TDR Targets

Basic information

Technical information

TDR Targets ID: 461523
Name: (3R)-3-amino-1-[4-[(4-fluorophenyl)methyl]-1- methyl-2-(trifluoromethyl)-6,7-dihydro-4H-imi dazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluoroph enyl)butan-1-one
MW: 528.465 | Formula: C25H23F7N4O
H donors: 1 H acceptors: 2 LogP: 3.74 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: N[C@H](Cc1cc(F)c(cc1F)F)CC(=O)N1CCc2c(C1Cc1ccc(cc1)F)nc(n2C)C(F)(F)F
InChi: 1S/C25H23F7N4O/c1-35-20-6-7-36(22(37)11-16(33)9-14-10-18(28)19(29)12-17(14)27)21(8-13-2-4-15(26)5-3-13)23(20)34-24(35)25(30,31)32/h2-5,10,12,16,21H,6-9,11,33H2,1H3/t16-,21?/m1/s1
InChiKey: SHXFVDFLOALCAW-UJONTBEJSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(3R)-3-amino-1-[4-[(4-fluorophenyl)methyl]-1-methyl-2-(trifluoromethyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)-1-butanone
(3R)-3-azanyl-1-[4-[(4-fluorophenyl)methyl]-1-methyl-2-(trifluoromethyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
(3R)-3-amino-1-[4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dipeptidyl-peptidase 4	Starlite/ChEMBL	References
Homo sapiens	dipeptidyl-peptidase 7	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K01276 dipeptidyl-peptidase II [EC3.4.14.2], putative	Get druggable targets OG5_139351	All targets in OG5_139351
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	Get druggable targets OG5_139351	All targets in OG5_139351
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_139351	All targets in OG5_139351
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_139351	All targets in OG5_139351
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma japonicum	ko:K01278 dipeptidyl-peptidase 4, putative	Get druggable targets OG5_128614	All targets in OG5_128614
Loa Loa (eye worm)	prolyl oligopeptidase	Get druggable targets OG5_128614	All targets in OG5_128614
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_128614	All targets in OG5_128614

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	serine carboxypeptidase S28, putative	dipeptidyl-peptidase 7	492 aa	471 aa	25.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0077	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0034	0.0095
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0098	0.0165	0.0434
Onchocerca volvulus		0.0098	0.0165	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0152	0.0467
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0031	0.0205
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0241	0.0633	1
Brugia malayi	Trypsin family protein	0.1019	0.3178	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0057	0.0031	0.0086
Echinococcus multilocularis	endothelin converting enzyme 1	0.0094	0.0152	0.1111
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0057	0.0031	0.0205
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0057	0.0031	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Loa Loa (eye worm)	neuropeptide F receptor	0.0057	0.0031	0.0086
Brugia malayi	hypothetical protein	0.0057	0.0031	0.0086
Brugia malayi	Serotonin receptor	0.0057	0.0031	0.0086
Brugia malayi	Trypsin-like protease protein 5	0.0098	0.0165	0.0506
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus granulosus	sex peptide receptor	0.0057	0.0031	0.0205
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0031	0.0083
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.007	0.0075	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0098	0.0165	0.0434
Schistosoma mansoni	histamine h1 receptor	0.0057	0.0031	0.0083
Schistosoma mansoni	neuropeptide f receptor 76f	0.0057	0.0031	0.0083
Schistosoma mansoni	cercarial elastase (S01 family)	0.0098	0.0165	0.0434
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0057	0.0031	0.0205
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0057	0.0031	0.0086
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0031	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0292	0.0906
Echinococcus multilocularis		0.0346	0.0976	0.7283
Echinococcus granulosus	neuropeptide receptor A26	0.0057	0.0031	0.0205
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0057	0.0031	0.0086
Echinococcus multilocularis	Furin 1	0.0101	0.0176	0.1288
Brugia malayi	G protein-coupled receptor F59B2.13	0.0057	0.0031	0.0086
Echinococcus granulosus	neuroendocrine convertase 2	0.0269	0.0726	0.541
Echinococcus granulosus	fmrfamide receptor	0.0057	0.0031	0.0205
Brugia malayi	putative neuropeptide receptor	0.0057	0.0031	0.0086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0057	0.0031	0.0205
Onchocerca volvulus		0.0057	0.0031	0.0086
Schistosoma mansoni	amine GPCR	0.0057	0.0031	0.0083
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0031	0.0083
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0069	0.0072	0.0214
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0057	0.0031	0.0086
Schistosoma mansoni	neuropeptide F-like receptor	0.0057	0.0031	0.0083
Echinococcus granulosus	serotonin receptor	0.0057	0.0031	0.0205
Echinococcus granulosus	biogenic amine 5HT receptor	0.0057	0.0031	0.0205
Brugia malayi	hypothetical protein	0.0057	0.0031	0.0086
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0098	0.0165	0.0434
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1019	0.3178	0.8369
Brugia malayi	hypothetical protein	0.0057	0.0031	0.0086
Brugia malayi	Dopamine receptor protein 2	0.0057	0.0031	0.0086
Schistosoma mansoni	neuropeptide F-like receptor	0.0057	0.0031	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Schistosoma mansoni	growth hormone secretagogue receptor	0.0057	0.0031	0.0083
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.0292	0.0768
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.026	0.0697	1
Onchocerca volvulus		0.0057	0.0031	0.0086
Onchocerca volvulus		0.0098	0.0165	0.0506
Loa Loa (eye worm)	proprotein convertase 2	0.0101	0.0176	0.0541
Brugia malayi	Kringle domain containing protein	0.0241	0.0633	0.198
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0098	0.0165	0.1204
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0031	0.0083
Onchocerca volvulus		0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0201	0.0504	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus granulosus	neuropeptides capa receptor	0.0057	0.0031	0.0205
Brugia malayi	RE15519p	0.0057	0.0031	0.0086
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0057	0.0031	0.0205
Brugia malayi	SWIRM domain containing protein	0.0218	0.0559	0.1749
Loa Loa (eye worm)	neuropeptide F receptor	0.0057	0.0031	0.0086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0057	0.0031	0.0086
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0057	0.0031	0.0086
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0101	0.0176	0.2479
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0069	0.0072	0.0214
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0057	0.0031	0.0083
Brugia malayi	hypothetical protein	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0456	0.1338	0.3524
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0031	0.0205
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0166	0.0387	0.1206
Brugia malayi	proprotein convertase 2	0.0269	0.0726	0.2274
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Echinococcus multilocularis	transmembrane protease serine 3	0.0098	0.0165	0.1204
Echinococcus multilocularis	neuropeptide receptor A26	0.0057	0.0031	0.0205
Echinococcus granulosus	G protein coupled receptor 139	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0077	0.0231
Treponema pallidum	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1895	0.6047	0.5
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0031	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0165	0.0506
Echinococcus granulosus	neuropeptides capa receptor	0.0057	0.0031	0.0205
Brugia malayi	Trypsin family protein	0.0098	0.0165	0.0506
Echinococcus granulosus	7TM GPCR rhodopsin	0.0057	0.0031	0.0205
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0116	0.1614
Giardia lamblia	High cysteine membrane protein Group 2	0.0159	0.0366	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0101	0.0176	0.2479
Schistosoma mansoni	cercarial elastase (S01 family)	0.0098	0.0165	0.0434
Schistosoma mansoni	hypothetical protein	0.0057	0.0031	0.0083
Schistosoma mansoni	cercarial elastase (S01 family)	0.0098	0.0165	0.0434
Mycobacterium leprae	3-dehydroquinate synthase AroB	0.1208	0.3798	0.3702
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.007	0.0075	0.1127
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0057	0.0031	0.0205
Echinococcus multilocularis	tissue type plasminogen activator	0.0241	0.0633	0.471
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0429	0.1247	0.3284
Echinococcus multilocularis	neuropeptide Y receptor	0.0057	0.0031	0.0205
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0031	0.0083
Schistosoma mansoni	amine GPCR	0.0057	0.0031	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0387	0.1206
Schistosoma mansoni	cercarial elastase (S01 family)	0.0098	0.0165	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Echinococcus granulosus	transmembrane protease serine 3	0.0098	0.0165	0.1204
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0201	0.0504	0.1326
Brugia malayi	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus multilocularis	neuropeptides capa receptor	0.0057	0.0031	0.0205
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.007	0.0075	0.1127
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0098	0.0165	0.1204
Schistosoma mansoni	hypothetical protein	0.0057	0.0031	0.0083
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0116	0.1614
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0057	0.0031	0.0086
Mycobacterium tuberculosis	3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS)	0.1208	0.3798	1
Mycobacterium ulcerans	3-dehydroquinate synthase	0.1208	0.3798	0.3702
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Schistosoma mansoni	hypothetical protein	0.0098	0.0165	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0403	0.1256
Brugia malayi	prolyl oligopeptidase family protein	0.0209	0.0529	0.1655
Echinococcus granulosus	allatostatin A receptor	0.0057	0.0031	0.0205
Schistosoma mansoni	cercarial elastase (S01 family)	0.0098	0.0165	0.0434
Loa Loa (eye worm)	endoprotease bli-4	0.0429	0.1247	0.3916
Onchocerca volvulus		0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0429	0.1247	0.3916
Onchocerca volvulus		0.0098	0.0165	0.0506
Loa Loa (eye worm)	hypothetical protein	0.1019	0.3178	1
Echinococcus multilocularis	cathepsin b	0.0137	0.0292	0.2155
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0633	0.198
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0456	0.1338	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.0292	0.0768
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus granulosus	Furin 1	0.0101	0.0176	0.1288
Echinococcus multilocularis	neuropeptide receptor	0.0057	0.0031	0.0205
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0057	0.0031	0.0083
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0057	0.0031	0.0083
Echinococcus granulosus	neuropeptide receptor	0.0057	0.0031	0.0205
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Entamoeba histolytica	cyclin, putative	0.0049	0.0004	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0057	0.0031	0.0205
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0057	0.0031	0.0083
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0057	0.0031	0.0205
Echinococcus granulosus	dro:myosuppressin receptor	0.0057	0.0031	0.0205
Brugia malayi	follicle stimulating hormone receptor	0.0057	0.0031	0.0086
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0057	0.0031	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0152	0.0467
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0031	0.0205
Echinococcus multilocularis	enteropeptidase	0.0098	0.0165	0.1204
Echinococcus granulosus	neuropeptide Y receptor	0.0057	0.0031	0.0205
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0098	0.0165	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0201	0.0504	0.1574
Echinococcus multilocularis	serotonin receptor	0.0057	0.0031	0.0205
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Schistosoma mansoni	cercarial elastase (S01 family)	0.0098	0.0165	0.0434
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0098	0.0165	0.1204
Echinococcus granulosus	enteropeptidase	0.0098	0.0165	0.1204
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0101	0.0176	0.2479
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Schistosoma mansoni	amine GPCR	0.0057	0.0031	0.0083
Echinococcus multilocularis	serotonin receptor	0.0057	0.0031	0.0205
Brugia malayi	hypothetical protein	0.0054	0.0021	0.0052
Mycobacterium ulcerans	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1895	0.6047	0.5986
Schistosoma mansoni	opsin-like receptor	0.0057	0.0031	0.0083
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0098	0.0165	0.0434
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0057	0.0031	0.0205
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0116	0.1614
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus multilocularis	neuropeptides capa receptor	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0072	0.0214
Echinococcus granulosus	neuropeptide FF receptor 2	0.0057	0.0031	0.0205
Brugia malayi	hypothetical protein	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0165	0.0506
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0116	0.1614
Plasmodium falciparum	cysteine repeat modular protein 1	0.0241	0.0633	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0057	0.0031	0.0205
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0031	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0077	0.0231
Toxoplasma gondii	shikimate dehydrogenase substrate binding domain-containing protein	0.3103	1	1
Brugia malayi	Peptidase family M13 containing protein	0.0094	0.0152	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0559	0.1749
Mycobacterium tuberculosis	3-dehydroquinate synthase AroB	0.1208	0.3798	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Brugia malayi	hypothetical protein	0.0057	0.0031	0.0086
Brugia malayi	neuroendocrine convertase 1 precursor	0.0269	0.0726	0.2274
Echinococcus multilocularis	allatostatin A receptor	0.0057	0.0031	0.0205
Brugia malayi	ORL1-like opioid receptor	0.0057	0.0031	0.0086
Brugia malayi	amine oxidase, flavin-containing family protein	0.0058	0.0034	0.0095
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0094	0.0152	0.0401
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0083	0.0116	0.1614
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0101	0.0176	0.0463
Onchocerca volvulus		0.0098	0.0165	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus granulosus	biogenic amine 5HT receptor	0.0057	0.0031	0.0205
Brugia malayi	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0201	0.0504	0.3743
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Brugia malayi	endoprotease bli-4 precursor	0.0429	0.1247	0.3916
Onchocerca volvulus		0.0921	0.2858	0.8992
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0101	0.0176	0.2479
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Schistosoma mansoni	furin-1 (S08 family)	0.0186	0.0455	0.1198
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0137	0.0292	0.0768
Brugia malayi	hypothetical protein	0.0057	0.0031	0.0086
Giardia lamblia	Furin precursor putative serine protease	0.0083	0.0116	0.3092
Loa Loa (eye worm)	G-protein coupled receptor	0.0057	0.0031	0.0086
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0057	0.0031	0.0205
Trypanosoma cruzi	hypothetical protein, conserved	0.0241	0.0633	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Loa Loa (eye worm)	melatonin receptor type 1A	0.0057	0.0031	0.0086
Brugia malayi	AKH receptor	0.0057	0.0031	0.0086
Echinococcus granulosus	orexin receptor type 2	0.0057	0.0031	0.0205
Brugia malayi	neuropeptide F receptor	0.0057	0.0031	0.0086
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Echinococcus multilocularis	fmrfamide receptor	0.0057	0.0031	0.0205
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0031	0.0205
Brugia malayi	hypothetical protein	0.0098	0.0165	0.0506
Onchocerca volvulus		0.0057	0.0031	0.0086
Schistosoma mansoni	opsin-like receptor	0.0057	0.0031	0.0083
Loa Loa (eye worm)	TYRA-2 protein	0.0057	0.0031	0.0086
Schistosoma mansoni	cyclin B	0.0049	0.0004	0.0011
Mycobacterium leprae	probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS	0.3103	1	1
Brugia malayi	prolyl oligopeptidase family protein	0.007	0.0075	0.0223
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0094	0.0152	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0021	0.0052
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.026	0.0697	1
Echinococcus granulosus	hypothetical protein	0.0057	0.0031	0.0205
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0057	0.0031	0.0205
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0057	0.0031	0.0205
Brugia malayi	GnHR receptor homolog	0.0057	0.0031	0.0086
Toxoplasma gondii	cathepsin CPC2	0.0167	0.039	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0152	0.0467
Onchocerca volvulus	CoRest homolog	0.0171	0.0403	0.1256
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0031	0.0083
Chlamydia trachomatis	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1895	0.6047	0.3627
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0031	0.0083
Onchocerca volvulus		0.0057	0.0031	0.0086
Echinococcus multilocularis	neuropeptide Y receptor	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0077	0.0231
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Echinococcus granulosus	endothelin converting enzyme 1	0.0094	0.0152	0.1111
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0057	0.0031	0.0086
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0057	0.0031	0.0205
Onchocerca volvulus		0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0072	0.0214
Onchocerca volvulus		0.0241	0.0633	0.198
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0116	0.1614
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.026	0.0697	0.5193
Onchocerca volvulus		0.0057	0.0031	0.0086
Brugia malayi	celfurPC protein	0.0346	0.0976	0.3062
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.0292	0.0768
Brugia malayi	neuropeptide F receptor	0.0057	0.0031	0.0086
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0031	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0165	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.1019	0.3178	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0057	0.0031	0.0083
Brugia malayi	putative neuropeptide receptor NPR1	0.0057	0.0031	0.0086
Echinococcus multilocularis	cathepsin b	0.0137	0.0292	0.2155
Echinococcus multilocularis	neuropeptide s receptor	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0165	0.0506
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.007	0.0075	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus granulosus	cathepsin b	0.0137	0.0292	0.2155
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0201	0.0504	0.3743
Echinococcus granulosus	neuropeptide receptor	0.0057	0.0031	0.0205
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0031	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Onchocerca volvulus		0.1019	0.3178	1
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0031	0.0205
Brugia malayi	hypothetical protein	0.0057	0.0031	0.0086
Schistosoma mansoni	cercarial elastase (S01 family)	0.0098	0.0165	0.0434
Toxoplasma gondii	kringle domain-containing protein	0.0241	0.0633	0.0562
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0031	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0057	0.0031	0.0086
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0057	0.0031	0.0205
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0057	0.0031	0.0083
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0395	0.1231
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0031	0.0205
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0116	0.1614
Brugia malayi	cathepsin B-like cysteine proteinase	0.0137	0.0292	0.0906
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0083	0.0116	0.1614
Onchocerca volvulus		0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0165	0.0506
Toxoplasma gondii	peptidase family M13 protein	0.0094	0.0152	0.0078
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0031	0.0205
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0031	0.0083
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0116	0.1614
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0031	0.0083
Echinococcus granulosus	Mastin	0.0098	0.0165	0.1204
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0031	0.0083
Echinococcus granulosus	cathepsin b	0.0137	0.0292	0.2155
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0057	0.0031	0.0086
Onchocerca volvulus		0.0057	0.0031	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0116	0.1614
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0077	0.0231
Echinococcus multilocularis	neuroendocrine convertase 2	0.0269	0.0726	0.541
Onchocerca volvulus		0.0218	0.0559	0.1749
Echinococcus multilocularis	glycoprotein Antigen 5	0.0098	0.0165	0.1204
Schistosoma mansoni	cercarial elastase (S01 family)	0.0098	0.0165	0.0434
Echinococcus multilocularis	dro:myosuppressin receptor	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Loa Loa (eye worm)	G-protein coupled receptor	0.0057	0.0031	0.0086
Echinococcus multilocularis	sex peptide receptor	0.0057	0.0031	0.0205
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0031	0.0205
Brugia malayi	sulfakinin receptor protein	0.0057	0.0031	0.0086
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0057	0.0031	0.0205
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.007	0.0075	0.1127
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0083	0.0116	0.1614
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0031	0.0083
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0101	0.0176	0.2479
Schistosoma mansoni	amine GPCR	0.0057	0.0031	0.0083
Echinococcus granulosus	glycoprotein Antigen 5	0.0098	0.0165	0.1204
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0057	0.0031	0.0083
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0057	0.0031	0.0205
Brugia malayi	Trypsin family protein	0.0098	0.0165	0.0506
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Onchocerca volvulus		0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus granulosus	neuropeptide s receptor	0.0057	0.0031	0.0205
Schistosoma mansoni	cercarial elastase (S01 family)	0.0098	0.0165	0.0434
Brugia malayi	G-protein coupled receptor	0.0057	0.0031	0.0086
Schistosoma mansoni	opsin-like receptor	0.0057	0.0031	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1019	0.3178	0.8369
Echinococcus multilocularis	G protein coupled receptor 139	0.0057	0.0031	0.0205
Echinococcus multilocularis	neuropeptide receptor	0.0057	0.0031	0.0205
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0057	0.0031	0.0086
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0057	0.0031	0.0205
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0116	0.1614
Echinococcus granulosus	somatostatin receptor	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0077	0.0231
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0057	0.0031	0.0083
Schistosoma mansoni	3-dehydroquinate synthase	0.1208	0.3798	1
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0031	0.0083
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0057	0.0031	0.0205
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0031	0.0205
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.026	0.0697	0.5193
Onchocerca volvulus		0.0057	0.0031	0.0086
Echinococcus multilocularis	orexin receptor type 2	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0072	0.0214
Brugia malayi	larval opioid receptor	0.0057	0.0031	0.0086
Onchocerca volvulus		0.0057	0.0031	0.0086
Echinococcus multilocularis	fmrfamide receptor	0.0057	0.0031	0.0205
Loa Loa (eye worm)	trypsin family protein	0.0098	0.0165	0.0506
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0456	0.1338	1
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.007	0.0075	0.0531
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.007	0.0075	1
Schistosoma mansoni	hypothetical protein	0.0057	0.0031	0.0083
Onchocerca volvulus		0.0057	0.0031	0.0086
Brugia malayi	G-protein coupled receptor	0.0057	0.0031	0.0086
Echinococcus granulosus	tissue type plasminogen activator	0.0241	0.0633	0.471
Echinococcus granulosus	g-protein coupled receptor	0.0057	0.0031	0.0205
Schistosoma mansoni	myosin xvIII	0.0057	0.0031	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0116	0.1614
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0057	0.0031	0.0083
Schistosoma mansoni	hypothetical protein	0.0241	0.0633	0.1666
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0098	0.0165	0.0434
Schistosoma mansoni	amine GPCR	0.0057	0.0031	0.0083
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0057	0.0031	0.0205
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0031	0.0205
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0137	0.0292	0.4575
Brugia malayi	Melatonin receptor type 1A	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus granulosus	neuropeptide Y receptor	0.0057	0.0031	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0209	0.0529	0.3937
Echinococcus multilocularis	g-protein coupled receptor	0.0057	0.0031	0.0205
Onchocerca volvulus		0.0057	0.0031	0.0086
Brugia malayi	Serotonin receptor	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Brugia malayi	Dopamine receptor	0.0057	0.0031	0.0086
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0057	0.0031	0.0083
Echinococcus granulosus	Dipeptidyl peptidase 9	0.007	0.0075	0.0531
Brugia malayi	Protein kinase domain containing protein	0.0241	0.0633	0.198
Loa Loa (eye worm)	prolyl oligopeptidase	0.0209	0.0529	0.1655
Echinococcus granulosus	7tm_1 domain containing protein	0.0057	0.0031	0.0205
Echinococcus multilocularis	somatostatin receptor	0.0057	0.0031	0.0205
Onchocerca volvulus		0.0057	0.0031	0.0086
Brugia malayi	G protein-coupled receptor	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0098	0.0165	0.1204
Brugia malayi	Dopamine receptor protein 1	0.0057	0.0031	0.0086
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0209	0.0529	0.1655
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0098	0.0165	0.0434
Schistosoma mansoni	hypothetical protein	0.0098	0.0165	0.0434
Schistosoma mansoni	cercarial elastase (S01 family)	0.0098	0.0165	0.0434
Echinococcus multilocularis	Mastin	0.0098	0.0165	0.1204
Schistosoma mansoni	hypothetical protein	0.0083	0.0116	0.0305
Schistosoma mansoni	adenoreceptor	0.0057	0.0031	0.0083
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0057	0.0031	0.0083
Onchocerca volvulus		0.0098	0.0165	0.0506
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0031	0.0083
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0116	0.1614
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0031	0.0083
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0098	0.0165	0.0434
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0057	0.0031	0.0205
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0031	0.0205
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0209	0.0529	0.1394
Schistosoma mansoni	hypothetical protein	0.0057	0.0031	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0072	0.0214
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1895	0.6047	0.5
Mycobacterium ulcerans	hypothetical protein	0.0098	0.0165	0.0012
Loa Loa (eye worm)	TK/ROR protein kinase	0.0241	0.0633	0.198
Leishmania major	hypothetical protein, conserved	0.0241	0.0633	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Onchocerca volvulus		0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus granulosus	furin	0.0429	0.1247	0.9316
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0101	0.0176	0.2479
Trichomonas vaginalis	hypothetical protein	0.0083	0.0116	0.1614
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0031	0.0086
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0057	0.0031	0.0205
Brugia malayi	Trypsin family protein	0.0098	0.0165	0.0506
Mycobacterium ulcerans	3-phosphoshikimate 1-carboxyvinyltransferase	0.3103	1	1
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0209	0.0529	0.3937

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.0058 uM	Inhibition of DPP4	ChEMBL.	17869513
IC50 (binding)	= 0.0058 uM	Inhibition of DPP4	ChEMBL.	17869513
IC50 (binding)	= 0.78 uM	Inhibition of DPP4	ChEMBL.	17869513
IC50 (binding)	= 0.78 uM	Inhibition of DPP4	ChEMBL.	17869513
IC50 (binding)	= 15 uM	Inhibition of QPP	ChEMBL.	17869513
IC50 (binding)	= 15 uM	Inhibition of QPP	ChEMBL.	17869513
IC50 (binding)	= 39 uM	Inhibition of QPP	ChEMBL.	17869513
IC50 (binding)	= 39 uM	Inhibition of QPP	ChEMBL.	17869513
IC50 (binding)	= 46 uM	Inhibition of DPP8	ChEMBL.	17869513
IC50 (binding)	= 46 uM	Inhibition of DPP8	ChEMBL.	17869513
IC50 (binding)	= 100 uM	Inhibition of DPP8	ChEMBL.	17869513
IC50 (binding)	> 100 uM	Inhibition of DPP9	ChEMBL.	17869513
IC50 (binding)	= 100 uM	Inhibition of DPP8	ChEMBL.	17869513
IC50 (binding)	> 100 uM	Inhibition of DPP9	ChEMBL.	17869513

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL250285
PubChem: 10324641

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 461523