TDR Targets

Basic information

Technical information

TDR Targets ID: 501562
Name: 9-cyclohexyl-6-(cyclohexylamino)purine-2-carb onitrile
MW: 324.423 | Formula: C18H24N6
H donors: 1 H acceptors: 4 LogP: 3.95 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1nc(NC2CCCCC2)c2c(n1)n(cn2)C1CCCCC1
InChi: 1S/C18H24N6/c19-11-15-22-17(21-13-7-3-1-4-8-13)16-18(23-15)24(12-20-16)14-9-5-2-6-10-14/h12-14H,1-10H2,(H,21,22,23)
InChiKey: ROMRXCCECCWMGR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

9-cyclohexyl-6-(cyclohexylamino)-2-purinecarbonitrile

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma brucei	cysteine peptidase C (CPC)	Starlite/ChEMBL	References
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative		References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 2b	cysteine peptidase C (CPC)	340 aa	321 aa	26.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0025	0.0082	0.2047
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0047	0.0399	0.0875
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0025	0.0082	0.0276
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.0082	0.0179
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0224	0.2957	0.6481
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0082	0.0082
Brugia malayi	Cathepsin L-like precursor	0.0038	0.0271	0.0593
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0025	0.0082	0.0276
Entamoeba histolytica	cysteine proteinase, putative	0.0034	0.0211	0.5271
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0082	0.0179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0059	0.0577	0.1264
Schistosoma mansoni	cathepsin C	0.0025	0.0082	0.0082
Plasmodium vivax	unspecified product	0.0034	0.0211	0.5271
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.0399	0.0399
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0335	0.4562	1
Leishmania major	cathepsin L-like protease	0.0047	0.0399	0.1351
Leishmania major	cathepsin L-like protease	0.0047	0.0399	0.1351
Echinococcus granulosus	cathepsin b	0.0335	0.4562	0.4562
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0059	0.0577	0.0577
Brugia malayi	Papain family cysteine protease containing protein	0.0034	0.0211	0.0461
Plasmodium vivax	serine-repeat antigen (SERA)	0.0025	0.0082	0.2047
Plasmodium falciparum	serine repeat antigen 7	0.0025	0.0082	0.2047
Plasmodium vivax	vivapain-2	0.0047	0.0399	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0025	0.0082	0.0082
Entamoeba histolytica	cysteine proteinase, putative	0.0038	0.0271	0.6776
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0059	0.0577	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Leishmania major	cysteine peptidase A (CPA)	0.0047	0.0399	0.1351
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0399	0.1351
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0047	0.0399	0.0399
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0034	0.0211	0.0712
Giardia lamblia	Cathepsin B precursor	0.0025	0.0082	0.0276
Giardia lamblia	Cathepsin L precursor	0.0025	0.0082	0.0276
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0399	0.1351
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0211	0.5271
Giardia lamblia	Cathepsin B precursor	0.0025	0.0082	0.0276
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0082	0.0276
Onchocerca volvulus		0.0047	0.0399	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0082	0.0276
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0399	0.1351
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0399	0.0875
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0025	0.0082	0.0179
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.0399	1
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0211	0.5271
Plasmodium falciparum	serine repeat antigen 4	0.0025	0.0082	0.2047
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0271	0.0593
Echinococcus granulosus	cathepsin l1	0.0038	0.0271	0.0271
Onchocerca volvulus		0.0047	0.0399	1
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0211	0.5271
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0025	0.0082	0.2047
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0034	0.0211	0.0211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0038	0.0271	0.0915
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0399	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0025	0.0082	0.2047
Onchocerca volvulus		0.0047	0.0399	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0025	0.0082	0.0179
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0025	0.0082	0.0082
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.0399	0.0399
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0211	0.5271
Giardia lamblia	Cathepsin B precursor	0.0224	0.2957	1
Plasmodium vivax	unspecified product	0.0025	0.0082	0.2047
Loa Loa (eye worm)	cathepsin B	0.0224	0.2957	0.6481
Brugia malayi	Cathepsin L-like precursor	0.0038	0.0271	0.0593
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0082	0.0276
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0034	0.0211	0.5271
Leishmania major	cathepsin L-like protease	0.0047	0.0399	0.1351
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0082	0.0179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0082	0.0276
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0	0.5
Brugia malayi	Cytochrome P450 family protein	0.002	0.0011	0.0024
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0034	0.0211	0.0211
Schistosoma mansoni	cathepsin S (C01 family)	0.0025	0.0082	0.0082
Onchocerca volvulus		0.0047	0.0399	1
Onchocerca volvulus		0.0047	0.0399	1
Echinococcus granulosus	cathepsin b	0.0335	0.4562	0.4562
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0025	0.0082	0.0082
Giardia lamblia	Cysteine protease	0.0025	0.0082	0.0276
Echinococcus granulosus	cathepsin L	0.0025	0.0082	0.0082
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0025	0.0082	0.2047
Entamoeba histolytica	cysteine proteinase, putative	0.0034	0.0211	0.5271
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0059	0.0577	0.1951
Plasmodium falciparum	serine repeat antigen 9	0.0025	0.0082	0.2047
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0399	0.0875
Echinococcus multilocularis	cysteine protease	0.0047	0.0399	0.0399
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0224	0.2957	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0034	0.0211	0.0461
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0025	0.0082	0.2047
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0399	0.0875
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0025	0.0082	0.2047
Giardia lamblia	Cathepsin L precursor	0.0025	0.0082	0.0276
Trypanosoma cruzi	cytochrome P450, putative	0.002	0.0011	0.0024
Giardia lamblia	Cathepsin L-like protease	0.0025	0.0082	0.0276
Giardia lamblia	Cathepsin L precursor	0.0025	0.0082	0.0276
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0025	0.0082	0.0276
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0399	0.1351
Loa Loa (eye worm)	CYP4Cod1	0.002	0.0011	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0271	0.0593
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0025	0.0082	0.2047
Trypanosoma brucei	cytochrome P450, putative	0.002	0.0011	0.0037
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0082	0.0082
Plasmodium vivax	serine-repeat antigen (SERA)	0.0025	0.0082	0.2047
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0082	0.0082
Brugia malayi	cathepsin B-like cysteine proteinase	0.0335	0.4562	1
Echinococcus multilocularis	cathepsin L	0.0034	0.0211	0.0211
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.0577	1
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0399	0.0875
Entamoeba histolytica	cysteine proteinase, putative	0.0034	0.0211	0.5271
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.0399	0.1351
Leishmania major	cathepsin L-like protease	0.0047	0.0399	0.1351
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0025	0.0082	0.0276
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0211	0.5271
Leishmania major	cathepsin L-like protease	0.0047	0.0399	0.1351
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0399	0.1351
Plasmodium vivax	vivapain-1	0.0034	0.0211	0.5271
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0399	0.1351
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0399	0.1351
Leishmania major	cytochrome p450-like protein	0.002	0.0011	0.0037
Plasmodium vivax	vivapain-2	0.0047	0.0399	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0047	0.0399	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0025	0.0082	0.2047
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0211	0.5271
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0082	0.0276
Onchocerca volvulus		0.0038	0.0271	0.5946
Giardia lamblia	Cathepsin B precursor	0.0224	0.2957	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Plasmodium falciparum	serine repeat antigen 3	0.0025	0.0082	0.2047
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0399	0.0875
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0034	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0271	0.0593
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Plasmodium vivax	vivapain-3	0.0034	0.0211	0.5271
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0399	0.1351
Entamoeba histolytica	hypothetical protein	0.0025	0.0082	0.2047
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0047	0.0399	1
Toxoplasma gondii	cathepsin CPC2	0.0025	0.0082	0.0276
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0025	0.0082	0.2047
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0082	0.0179
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0399	0.0875
Plasmodium falciparum	serine repeat antigen 6	0.0025	0.0082	0.2047
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0399	0.1351
Onchocerca volvulus	Cathepsin F homolog	0.0047	0.0399	1
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0055	0.0519	0.1138
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0025	0.0082	0.2047
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0082	0.0276
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0025	0.0082	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0082	0.0179
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0082	0.0179
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0025	0.0082	0.0276
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0025	0.0082	0.0276
Giardia lamblia	Cathepsin B precursor	0.0025	0.0082	0.0276
Plasmodium falciparum	serine repeat antigen 2	0.0025	0.0082	0.2047
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0399	0.1351
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0399	0.0875
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0038	0.0271	0.0593
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.0211	0.0712
Entamoeba histolytica	cysteine proteinase 2	0.0034	0.0211	0.5271
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0082	0.0276
Leishmania major	cathepsin L-like protease	0.0047	0.0399	0.1351
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0224	0.2957	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0025	0.0082	0.0276
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0082	0.2047
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0399	0.1351
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0211	0.5271
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0082	0.2047
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0025	0.0082	0.0179
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0399	0.0875
Schistosoma mansoni	microtubule-associated protein tau	0.0711	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0082	0.0276
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.0399	0.0399
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.0011	0.0024
Echinococcus granulosus	cathepsin L	0.0034	0.0211	0.0211
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0082	0.0082
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0038	0.0271	0.0593
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0025	0.0082	0.0179
Giardia lamblia	Cathepsin L precursor	0.0025	0.0082	0.0276
Brugia malayi	fibroinase precursor	0.0025	0.0082	0.0179
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0211	0.5271
Echinococcus multilocularis	cathepsin L	0.0025	0.0082	0.0082
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.0577	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0025	0.0082	0.2047
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0082	0.2047
Brugia malayi	Cytochrome P450 family protein	0.002	0.0011	0.0024
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0335	0.4562	0.4562
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0082	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0082	0.0179
Plasmodium falciparum	serine repeat antigen 5	0.0025	0.0082	0.2047
Echinococcus multilocularis	cathepsin b	0.0335	0.4562	0.4562
Giardia lamblia	Encystation-specific protease	0.0025	0.0082	0.0276
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0047	0.0399	0.0399
Giardia lamblia	Hypothetical protein	0.0025	0.0082	0.0276
Onchocerca volvulus		0.0047	0.0399	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0335	0.4562	0.4562
Loa Loa (eye worm)	cysteine protease	0.0047	0.0399	0.0875
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0082	0.2047
Giardia lamblia	Cathepsin B precursor	0.0025	0.0082	0.0276
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0082	0.2047
Trypanosoma cruzi	cysteine peptidase, putative	0.0034	0.0211	0.0461
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.0399	0.0399
Brugia malayi	cathepsin F-like cysteine proteinase	0.0025	0.0082	0.0179
Giardia lamblia	Cysteine protease	0.0025	0.0082	0.0276
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0399	0.1351
Giardia lamblia	Cysteine protease	0.0025	0.0082	0.0276
Brugia malayi	cathepsin L-like cysteine proteinase	0.0025	0.0082	0.0179
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0399	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0224	0.2957	0.2957
Plasmodium falciparum	serine repeat antigen 8	0.0025	0.0082	0.2047
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0082	0.0276
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.0399	0.0399
Leishmania major	cathepsin L-like protease	0.0047	0.0399	0.1351
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0399	0.1351
Echinococcus multilocularis	cathepsin b	0.0335	0.4562	0.4562
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.0577	0.0577
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Giardia lamblia	Hypothetical protein	0.0025	0.0082	0.0276
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0034	0.0211	0.0712
Toxoplasma gondii	cathepsin B	0.0224	0.2957	1
Trypanosoma cruzi	cytochrome P450, putative	0.002	0.0011	0.0024
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0082	0.0179
Leishmania major	cathepsin L-like protease	0.0047	0.0399	0.1351
Giardia lamblia	Cathepsin L-like protease	0.0025	0.0082	0.0276
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0025	0.0082	0.0276
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0335	0.4562	0.4562
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0025	0.0082	0.0276
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0399	0.0875
Echinococcus multilocularis	cysteine protease	0.0047	0.0399	0.0399
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.0399	0.1351
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.0011	0.0024
Echinococcus multilocularis	microtubule associated protein 2	0.0711	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0082	0.0276
Trypanosoma cruzi	cysteine proteinase, putative	0.0034	0.0211	0.0461
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0399	0.1351
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0038	0.0271	0.0915
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.0399	0.0399
Echinococcus granulosus	cysteine protease	0.0034	0.0211	0.0211
Giardia lamblia	Cysteine protease	0.0025	0.0082	0.0276
Brugia malayi	Cytochrome P450 family protein	0.005	0.0449	0.0984
Echinococcus granulosus	cathepsin l1	0.0047	0.0399	0.0399
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0082	0.2047
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0399	0.1351
Giardia lamblia	Cathepsin B precursor	0.0224	0.2957	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.0211	0.0712
Toxoplasma gondii	cathepsin CPC1	0.0025	0.0082	0.0276
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0025	0.0082	0.2047
Brugia malayi	Papain family cysteine protease containing protein	0.0034	0.0211	0.0461
Loa Loa (eye worm)	cytochrome P450 family protein	0.005	0.0449	0.0984
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0047	0.0399	1
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0399	0.0875
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0025	0.0082	0.0082
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0224	0.2957	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.0082	0.0179
Brugia malayi	cathepsin L-like precursor	0.0038	0.0271	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0335	0.4562	1
Trypanosoma cruzi	cysteine protease, putative	0.0034	0.0211	0.0461
Loa Loa (eye worm)	ctsf protein	0.0047	0.0399	0.0875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0025	0.0082	0.0276
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0211	0.5271
Brugia malayi	cathepsin L precursor	0.0025	0.0082	0.0179
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0399	0.1351
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0025	0.0082	0.0276
Plasmodium falciparum	serine repeat antigen 1	0.0025	0.0082	0.2047
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0399	0.1351
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0335	0.4562	0.4562
Giardia lamblia	Cathepsin L precursor	0.0025	0.0082	0.0276
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0399	0.0875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0082	0.0276
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0034	0.0211	0.0461
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.0577	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0082	0.0179
Onchocerca volvulus		0.0047	0.0399	1
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.0399	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0034	0.0211	0.5271
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0025	0.0082	0.0082
Trypanosoma cruzi	major cysteine proteinase, putative	0.0025	0.0082	0.0179
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0025	0.0082	0.2047
Loa Loa (eye worm)	fibroinase	0.0047	0.0399	0.0875
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0025	0.0082	0.2047
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0211	0.5271
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0399	0.1351
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0399	1
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0211	0.5271
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0399	0.0875
Giardia lamblia	Cathepsin B precursor	0.0025	0.0082	0.0276
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.002	0.0011	0.019
Toxoplasma gondii	cathepsin CPL	0.0047	0.0399	0.1351
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0047	0.0399	0.0875
Schistosoma mansoni	cathepsin F (C01 family)	0.0038	0.0271	0.0271
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0025	0.0082	0.0276
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0399	0.1351
Echinococcus granulosus	cathepsin L cysteine protease	0.0034	0.0211	0.0211
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0025	0.0082	0.2047
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0025	0.0082	0.0082
Trypanosoma cruzi	cruzipain precursor, putative	0.0047	0.0399	0.0875
Giardia lamblia	Cathepsin L precursor	0.0025	0.0082	0.0276
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0399	0.1351
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0211	0.5271
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0399	0.1351
Entamoeba histolytica	cysteine proteinase, putative	0.0034	0.0211	0.5271
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0025	0.0082	0.0179
Entamoeba histolytica	cysteine protease, putative	0.0034	0.0211	0.5271

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 1.4 uM	Antitrypanosomal activity against Trypanosoma brucei	ChEMBL.	18173229
IC50 (functional)	= 1.4 uM	Antitrypanosomal activity against Trypanosoma brucei	ChEMBL.	18173229
IC50 (binding)	= 3.3 uM	Inhibition of human liver cathepsin L	ChEMBL.	18173229
IC50 (binding)	= 3.3 uM	Inhibition of human liver cathepsin L	ChEMBL.	18173229
IC50 (binding)	= 8.3 uM	Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease	ChEMBL.	18173229
IC50 (binding)	= 8.3 uM	Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease	ChEMBL.	18173229
IC50 (binding)	= 23.6 uM	Inhibition of human liver cathepsin B	ChEMBL.	18173229
IC50 (binding)	= 23.6 uM	Inhibition of human liver cathepsin B	ChEMBL.	18173229

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma brucei	ChEMBL23	18173229
Trypanosoma brucei gambiense		18173229

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL252360
PubChem: 24778049

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 501562