Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0038 | 0.0046 | 0.0049 |
Brugia malayi | fructose-bisphosphate aldolase 2 | 0.0297 | 0.9238 | 1 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0038 | 0.0046 | 0.0046 |
Mycobacterium leprae | Probable 6-phosphogluconolactonase DevB (6PGL) | 0.013 | 0.3301 | 0.7812 |
Plasmodium vivax | fructose 1,6-bisphosphate aldolase, putative | 0.0297 | 0.9238 | 1 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 1 | 0.0297 | 0.9238 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0 | 0.5 |
Giardia lamblia | 6-phosphogluconate dehydrogenase, decarboxylating | 0.0124 | 0.3099 | 0.3099 |
Schistosoma mansoni | 6-phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.013 | 0.3301 | 0.0294 |
Leishmania major | fructose-1,6-bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Toxoplasma gondii | fructose-bisphosphate aldolase, putative | 0.0297 | 0.9238 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0297 | 0.9238 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Mycobacterium ulcerans | 6-phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.7333 |
Trypanosoma cruzi | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0049 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphogluconolactonase DevB (6PGL) | 0.0092 | 0.1968 | 0.4656 |
Mycobacterium tuberculosis | Probable 6-phosphogluconate dehydrogenase, decarboxylating Gnd2 | 0.0124 | 0.3099 | 0.7333 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Echinococcus multilocularis | fructose bisphosphate aldolase class I | 0.0297 | 0.9238 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0046 |
Trypanosoma brucei | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0049 |
Mycobacterium tuberculosis | Probable 6-phosphogluconate dehydrogenase Gnd1 | 0.0124 | 0.3099 | 0.7333 |
Trypanosoma brucei | 6-phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 2 | 0.0297 | 0.9238 | 1 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Trypanosoma cruzi | 6-phosphogluconolactonase, putative | 0.013 | 0.3301 | 0.3574 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Plasmodium falciparum | fructose-bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Trypanosoma cruzi | 6-phosphogluconolactonase, putative | 0.013 | 0.3301 | 0.3574 |
Trypanosoma cruzi | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.005 | 0.0485 | 0.0525 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Echinococcus granulosus | fructose bisphosphate aldolase class I | 0.0297 | 0.9238 | 1 |
Schistosoma mansoni | glucosamine-6-phosphate isomerase | 0.0038 | 0.0046 | 0.0049 |
Schistosoma mansoni | 6-phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | 6 phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.3355 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0297 | 0.9238 | 1 |
Brugia malayi | fructose-bisphosphate aldolase 1 | 0.0297 | 0.9238 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Giardia lamblia | Glucosamine-6-phosphate deaminase | 0.0038 | 0.0046 | 0.0046 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0038 | 0.0046 | 0.0046 |
Mycobacterium ulcerans | 6-phosphogluconolactonase | 0.013 | 0.3301 | 0.7812 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0038 | 0.0046 | 0.0049 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0297 | 0.9238 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0319 | 1 | 1 |
Leishmania major | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0049 |
Echinococcus granulosus | 6 phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.3355 |
Plasmodium falciparum | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0124 | 0.3099 | 0.3355 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0319 | 1 | 1 |
Brugia malayi | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0124 | 0.3099 | 0.3355 |
Echinococcus multilocularis | 6 phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Brugia malayi | 6-phosphogluconolactonase family protein | 0.013 | 0.3301 | 0.3574 |
Loa Loa (eye worm) | pgd protein | 0.0124 | 0.3099 | 0.3355 |
Trichomonas vaginalis | 3-hydroxyisobutyrate dehydrogenase, putative | 0.0124 | 0.3099 | 0.3099 |
Echinococcus granulosus | 6 phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Toxoplasma gondii | 6-phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.3355 |
Trypanosoma cruzi | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0049 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Schistosoma mansoni | transcription initiation factor iia (tfiia) gamma chain | 0.005 | 0.0485 | 0.0525 |
Toxoplasma gondii | 6-phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.3355 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0046 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Mycobacterium ulcerans | 6-phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.7333 |
Leishmania major | 6-phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Giardia lamblia | Glucosamine-6-phosphate deaminase | 0.0038 | 0.0046 | 0.0046 |
Chlamydia trachomatis | 6-phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.9386 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0297 | 0.9238 | 1 |
Trypanosoma cruzi | 6-phosphogluconate dehydrogenase, decarboxylating | 0.0074 | 0.1325 | 0.1434 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0038 | 0.0046 | 0.0049 |
Leishmania major | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0124 | 0.3099 | 0.3355 |
Schistosoma mansoni | 6-phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.3355 |
Trypanosoma brucei | 6-phosphogluconate dehydrogenase, decarboxylating | 0.0124 | 0.3099 | 0.3355 |
Trichomonas vaginalis | 6-phosphogluconate dehydrogenase, putative | 0.0124 | 0.3099 | 0.3099 |
Trypanosoma brucei | fructose-bisphosphate aldolase, glycosomal, putative | 0.0297 | 0.9238 | 1 |
Loa Loa (eye worm) | 6-phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Plasmodium vivax | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0124 | 0.3099 | 0.3355 |
Trichomonas vaginalis | 6-phosphogluconate dehydrogenase, putative | 0.0124 | 0.3099 | 0.3099 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0 | 0.5 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0156 | 0.4226 | 1 |
Chlamydia trachomatis | 6-phosphogluconolactonase | 0.013 | 0.3301 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0156 | 0.4226 | 1 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE GND1 | 0.0124 | 0.3099 | 0.7333 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0046 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0156 | 0.4226 | 1 |
Trypanosoma cruzi | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0124 | 0.3099 | 0.3355 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
HACU improvement (functional) | = 5 % | Effect on the uptake amount of [3H]-choline in the hippocampal synaptosomes of AF64A-treated rats at 10e-5 M | ChEMBL. | No reference |
HACU improvement (functional) | = 10 % | Effect on the uptake amount of [3H]-choline in the hippocampal synaptosomes of AF64A-treated rats at 10e-6 M | ChEMBL. | No reference |
HACU improvement (functional) | = 26 % | Effect on the uptake amount of [3H]-choline in the hippocampal synaptosomes of AF64A-treated rats at 10e-7 M | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.