Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein | 0.0049 | 0.0609 | 0.0609 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0049 | 0.0609 | 0.0609 |
Trypanosoma brucei | tyrosyl-tRNA synthetase, putative | 0.0063 | 0.233 | 0.233 |
Giardia lamblia | Tyrosyl-tRNA synthetase | 0.0063 | 0.233 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0127 | 1 | 1 |
Echinococcus multilocularis | tyrosyl tRNA synthetase | 0.0112 | 0.8243 | 0.8243 |
Trypanosoma brucei | tyrosyl-tRNA synthetase, putative | 0.0049 | 0.0609 | 0.0609 |
Trypanosoma cruzi | tyrosyl or methionyl-tRNA synthetase, putative | 0.0049 | 0.0609 | 0.0609 |
Entamoeba histolytica | tyrosyl-tRNA synthetase, putative | 0.0063 | 0.233 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0127 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0127 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit beta | 0.0049 | 0.0609 | 1 |
Plasmodium vivax | tyrosine--tRNA ligase, putative | 0.0063 | 0.233 | 0.233 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0044 | 0 | 0.5 |
Trypanosoma cruzi | tyrosyl or methionyl-tRNA synthetase, putative | 0.0049 | 0.0609 | 0.0609 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0127 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0127 | 1 | 1 |
Plasmodium falciparum | tRNA import protein tRIP | 0.0049 | 0.0609 | 0.0609 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.0609 | 0.2615 |
Echinococcus granulosus | aminoacyl tRNA synthase complex interacting | 0.0049 | 0.0609 | 0.0609 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0049 | 0.0609 | 0.0609 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.0609 | 0.2615 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0049 | 0.0609 | 0.2615 |
Brugia malayi | methionyl-tRNA synthetase | 0.0049 | 0.0609 | 0.0609 |
Leishmania major | tyrosyl-tRNA synthetase, putative | 0.0063 | 0.233 | 0.233 |
Schistosoma mansoni | tyrosyl-tRNA synthetase | 0.0112 | 0.8243 | 0.8243 |
Echinococcus granulosus | tyrosyl tRNA synthetase | 0.0112 | 0.8243 | 0.8243 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0049 | 0.0609 | 1 |
Trichomonas vaginalis | isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative | 0.0063 | 0.233 | 1 |
Schistosoma mansoni | methionyl-tRNA synthetase | 0.0049 | 0.0609 | 0.0609 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0127 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0127 | 1 | 1 |
Chlamydia trachomatis | phenylalanine--tRNA ligase subunit beta | 0.0049 | 0.0609 | 1 |
Trypanosoma brucei | tyrosyl/methionyl-tRNA synthetase, putative | 0.0049 | 0.0609 | 0.0609 |
Toxoplasma gondii | tRNA binding domain-containing protein | 0.0049 | 0.0609 | 0.0609 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, beta chain PheT | 0.0049 | 0.0609 | 0.0609 |
Plasmodium vivax | glutathione reductase, putative | 0.0127 | 1 | 1 |
Plasmodium falciparum | tyrosine--tRNA ligase | 0.0063 | 0.233 | 0.233 |
Toxoplasma gondii | tRNA synthetases class I family protein | 0.0063 | 0.233 | 0.233 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0127 | 1 | 1 |
Echinococcus multilocularis | aminoacyl tRNA synthase complex interacting | 0.0049 | 0.0609 | 0.0609 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0127 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0049 | 0.0609 | 0.0609 |
Brugia malayi | Thioredoxin reductase | 0.0127 | 1 | 1 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0049 | 0.0609 | 0.0609 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit beta | 0.0049 | 0.0609 | 1 |
Trichomonas vaginalis | methionyl-tRNA synthetase, putative | 0.0049 | 0.0609 | 0.2615 |
Leishmania major | trypanothione reductase | 0.0127 | 1 | 1 |
Leishmania major | tyrosyl or methionyl-tRNA synthetase-like protein | 0.0049 | 0.0609 | 0.0609 |
Trypanosoma cruzi | tyrosyl-tRNA synthetase, putative | 0.0063 | 0.233 | 0.233 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.0609 | 0.2615 |
Plasmodium vivax | methionine-tRNA ligase, putative | 0.0049 | 0.0609 | 0.0609 |
Toxoplasma gondii | thioredoxin reductase | 0.0127 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.0609 | 0.2615 |
Trypanosoma brucei | trypanothione reductase | 0.0127 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.75 uM | Antioxidant activity in bovine heart mitochondria using iron(II) / dihydroxy fumaric acid (DHF) | ChEMBL. | 8496914 |
IC50 (binding) | = 8 uM | Inhibition against peroxidation of liposomal suspension of dilinoleoylphosphatidylcholine (DPLC) intiated by DMVN at 40 degree centigrade | ChEMBL. | 8496914 |
Inhibition (binding) | = 10 % | Percent inhibition at 100 microM against peroxidation of methyl linoleate / DMVN in TBA /methanol medium at 40 degree centigrade | ChEMBL. | 8496914 |
RC10 (functional) | = 4.5 uM | Reducing activity to scavenge 10 uM 1, 1-diphenylpicrylhydrazyl (DPPH) | ChEMBL. | 8496914 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.