Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0497 | 0.239 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.0935 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.1801 | 1 | 0.5 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0935 | 0.2146 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.1801 | 1 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.0935 | 0.3915 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0834 | 0.4359 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0088 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0134 | 0.0272 | 0.0624 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0497 | 0.239 | 1 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0497 | 0.239 | 1 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.0935 | 0.3915 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0497 | 0.239 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.0935 | 0.3915 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.0272 | 0.0624 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.0272 | 0.1138 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0935 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0935 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.1801 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Toxoplasma gondii | hypothetical protein | 0.0134 | 0.0272 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.1801 | 1 | 0.5 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Schistosoma mansoni | apoptosis regulator bax | 0.0497 | 0.239 | 0.5482 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.0935 | 0.3915 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0088 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0935 | 0.2146 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.239 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Plasmodium falciparum | carbonic anhydrase | 0.0134 | 0.0272 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.0935 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.0935 | 0.3915 |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.0935 | 0.3915 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.1801 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0497 | 0.239 | 0.5482 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0497 | 0.239 | 1 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0497 | 0.239 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.0272 | 0.1138 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 13 nM | Inhibition of cloned isozyme, human carbonic anhydrase II | ChEMBL. | 11229775 |
Ki (binding) | = 13 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 13 nM | Inhibition of cloned isozyme, human carbonic anhydrase II | ChEMBL. | 11229775 |
Ki (binding) | = 13 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 29 nM | Inhibition of cloned isozyme, human carbonic anhydrase IV | ChEMBL. | 11229775 |
Ki (binding) | = 29 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 29 nM | Inhibition of cloned isozyme, human carbonic anhydrase IV | ChEMBL. | 11229775 |
Ki (binding) | = 29 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 180 nM | Inhibition of cloned isozyme, human carbonic anhydrase I | ChEMBL. | 11229775 |
Ki (binding) | = 180 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Ki (binding) | = 180 nM | Inhibition of cloned isozyme, human carbonic anhydrase I | ChEMBL. | 11229775 |
Ki (binding) | = 180 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.