TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 228.714 | Formula: C12H16ClFN-
H donors: 1 H acceptors: 0 LogP: 3.28 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cccc(c1)C1(N)CCCCC1.[Cl-]
InChi: 1S/C12H16FN.ClH/c13-11-6-4-5-10(9-11)12(14)7-2-1-3-8-12;/h4-6,9H,1-3,7-8,14H2;1H/p-1
InChiKey: BARCOTMUPUMNSC-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0037	0.0347	0.0347
Brugia malayi	Cation transporter family protein	0.0037	0.0347	0.2719
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0052	0.0214
Loa Loa (eye worm)	hypothetical protein	0.002	0.0095	0.0574
Echinococcus multilocularis	RNA directed DNA polymerase	0.0038	0.0365	0.0365
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0746	0.0746
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0024	0.016	1
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0195	0.2681	1
Echinococcus granulosus	nAChR subunit	0.002	0.0095	0.0095
Onchocerca volvulus	Putative nachr subunit	0.0037	0.0347	0.287
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0037	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0024	0.016	1
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0037	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0746	0.6108
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0161	1
Schistosoma mansoni	nAChR subunit	0.0037	0.0347	0.0347
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0037	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0024	0.016	1
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0087	0.1079	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Onchocerca volvulus		0.0037	0.0347	0.287
Loa Loa (eye worm)	hypothetical protein	0.002	0.0095	0.0574
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0017	0.0052	0.0214
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0017	0.0052	0.0052
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0017	0.0052	0.0052
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0017	0.0052	0.0214
Schistosoma mansoni	hypothetical protein	0.0194	0.2664	0.2664
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0592	0.0592
Schistosoma mansoni	nAChR subunit	0.0037	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0365	0.2872
Schistosoma mansoni	nAChR subunit	0.0017	0.0052	0.0052
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0037	0.0347	0.2719
Loa Loa (eye worm)	hypothetical protein	0.002	0.0095	0.0574
Echinococcus granulosus	glycine receptor subunit beta	0.0037	0.0347	0.0347
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0037	0.0347	0.0347
Echinococcus multilocularis	geminin	0.0194	0.2664	0.2664
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0037	0.0347	0.0347
Onchocerca volvulus		0.0037	0.0347	0.287
Brugia malayi	hypothetical protein	0.0017	0.0052	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0452	0.3608
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0037	0.0347	0.2719
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0037	0.0347	0.2719
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0037	0.0347	0.0347
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0746	0.0746
Echinococcus granulosus	nAChR subunit	0.0037	0.0347	0.0347
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0746	0.0746
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0746	0.6108
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Entamoeba histolytica	hypothetical protein	0.0024	0.016	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.002	0.0095	0.0574
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0017	0.0052	0.0214
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0538	0.0538
Schistosoma mansoni	nAChR subunit	0.0037	0.0347	0.0347
Echinococcus granulosus	geminin	0.0194	0.2664	0.2664
Loa Loa (eye worm)	hypothetical protein	0.002	0.0095	0.0574
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0037	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Brugia malayi	Cation transporter family protein	0.0037	0.0347	0.2719
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0195	0.2681	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0037	0.0347	0.2719
Onchocerca volvulus		0.0037	0.0347	0.287
Echinococcus multilocularis	nAChR subunit	0.002	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0746	0.6108
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0017	0.0052	0.0052
Echinococcus multilocularis	microtubule associated protein 2	0.0691	1	1
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.002	0.0095	0.0095
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0347	0.2719
Brugia malayi	hypothetical protein	0.0016	0.0033	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0746	0.0746
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0746	0.0746
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0017	0.0052	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0037	0.0347	0.2719
Brugia malayi	hypothetical protein	0.0017	0.0052	0.0214
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0037	0.0347	0.0347
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0054	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0024	0.016	1
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0037	0.0347	0.0347
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0037	0.0347	0.0347
Onchocerca volvulus		0.002	0.0095	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Echinococcus multilocularis	glycine receptor subunit beta	0.0037	0.0347	0.0347
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0037	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0017	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0746	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1204	1
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0037	0.0347	0.0347
Echinococcus granulosus	nmda type glutamate receptor	0.0032	0.0271	0.0271
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0037	0.0347	0.2719
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Echinococcus multilocularis	nmda type glutamate receptor	0.0032	0.0271	0.0271
Schistosoma mansoni	neurotransmitter gated ion channel	0.0017	0.0052	0.0052
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0032	0.0271	0.0271
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0746	0.6108
Brugia malayi	hypothetical protein	0.0017	0.0052	0.0214
Echinococcus multilocularis	protein kinase c iota type	0.0014	0.0009	0.0009
Leishmania major	sterol 24-c-methyltransferase, putative	0.0195	0.2681	1
Brugia malayi	S-adenosyl-methionine cycloartenol-C24-methyltransferase	0.0095	0.1204	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0347	0.2719
Echinococcus granulosus	RNA directed DNA polymerase	0.0038	0.0365	0.0365
Echinococcus multilocularis	tumor protein p63	0.0342	0.4846	0.4846
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0095	0.0095
Echinococcus granulosus	Protein kinase C brain isozyme	0.0054	0.0592	0.0592
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0347	0.2719
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0037	0.0347	0.2719
Schistosoma mansoni	neurotransmitter gated ion channel	0.0017	0.0052	0.0052
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0024	0.016	0.5
Echinococcus granulosus	protein kinase c iota type	0.0014	0.0009	0.0009
Echinococcus multilocularis	serine threonine protein kinase	0.0048	0.0506	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Loa Loa (eye worm)	hypothetical protein	0.002	0.0095	0.0574
Onchocerca volvulus		0.0037	0.0347	0.287
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0037	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Schistosoma mansoni	microtubule-associated protein tau	0.0691	1	1
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0087	0.1079	0.1079
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0095	0.0574
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0161	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0161	1
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.004	0.0386	0.3047
Trypanosoma brucei	Sterol methyltransferase, putative	0.0195	0.2681	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0037	0.0347	0.0347
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0017	0.0052	0.0052
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0037	0.0347	0.2719
Echinococcus granulosus	tumor protein p63	0.0342	0.4846	0.4846
Onchocerca volvulus		0.005	0.0538	0.4734
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0037	0.0347	0.2719
Loa Loa (eye worm)	hypothetical protein	0.002	0.0095	0.0574
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0037	0.0347	0.0347
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0037	0.0347	0.2719
Loa Loa (eye worm)	LGC-31 protein	0.0037	0.0347	0.2719
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0052	0.0214
Brugia malayi	Cation transporter family protein	0.0037	0.0347	0.2719
Mycobacterium leprae	conserved hypothetical protein	0.0024	0.016	0.5
Echinococcus multilocularis	protein kinase c epsilon type	0.0015	0.0027	0.0027
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0037	0.0347	0.2719
Brugia malayi	hypothetical protein	0.0017	0.0052	0.0214
Echinococcus multilocularis	nAChR subunit	0.0037	0.0347	0.0347
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0347	0.2719
Schistosoma mansoni	nAChR subunit	0.0037	0.0347	0.0347
Echinococcus granulosus	glycine receptor subunit beta	0.0037	0.0347	0.0347
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0024	0.016	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.0037	0.0347	0.2719
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0038	0.0365	0.0365
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0037	0.0347	0.2719
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0037	0.0347	0.2719
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0037	0.0347	0.2719
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0017	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Schistosoma mansoni	nAChR subunit	0.0037	0.0347	0.0347
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0037	0.0347	0.0347
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0347	0.2719
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0052	0.0214
Echinococcus granulosus	protein kinase c epsilon type	0.0015	0.0027	0.0027
Schistosoma mansoni	atypical protein kinase C	0.0014	0.0009	0.0009
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0017	0.0052	0.0214
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.002	0.0095	0.0574
Brugia malayi	RNA binding protein	0.0064	0.0746	0.6108
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0087	0.1079	0.894
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Onchocerca volvulus		0.0037	0.0347	0.287
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0037	0.0347	0.0347
Echinococcus granulosus	protein kinase C gamma type	0.0048	0.0506	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0037	0.0347	0.0347
Schistosoma mansoni	nAChR subunit	0.0017	0.0052	0.0052
Schistosoma mansoni	hypothetical protein	0.0194	0.2664	0.2664
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0037	0.0347	0.0347
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0592	0.0592
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0746	0.0746
Onchocerca volvulus		0.0087	0.1079	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0037	0.0347	0.0347
Echinococcus multilocularis	glycine receptor subunit beta	0.0037	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0161	0.1136
Loa Loa (eye worm)	hypothetical protein	0.005	0.0538	0.4345
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0037	0.0347	0.2719
Leishmania major	sterol 24-c-methyltransferase, putative	0.0195	0.2681	1
Schistosoma mansoni	acetylcholine receptor-related	0.0017	0.0052	0.0052
Onchocerca volvulus		0.002	0.0095	0.0413
Loa Loa (eye worm)	hypothetical protein	0.002	0.0095	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1079	0.894
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0195	0.2681	1
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0037	0.0347	0.0347
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0161	0.0004
Loa Loa (eye worm)	ACC-1 protein	0.0037	0.0347	0.2719
Loa Loa (eye worm)	hypothetical protein	0.002	0.0095	0.0574
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0095	0.0574
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0037	0.0347	0.0347
Brugia malayi	TAR-binding protein	0.0064	0.0746	0.6108
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0052	0.0214
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0195	0.2681	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0037	0.0347	0.0347
Brugia malayi	hypothetical protein	0.0024	0.0161	0.1136
Schistosoma mansoni	nAChR subunit	0.0037	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.002	0.0095	0.0574
Loa Loa (eye worm)	acetylcholine receptor protein	0.0017	0.0052	0.0214
Echinococcus granulosus	L aminoadipate semialdehyde	0.0087	0.1079	0.1079
Brugia malayi	hypothetical protein	0.0017	0.0052	0.0214
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0102	0.1302	0.4532
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0347	0.2719
Brugia malayi	Protein kinase c protein 2	0.0046	0.0472	0.3783
Schistosoma mansoni	neurotransmitter gated ion channel	0.002	0.0095	0.0095
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0037	0.0347	0.0347
Schistosoma mansoni	nAChR subunit	0.0037	0.0347	0.0347
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0195	0.2681	1
Onchocerca volvulus		0.0037	0.0347	0.287
Loa Loa (eye worm)	ACC-1 protein	0.0037	0.0347	0.2719
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0037	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Leishmania major	hypothetical protein, conserved	0.0024	0.0161	0.0004
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0037	0.0347	0.2719
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0161	1
Loa Loa (eye worm)	GABA receptor subunit	0.002	0.0095	0.0574
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0037	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.2719
Schistosoma mansoni	serine/threonine protein kinase	0.0015	0.0027	0.0027

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 675 nM	Evaluated in vitro binding affinity against PCP receptor using [3H]-TCP as radioligand in rat brain membranes	ChEMBL.	2329567
MES ED50 (functional)	= 9.36000000000002 mg kg-1	Evaluated for anticonvulsant activity (ED50) by maximal electroshock (MES) seizure test in mouse by intraperitoneal administration.	ChEMBL.	2329567
TD50 (functional)	= 20.16 mg kg-1	Evaluated for anticonvulsant activity (TD50) by motor toxicity assay in mouse by intraperitoneal administration.	ChEMBL.	2329567
TI (functional)	= 2.15	TI value is the ratio between TD50 and ED50	ChEMBL.	2329567

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 148334

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 47665