Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0935 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0935 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.1801 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0497 | 0.239 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.0935 | 0.3915 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.0272 | 0.0624 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.0272 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.0935 | 0.3915 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0497 | 0.239 | 1 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0497 | 0.239 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0935 | 0.2146 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.1801 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0834 | 0.4359 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0088 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0134 | 0.0272 | 0.0624 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.0935 | 0.3915 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.0935 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0497 | 0.239 | 1 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.1801 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.0272 | 0.1138 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.1801 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0497 | 0.239 | 1 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0497 | 0.239 | 0.5482 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0497 | 0.239 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.0935 | 0.5 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.0935 | 0.3915 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.0935 | 0.3915 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.239 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Plasmodium falciparum | carbonic anhydrase | 0.0134 | 0.0272 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0088 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0935 | 0.2146 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Schistosoma mansoni | apoptosis regulator bax | 0.0497 | 0.239 | 0.5482 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.0935 | 0.3915 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.1801 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0134 | 0.0272 | 0.5 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 31 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 31 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 40 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 40 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 360 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Ki (binding) | = 360 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.