain containing protein | 0.0054 | 0.0069 | 0.0354 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.0091 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1574 | 0.6198 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.254 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 20 nM | Displacement of [3H]N-methylscopolamine from muscarinic M3 receptor in rat submandibular gland | ChEMBL. | 17629699 |
Ki (binding) | = 20 nM | Displacement of [3H]N-methylscopolamine from muscarinic M3 receptor in rat submandibular gland | ChEMBL. | 17629699 |
Ki (binding) | = 277 nM | Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart | ChEMBL. | 17629699 |
Ki (binding) | = 277 nM | Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart | ChEMBL. | 17629699 |
Ratio Ki (binding) | = 14 | Selectivity for rat muscarinic M3 receptor over rat muscarinic M2 receptor | ChEMBL. | 17629699 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.