Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine receptor | 475 aa | 405 aa | 33.3 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Dopamine receptor | 475 aa | 398 aa | 34.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0219 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0144 | 0.2786 | 0.7917 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0144 | 0.2786 | 0.2786 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.0219 | 1 | 0.5 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0219 | 1 | 0.5 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0219 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.0219 | 1 | 0.5 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0151 | 0.3519 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0219 | 1 | 0.5 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.0219 | 1 | 0.5 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0219 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.0219 | 1 | 0.5 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0219 | 1 | 1 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0114 | 0 | 0.5 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0219 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0114 | 0 | 0.5 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0151 | 0.3519 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0144 | 0.2786 | 0.7917 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.0219 | 1 | 0.5 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0219 | 1 | 1 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0219 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0219 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0219 | 1 | 1 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.0219 | 1 | 0.5 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0219 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.2786 | 0.7917 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.0219 | 1 | 0.5 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0144 | 0.2786 | 0.2786 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0219 | 1 | 1 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0219 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0219 | 1 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0219 | 1 | 0.5 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.0219 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.