Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Muscarinic acetylcholine receptor M3 | Starlite/ChEMBL | References |
Rattus norvegicus | Muscarinic acetylcholine receptor M2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1142 | 0.602 | 0.5 |
Brugia malayi | hypothetical protein | 0.0329 | 0.1574 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0044 | 0.0013 | 0.0035 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0054 | 0.0069 | 0.1156 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0058 | 0.0091 | 0.0297 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0058 | 0.0091 | 0.0359 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0044 | 0.0013 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0026 | 0.0102 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0044 | 0.0013 | 0.0035 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0728 | 0.3755 | 0.5 |
Loa Loa (eye worm) | fli-1 protein | 0.0163 | 0.0668 | 0.2629 |
Schistosoma mansoni | gabp alpha | 0.0054 | 0.0069 | 0.0182 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0728 | 0.3755 | 0.5 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.187 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0131 | 0.0491 | 0.1601 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.254 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0058 | 0.0091 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0091 | 0.0243 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0058 | 0.0091 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0044 | 0.0013 | 0.0043 |
Brugia malayi | Ets-domain containing protein | 0.0054 | 0.0069 | 0.0354 |
Schistosoma mansoni | ets-related | 0.0163 | 0.0668 | 0.1779 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0091 | 0.0359 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1574 | 0.6198 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0491 | 0.1309 |
Onchocerca volvulus | 0.0329 | 0.1574 | 1 | |
Brugia malayi | Ets-domain containing protein | 0.0054 | 0.0069 | 0.0354 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.0091 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1574 | 0.6198 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0054 | 0.0069 | 0.0223 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.254 | 1 |
Echinococcus granulosus | geminin | 0.0131 | 0.0491 | 1 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0728 | 0.3755 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0044 | 0.0013 | 0.0043 |
Brugia malayi | Kringle domain containing protein | 0.0058 | 0.0091 | 0.05 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1142 | 0.602 | 0.3627 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0058 | 0.0091 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0058 | 0.0091 | 0.1633 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1142 | 0.602 | 0.5 |
Brugia malayi | Fli-1 protein | 0.0163 | 0.0668 | 0.4193 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0603 | 0.307 | 1 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1142 | 0.602 | 0.3627 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0058 | 0.0091 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0491 | 0.1309 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.187 | 1 | 1 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0054 | 0.0069 | 0.027 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0044 | 0.0013 | 0.0035 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.187 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 12.3 nM | Displacement of [3H]N-methylscopolamine from muscarinic M3 receptor in rat submandibular gland | ChEMBL. | 17629699 |
Ki (binding) | = 12.3 nM | Displacement of [3H]N-methylscopolamine from muscarinic M3 receptor in rat submandibular gland | ChEMBL. | 17629699 |
Ki (binding) | = 646 nM | Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart | ChEMBL. | 17629699 |
Ki (binding) | = 646 nM | Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart | ChEMBL. | 17629699 |
Ratio Ki (binding) | = 52 | Selectivity for rat muscarinic M3 receptor over rat muscarinic M2 receptor | ChEMBL. | 17629699 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.