Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0497 | 0.239 | 1 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0497 | 0.239 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.0935 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.1801 | 1 | 0.5 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.1801 | 1 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.0935 | 0.3915 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0088 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0834 | 0.4359 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0134 | 0.0272 | 0.0624 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0935 | 0.2146 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.0272 | 0.0624 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.0272 | 0.1138 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0497 | 0.239 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.0935 | 0.3915 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.1801 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0935 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0935 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0497 | 0.239 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.0935 | 0.3915 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0935 | 0.2146 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0088 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Plasmodium falciparum | carbonic anhydrase | 0.0134 | 0.0272 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.239 | 1 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Toxoplasma gondii | hypothetical protein | 0.0134 | 0.0272 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.1801 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.0935 | 0.3915 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Schistosoma mansoni | apoptosis regulator bax | 0.0497 | 0.239 | 0.5482 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0497 | 0.239 | 0.5482 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0497 | 0.239 | 1 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0497 | 0.239 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.1801 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.0272 | 0.1138 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.0935 | 0.3915 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.0935 | 0.3915 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.0935 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 20 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 20 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 35 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 35 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 240 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Ki (binding) | = 240 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.