TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 348.437 | Formula: C19H28N2O4
H donors: 2 H acceptors: 2 LogP: 1.8 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCCNC(=O)CCCOc1cc(ccc1OC)C1CNC(=O)C1
InChi: 1S/C19H28N2O4/c1-3-4-9-20-18(22)6-5-10-25-17-11-14(7-8-16(17)24-2)15-12-19(23)21-13-15/h7-8,11,15H,3-6,9-10,12-13H2,1-2H3,(H,20,22)(H,21,23)
InChiKey: YLZGZAHCELCJBB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4B, cAMP-specific		References
Homo sapiens	phosphodiesterase 4A, cAMP-specific		References
Homo sapiens	phosphodiesterase 4D, cAMP-specific	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 4C, cAMP-specific		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0272	0.0092
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0054	0.0272	0.0272
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0112	0.1016	0.3263
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0447	0.5371	0.5364
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Giardia lamblia	hypothetical protein	0.0054	0.0272	0.0069
Loa Loa (eye worm)	PDE1B protein	0.0054	0.0272	0.0477
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0447	0.5371	0.5364
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.01	0.087	0.2722
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.2969
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.4445
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.3985	1
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0054	0.0272	0.0256
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0079	0.0591	0.0944
Echinococcus multilocularis	microtubule associated protein 2	0.0802	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0272	0.0092
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.2969
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0054	0.0272	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0272	0.0477
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0079	0.0591	0.0944
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0052	0.0237	0.0221
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Plasmodium vivax	glutathione reductase, putative	0.0044	0.0137	0.21
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0052	0.0237	0.0412
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH1	0.0079	0.0591	0.1073
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Brugia malayi	glutathione reductase	0.0044	0.0137	0.0259
Loa Loa (eye worm)	glutathione reductase	0.0044	0.0137	0.0225
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0054	0.0272	0.0549
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0052	0.0237	0.0412
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0079	0.0591	0.0591
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0054	0.0272	0.0256
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0054	0.0272	0.0272
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0079	0.0591	0.0944
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0054	0.0272	0.0256
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.3985	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.034	0.3985	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0112	0.1016	0.1705
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0054	0.0272	0.0477
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.3985	1
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0052	0.0237	0.2193
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.2969
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.01	0.087	0.2722
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0079	0.0591	0.069
Chlamydia trachomatis	glyceraldehyde-3-phosphate dehydrogenase	0.0079	0.0591	0.5
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0079	0.0591	1
Treponema pallidum	fructose-bisphosphate aldolase	0.034	0.3985	1
Leishmania major	glyceraldehyde-3-phosphate dehydrogenase-like protein	0.0052	0.0237	0.2193
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.4445
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0079	0.0591	0.0944
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0054	0.0272	0.2969
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0166	0.1724	0.5063
Giardia lamblia	Hypothetical protein	0.0054	0.0272	0.0069
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0054	0.0272	0.2969
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0054	0.0272	0.2969
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0392	0.4665	0.868
Plasmodium vivax	phosphodiesterase gamma, putative	0.0054	0.0272	0.4445
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.0054	0.0273	0.0479
Mycobacterium tuberculosis	Probable oxidoreductase	0.0112	0.1016	0.3263
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, cytosolic	0.0079	0.0591	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0079	0.0591	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0392	0.4665	0.4656
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Mycobacterium ulcerans	L-lysine aminotransferase	0.0251	0.2829	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0054	0.0272	0.0256
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0054	0.0272	0.2969
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0079	0.0591	0.0575
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0272	0.0477
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.3985	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0447	0.5371	0.5371
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0045	0.0145	0.0128
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.01	0.087	0.2722
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0054	0.0272	0.0092
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.034	0.3985	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.3985	1
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0054	0.0272	0.2969
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0052	0.0237	0.0237
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Leishmania major	hypothetical protein, conserved	0.0054	0.0272	0.2969
Trypanosoma cruzi	hypothetical protein, conserved	0.0054	0.0272	0.2969
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0079	0.0591	1
Plasmodium vivax	thioredoxin reductase, putative	0.0044	0.0137	0.21
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0054	0.0272	0.0256
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Trypanosoma cruzi	hypothetical protein, conserved	0.0054	0.0272	0.2969
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0054	0.0272	0.2969
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0054	0.0272	0.0549
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Plasmodium vivax	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0079	0.0591	1
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0054	0.0272	0.0256
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0447	0.5371	0.5371
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Trypanosoma cruzi	hypothetical protein, conserved	0.0054	0.0272	0.2969
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.3985	1
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0054	0.0272	0.2969
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0079	0.0591	0.0575
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Trypanosoma cruzi	hypothetical protein, conserved	0.0054	0.0272	0.2969
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0054	0.0272	0.2969
Brugia malayi	NNMT/PNMT/TEMT family protein	0.0286	0.328	0.7022
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0079	0.0591	1
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0052	0.0237	0.2193
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.2969
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0079	0.0591	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0054	0.0272	0.0256
Plasmodium falciparum	phosphodiesterase delta, putative	0.0054	0.0272	0.2969
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0054	0.0272	0.2969
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0447	0.5371	0.5364
Trypanosoma cruzi	hypothetical protein, conserved	0.0054	0.0272	0.2969
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0251	0.2829	0.6051
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0079	0.0591	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0237	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0272	0.0477
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0079	0.0591	0.0944
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0112	0.1016	0.3263
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0054	0.0272	0.0272
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0392	0.4665	0.4665
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Echinococcus granulosus	thioredoxin glutathione reductase	0.0045	0.0145	0.0145
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0054	0.0272	0.0256
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0079	0.0591	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0054	0.0272	0.0256
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0251	0.2829	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0054	0.0272	0.0272
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0079	0.0591	0.0575
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0242	0.2712	0.5034
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.0286	0.328	0.6095
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0079	0.0591	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.01	0.087	0.2722
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0079	0.0591	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.3985	1
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0079	0.0591	1
Wolbachia endosymbiont of Brugia malayi	glyceraldehyde-3-phosphate dehydrogenase, GapA	0.0079	0.0591	0.5
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0079	0.0591	0.0591
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0079	0.0591	1
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0054	0.0272	0.0256
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0447	0.5371	1
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0079	0.0591	0.0575
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0054	0.0272	0.0549
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0054	0.0272	0.0256
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0392	0.4665	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0054	0.0272	0.0549
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0054	0.0272	0.2969
Mycobacterium tuberculosis	Probable dehydrogenase	0.01	0.087	0.2722
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0054	0.0272	0.0256
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0079	0.0591	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.328	0.6095
Trypanosoma brucei	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0052	0.0237	0.2193
Onchocerca volvulus		0.0275	0.3147	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0054	0.0272	0.2969
Toxoplasma gondii	thioredoxin reductase	0.0044	0.0137	0.0225
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0054	0.0272	0.2969
Schistosoma mansoni	microtubule-associated protein tau	0.0802	1	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0017	0.0017
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Brugia malayi	Pre-SET motif family protein	0.0242	0.2712	0.58
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0166	0.1724	1
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.0054	0.0273	0.0479
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0054	0.0272	0.0256
Brugia malayi	Thioredoxin reductase	0.0044	0.0137	0.0259
Trichomonas vaginalis	set domain proteins, putative	0.0275	0.3147	0.7765
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0272	0.0477
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0054	0.0272	0.0549
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0054	0.0272	0.2969
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0054	0.0272	0.0256
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.4445
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0272	0.0092
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0054	0.0272	0.0549
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Giardia lamblia	Fructose-bisphosphate aldolase	0.034	0.3985	0.73
Loa Loa (eye worm)	hypothetical protein	0.0286	0.328	0.6095
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0054	0.0272	0.0272
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0054	0.0272	0.0272
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0054	0.0272	0.0256
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH2	0.0079	0.0591	0.1073
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0079	0.0591	0.1236
Plasmodium falciparum	glyceraldehyde-3-phosphate dehydrogenase	0.0079	0.0591	1
Leishmania major	hypothetical protein, conserved	0.0054	0.0272	0.2969
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0054	0.0272	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0272	0.0092
Trypanosoma brucei	hypothetical protein, conserved	0.0054	0.0272	0.2969
Loa Loa (eye worm)	thioredoxin reductase	0.0044	0.0137	0.0225
Mycobacterium tuberculosis	Probable reductase	0.01	0.087	0.2722
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0054	0.0272	0.0092
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0054	0.0272	0.2969
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0054	0.0272	0.0256
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0054	0.0272	0.2969
Trypanosoma cruzi	hypothetical protein, conserved	0.0054	0.0272	0.2969
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0166	0.1724	0.5895
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0054	0.0272	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0447	0.5371	1
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0079	0.0591	0.0575
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0054	0.0272	0.2969
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.034	0.3985	1
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0447	0.5371	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 0.001 M	Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 microM) and calmodulin (15 nM)	ChEMBL.	2544722
IC50 (binding)	> 0.001 M	Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.	ChEMBL.	2544722
IC50 (binding)	> 0.001 M	Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 microM) and calmodulin (15 nM)	ChEMBL.	2544722
IC50 (binding)	> 0.001 M	Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.	ChEMBL.	2544722
IC50 (binding)	= 16 uM	Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.	ChEMBL.	2544722
IC50 (binding)	= 16 uM	Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.	ChEMBL.	2544722

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL36290

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 47686