Detailed information for compound 501575

Basic information

Technical information
  • TDR Targets ID: 501575
  • Name: 9-benzyl-6-[(3-methylphenyl)methylamino]purin e-2-carbonitrile
  • MW: 354.408 | Formula: C21H18N6
  • H donors: 1 H acceptors: 4 LogP: 3.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1nc(NCc2cccc(c2)C)c2c(n1)n(cn2)Cc1ccccc1
  • InChi: 1S/C21H18N6/c1-15-6-5-9-17(10-15)12-23-20-19-21(26-18(11-22)25-20)27(14-24-19)13-16-7-3-2-4-8-16/h2-10,14H,12-13H2,1H3,(H,23,25,26)
  • InChiKey: RQZKMGQIIYHOMZ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 9-benzyl-6-(m-tolylmethylamino)purine-2-carbonitrile
  • 9-benzyl-6-(m-tolylmethylamino)-2-purinecarbonitrile
  • 6-[(3-methylphenyl)methylamino]-9-(phenylmethyl)purine-2-carbonitrile
  • 9-benzyl-6-[(3-methylbenzyl)amino]purine-2-carbonitrile
  • 6-[(3-methylphenyl)methylamino]-9-(phenylmethyl)-2-purinecarbonitrile
  • 9-(benzyl)-6-[(3-methylbenzyl)amino]purine-2-carbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma brucei cysteine peptidase C (CPC) Starlite/ChEMBL References
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum cysteine proteinase falcipain 2b cysteine peptidase C (CPC) 340 aa 321 aa 26.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.1834 0.1473
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0424 0.0277
Toxoplasma gondii cathepsin CPL 0.0042 0.1834 0.1473
Loa Loa (eye worm) hypothetical protein 0.002 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.1834 0.1473
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.1262 0.1129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0995 0.0597
Brugia malayi cahepsin L-like non-peptiedase homolog 0.002 0.0424 0.0333
Echinococcus granulosus cathepsin b 0.0169 1 1
Brugia malayi cathepsin L precursor 0.002 0.0424 0.0333
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0424 0.0333
Brugia malayi cathepsin L-like cysteine proteinase 0.002 0.0424 0.0333
Loa Loa (eye worm) inositol-1 0.0036 0.1436 0.1436
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.002 0.0424 0.0277
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.1834 0.0931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473
Entamoeba histolytica cysteine protease, putative 0.0029 0.0995 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0424 0.0277
Echinococcus granulosus cathepsin L 0.002 0.0424 0.0424
Echinococcus multilocularis cathepsin b 0.0169 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0151 0.0151
Onchocerca volvulus 0.0042 0.1834 1
Entamoeba histolytica cysteine protease, putative 0.0042 0.1834 1
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0995 0.0597
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0424 0.0277
Entamoeba histolytica cysteine protease, putative 0.0029 0.0995 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0042 0.1834 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.232 0.2247
Trypanosoma cruzi cysteine peptidase, putative 0.0042 0.1834 0.1473
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1982 0.1982
Entamoeba histolytica cysteine proteinase 2 0.0029 0.0995 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0424 0.0424
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0029 0.0995 0.0597
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.1834 0.1473
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0042 0.1834 0.1834
Brugia malayi Inositol-1 0.0036 0.1436 0.1355
Loa Loa (eye worm) hypothetical protein 0.0042 0.1834 0.1834
Plasmodium falciparum cysteine proteinase falcipain 1 0.0029 0.0995 0.4054
Entamoeba histolytica cysteine proteinase 1, putative 0.0029 0.0995 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.1834 0.0931
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0169 1 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.1436 0.1305
Brugia malayi intermediate filament protein 0.0028 0.0915 0.0829
Leishmania major cathepsin L-like protease 0.0042 0.1834 0.0465
Echinococcus granulosus cathepsin l1 0.0042 0.1834 0.1834
Brugia malayi Cathepsin L-like precursor 0.0042 0.1834 0.1757
Entamoeba histolytica cysteine protease, putative 0.0029 0.0995 0.4054
Brugia malayi fibroinase precursor 0.002 0.0424 0.0333
Onchocerca volvulus 0.0042 0.1834 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0151 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.1834 0.0931
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.1196 0.5
Plasmodium vivax vivapain-2 0.0042 0.1834 1
Onchocerca volvulus 0.0042 0.1834 1
Brugia malayi Cathepsin L-like precursor 0.0033 0.1262 0.118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1982 0.1859
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.1834 0.0931
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.1834 0.0931
Loa Loa (eye worm) hypothetical protein 0.002 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.1262 0.0876
Echinococcus granulosus cathepsin l cysteine peptidase 0.0042 0.1834 0.1834
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.1834 0.0931
Onchocerca volvulus 0.0042 0.1834 1
Leishmania major cathepsin L-like protease 0.0042 0.1834 0.0465
Entamoeba histolytica cysteine protease, putative 0.0029 0.0995 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.1834 0.1473
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.1834 0.0931
Entamoeba histolytica cysteine protease, putative 0.0029 0.0995 0.4054
Loa Loa (eye worm) hypothetical protein 0.002 0.0424 0.0424
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.0995 0.0597
Loa Loa (eye worm) cathepsin B 0.0169 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.1982 0.1906
Brugia malayi Cathepsin L-like cysteine proteinase 0.0033 0.1262 0.118
Onchocerca volvulus Cathepsin L homolog 0.0042 0.1834 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.1834 0.1473
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.1834 0.0931
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1982 0.1982
Brugia malayi Papain family cysteine protease containing protein 0.0042 0.1834 0.1757
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.1436 0.1057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.002 0.0424 0.0277
Echinococcus multilocularis cathepsin L 0.0029 0.0995 0.0995
Entamoeba histolytica cysteine protease, putative 0.0029 0.0995 0.4054
Echinococcus multilocularis lamin 0.0028 0.0915 0.0915
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0169 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1436 0.1057
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0995 0.4054
Schistosoma mansoni lamin 0.0028 0.0915 0.0776
Echinococcus granulosus cysteine protease 0.0029 0.0995 0.0995
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473
Leishmania major cathepsin L-like protease 0.0042 0.1834 0.0465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0169 1 1
Brugia malayi Cathepsin L-like precursor 0.0042 0.1834 0.1757
Entamoeba histolytica cysteine protease, putative 0.0029 0.0995 0.4054
Echinococcus multilocularis lamin dm0 0.0028 0.0915 0.0915
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.232 0.2247
Onchocerca volvulus Cathepsin F homolog 0.0042 0.1834 1
Echinococcus granulosus lamin 0.0028 0.0915 0.0915
Echinococcus multilocularis cathepsin L cysteine protease 0.0042 0.1834 0.1834
Loa Loa (eye worm) hypothetical protein 0.0034 0.1316 0.1316
Echinococcus granulosus cathepsin L cysteine protease 0.0029 0.0995 0.0995
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0151 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.1834 0.1473
Echinococcus multilocularis cysteine protease 0.0042 0.1834 0.1834
Trypanosoma cruzi cysteine protease, putative 0.0029 0.0995 0.0597
Schistosoma mansoni inositol monophosphatase 0.0036 0.1436 0.1305
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0042 0.1834 0.1834
Brugia malayi Cathepsin L-like precursor 0.0042 0.1834 0.1757
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0995 0.0858
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0995 0.0858
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0424 0.0277
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0169 1 1
Echinococcus multilocularis cathepsin b 0.0169 1 1
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.1436 0.1436
Schistosoma mansoni cathepsin F (C01 family) 0.0042 0.1834 0.1709
Brugia malayi Cathepsin L-like precursor 0.0042 0.1834 0.1757
Loa Loa (eye worm) hypothetical protein 0.0033 0.1262 0.1262
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.1834 0.1473
Echinococcus multilocularis cysteine protease 0.0042 0.1834 0.1834
Echinococcus granulosus cathepsin l1 0.0033 0.1262 0.1262
Plasmodium vivax vivapain-1 0.0029 0.0995 0.4054
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.1436 0.1057
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.1436 0.1057
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0995 0.4054
Brugia malayi Cathepsin L-like precursor 0.0033 0.1262 0.118
Loa Loa (eye worm) fibroinase 0.0042 0.1834 0.1834
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.1834 0.0931
Echinococcus granulosus lamin dm0 0.0028 0.0915 0.0915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.1982 0.1982
Leishmania major cathepsin L-like protease 0.0042 0.1834 0.0465
Plasmodium vivax vivapain-2 0.0042 0.1834 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0424 0.0277
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.1316 0.1233
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.002 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0033 0.1262 0.1262
Brugia malayi Cathepsin L-like precursor 0.0042 0.1834 0.1757
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0169 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.1834 0.1473
Entamoeba histolytica cysteine protease, putative 0.0029 0.0995 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0042 0.1834 1
Plasmodium vivax unspecified product 0.0029 0.0995 0.4054
Leishmania major cathepsin L-like protease 0.0042 0.1834 0.0465
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0424 0.0277
Loa Loa (eye worm) hypothetical protein 0.0033 0.1262 0.1262
Loa Loa (eye worm) cysteine protease 0.0042 0.1834 0.1834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.1262 0.0876
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.1436 0.5
Loa Loa (eye worm) hypothetical protein 0.0169 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0915 0.0915
Trypanosoma brucei cysteine peptidase C (CPC) 0.0169 1 1
Schistosoma mansoni cathepsin C 0.002 0.0424 0.0277
Toxoplasma gondii cathepsin B 0.0169 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0042 0.1834 0.1834
Trypanosoma cruzi cysteine peptidase, putative 0.0042 0.1834 0.1473
Schistosoma mansoni cathepsin F (C01 family) 0.0042 0.1834 0.1709
Schistosoma mansoni lamin 0.0028 0.0915 0.0776
Giardia lamblia Cathepsin B precursor 0.0169 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0042 0.1834 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0042 0.1834 0.1834
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.002 0.0424 0.0424
Echinococcus multilocularis cathepsin L cysteine protease 0.0042 0.1834 0.1834
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.0995 0.0597
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.1834 0.1473
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1436 0.1057
Onchocerca volvulus 0.0042 0.1834 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0995 0.0597
Loa Loa (eye worm) hypothetical protein 0.0016 0.0151 0.0151
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0424 0.0333
Leishmania major cysteine peptidase A (CPA) 0.0042 0.1834 0.0465
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0995 0.091
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.1436 0.1436
Trypanosoma cruzi cruzipain precursor, putative 0.0042 0.1834 0.1473
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.1436 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.1834 0.0931
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0995 0.091
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0424 0.0333
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0995 0.0858
Trypanosoma cruzi cysteine peptidase, putative 0.0042 0.1834 0.1473
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1436 0.0489
Leishmania major cathepsin L-like protease 0.0042 0.1834 0.0465
Brugia malayi Cathepsin L-like precursor 0.0042 0.1834 0.1757
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0151 0.0151
Schistosoma mansoni intermediate filament proteins 0.0028 0.0915 0.0776
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473
Brugia malayi cathepsin L-like precursor 0.0033 0.1262 0.118
Loa Loa (eye worm) ctsf protein 0.0042 0.1834 0.1834
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1982 0.1982
Entamoeba histolytica cysteine protease, putative 0.0029 0.0995 0.4054
Onchocerca volvulus 0.0028 0.0915 0.3482
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.1262 0.5946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.1834 0.0931
Giardia lamblia Cathepsin B precursor 0.0169 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473
Onchocerca volvulus 0.0033 0.1262 0.5946
Entamoeba histolytica cysteine protease, putative 0.0029 0.0995 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0424 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0042 0.1834 0.1473
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0169 1 1
Echinococcus multilocularis musashi 0.0028 0.0915 0.0915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473
Plasmodium falciparum cysteine proteinase falcipain 3 0.0042 0.1834 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0094 0.0094
Entamoeba histolytica cysteine protease, putative 0.0029 0.0995 0.4054
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.0424 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473
Echinococcus granulosus GPCR family 2 0.0016 0.0151 0.0151
Plasmodium vivax vivapain-3 0.0029 0.0995 0.4054
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0915 0.0915
Schistosoma mansoni cathepsin S (C01 family) 0.002 0.0424 0.0277
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.1436 0.7179
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0151 0.0151
Echinococcus granulosus cathepsin L 0.0029 0.0995 0.0995
Schistosoma mansoni cathepsin B (C01 family) 0.002 0.0424 0.0277
Echinococcus granulosus intermediate filament protein 0.0028 0.0915 0.0915
Onchocerca volvulus 0.0028 0.0915 0.3482
Loa Loa (eye worm) hypothetical protein 0.0027 0.0882 0.0882
Loa Loa (eye worm) hypothetical protein 0.002 0.0424 0.0424
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1982 0.1982
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0169 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0042 0.1834 1
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0995 0.4054
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0033 0.1262 0.0876
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.1436 0.1057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0042 0.1834 0.1473
Entamoeba histolytica cysteine protease, putative 0.0029 0.0995 0.4054
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0915 0.0829
Entamoeba histolytica cysteine protease, putative 0.0029 0.0995 0.4054
Leishmania major cathepsin L-like protease 0.0042 0.1834 0.0465
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0169 1 1
Leishmania major cathepsin L-like protease 0.0042 0.1834 0.0465
Entamoeba histolytica cysteine proteinase, putative 0.0042 0.1834 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.232 0.232
Trypanosoma cruzi cysteine peptidase, putative 0.0042 0.1834 0.1473
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0424 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473
Loa Loa (eye worm) hypothetical protein 0.002 0.0424 0.0424
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.232 0.232
Schistosoma mansoni hypothetical protein 0.0034 0.1316 0.1183
Onchocerca volvulus 0.0042 0.1834 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1982 0.1859
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0995 0.4054
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0169 1 1
Echinococcus multilocularis cathepsin L 0.002 0.0424 0.0424
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0915 0.0915
Echinococcus granulosus cathepsin b 0.0169 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0151 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1982 0.1859
Echinococcus multilocularis GPCR, family 2 0.0016 0.0151 0.0151
Onchocerca volvulus 0.0042 0.1834 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.1196 0.5
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0424 0.0333
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0042 0.1834 0.1834
Giardia lamblia Cathepsin B precursor 0.0169 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.1834 0.1473

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.48 uM Antitrypanosomal activity against Trypanosoma brucei ChEMBL. 18173229
IC50 (functional) = 0.48 uM Antitrypanosomal activity against Trypanosoma brucei ChEMBL. 18173229
IC50 (binding) = 3.3 uM Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease ChEMBL. 18173229
IC50 (binding) = 3.3 uM Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease ChEMBL. 18173229
IC50 (binding) = 10.52 uM Inhibition of human liver cathepsin L ChEMBL. 18173229
IC50 (binding) = 10.52 uM Inhibition of human liver cathepsin L ChEMBL. 18173229
IC50 (binding) > 30 uM Inhibition of human liver cathepsin B ChEMBL. 18173229
IC50 (binding) > 30 uM Inhibition of human liver cathepsin B ChEMBL. 18173229

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense 18173229
Trypanosoma brucei ChEMBL23 18173229

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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