Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.008 | 0 | 0.5 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0305 | 0.9816 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.008 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.008 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.008 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.008 | 0 | 0.5 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0305 | 0.9816 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0305 | 0.9816 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0207 | 0.5523 | 0.4101 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.008 | 0 | 0.5 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0309 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0309 | 1 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.008 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.008 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 193.7 uM | Inhibitory constant for human neutrophil elastase | ChEMBL. | 10360758 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.